JP2007105262A5 - - Google Patents
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- JP2007105262A5 JP2007105262A5 JP2005299540A JP2005299540A JP2007105262A5 JP 2007105262 A5 JP2007105262 A5 JP 2007105262A5 JP 2005299540 A JP2005299540 A JP 2005299540A JP 2005299540 A JP2005299540 A JP 2005299540A JP 2007105262 A5 JP2007105262 A5 JP 2007105262A5
- Authority
- JP
- Japan
- Prior art keywords
- blood
- filtrate
- hollow fiber
- fiber membrane
- filtration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004369 Blood Anatomy 0.000 claims 37
- 239000008280 blood Substances 0.000 claims 37
- 239000000706 filtrate Substances 0.000 claims 22
- 238000001914 filtration Methods 0.000 claims 22
- 239000012528 membrane Substances 0.000 claims 19
- 239000012510 hollow fiber Substances 0.000 claims 18
- 239000012530 fluid Substances 0.000 claims 6
- 238000002637 fluid replacement therapy Methods 0.000 claims 4
- 229920001477 hydrophilic polymer Polymers 0.000 claims 4
- 229920001600 hydrophobic polymer Polymers 0.000 claims 4
- 229920001515 polyalkylene glycol Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920003288 polysulfone Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 238000011017 operating method Methods 0.000 claims 1
Claims (8)
該動脈ライン上の血液を送液するための血液ポンプ、
中空糸膜型血液濾過器、
該中空糸膜型血液濾過器の血液出口側に接続され、血液を患者に戻す静脈ライン、
前記中空糸膜型血液濾過器の濾液側に接続され、濾液を導出する濾液ライン、
および該濾液ライン上の濾液を送液するための濾液ポンプを少なくとも有する
持続式血液濾過装置において、
該濾液ポンプにより中空糸膜型血液濾過器の有効濾過面積１ｍ２当たり２〜５００ｍｌの濾液を得る毎に中空糸膜型血液濾過器の有効濾過面積１ｍ２当たり０．５〜２０ｍｌ、かつ前記濾液量の０．１〜５０％容量の濾液を逆流させる逆流手段を有することを特徴とする
持続式血液濾過装置。 An arterial line for introducing blood into the blood inlet side of the hollow fiber membrane blood filter,
A blood pump for delivering blood on the arterial line;
Hollow fiber membrane blood filter,
A venous line connected to the blood outlet side of the hollow fiber membrane blood filter and returning blood to the patient;
A filtrate line connected to the filtrate side of the hollow fiber membrane blood filter and leading to the filtrate,
And a continuous blood filtration device having at least a filtrate pump for feeding the filtrate on the filtrate line,
The filtrate effective filtration area 1 m 2 per 0.5~20ml hollow fiber membrane type blood filter for each yield the filtrate effective filtration area 1 m 2 per 2~500ml hollow fiber membrane type blood filter by the pump and the filtrate A continuous blood filtration device comprising backflow means for backflowing a filtrate having a volume of 0.1 to 50%.
および前記補液ライン上の補液を送液するための補液ポンプ、
を有することを特徴とする
請求項１記載の持続式血液濾過装置。 A fluid replacement line connected to the venous line to introduce fluid replacement;
And a replacement fluid pump for supplying the replacement fluid on the replacement fluid line,
The continuous blood filtration device according to claim 1, comprising:
疎水性高分子と親水性高分子よりなる中空糸膜であることを特徴とする
請求項１または２記載の持続式血液濾過装置。 The hollow fiber membrane incorporated in the hollow fiber membrane blood purifier is,
3. The continuous blood filtration device according to claim 1, wherein the continuous blood filtration device is a hollow fiber membrane comprising a hydrophobic polymer and a hydrophilic polymer.
請求項３記載の持続式血液濾過装置。 4. The continuous blood filtration device according to claim 3, wherein the hydrophobic polymer is a polysulfone polymer, and the hydrophilic polymer is polyvinyl pyrrolidone and / or polyalkylene glycol.
