JP2007195742A - Oral agent feeder for liquid food and the like - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an oral agent feeder for liquid food and the like having a superior hygienic property and a high feeding performance of an oral agent such as the liquid food. <P>SOLUTION: This oral agent feeder for the liquid food and the like is formed of a cylindrical external cylinder 3 having a nozzle 1 at its tip and an opening part 2 at its rear end, a nozzle cap 4 covering the nozzle 1, and a piston 5 slidably inserted into the cylindrical external cylinder 3; and is characterized in that the inner face of the nozzle cap 4 and the liquid contact face of the piston 5 are covered with fluororesin film. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an oral drug supply device such as a syringe-type liquid food, and more particularly to an oral drug supply device such as a liquid food excellent in hygiene.

  Conventionally, there are many cases where a patient eats a liquid food in a hospital or the like. Among patients who eat such liquid food, many liquid food containers are used for patients with swallowing ability (for example, Patent Document 1). However, in the case of patients who have low or no swallowing ability, it is necessary to supply a liquid food into the patient's stomach via a liquid food supply tube. When such a liquid food supply tube is used, it is necessary to forcibly supply the liquid food from the supply port.

A syringe-type device has been proposed as the supply device (for example, Patent Document 2). However, the syringe-type device described in Patent Document 2 has no description on hygiene and no description on the ease of supply of liquid food.
JP 2003-126217 A Japanese Patent Publication No. 7-47045

  Accordingly, an object of the present invention is to provide an oral drug supply device such as a liquid food that is excellent in hygiene and is also excellent in the supply of oral drugs such as a liquid food.

  The above object is achieved by the present invention described below. That is, the present invention has a cylindrical outer cylinder having a nozzle at the front end and an opening at the rear end, a nozzle cap covering the nozzle, and is slidably inserted into the cylindrical outer cylinder. An oral drug supply device such as liquid food (hereinafter simply referred to as “supply device”), characterized in that it comprises a piston, and the inner surface of the nozzle cap and the liquid contact surface of the piston are covered with a fluororesin film. )I will provide a.

In the supply apparatus of the present invention, the fluororesin film has a thickness of 1 to 200 μm; and the nozzle tip outer diameter is 4.20 to 6.0 mm; the nozzle inner diameter is 1 to 3 mm; The inner volume of the cylinder is preferably 20 to 50 cm ³ . In the present invention, “oral drug such as liquid food” means a nutrient or drug that is absorbed into the human body via the human stomach or intestine, including liquid food, oral drugs, and enteral drugs. Hereinafter, these are collectively referred to as “liquid food”.

  ADVANTAGE OF THE INVENTION According to this invention, the supply apparatus which is excellent in hygiene and is excellent also in the supply property of a liquid food can be provided.

  The present invention will now be described in more detail with reference to the accompanying drawings showing the best mode for carrying out the invention. FIG. 1 is a partially cutaway cross-sectional view showing the overall configuration of the supply apparatus 100 of the present invention. As shown in FIG. 1, the supply device of the present invention includes a cylindrical outer cylinder 3 having a nozzle 1 at the front end and an opening 2 at the rear end, a nozzle cap 4 covering the nozzle 1, The piston 5 includes a piston 5 that is slidably inserted into the cylindrical outer cylinder 3, and a plunger 6 that is attached to the piston 5 and moves the piston 5.

  FIG. 2 is an enlarged view of the nozzle cap 4, and the nozzle cap 4 characterizing the present invention is that the cap body 7 and the inner surface of the nozzle storage space 8 formed in the cap body 7 are all made of a fluororesin film 9. It is covered. FIG. 3 is an enlarged view of the piston 5, and the piston 5 characterizing the present invention is that the top surface of the piston in contact with the liquid corrosion of the piston body 10 and the side surface of the piston in contact with the inner surface of the outer cylinder are all fluororesin film. 11 is covered.

  In the supply device shown in FIG. 1, the configuration other than the nozzle cap 4 and the piston 5 is the same as that of various syringes of the prior art, but the size is larger than that of a normal syringe. For example, the outer diameter of the nozzle is increased so that the needle cannot be attached to the nozzle so that the nurse does not accidentally inject the liquid food into the patient. A normal syringe has an outer diameter of the tip of the nozzle of about 3.95 mm, and gradually increases in diameter from the tip of the nozzle toward the opening with an inclination of 6/100 °. The tip outer diameter of the nozzle of the supply device of the present invention is 4.20 mm or more, preferably 6.0 mm or less, and the inclination of the diameter expansion is not limited to 6/100 °, and is appropriately in the range of 1 to 15/100 °. Selectable. However, since it is necessary to connect a nozzle with a tube as it is depending on the case, it is necessary to make it a shape connectable with such a tube.

