JP2007091712A - Tooth-bleaching set - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a tooth-bleaching set exhibiting a high tooth-bleaching effect even by an application for a short time, having a lasting property of bleaching effect, also having a good adhering effect to the tooth and excellent in close adhesion, without having a mucosal irritation and capable of being used safely and simply. <P>SOLUTION: This tooth-bleaching set is characterized by being equipped with a tooth-bleaching composition containing (A) 50-94 mass% polyglycerol having 3-10 average degree of polymerization and (B) 2-20 mass% thickening agent, wherein, the mass ratio of the components (A) to (B), (A)/(B) is 4-45, and without containing a bleaching component, with an application tool worn on the tooth as attachable and detachable in a state of holding the composition. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention is for tooth whitening that has high tooth whitening effect and long-lasting whitening effect when applied for a short time, has good adhesiveness to teeth, and is safe and easy to use without mucous membrane irritation. Regarding the set.

  As a technique for whitening or whitening teeth, bleaching of the tooth surface with peroxide is generally used, and a technique for applying a peroxide-containing composition to the tooth surface is disclosed (Patent Literature). 1: Special Table 2003-526648, Patent Document 2: Special Table 2002-503990). However, peroxides are generally handled by specialists such as dentists from the viewpoint of complexity of operation and safety, but can be recognized if the peroxide concentration is lowered from the viewpoint of safety. When a sufficient effect is not obtained by bleaching a tooth with a peroxide to obtain a sufficient effect, it is necessary to use it several times to ten times or more.

  On the other hand, as a technique that can be easily used, a technique that makes a tooth appear white by directly applying a film-forming component, a white pigment, or the like to the tooth is also disclosed (Patent Document 3: Japanese Patent Laid-Open No. 05-58844, Patent Document 4). : JP 09-202718 A). Although these can be used easily, it is difficult to apply uniformly and thinly, and they tend to become application spots, and often cause problems such as peeling due to saliva erosion.

  Further, as a technique for making teeth appear whiter safely and easily, a method of changing the optical properties of the enamel part without chemical reaction such as bleaching has been proposed (Patent Document 5: International Publication No. 03/030851 pamphlet). ), Polyethylene glycol and the like are disclosed as a whitening component. These whitening components exhibit a high whitening effect when applied to teeth, but short-time application may be insufficient in terms of initial whitening level and durability of the effect. In addition, the applicant has proposed Japanese Patent Application Laid-Open No. 2005-187330 and Japanese Patent Application No. 2003-432095 as a whitening component such as polyethylene glycol.

  Therefore, a tooth whitening set having high tooth whitening effect and long-lasting whitening effect with a short application time and good adhesion to teeth is desired.

Special table 2003-526648 gazette JP 2002-503990 Gazette JP 05-58844 A JP 09-202718 A International Publication No. 03/030851 Pamphlet

  The present invention was made in view of the above circumstances, exhibits a high tooth whitening effect by applying for a short time, has a persistence of the whitening effect, and has good adhesiveness to teeth and excellent adhesion, An object of the present invention is to provide a set for teeth whitening which is safe and easy to use without mucous membrane irritation.

  As a result of intensive studies to achieve the above object, the present inventor has (A) polyglycerin having an average degree of polymerization of 3 to 10 in the composition of 50 to 94% by mass, and (B) 2 to 2 thickeners. A tooth whitening composition containing 20% by mass, having a mass ratio (A) / (B) of components (A) and (B) of 4 to 45 and not containing a bleaching component is used in combination with an application tool. By sticking to the teeth, it shows a high whitening effect of the tooth by applying for a short time, has an excellent persistence of the whitening effect, has good adhesion to the tooth, does not irritate the mucous membrane, and is safe and easy It has been found that it can be used, and the present invention has been made.

