JPH04297277A - Drug permeator using electrophoresis - Google Patents

Abstract

PURPOSE:To provide an apparatus by allowing permeation of ionic effective components of a drug into a cutaneous lesion quickly and appropriately by electrophoresis. CONSTITUTION:In a permeator of a drug by using electrophoresis, a drug holding material for holding ionic effective components of the drug and an cationic and/or anionic ion exchange resin film are arranged on the front of an electrode of a power source for electrophoresis to let the effective components of the drug pass quickly and appropriately because of selective transmittance of the ion exchange resin film.

Description

[Detailed description of the invention]

0001

[Industrial Application Field] The present invention relates to iontophoretic therapy (Io
In other words, it relates to a device that uses electrophoresis to painlessly infiltrate a desired affected area with a medicinal solution in the form of ions using electrophoresis.

0002

BACKGROUND OF THE INVENTION Iontophoretic therapy is widely known, and is a treatment method that takes advantage of the fact that most drugs are electrolytes (ionically dissociable) and that ions are always present. That is, the active ingredient of the drug is an electrolyte, and when an electric field is applied to an aqueous solution containing the electrolyte, cations in the aqueous solution move to the cathode, and anions move to the anode by electrophoresis. Therefore, based on this principle, the active ingredients (ions) of the drug can be permeated into the desired affected area in a painless manner.

[0003] This will be explained with reference to the drawings. FIG. 4 illustrates a mode in which sodium ascorbate is used as a drug and the active ingredient of the drug is permeated into the skin (desired affected area) by electrophoresis, and belongs to the prior art. In FIG. 4, ascorbic acid ions are shown as A-, sodium ions are shown as Na+, and phosphate ions contained in a phosphate buffer solution added as a pH stabilizer for drugs are shown as H2PO4-. In Figure 4, a drug-retaining material (gauze) impregnated with a sodium ascorbate solution is connected to the skin (affected area) and an electrode (- electrode) connected to a power source.
The other pole (+ pole) is constructed in the same way. When a voltage is applied between the electrodes in such a state, the following phenomenon occurs. In this case, sodium ascorbate, which is the active ingredient of the drug impregnated into the gauze serving as the drug-retaining material, is ascorbate ion (A-).
and sodium ions (Na+), and both of them migrate to the electrodes opposite to their respective polarities due to the electric field, and electricity is applied, that is, a current flows. What we must pay attention to here is the transference number of each ion. In the case of the above example, the transport number of Na+ is extremely larger than that of A-, and A-, which is the active ingredient of the drug, hardly moves. Therefore, in such an embodiment, the active ingredient of the drug cannot be quickly and effectively penetrated into the desired affected area. When the applied electric field is increased in an attempt to eliminate the above-mentioned drawbacks, the active ingredients of the drug cause an electrode reaction at the electrodes, which seriously affects the skin (affected area). For example, in the case of FIG. 1, at the negative pole, harmful components and hydrogen are generated due to reductive decomposition of ascorbic acid. On the other hand, at the positive electrode, harmful components and oxygen are generated due to oxidative decomposition of ascorbic acid. From the above points, the conventional iontophoretic method using electrophoresis as shown in Figure 4 cannot efficiently penetrate the active ingredients of drugs into the skin (affected area), even deep into the dermis (dermis). .

0004

SUMMARY OF THE INVENTION The present inventors have made extensive studies in order to eliminate the drawbacks of the conventional ion permeation method described above. As a result, they discovered that by using an ion-exchange resin membrane that is selective in ion permeability, the active ingredients of a drug can be penetrated into the desired affected area extremely efficiently, leading to the completion of the present invention. .

[0005]

[Means for Solving the Problems] To summarize the present invention, in a drug infiltration device using electrophoresis, an electrode, a drug holding material for holding a drug, and a drug are provided on the front side of a power supply unit for electrophoresis. The present invention relates to a drug permeation device using electrophoresis, characterized in that it is provided with an ion exchange resin membrane that selectively permeates ionic active ingredients.

[0006] The technical configuration and embodiments of the present invention will be explained below with reference to the drawings. It goes without saying that the present invention is not limited to what is shown in the drawings. The greatest feature of the present invention is that, as described above, a drug-retaining material for simply holding a drug is not placed on the electrode on the front side of the electrophoresis power supply section that constitutes a drug infiltration device by electrophoresis. , in that an ion exchange resin membrane that selectively transmits the ionic active ingredient of the drug is provided together with the drug holding material. The advantages of using the ion exchange resin membrane in the present invention will be explained with reference to FIGS. 1 and 2.

FIG. 1 shows a part of a drug infiltration device using electrophoresis, which includes gauze as a drug holding material on top of the electrophoresis power source and an anion exchange resin membrane disposed on the gauze.
The overall structure will be explained with reference to FIG. 3, which will be described later. )It is shown. In addition, in FIG. 1, it is assumed that the negative pole side is brought into contact with the skin on the affected area side. Further, as in FIG. 4, an aqueous solution of sodium ascorbate is used as the drug. In Figure 1, since an anion exchange membrane is used, unlike in Figure 4, Na+ cannot pass through the anion exchange membrane, and the movement of cations is effectively suppressed, so the movement of anions (ascorbate ions) only occurs. In Figure 4, Na+ mainly penetrates into the skin, whereas in Figure 1, only ascorbic acid ion (A-) selectively penetrates into the skin because an anion exchange membrane is used. I will continue to do so. In other words, the anion exchange membrane can be considered to greatly contribute to the administration of ascorbic acid to the skin (affected area) using electrophoretic phenomena.

