JP2007181408A - Squalene processed food - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide high-quality squalene processed food having a sufficient content rate of any of coenzyme Q-10, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) through regulating unevenness in the content rate of active ingredients of squalene in liver oil of deep-sea shark in accordance with the kind and the habitat area thereof. <P>SOLUTION: The squalene processed food highly contains coenzyme Q-10, and is obtained by mixing liver oil of deep-sea shark having 20-50 wt.% of a low content rate of squalene, with the liver oil of deep-sea shark having 50-80 wt.% of a high content rate of squalene. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a squalene-processed food highly containing coenzyme Q10, and at the same time to a squalene-processed food capable of increasing the content of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid).

  Coenzyme Q-10 (hereinafter referred to as CoQ-10, also known as ubiquinone, 2,3-dimethyl-5-methyl-6-ulti-preny1-1,4-benzquinone.) Was introduced from Crane et al. A coenzyme that was isolated and whose chemical structure was determined by Folkers et al. In 1958, has a molecular weight of 863, and has 10 isoprenoid side chains at the 6-position.

  Moreover, it exists in many mitochondria, such as a heart, a kidney, a liver, and a pancreas, as a fat-soluble substance.

  In nature, it is a substance widely contained in animals and plants to microorganisms, but the amount is extremely small.

  CoQ-10 is also called vitamin Q because of its fine vitamin-like function.

  In Japan, it has been sold as a pharmaceutical for more than 25 years, and 6 million people received CoQ-10 in the early 1980s. Until now, no serious side effects have been reported, and it is also highly safe. One.

  In addition, it was certified as a pharmaceutical in Italy overseas, but it is widely used as a dietary supplement in Europe and the United States.

  In the United States, it has a track record of over 10 years as a dietary supplement as well as a pharmaceutical product. It shows a market growth of around 10% and is a top five popular product in the category of specialty supplements.

  In addition, CoQ-10 has been sold as a pharmaceutical in Japan for over 25 years, and in Europe and America as a dietary supplement for over 10 years, during which no side effects have been reported and high safety has been recognized.

  For example, Kaneka Chemical Co., Ltd. conducted a one-year chronic toxicity test on rats at Covance Laboratories (formerly Hazelton), the world's leading safety evaluation facility, in 1998. However, no toxic findings were observed, confirming high safety.

  Chemical properties are yellow-orange bloody powder with no odor or taste.

  Fat-soluble and hardly soluble in water.

  Although the melting point is 48 ° C., depending on the conditions, it is unstable to light and alkali, and may be unstable to heat, and caution may be required during use and storage.

  There are many soft capsule product forms in the United States, which are distributed in Japan as food.

  Since the raw materials are relatively expensive, so as to increase the effectiveness with a small amount of intake, solubilized soft capsule products are also marketed as a form with increased absorption rate in the body, compared with dry preparations (tablets and hard capsules), There is a higher advantage in the absorption rate in the body, blood concentration, and amount of generated energy.

  Sansei Pharmaceutical (head office: Shimizu City, Shizuoka Prefecture), a capsule manufacturer, has completed the technology of “solubilized capsule” for CoQ-10.

  It is a liquid formulation (soft capsule) in which lipophilic CoQ-10 powder is safely melted in cooking oil using a unique technique.

  In addition, there are two main effects on the human body: energy production activation and antioxidant action.

  Regarding “energy production activation action”, CoQ-10 is an essential component necessary for generating energy by being involved in the electron transfer system in mitochondria that produces cellular energy.

  By giving the reduced CoQ-10 from the outside due to fatigue or aging, the electron transfer system operates efficiently and energy is generated.

  Regarding the “antioxidant action”, the action of reducing oxidized vitamin E radicals back to vitamin E has become clear.

  When CoQ-10 is decreased, vitamin E radicals extract hydrogen from other lipids to produce lipid radicals, and vitamin E cannot suppress the oxidation reaction of lipids, but rather accelerates.

  A reducing agent such as reduced CoQ-10 is indispensable for vitamin E to exert its antioxidant ability to the maximum.

  Currently, the effectiveness of CoQ-10 is being understood in lipoprotein (LDL), which is closely related to arteriosclerosis.

  CoQ-10 is biosynthesized in the body, but it has been confirmed that the amount of CoQ-10 produced decreases year by year.

  For this reason, it becomes necessary to replenish moderately as it gets older.

  On the other hand, young people also suffer from oxidative stress disorders, such as those pointed out during marathons and excessive exercise, such as extreme aerobic movements up to the maximum enzyme intake. Since the CoQ-10 value decreases, it is important to increase the antioxidant capacity of the living body by supplementing CoQ-10 exogenously in advance at such times.

  Many clinical research results of CoQ-10 have been published.

  Major research suggests a link to treatment of heart disease, treatment of muscular dystrophy, gingival disease, improvement of periodontal disease, prevention of breast cancer, Parkinson's disease, etc., and reports on effects after cardiac bypass surgery .