  Accordingly, the present invention comprises (A) 50 to 94% by mass of polyglycerol having an average degree of polymerization of 3 to 10, and (B) 2 to 20% by mass of a thickener, and the (A) and (B ) Component weight ratio (A) / (B) of 4 to 45, a tooth whitening composition not containing a bleaching component, and an application tool that is detachably attached to a tooth while holding this composition; A set for teeth whitening characterized by comprising:

  The tooth whitening set of the present invention exhibits high tooth whitening effect and long-lasting whitening effect when applied for a short time, has good adhesiveness to teeth, has no mucosal irritation, and is used safely and easily. It is possible.

  Hereinafter, the present invention will be described in more detail. The tooth whitening set of the present invention comprises (A) a polyglycerin having an average degree of polymerization of 3 to 10 and (B) a thickener, and contains excess hydrogen peroxide or the like. A tooth whitening composition that does not contain a bleaching component such as an oxide, and an application tool that is detachably attached to the tooth.

  In the present invention, the tooth whitening component is a polyglycerin having an average degree of polymerization of 3 to 10, preferably 5 to 7, from the viewpoint of enhancing the whitening effect and the sustainability of the whitening effect without causing mucosal irritation. It is essential to blend.

  As the polyglycerin, a commercially available product can be used. For example, polyglycerin # 310 (manufactured by Sakamoto Pharmaceutical Co., Ltd., average polymerization degree n = 4, glycerin: 7.4%, water: 5.1% contained), polyglycerin # 500 Anhydride (Sakamoto Pharmaceutical Co., Ltd., average polymerization degree n = 6.5, diglycerin: 3.6%, glycerin: 0.1% contained), Polyglycerin # 500 (Sakamoto Pharmaceutical Co., Ltd., average polymerization degree n) = 6.5, diglycerin: 3.2%, glycerin: 0.1%, water: 10.2%), polyglycerin # 750 (manufactured by Sakamoto Yakuhin Co., Ltd., average polymerization degree n = 10, glycerin: 1) 0.2%, water: 10.4% contained).

  The compounding quantity of the said polyglycerin is 50-94 mass% in a composition, Preferably it is 75-90 mass%. When the blending amount is less than 50% by mass, the whitening effect and the persistence of the whitening effect may be insufficient. When the blending amount exceeds 94% by mass, the gelling agent and the viscosity adjusting component cannot be sufficiently added, and sufficient teeth Adhesion may not be obtained.

  In the present invention, in addition to the polyglycerin, as a solvent, for example, glycerin, diglycerin, 1,3-butylene glycol, polyethylene glycol, diethylene glycol, ethylene glycol, propylene glycol and other polyhydric alcohols, ethanol, isopropyl alcohol, etc. Lower alcohol or water can be added. 4-40 mass% of the whole composition is suitable for the compounding quantity of a solvent. In addition, since water tends to have a bad influence on the whitening effect among these solvents, the amount of water is preferably 10% by mass or less, more preferably 5% by mass or less of the entire composition.

  As the thickener of the component (B) in the present invention, any one can be used as long as it is soluble in the above solvent and can be swollen. Specifically, xanthan gum, carboxyvinyl polymer, polyvinylpyrrolidone, vinylpyrrolidone-vinyl acetate. A copolymer, sodium carboxymethyl cellulose, hydroxyethyl cellulose and the like can be mentioned, and it is preferable to use one or more selected from xanthan gum, carboxyvinyl polymer, and polyvinylpyrrolidone from the viewpoint of thickening and adhesiveness to teeth.

  Here, xanthan gum is a natural polysaccharide produced by Xanthomonas campestiris, and the viscosity (20 ° C.) of a 0.5 mass% aqueous solution is a BL viscometer (manufactured by Toki Sangyo Co., Ltd., rotor). No. 3, rotation speed of 60 rpm, measurement of 1 minute) is preferably 200 to 1000 mPa · s. As an example of a commercially available product, Sanei Gen F / F, Sanace NXG-S, large Examples include Monart Gum DA (both viscosities of 300 to 500 mPa · s) manufactured by Nippon Pharmaceutical.