該動脈ライン上の血液を送液するための血液ポンプ、A blood pump for delivering blood on the arterial line;
中空糸膜型血液濾過器、Hollow fiber membrane blood filter,
該中空糸膜型血液濾過器の血液出口側から血液を導出する静脈ライン、A venous line for drawing blood from the blood outlet side of the hollow fiber membrane blood filter;
前記中空糸膜型血液濾過器の濾液側に接続され、濾液を導出する濾液ライン、A filtrate line connected to the filtrate side of the hollow fiber membrane blood filter, and leading out the filtrate;
および該濾液ライン上の濾液を送液するための濾液ポンプAnd a filtrate pump for feeding the filtrate on the filtrate line
を少なくとも有する持続式血液濾過装置の作動方法において、In a method of operating a continuous blood filtration device having at least
前記作動方法はThe operating method is
該濾液ポンプにより中空糸膜型血液濾過器の濾液を得る正濾過工程とA positive filtration step of obtaining a filtrate of a hollow fiber membrane blood filter by the filtrate pump;
中空糸膜型血液濾過器の濾液を逆流させる逆濾過工程とを有し、A reverse filtration step of flowing back the filtrate of the hollow fiber membrane blood filter,
前記正濾過工程は、有効濾過面積１ｍ2当たり２〜５００ｍｌの濾液を得、The positive filtration step obtains 2-500 ml of filtrate per 1 m 2 of effective filtration area,
前記逆濾過工程は、有効濾過面積１ｍ2当たり０．５〜２０ｍｌかつ前記濾液量の０．１〜５０％容量の濾液を逆流させ、In the reverse filtration step, a filtrate having a volume of 0.5 to 20 ml per 1 m 2 of effective filtration area and a volume of 0.1 to 50% of the filtrate amount is reversely flowed,
前記正濾過工程が一定量の濾過量に達した後、一定量を逆流させる前記逆濾過工程を行う1サイクルを複数回繰り返す制御を行うAfter the normal filtration step reaches a certain amount of filtration, a control is performed to repeat the reverse filtration step of performing a reverse flow of the constant amount a plurality of times.
ことを特徴とする持続式血液濾過装置の作動方法。A method for operating a continuous blood filtration device.
および前記補液ライン上の補液を送液するための補液ポンプ、
を有することを特徴とする請求項５記載の持続式血液濾過装置の作動方法。 A fluid replacement line connected to the venous line to introduce fluid replacement;
And a replacement fluid pump for supplying the replacement fluid on the replacement fluid line,
The operation method of the continuous blood filtration apparatus according to claim 5, wherein:
疎水性高分子と親水性高分子よりなる中空糸膜であることを特徴とする請求項５または６記載の持続式血液濾過装置の作動方法。The method for operating a continuous blood filtration device according to claim 5 or 6, wherein the membrane is a hollow fiber membrane comprising a hydrophobic polymer and a hydrophilic polymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005299540A JP4493097B2 (en) | 2005-10-14 | 2005-10-14 | Continuous blood filtration device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005299540A JP4493097B2 (en) | 2005-10-14 | 2005-10-14 | Continuous blood filtration device |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007105262A JP2007105262A (en) | 2007-04-26 |
| JP2007105262A5 true JP2007105262A5 (en) | 2008-11-27 |
| JP4493097B2 JP4493097B2 (en) | 2010-06-30 |
Family
ID=38031589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005299540A Expired - Fee Related JP4493097B2 (en) | 2005-10-14 | 2005-10-14 | Continuous blood filtration device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4493097B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6418641B2 (en) * | 2015-01-05 | 2018-11-07 | 学校法人早稲田大学 | Blood purifier circulation test apparatus and test evaluation method |
| JP6590278B2 (en) * | 2015-10-08 | 2019-10-16 | 学校法人早稲田大学 | Blood purifier flow visualization test apparatus and visualization test method, and holder used in the same |
| CN106344985B (en) * | 2016-09-20 | 2018-06-12 | 黄昱 | A kind of multifunctional recycled blood purification system |
| WO2021201181A1 (en) * | 2020-03-31 | 2021-10-07 | 旭化成メディカル株式会社 | Closed circulation system test apparatus for blood purification device using whole blood |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6125564A (en) * | 1984-07-17 | 1986-02-04 | 日機装株式会社 | Artificial kidney apparatus |
| JP4265701B2 (en) * | 1998-11-16 | 2009-05-20 | 旭化成クラレメディカル株式会社 | Polysulfone porous membrane |
| US7442546B2 (en) * | 2002-03-15 | 2008-10-28 | The Regents Of The University Of Michigan | Method of modulating inflammatory response |
-
2005
- 2005-10-14 JP JP2005299540A patent/JP4493097B2/en not_active Expired - Fee Related
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