JP2007135882A - Clay type iontophoresis device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a clay type iontophoresis device which enables a medicament ion to be administered even to a lesion having a large unevenness such as the root of the toe or the gum. <P>SOLUTION: This iontophoresis device 10 has an operation side electrode structure 20, a non-operation side electrode structure 40, and a DC power source 12 which is connected with them. The operation side electrode structure 20 is constituted of a clay-like substance 22, and an operation side electrode 24. In this case, a medicament which becomes the medicament ion to be administered is blended to the clay-like substance 22, and also, the clay-like substance 22 is freely plastic-deformable. The operation side electrode 24 is formed into a bar form which can be inserted in the clay-like substance 22 at an arbitrary position, and also, is connected with a polarity of the same kind as the medicament ion in the DC power source 12. At the time of use, the clay-like substance 22 is plastic-deformed in a manner to go along the uneven shape of a lesion and closely joined to the lesion. Then, the operation side electrode 24 is inserted in the clay-like substance 22 at a position closer to the lesion, and is set. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a clay-type iontophoresis device for administering drug ions to a living body using a clay-like substance.

  As an iontophoresis device, for example, as described in Patent Document 1, it has a working electrode structure and a non-working electrode structure, and drug ions are removed from the ion exchange membrane of the working electrode structure to the skin or Some penetrate the mucous membrane.

  The iontophoresis device as described above administers drug ions by bringing a flat ion exchange membrane such as a circle at the tip thereof into close contact with the skin or mucous membrane.

  However, skin and mucous membranes to which drug ions are administered by an iontophoresis device are not necessarily flat. For example, in the case of athlete's foot, the base of the toes often becomes an affected area, and this part has a conventional action. It is difficult to bring the drug release site of the side electrode structure into close contact. In addition, there are similar problems in the administration of anesthetics to gums and the like and the administration of periodontal diseases in dentistry.

WO03037425

  An object of the present invention is to provide a clay-type iontophoresis device that can administer drug ions to an uneven affected part such as the base of a toe.

  As a result of diligent research, the present inventor has incorporated a drug that becomes a drug ion into a material that can be plastically deformed in a clay shape (it is not necessarily required to be completely dissolved but may be suspended). The working electrode is freely arranged outside the substance or in the clay-like substance, and when used, the clay-like substance is plastically deformed according to, for example, the V-shaped part of the toes and the base, and is in close contact with the affected part. It was found that drug ions can be administered to the affected area with unevenness of the toe root by energizing from the side electrode.

  That is, the following problems can be solved by the following embodiments.

  (1) A working electrode structure used for administering drug ions by iontophoresis, a non-working electrode structure as a counter electrode, and these working electrode structures and non-working A DC power source connected to the side electrode structure with different polarities, and the working side electrode structure is plastically deformable, and a drug that becomes the drug ion is blended (mixing is addition, impregnation or A clay-like substance that is dissolved), and a working electrode that is electrically connected to the clay-like substance and is connected to the same polarity as the drug ion in the DC power source. A clay-type iontophoresis device.

  (2) The clay-type iontophoresis device according to (1), wherein the working electrode is provided so as to be inserted and set at an arbitrary position in the clay-like substance.

  (3) A container filled with the clay-like substance, and a seal member that seals the container in a state filled with the clay-like substance and is removable from the container (1) or The clay-type iontophoresis device according to (2).

  (4) The clay-type iontophoresis device according to (3), wherein the container is elastically deformable so as to extrude the filled clay-like substance.

  (5) The clay iontophoresis device according to (3) or (4), wherein a part or all of the seal member is configured to be the working electrode.

  (6) The clay-type iontophoresis according to any one of (1) to (5), wherein the working electrode is formed into a sheet shape that can be freely bent, wound, or curved. Cis equipment.

  (7) The clay according to any one of (1) to (4), wherein the working electrode is made of any one of rod-like or plate-like carbon, silver, silver chloride, gold, platinum, and aluminum. Type iontophoresis device.