Regarding the inner diameter of the nozzle, the larger the inner diameter of the nozzle, the more advantageous it is for discharging a liquid food with high viscosity, but there is a problem that the strength of the nozzle is lowered if it is too large. In the present invention, the optimum range of the inner diameter of the nozzle is about 1 to 3 mm and is determined by the outer diameter of the nozzle. The thickness of the nozzle needs to be at least 0.6 mm. However, the larger the outer diameter of the nozzle, the larger the thickness required for maintaining the strength. The inner volume of the outer cylinder is preferably in the range of 20 to 50 cm ³ .

  The outer cylinder 3 having the nozzle 1, the flange 12 and the like is preferably made of a transparent (colorless and transparent), colored transparent or translucent resin, and the resin is not particularly limited. For example, polyethylene terephthalate, copolymer Polyesters such as polyethylene terephthalate, acrylic resins such as polyacrylonitrile, polymethyl methacrylate, polymethacrylic acid, polyolefins such as polypropylene and polyethylene, polyamides such as polyvinyl chloride and nylon, polystyrene, polyethylene naphthalate, cyclic polyolefins (for example, Of ethylene and tetracyclododecene (COC) and norbornene resin ring-opening polymer (COP)), polypropylene, polystyrene, polymethylpentene, polycarbonate, polysulfone Unanetsu thermoplastic resins. Of these resins, cyclic polyolefin is most preferable from the viewpoints of gas barrier property, low elution property, and discardability of the outer cylinder. Use of such a thermoplastic resin is advantageous in terms of reducing the manufacturing cost of the outer cylinder including the nozzle and the flange, reducing the weight, and increasing the range of shape selection, and improves the damage resistance of the outer cylinder.

  The nozzle cap 4 and the piston 5 can be manufactured using rubber materials, vulcanizing agents, and other compounding agents conventionally used for manufacturing various rubber stoppers. The nozzle cap and piston are covered with a fluororesin film at their wetted parts, so there is no concern about contamination due to the eluate from the nozzle cap and piston to the liquid food. Absent. The nozzle cap and the piston need only be covered with a fluororesin film at the liquid contact portion, and the portion in contact with the outer cylinder may be without a film. If it is not covered with a film, the sliding property at the contact portion with the inner surface of the outer cylinder is deteriorated, but the sealing property is improved. Both the nozzle cap and the piston are designed to have the desired lubricity and sealing performance.

  Examples of rubber materials include natural rubber (NR), polyisoprene rubber (IR), polybutadiene rubber (BR), styrene-butadiene copolymer rubber (SBR), butyl rubber (IIR), and butyl rubber further copolymerized with divinylbenzene ( XL-IIR), chlorinated or brominated butyl rubber (Cl-IIR, Br-IIR), ethylene-propylene copolymer rubber (EPM), ethylene-propylene-diene monomer terpolymer rubber (EPDM), acrylonitrile-butadiene copolymer Examples thereof include, but are not limited to, polymer rubber (NBR) and hydrogenated NBR.

  Compounding agents include, for example, organic peroxide vulcanization systems (organic peroxides, multifunctional monomers, etc.), sulfur vulcanization systems (sulfur or sulfur donating compounds and zinc white, stearic acid, various vulcanization accelerators. Etc.), reinforcement / filler, anti-aging agent, processing aid and the like. A rubber composition is prepared by mixing these compounding agents and the rubber material described above using an ordinary mixer such as a roll, a banbury, or a kneader, and this is used for manufacturing a nozzle cap and a piston.

  As the fluororesin film used in the present invention, any film that is inactive (does not swell or dissolve) to the liquid food filled in the supply device can be used. For example, polytetrafluoroethylene (PTFE) , Tetrafluoroethylene-ethylene copolymer (ETFE), tetrafluoroethylene-hexafluoropropylene copolymer (FEP), tetrafluoroethylene-fluoroalkyl vinyl ether copolymer (PFA), polyvinylidene fluoride (PVDF), polychloro Examples thereof include trifluoroethylene (PCTFE). These resins are used as sheets or films.

  For example, the thickness of the fluororesin film is preferably about 1 to 200 μm, and more preferably about 10 to 60 μm. If the thickness of the fluororesin film is less than the lower limit, molding defects such as film tearing may occur when the nozzle cap and the piston are molded. On the other hand, if the thickness of the fluororesin film exceeds the above upper limit value, depending on the constituent material, the followability of the fluororesin film to the nozzle cap and the piston body may be reduced when the nozzle cap and the piston are deformed. May decrease.

  The nozzle cap and the piston are usually manufactured by compression molding using the rubber composition and the fluororesin film, but the manufacturing method is not particularly limited. For example, in the case of manufacturing by a compression molding method, an upper mold and a lower mold in which a predetermined shape is formed in advance are used, and a sheet-like compounded rubber composition and a predetermined portion or the entire surface of fluorine are used in the lower mold. It is manufactured by placing a laminate of resin films, compressing the laminate with an upper mold, and heating the pressure composition under pressure to vulcanize the rubber composition.