  Overseas, it is used for sports drinks and coffee drinks in addition to capsules and tablets, and as a cosmetic, it has a high level of effect in removing wrinkles from skin with age.

  Some products are added to toothpaste to prevent gingivitis and periodontal disease.

  On the other hand, squalene is an oil obtained by distilling and refining deep sea coral liver oil (squalene) that lives in the deep sea of 300m to 1,000m deep in the main trench extending from Japan to the Philippines.

  Deep-sea sharks that live in the deep sea are able to operate in harsh environments where high water pressure, low oxygen, and light do not reach. They have a strong vitality that can withstand the environment, and support that vitality accounts for 25% of the total weight. It is said to be in liver oil contained in the liver.

  When squalene decreases, it becomes impossible to supply oxygen enough to the cells, aging of the cells progresses, the aging is stopped, and squalene is said to be effective in order to keep the fresh bare skin forever.

  EPA (eicosapentaenoic acid) is a substance that does not exist in land animals or vegetable oils.

  Fish oil has highly unsaturated fatty acids such as "EPA / DHA" (acting to promote the breakdown of blood cholesterol), not fats and saturated fatty acids that are prone to arteriosclerosis, preventing blood clots and arteriosclerosis in the blood. It has the role of reducing cholesterol.

  DHA (docosahexaenoic acid) is an unsaturated fatty acid called docosahexaenoic acid.

  It is said that the function of the brain is improved and is a substance that is attracting attention in the world, and 10% of the fat in the brain is DHA, which is the key to brain cells.

  Coenzyme Q10 is industrially produced, for example, by isolating coenzyme derived from plants such as tobacco and adjusting the side chain length by a synthetic method.

JP-A-12-228987, JP-A-13-061478, and JP-A-14-191367 disclose methods for culturing microorganisms and extracting them from the cells.
JP-A-12-228987 Japanese Patent Laid-Open No. 13-061478 JP-A-14-191367

  However, it is hardly known that such coenzyme Q10 is contained in squalene, and such a report example is not found.

  In the analysis of squalene, the present inventor focused on high energy, foreseen that the content of coenzyme Q10 is high, and as a result of investigating the content of coenzyme Q10 in various deep-sea shark liver oils, It was confirmed that the squalene composed of the liver oil of the eyelid has a higher coenzyme Q10 content than the squalene composed of the normal deep-sealed liver oil in other regions.

  Conversely, it was confirmed that squalene having a high content of coenzyme Q10 has a low content of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid).

  Further, it was confirmed that those having a small content of squalene in liver oil have a high content of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid).

  The present invention has been made in view of the above-mentioned problems, and by adjusting the variation in the content of the active ingredient of squalene in the liver oil according to the type and habitat of deep sea bream, coenzyme Q10, EPA (eicosapentaenoic acid) ) And DHA (docosahexaenoic acid), it is an object to provide a high-quality squalene having a sufficient content.

  In order to solve the above-mentioned problems, claim 1 of the present invention is a squalene processed food characterized in that coenzyme Q10 is highly contained in claim 1 of the present invention.

  In Claim 2 of this invention, it is set as the squalene processed food characterized by containing said Coenzyme Q10 0.01%-10%.

  In claim 3 of the present invention, the deep-sea shark liver oil inhabiting a relatively shallow sea area with a water depth of 500 m to 700 m and the deep-sea shark liver oil inhabiting a deep sea area with a water depth of 700 m to 1400 m are mixed. It is a processed squalene processed food.

  In claim 4 of the present invention, a deep-sea shark liver oil with a low squalene content of 20-50% and a deep-sea shark liver oil with a high squalene content of 50-80% are mixed. It is made into the squalene processed food characterized by being.

  According to claim 5 of the present invention, a deep-sea shark liver oil having a high content of EPA (eicosapentaenoic acid) and a deep-sea shark liver oil having a high content of coenzyme Q10 are mixed. It is what.

  Claim 6 of the present invention is a squalene processed food characterized in that a deep-sea shark liver oil with a high DHA (docosahexaenoic acid) content and a deep-sea shark liver oil with a high content of coenzyme Q10 are mixed. To do.

  According to claim 7 of the present invention, the deep-sea bream is an eye bream, which is a squalene processed food.

  The present invention has the following effects.

  1) It is possible to provide a squalene-processed food that can exert the effect of coenzyme Q10.

  2) A squalene processed food with an increased content of coenzyme Q10 can be provided.

  3) A squalene-processed food with an increased content of EPA (eicosapentaenoic acid) can be provided.

  4) A squalene processed food with an increased content of DHA (docosahexaenoic acid) can be provided.

  5) The squalene processed food which fully contains all the components of coenzyme Q10, EPA (eicosapentaenoic acid), and DHA (docosahexaenoic acid) can be provided.