  (8) The clay electrode according to any one of (1) to (6), wherein the working electrode is made of any one of a sheet-like carbon fiber, silver, silver chloride, gold, platinum, and aluminum. Iontophoresis device.

  (9) The non-working side electrode structure includes a non-working side ion exchange membrane that selects ions opposite to the drug ions, and a non-working side electrode connected to the polarity opposite to the drug ions in the DC power supply A clay-type iontophoresis device according to any one of (1) to (8), further comprising: an electrolyte solution holding unit disposed on the front surface of the non-working side electrode. .

  In this invention, since the working electrode structure is blended with a drug serving as a drug ion and is provided with a material that can be freely plastically deformed, the working electrode structure can be reliably applied to uneven affected parts such as the bases of toes. The drug ions can be administered here.

  The clay-type iontophoresis device according to this best mode includes a working electrode structure that can be plastically deformed into a clay-like shape, a clay-like substance that contains a drug that becomes drug ions, and a drug ion in a DC power source. And a working electrode provided in electrical connection with the clay-like substance, and the clay-like substance is plastically deformed according to the unevenness of the affected part and affected part. The rod-like or sheet-like working electrode is inserted into the clay-like substance and set.

  Hereinafter, a clay iontophoresis device according to a first embodiment of the present invention will be described in detail with reference to FIGS.

  The clay-type iontophoresis device 10 according to the first embodiment includes a working electrode structure 20 and a non-working electrode structure 40 that are used for administering drug ions by iontophoresis, and their functions. A DC power source 12 connected to the side electrode structure 20 and the non-working side electrode structure 40 with different polarities.

  The working electrode structure 20 has an ion exchange property that allows ions of the same type as the drug ions to be administered to selectively pass through, and can be plastically deformed into a clay shape. And a working electrode 24 that is connected to the same polarity as the drug ions in the DC power source 12 and is electrically connectable to the clay-like material 22. It is configured. Note that a part of the drug may be dissolved in the clay-like substance 22, and the clay-like substance 22 may be non-ion-exchangeable.

  The working electrode 24 is made of a material that does not harm the human body such as plate-like or fan-like carbon (including carbon fiber), silver, silver chloride, gold, platinum, aluminum, and the like, and is in an arbitrary position in the clay-like substance. It can be inserted and set. Reference numeral 25 in FIG. 1 denotes a cord that connects the working electrode 24 and the power source 12.

The clay-like substance 22 includes an ion exchange resin into which an ion exchange group that selectively allows the same kind of ions as the drug ions to be introduced, for example, a sol, a gelatin gel, a starch gel, or a viscous substance. In addition, a drug in which the medicinal component dissociates into drug ions by being dissolved in a solvent such as water, for example, an athlete's foot treatment drug or an antibiotic is blended. Furthermore, the clay-like substance 22 does not need to contain an ion exchange resin when the electroosmotic action mainly works.

  Here, the clay-like substance 22 may be anything as long as it can be plastically deformed into a clay-like shape, and can be brought into close contact with the surface of the body (affected part).

  When the drug compounded in the clay-like substance 22 is an athlete's foot therapeutic agent, for example, itraconazole (triazole antifungal agent), undecylenic acid-zinc (parasitic skin disease agent), undecylen-salicylic acid (parasitic skin disease) Therapeutic agent), amorolfine hydrochloride (antifungal agent), croconazole hydrochloride (imidazole antifungal agent), terbinafine hydrochloride (allylamine antifungal agent), neticonazole hydrochloride (imidazole antifungal agent), butenafine hydrochloride (benzylamine antifungal agent) Fungi), clotrimazole (antifungal), griseofulvin (antifungal antibiotic), ketoconazole (imidazole antifungal), salicylic acid (keratin softening / anti-tinea), zinc oxide (dermatological treatment) , Ciclopirox olamine (antifungal agent), siccanin (antifungal antibiotic), isonitrate Nazole (antifungal agent), econazole nitrate (imidazole antifungal agent), oxyconazole nitrate (imidazole antifungal agent), sulconazole nitrate (imidazole antifungal agent), tolnaphthalate (anti-angiotic agent), tolnaphthalate / chlorhexidine hydrochloride (Anti-tinea), bifonazole (antimycotic), miconazole (phenethylimidazole antifungal), moctar (external preparation for skin diseases), lanoconazole (imidazole antifungal), or riranaphthate (anti-tinea) .