  The above-described supply device of the present invention engages the nozzle at one end of a liquid food supply tube (catheter), fills the storage space with the liquid food, and slides the piston, thereby providing the liquid food. It can be forced into the patient's stomach. At this time, since the entire surface of the piston in contact with the liquid food and the inner surface of the nozzle cap are covered with the fluororesin film, the liquid food is not contaminated by the external atmosphere. Further, various additives contained in the piston main body and the nozzle cap main body are not mixed in the liquid food, and these active ingredients are not adsorbed by the piston or the nozzle cap. The feeding device according to the invention is therefore very hygienic. In addition, the supply device of the present invention is superior in supply of liquid food because the nozzle portion is formed in a larger size than the conventional syringe-type supply device.

Next, the present invention will be described more specifically with reference to examples and comparative examples.
Example 1
Using butyl rubber (trade name: Bayer butyl rubber XL-10000, divinylbenzene copolymer partially crosslinked butyl rubber, manufactured by Bayer), a crosslinkable rubber composition for forming a main body of a rubber piston was prepared according to the following formulation.

  On the other hand, a PTFE film (film thickness 20 μm) was prepared for forming a fluororesin coating. The above-mentioned crosslinkable rubber composition sheet and PTFE film are placed in a molding die, press molded at 150 ° C. for 10 minutes, and the predetermined contact surface and the surface in contact with the chemical are PTFE thin films A rubber piston was made that was connected to the coated piston push rod. Similarly, a rubber nozzle cap in which a surface in contact with the nozzle for covering the nozzle portion of the outer cylinder was covered with a PTFE film was prepared. The outer cylinder had a capacity of 50 mL and was made of cyclic polyolefin (COP). A combination of these was designated as Example 1.

Comparative Example 1
Using the rubber composition of the same composition as in Example 1, the above piston and nozzle cap were prepared without forming a fluororesin coating, and silicone oil (made by Shin-Etsu Chemical Co., Ltd., (Product name: Silicone KF-96-350, dimethylpolysiloxane) was applied. These were combined with the outer ring made of cyclic polyolefin used in Example 1 to obtain Comparative Example 1.

(Dissolution test)
The eluate test was performed as follows for Example 1 and Comparative Example 1. The test samples prepared by attaching the pistons of Example 1 and Comparative Example 1 to the syringe barrels of Example 1 and Comparative Example 1 and sucking WFI and heating at 70 ° C. for 30 minutes are sterilized. The measurement was performed in accordance with the measurement method of the eluate test according to the used syringe standard (December 11, 1998, Pharmaceuticals No. 1079, Pharmaceutical Safety Bureau Director's notice). The measurement results are shown in Table 1.

(Drug adsorption test)
(1) Preparation of standard solution Accurately weigh 100 ml of commercially available nitroglycerin (Myristol injection 5 mg / 10 ml, manufactured by Nippon Kayaku) into a 500 ml volumetric flask, and add 400 ml of 5 mass% glucose injection solution to make a standard solution. (The nitroglycerin concentration in this standard solution is 100 mg / l).

(2) A clean outer cylinder having a capacity of 5 mL was filled with the above standard solution, and sealed with the piston and nozzle cap of Example 1 and Comparative Example 1. Place in a thermostat set at 40 ° C with the tip facing up. Collect the standard solution filled every 1 hour, 6 hours, 1 day, 2 days, 4 days, 8 days, and 16 days, and measure the nitroglycerin concentration in the standard solution by liquid chromatography. The nitroglycerin adsorption rate (or residual rate) was calculated from the concentration ratio of each measured value and the standard solution. The results are shown in Table 2.

Measurement conditions (outline)
HPLC: Shimadzu LC-6A
Column: Shim-Pack CLC-ODS
Eluent A: Methanol eluent B: Water detector: UV
Wavelength: 212nm

  According to the present invention as described above, it is possible to provide a supply device that is excellent in hygiene and also in supply of liquid food.

It is a figure explaining the whole supply device of the present invention. It is a figure explaining a nozzle cap. It is a figure explaining a piston.

Explanation of symbols

1: Nozzle 2: Opening portion 3: Cylindrical outer cylinder 4: Nozzle cap 5: Piston 6: Plunger 7: Cap body 8: Nozzle storage space 9: Fluorine resin film 10: Piston body 11: Fluorine resin film 12: Flange 13 : Storage space 100: Supply device

Claims (3)

  A cylindrical outer cylinder having a nozzle at the front end and an opening at the rear end, a nozzle cap covering the nozzle, and a piston slidably inserted into the cylindrical outer cylinder, An oral drug supply device such as a liquid food, wherein an inner surface of a nozzle cap and a liquid contact surface of the piston are covered with a fluororesin film.   The oral drug supply device such as liquid food according to claim 1, wherein the fluororesin film has a thickness of 1 to 200 μm. The oral medicine such as liquid food according to claim 1, wherein the outer diameter of the tip of the nozzle is 4.20 to 6.0 mm, the inner diameter of the nozzle is 1 to 3 mm, and the inner volume of the outer cylinder is 20 to 50 cm ^3. Feeding device.

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