  6) The squalene processed food which adjusted the content rate of coenzyme Q10, EPA (eicosapentaenoic acid), and DHA (docosahexaenoic acid) can be provided.

  Embodiments of the present invention will be described with reference to the drawings.

  FIG. 1 is a flow chart showing a process for producing a squalene processed food that sufficiently contains all the components of coenzyme Q10, EPA (eicosapentaenoic acid), and DHA (docosahexaenoic acid) according to the present invention.

  The procedure will be described below.

S-1) Liver collection of deep sea cormorant The liver of the eye coral (deep sea cormorant) caught in the sea near Okinawa Prefecture is taken out.

S-2) Crushing process The taken-out liver is crushed finely with a crushing device.

S-3) Separation treatment The crushed liver is allowed to stand for 1 to 4 days to separate the oil and solids, and only the liver is taken out to obtain liver oil.

S-4) Purification treatment The separated liver oil is filtered to remove fine solids and purified.

S-5) Component measurement Component analysis is performed using a part of purified liver oil.

  The components to be analyzed were 1) squalene 2) coenzyme Q103) EPA (eicosapentaenoic acid) 4) DHA (docosahexaenoic acid).

S-6) High content component Liver oil component analysis classifies liver oil having a high content of coenzyme Q10 (0.01% or more).

  High squalene content (50% or more), low EPA (eicosapentaenoic acid) content (less than 0.1%), or low DHA (docosahexaenoic acid) content (less than 1%) The thing corresponds.

S-7) Low content component Liver oil with a low content of Coenzyme Q10 (less than 0.01%) is classified by liver oil component analysis.

  Low squalene content (less than 50%), high EPA (eicosapentaenoic acid) content (0.1% or higher), or high DHA (docosahexaenoic acid) content (1% or higher) The thing corresponds.

S-8) Mixing treatment Liver oil with a high content of the above-mentioned high content component liver oil, ie, coenzyme Q10, and low content component liver oil, ie, high content of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) Is mixed with each other to make up high quality liver oil by supplementing each other's effective amount.

S-9) Filling treatment The mixed liver oil is filled into capsules.

  The capsule may be a hard capsule or a soft capsule.

S-10) A high-quality squalene-processed food containing an effective amount of coenzyme Q10, EPA (eicosapentaenoic acid), and DHA (docosahexaenoic acid) in a squalene-processed food capsule.

  In the above mixing treatment, coenzyme Q10, EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), or the like may be added separately. In that case, a mixing aid or the like may be mixed.

  In the present invention, since heat- and light-sensitive coenzyme Q10 is highly contained, no heat treatment is performed in the production process.

  In addition, since commercially available coenzyme Q10 is hardly soluble and highly coagulable, the addition requires sufficient consideration, and the amount added cannot be expected.

  Mixing with emulsifiers is not preferred.

  In addition, the above-described component measurement need not measure all four components, and may measure any one component.

  In addition, the component measurement step can be omitted if the depth of the collected deep sea bream can be specified, and the deep sea bream that lives in relatively shallow water at a depth of 200 m to 700 m has a low squalene content, so the content is low. Deep sea corals that are classified into component liver oil and inhabit in a relatively deep sea area with a water depth of 700 m to 1400 m can be classified into high component liver oil because of the high content of squalene.

It is a flowchart which shows the manufacturing process of the squalene processed food which fully contains all the components of Coenzyme Q10 by this invention, EPA (eicosapentaenoic acid), and DHA (docosahexaenoic acid).

Explanation of symbols

S-1 Deep sea coral liver sampling S-2 Crushing treatment S-3 Separation treatment S-4 Purification treatment S-5 Component measurement S-6 High content liver oil S-7 Low content liver oil S-8 Mixing treatment S-9 Filling Processing S-10 Squalene processed food

Claims (7)

  A squalene-processed food characterized by containing a high amount of coenzyme Q10.   The squalene processed food according to claim 1, wherein the coenzyme Q10 is contained in an amount of 0.01% to 10%.   A squalene-processed food, characterized in that a deep-sea shark liver oil that inhabits a relatively shallow sea area with a water depth of 200 to 700 m and a deep-sea shark liver oil that lives in a deep sea area with a water depth of 700 to 1400 m are mixed.   A squalene characterized in that a deep-sea shark liver oil having a low squalene content of 20 to 50% and a deep-sea shark liver oil having a high squalene content of 50 to 80% are mixed. processed food.   A squalene processed food, characterized in that a deep-sea shark liver oil with a high content of EPA (eicosapentaenoic acid) and a deep-sea shark liver oil with a high content of coenzyme Q10 are mixed.   A squalene-processed food comprising a mixture of deep-sea shark liver oil having a high DHA (docosahexaenoic acid) content and deep-sea shark liver oil having a high content of coenzyme Q10.   The squalene processed food according to any one of claims 1 to 6, wherein the deep sea bream is an eye bream.

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