  When the drug compounded in the clay-like substance 22 is an antibiotic, for example, actinomycin D, azithromycin hydrate, aztreonam, acetyl kitasamycin, acetyl spiramycin, amoxicillin, potassium clavulanate, sulbactam sodium, imipenem Erythromycin ethyl succinate, erythromycin, aclarubicin hydrochloride, amrubicin hydrochloride, oxytetracycline hydrochloride, oxytetracycline hydrochloride, oxytetracycline hydrochloride, spectinomycin hydrochloride, cefepime hydrochloride, cefozopran hydrochloride, cefotiam hydrochloride, cefotiam hexetyl hydrochloride, cefcapene pivoxil hydrochloride, Cefmenoxime hydrochloride, tetracycline hydrochloride, tetracycline hydrochloride, demethylchlortetracycline hydrochloride, doxycycline hydrochloride Minocycline hydrochloride, lincomycin hydrochloride, carmonam sodium, kitasamycin, betamethasone valerate, clarithromycin, clindamycin, chloramphenicol, griseofulvin, chloramphenicol sodium succinate, colistin sodium methanesulfonate, cycloserine, Midecamycin acetate, Siccanin, Kitasamycin tartrate, Josamycin, Erythromycin stearate, Cefaclor, Cefazolin sodium, Cephatrizine propylene glycol, Cephadroxyl, Cephalexin, Cephalothin sodium, Cefixime, Cefodizime sodium, Cefotetan sodium, Cefotetane, Cefoperazone cefoperazone Pivoxil, cefdinir, cefrosin sodium , Ceftazidime, ceftizoxime sodium, ceftibutene, cefteram pivoxil, ceftriaxone sodium, cefpiramide sodium, cefbuperazone sodium, cefpodoxime proxetil, cefminox sodium, cefmetazole sodium, cefloxazine, cefur Ximexetil, tazobactam sodium, teicoplanin, telithromycin, tobramycin, nystatin, bacitracin, bacitracin, panipenem betamipron, chloramphenicol palmitate, biapenem, faropenem sodium, sodium fusidate, flomoxef sodium, propionate josamycin , Benzylpenicillin potassium, benzylpenicillin benzathine, fosfomycin, mitomycin C, midecamycin , Meropenem trihydrate, erythromycin lactobionate, erythromycin lactobionate, latamoxef sodium, rifampicin, astromycin sulfate, amikacin sulfate, arbekacin sulfate, isepamicin sulfate, enviomycin sulfate, kanamycin sulfate, gentamicin sulfate, colistin sulfate, sulfate Sisomycin, dibekacin sulfate, streptomycin sulfate, cefocery sulfate, cefpirome sulfate, netilmycin sulfate, fradiomycin sulfate, bleomycin sulfate, bekanamycin sulfate, pepromycin sulfate, polymyxin B sulfate, micronomycin sulfate, ribostamycin sulfate, or roxithromycin There is rokitamycin.

  When the ion exchange resin contained in the clay-like substance 22 is a cation exchange resin, it is a three-dimensional one such as a hydrocarbon resin such as a polystyrene resin or an acrylic acid resin or a fluorine resin having a perfluorocarbon skeleton. An ion exchange resin in which a cation exchange group such as a sulfonic acid group, a carboxylic acid group, or a phosphonic acid group (an exchange group whose counter ion is a cation) is introduced into a polymer having a network structure can be used without limitation. it can.

  In the case of an anion exchange resin, a polymer having the same three-dimensional network structure as the cation exchange resin is added to a primary to tertiary amino group, a quaternary ammonium group, a pyridyl group, an imidazole group, a quaternary group. An ion exchange resin into which an anion exchange group (an exchange group in which the counter ion is an anion) such as a pyridium group or a quaternary imidazolium group is introduced can be used without limitation.