  The carboxyvinyl polymer is a polymer obtained by crosslinking acrylic acid mainly with allyl sucrose and the like, and the viscosity (25 ° C.) of a 0.5 mass% aqueous solution neutralized with sodium hydroxide has a BH viscometer (Toki Sangyo ( Co., Ltd., rotor 3-7, rotation speed 20 rpm, measurement time 1 minute), preferably 4,000-100,000 mPa · s. As an example of a commercially available product, Carbopol 980 (viscosity: 40000 to 60000 mPa · s), 2984 (viscosity: 30000 to 40000 mPa · s), 5984 (viscosity: 30000 to 40000 mPa · s), 981 (viscosity 5000 to 8000 mPa · s), and the like.

  The polyvinyl pyrrolidone preferably has a weight average molecular weight of 10,000 to 3,000,000, more preferably 200,000 to 3,000,000. Examples of the commercially available polyvinylpyrrolidone include Kollidon 30 (K value: 26 to 35, weight average molecular weight 40,000), Kollidon 60 (K value: 50 to 65, weight average molecular weight 220,000), Kollidon 90F (K value) manufactured by BASF. : 88-100, weight average molecular weight 1,200,000).

  In addition, the said weight average molecular weight converts K value computed according to the method defined in the US Pharmacopoeia into the weight average molecular weight measured by the light-scattering method with the analytical curve.

  The total amount of the thickener of the component (B) is 2 to 20% by mass, preferably 3 to 15% by mass, based on the entire composition. If the blending amount of the thickener is less than 2% by mass, sufficient tooth adhesion may not be obtained, and if it exceeds 20% by mass, the whitening effect may be inhibited.

  Furthermore, in this invention, it is necessary for mass ratio (A) / (B) of (A) component and (B) component to be 4-45, Preferably it is 6-25. When the mass ratio is less than 4, the thickening agent inhibits the whitening effect and the persistence of the whitening effect. When the mass ratio exceeds 45, the gelling is insufficient and cannot be adhered to the tooth surface.

  The composition of the present invention is further selected from (C) a water-insoluble acrylic acid copolymer, cationized cellulose, shellac, and white petrolatum as a component for promoting adsorption of a tooth whitening component on the tooth surface or as a film forming component. It is preferable to add at least one selected from the viewpoint of improving the sustainability of the whitening effect.

Examples of the water-insoluble acrylic acid copolymer include ethyl acrylate / methyl methacrylate / methacrylic acid trimethylammonium ethyl copolymer, methyl acrylate / methacrylic acid copolymer, methyl methacrylate / methacrylic acid. Examples thereof include a copolymer, a methacrylic acid octylamide / acrylic acid ester copolymer, and an acrylic acid / acrylic acid amide / ethyl acrylate copolymer. Among these, an ethyl acrylate / methyl methacrylate / methacrylated trimethylammonium ethyl copolymer containing a quaternary ammonium salt is particularly preferable. Although the weight average molecular weight of a water-insoluble acrylic acid copolymer is not specifically limited, Preferably it is 50,000-2 million. Water-insoluble here means that the solubility in 100 g of purified water at 25 ° C. is less than 0.1 g.
The ethyl acrylate / methyl methacrylate / methacrylated trimethylammonium ethyl copolymer corresponds to the aminoalkyl methacrylate copolymer RS listed in the pharmaceutical additive standard, which is the amino acid of the pharmaceutical additive standard. Dissolved in acetone according to the viscosity test of the alkyl methacrylate copolymer RS, and the kinematic viscosity measured at 20 ° C. using an Ubbelohde viscometer is 1.0 according to the first viscosity measurement method described in the general test method of the Japanese Pharmacopoeia method. It is -4.0 mm < ² > / s. Examples of commercially available products include Eudragit RSPO (weight average molecular weight 150,000) and Eudragit RLPO (weight average molecular weight 150,000) manufactured by Degussa.
The methyl methacrylate / methacrylic acid copolymer is equivalent to the methacrylic acid copolymer L listed in the pharmaceutical additive standard, which is used for the viscosity test of the methacrylic acid copolymer L of the pharmaceutical additive standard. The kinematic viscosity measured at 20 ° C. using a Ubbelohde viscometer is 10 to 24 mm ² / s according to the first method of viscosity measurement described in the general test method of the general test method of the Japanese Pharmacopoeia. Is. Examples of commercially available products include Eudragit L-100 (weight average molecular weight: 135,000) manufactured by Degussa.