[0008] In the present invention, the embodiment in which the ion exchange resin membrane is used is not limited to the above example. FIG. 2 shows the embodiment of FIG. 1 in which a cation exchange membrane is further provided on the negative pole side. In this case, even if the applied voltage is higher than that in FIG. 1, the electrode reaction at the ascorbic acid electrode can be suppressed. In other words, even if the applied voltage is increased, the cation exchange membrane prevents the ascorbic acid ion (A-), which is the active ingredient of the drug, from moving toward the negative electrode, and the electrode reaction (ascorbic acid) on the negative electrode occurs. acid decomposition)
is prevented. Thereby, ascorbic acid ion (A-) can be effectively and efficiently penetrated into the desired affected area.

As described above, by using an anion exchange membrane as shown in FIG. 1, when administering a drug using an electric field, only the desired ionic species can be selectively administered, making it more effective. drug administration by iontophoresis. On the other hand, as can be seen from FIG. 2, if it is desired to selectively administer cations, a cation exchange membrane may be used. As these ion exchange resin membranes, ordinary ones may be used and there are no particular restrictions. for example,
As anion exchange membranes, membranes with quaternized ammonium groups in the polymer side chains may be used, and as cation exchange membranes, membranes with sulfonic acid groups in the polymer side chains may be used. Alternatively, as shown in FIG. 2, they are used in appropriate combinations depending on the type of ionic species of the drug. Any drug that undergoes ion dissociation and electrophoresis can be used as a pharmaceutical agent, but the ion exchange resin membrane to be used may be selected depending on how these active ingredients are ion-dissociated. Commonly used drugs include local anesthetics (cocaine, novocaine, narcaine), iodopotassium, calcium chloride, histamine, various vitamins (B1, C, etc.), and cathodic drugs such as chloride (corrosive). ), titrate (an analgesic), potassium iodide, and penicillin. The ion exchange resin membrane to be used may be selected depending on the polarity of these drugs.

FIG. 3 shows a schematic diagram of the electrophoretic drug permeation device of the present invention. The drug infiltration device (1) of the present invention shown in FIG.
A drug holding material (4) is placed on the top surface, and two ion exchange resin membranes (5, 51) sandwiching a drug holding material (41) on top of the drug holding material (4).
), and is constructed by arranging a drug holding material (42) at the top. In addition, in FIG. 3, the drug infiltration device (
1) A lid holder (6) surrounding the electrode (3) and drug holding material (4) and a lid (7) fixed to the lid holder (6) are shown on the front side of the device. There is. Lid holder (6)
and the lid (7) are fixed at the drug holding material (4).
, 41, 42) are provided with a packing (8) to prevent the chemical solution impregnated into the parts from leaking to other parts. However, in the present invention, the structures of the lid holder (6) and the lid (7) may be of any desired structure, and their fixing means may be of any type, such as a screw type or a hook type. The drug penetration device (1
), the drug holding material may be any material that can hold the drug solution, such as gauze, degreased or physiological cloth, or synthetic resin sponge material. As mentioned above, when administering a drug by electrophoretic effect, the amount administered is related to the amount of electricity that flows.Especially when selective administration is performed using an ion exchange resin membrane, administration is easy. quantity can be estimated. For example, using the drug penetration device of the present invention, 1 mg of ascorbic acid (molecular weight 181)
When administering the drug, the current can be set to 0.5 mA, and the administration can be carried out in an extremely short period of about 20 minutes.

[0011]

Effects of the Invention The electrophoretic drug permeation device of the present invention has the following excellent effects. (i) The ionically dissociable active ingredient of the drug can be rapidly and properly penetrated into the skin (affected area) by electrophoresis. (ii) It is extremely safe because electrochemical reactions (electrode reactions) of drug components on the electrodes can be prevented. (iii) Since the optimal ion exchange resin membrane can be selected depending on the polarity of the active ingredient of the drug, any drug can be efficiently penetrated into the skin (affected area).

[Brief explanation of drawings]

FIG. 1 is a diagram illustrating the electrophoresis process of a drug under a predetermined arrangement state of an ion exchange resin membrane in a drug permeation device of the present invention.

FIG. 2 is a diagram illustrating the electrophoresis process of a drug under another arrangement of the ion exchange membrane in the drug permeation device of the present invention.

FIG. 3 is a schematic diagram of the drug permeation device of the present invention.

FIG. 4 is a diagram illustrating a drug electrophoresis process in a conventional drug permeation device.

[Explanation of symbols]

1......Drug infiltration device 2......Electrophoresis power supply section 3,31......electrode 4, 41, 42...Drug holding material 5,51……Ion exchange membrane

Claims (6)

[Claims] Claim 1: In a drug permeation device using electrophoresis, an electrode, a drug holding material for holding the drug, and an ion exchange device for selectively permeating the ionic active ingredient of the drug are provided on the front side of the electrophoresis power source. A drug infiltration device using electrophoresis, characterized by being provided with a resin membrane. [Claim 2] The ion exchange resin membrane is cationic and/or
or an anionic ion exchange resin membrane, the electrophoretic drug permeation device according to claim 1. 3. The electrophoretic drug permeation device according to claim 2, wherein a drug holding material is interposed between the cationic ion exchange resin membrane and the anionic ion exchange resin membrane. 4. The electrophoretic drug infiltration device according to claim 1, wherein a drug holding material is interposed between the electrode and the ion exchange resin membrane. 5. The electrophoretic drug infiltration device according to claim 4, wherein a drug holding material is also provided on the front side of the ion exchange resin membrane. 6. In a drug permeation method using electrophoresis, an electrode, a drug holding material for holding the drug, and an ion exchange device for selectively permeating the ionic active ingredient of the drug are provided on the front side of the electrophoresis power source. 1. A method for drug infiltration by electrophoresis, characterized in that a resin membrane is provided to allow ionic active ingredients of the drug to penetrate by electrophoresis.