  The non-working side electrode structure 40 has a patch shape, and a button battery serving as the DC power source 12 is integrally provided on one surface of the base sheet 42, and the non-working side is provided on the other surface. The side electrode 44, the electrode side electrolyte solution holding part 46, the electrode side ion exchange membrane 48, the tip side electrolyte solution holding part 50, and the tip side ion exchange membrane 52 are laminated in this order. The non-working side electrode 44 is connected to a polarity different from that of the drug ion of the DC power supply 12.

  Reference numeral 54 in FIG. 1 denotes an adhesive layer disposed on the outer side of the front-end side ion exchange membrane 52 and flush therewith. The pressure-sensitive adhesive layer 54 is used to bring the non-working side electrode structure 40 into close contact with the skin or the like.

  The non-working side electrode 44 may be made of a conductive material mixed with a non-metallic conductive filler such as a carbon paste applied to the other surface of the base sheet 42. The non-working side electrode 44 can be formed of a copper plate or a metal thin film. However, since the metal eluted from the non-working side electrode 44 may be transferred to a living body upon drug administration, non-metallicity is preferable. Alternatively, a metal that does not adversely affect the living body is preferable.

  The electrode side electrolyte solution holding part 46 is composed of an electrolyte disposed in contact with the non-working side electrode 44. Examples of the electrolyte include electrolytes that are more easily oxidized or reduced than water electrolysis (oxidation at the positive electrode and reduction at the negative electrode), such as drugs such as ascorbic acid (vitamin C) and sodium ascorbate, lactic acid, It is particularly preferable to use an organic acid such as acid, malic acid, succinic acid, and fumaric acid and / or a salt thereof, which can suppress the generation of oxygen gas and hydrogen gas, By blending a plurality of types of electrolytes that become buffer electrolytes when dissolved, pH fluctuations during energization can also be suppressed. The tip side electrolyte solution holding unit 50 has the same configuration.

  The electrode side electrolyte solution holding unit 46 and the tip side electrolyte solution holding unit 50 may be made of a fiber sheet such as gauze or filter paper, an acrylic resin hydrogel (acrylic hydrogel), a segmented polyurethane gel, or the like. The carrier is made of an arbitrary material having water retention properties such as a molecular gel sheet, and the electrolytic solution is impregnated or contained therein. Alternatively, the electrolytic solution may be held in a liquid state.

  The electrode side ion exchange membrane 48 is made of an ion exchange resin that selectively passes ions different from the drug ions, and an anion exchange is used when a drug in which the medicinal component in the drug holding unit 28 is dissociated into cations is used. On the contrary, when a drug in which a medicinal component dissociates into an anion is used, a cation exchange resin is blended.

  The tip side ion exchange membrane 52 is made of an ion exchange resin that selectively passes the same type of ions as the drug ions. When the drug ions are cations or anions, a cation exchange resin or an anion exchange resin is used. Blended.

  Examples of the cation exchange resin include a sulfonic acid group, a carboxylic acid, a polymer having a three-dimensional network structure such as a hydrocarbon resin such as a polystyrene resin or an acrylic acid resin, or a fluorine resin having a perfluorocarbon skeleton. An ion exchange resin into which a cation exchange group such as a group or a phosphonic acid group (an exchange group in which the counter ion is a cation) is introduced can be used without limitation.

  The anion exchange resin includes a polymer having the same three-dimensional network structure as the cation exchange resin, a primary to tertiary amino group, a quaternary ammonium group, a pyridyl group, an imidazole group, a quaternary group. An ion exchange resin into which an anion exchange group such as a pyridinium group or a quaternary imidazolium group (an exchange group in which the counter ion is an anion) is introduced can be used without limitation.

  Reference numeral 55 in FIG. 1 denotes a connection terminal that penetrates the base sheet 42 and connects the non-working side electrode 44 and the DC power source 12. The DC power supply 12 and the working electrode structure 20 are connected via the cord 25.

  In the working side electrode 20, the clay-like substance 22 is stored in a container 26 during storage and is sealed by a sealing film 28 serving as a lid, thereby preventing the drug from being diffused.

  When the clay-like material type iontophoresis device 10 is used, the clay-like material 22 is extruded by peeling the seal film 28 from the container 26 and elastically deforming the container 26 by pushing the container 26 from the outside. Or you may take out with a clean hand.

  Next, when treating athlete's foot under the toes, for example, the clay-like substance 22 is plastically deformed so that the tip becomes V-shaped, and this is further converted into toes 60A and 60B as shown in FIG. The surface of the clay-like substance 22 is plastically deformed in a state corresponding to the affected part 62 and fixed between the toes 60A and 60B. At this time, if necessary, for example, the clay-like substance 22 may be wrapped together with the affected part by a polyethylene film or the like. Furthermore, the rod-like or plate-like working electrode 24 is inserted into the clay-like substance 22 at a position near the affected part 62 and set.

  Next, the tip side ion exchange membrane 52 at the tip of the non-working side electrode structure 40 is fixed in contact with the vicinity of the toes, so that the current from the DC power source 12 is applied to the working side electrode 24, the clay-like shape. DC from the affected part 62 of the substance 22, the toes 60A and 60B, the tip side ion exchange membrane 52, the tip side electrolyte solution holding unit 50, the electrode side ion exchange membrane 48, the electrode side electrolyte solution holding unit 46, and the non-working side electrode 44. The anthracnose therapeutic agent mixed in the clay-like substance 22 flows through the circuit returning to the power source 12 and its medicinal components become drug ions, and penetrates from the surface of the clay-like substance 22 to the affected part 62 at the base of the toes 60A and 60B. Will be.

  At this time, since the clay-like substance 22 can be freely plastically deformed along the shape of the toes 60A and 60B, it is in a state of being in close contact with the affected area 62, and drug ions are administered to the affected area 62 with a high transportation number. Is done. Further, even if the toes 60A and 60B are moved a little during treatment, the close contact state of the clay-like substance 22 does not change, so that a sufficient transport number can be obtained.

  Next, a clay iontophoresis device 70 according to Embodiment 2 of the present invention shown in FIG. 3 will be described.

  The working electrode structure 72 in the clay iontophoresis device 70 uses a sheet-like working electrode 74 that can be deformed by at least one of bending, winding, and bending. That is, the sheet-like working electrode 74 has a bent shape 74A as shown in FIG. 4A, a wound shape 74B as shown in FIG. 4B, and a curve as shown in FIG. 4C. The shape 74C can be deformed, and is made of, for example, a film made of the same material as the working electrode 24 such as silver or silver chloride, or a resin sheet bonded with these. The working side electrode 74 is inserted into or stuck to the clay-like material 22 after being deformed.

  The configuration of the clay-type iontophoresis device 70 according to the second embodiment is the same as the configuration of the clay-type iontophoresis device 10 of the first embodiment, except for the working electrode structure 72. The same reference numerals as those in FIGS. 1 and 2 are assigned to the portions, and the description thereof will be omitted.

  The sheet-like working electrode 74 in the working electrode structure 72 of the clay-type iontophoresis device 70 according to the second embodiment is configured to be freely deformable, and is adapted to the shape of the clay-like substance 22 when used. And an optimum shape.

  In the second embodiment, the sheet-like member constituting the working electrode 74 may be constituted by the seal film 28 that serves as a lid for the container 26. In this case, as shown in FIG. 5, a film 30 made of the same material as the working electrode 24, such as silver or silver chloride, is formed on the outside of the seal film 28, and the seal film 28 after peeling off is appropriately used. It is preferable that the membrane 30 be an electrode by being deformed.

  Further, in Examples 1 and 2 above, the working electrode structure is composed of a clay-like substance containing a drug and the working electrode, but the present invention is not limited to this. For example, FIG. As in the clay-type iontophoresis device 80 according to Example 3 shown in FIG. 4, the working-side electrode structure 82 is disposed between the working-side electrode 24 and the clay-like substance 22. In addition, a working ion exchange membrane 86 may be provided.

  In this case, the working side electrolyte holding part 84 may have the same configuration as the electrode side electrolyte holding part 46 of the non-working side electrode 44 in the first embodiment. The working side ion exchange membrane 86 may be formed of an ion exchange membrane that selects ions opposite to the drug ions.

  Furthermore, in each of the above embodiments, the working electrode is composed of carbon containing carbon fiber, silver, silver chloride, gold, platinum, or aluminum, but the present invention is not limited to this, Another conductive material, for example, a conductive paint in which a non-metallic conductive filler such as a carbon paste similar to the non-working side electrode 44 is blended may be used. In this case, a conductive paint is applied to the base sheet in a belt state.

Schematic sectional view showing a clay-type iontophoresis device according to Embodiment 1 of the present invention. Schematic perspective view showing the wearing state when treating footworm base athlete's foot with the clay-type iontophoresis device The perspective view which shows the working side electrode structure of the clay type iontophoresis apparatus which concerns on Example 2 of this invention. The perspective view which shows the example of the deformation | transformation state of the action | operation side electrode in Example 2 The perspective view which shows the other example of the working side electrode in the Example 2 Schematic sectional view showing a working electrode structure in a clay iontophoresis device according to Embodiment 3 of the present invention

Explanation of symbols

DESCRIPTION OF SYMBOLS 10, 70, 80 ... Clay type | mold iontophoresis apparatus 12 ... DC power supply 20, 72, 82 ... Working side electrode structure 22, 23 ... Clay-like substance 24, 74 ... Working side electrode 26 ... Container 28 ... Seal film 30 ... Membrane 40 ... Non-working side electrode structure 42 ... Base sheet 44 ... Non-working side electrode 46 ... Electrode side electrolyte holding part 48 ... Electrode side ion exchange membrane 50 ... Tip side electrolyte holding part 52 ... Tip side ion exchange membrane 55 ... Connection terminal 60A, 60B ... Toe 62 ... Affected part 84 ... Working side electrolyte holding part 86 ... Working side ion exchange membrane

Claims (9)

Working electrode structure used for administering drug ions by iontophoresis, non-working electrode structure as a counter electrode, and working and non-working electrode structures A DC power source connected to the body with different polarities,
The working electrode structure is
A clay-like substance which is plastically deformable and contains a drug that becomes the drug ion;
A working electrode connected to the same kind of polarity as the drug ion in the DC power source and electrically connectable to the clay-like substance;
A clay-type iontophoresis device comprising: In claim 1,
The clay-type iontophoresis device is characterized in that the working electrode is provided so as to be inserted and set at an arbitrary position in the clay-like substance. In claim 1 or 2,
A clay iontophoresis device comprising: a container filled with the clay-like substance; and a seal member that seals the container in a state filled with the clay-like substance and is removable from the container. . In claim 3,
The clay iontophoresis device is characterized in that the container is elastically deformable so as to extrude the filled clay-like substance. In claim 3 or 4,
The clay-type iontophoresis device is characterized in that a part or all of the seal member is configured to be the working electrode. In any one of Claims 1 thru | or 5,
The clay-type iontophoresis device, wherein the working electrode is formed into a sheet shape that can be freely bent, wound, or curved. In any one of Claims 1 thru | or 4,
The clay iontophoresis device, wherein the working electrode is made of any one of rod-like or plate-like carbon, silver, silver chloride, gold, platinum, and aluminum. In any one of Claims 1 thru | or 6.
The working electrode is a clay-type iontophoresis device comprising any one of a sheet-like carbon fiber, silver, silver chloride, gold, platinum, and aluminum. In any one of Claims 1 thru | or 8.
The non-working side electrode structure includes a non-working side ion exchange membrane that selects ions opposite to the drug ions;
In the DC power supply, at least a non-working side electrode connected to a polarity opposite to that of the drug ion, and an electrolyte solution holding unit disposed in front of the non-working side electrode are provided. Clay type iontophoresis device.

Images