  The cationized cellulose is hydroxyethyl cellulose / dimethyl diallylammonium salt, and a cationic polymer obtained by graft polymerization of dimethyl diallylammonium salt to hydroxyethyl cellulose is preferable. The weight average molecular weight is 30 to 3000 mPa · s when the viscosity (20 ° C.) of the 2 mass% aqueous solution is measured with a BH viscometer (manufactured by Toki Sangyo Co., Ltd., rotor No. 2, rotation speed 20 rpm, measurement 1 minute). It is preferable that it is s, and a commercial product includes Cell Coat L-200 (viscosity: 35 to 350 mPa · s), Cell Coat H-100 (viscosity: 500 to 2750 mPa · s) and the like manufactured by Nippon NC. These counter ions are chloride ions.

  Shellac is a product obtained by purifying a resinous substance secreted by the shellworm, and a commercially available product can be used. Specific examples thereof include a dry transparent white rack manufactured by Nippon Shellac Kogyo Co., Ltd.

  White petrolatum is obtained by decolorizing and purifying a mixture of hydrocarbons obtained from petroleum or the like, and white petrolatum manufactured by Nikko Pharmaceutical Co., Ltd. can be suitably used as a commercial product. Hydrophilic petroleum jelly (manufactured by Nikko Pharmaceutical Co., Ltd.) in which white petrolatum is mixed with white beeswax, stearyl alcohol, and cholesterol can also be used.

  When mix | blending the said (C) component, 0.1-10 mass% of the whole composition is preferable, More preferably, it is 0.2-5 mass%. When the blending amount is less than 0.1% by mass, the improvement of the sustaining effect due to the addition may not be observed. When the blending amount exceeds 10% by mass, the whitening effect may be impaired.

  Furthermore, the whitening composition of the present invention preferably contains an inorganic powder for the purpose of controlling physical properties such as gel viscosity and elasticity and bringing it into close contact with the teeth. Examples of the inorganic powder include amorphous thickening silica, anhydrous zeolite, smectite, and anhydrous silicic acid, aluminum silicate, zirconium silicate, dicalcium phosphate dihydrate, which are widely used as a dentifrice abrasive. Anhydrous, insoluble sodium metaphosphate, calcium carbonate, titanium oxide, alumina, aluminum hydroxide and the like can be blended, and amorphous thickening silica, anhydrous zeolite, and smectite are preferable.

  When these inorganic powders are blended, the blending amount is preferably 1 to 30% by mass, more preferably 2 to 10% by mass based on the entire composition. If the blending amount is less than 1% by mass, the gel properties may not be sufficiently controlled, and if it exceeds 30% by mass, the whitening effect may be reduced.

  Further, the composition of the present invention can be appropriately mixed with other components as necessary. For example, active ingredients, surfactants, sweeteners, fragrances, preservatives, antioxidants, pH adjusters, etc. Can be blended.

  Specifically, fluoride (such as sodium fluoride) as an active ingredient as an active ingredient, dextranase, mutanase, prevention of hypersensitivity, aluminum lactate, potassium nitrate, piroctone olamine and others as inhibitory ingredients, potassium pyrophosphate One or more water-soluble polyphosphates such as sodium tripolyphosphate and sodium metaphosphate, ascorbic acid and salts thereof, herbal extracts such as tocopherol acetate, rosemary, clove, and thyme can be blended.

  Further, a surfactant can be blended for the purpose of solubilizing components insoluble in the solvent and removing dirt on the tooth surface. In this case, anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate, sodium myristyl sulfate and sodium cetyl sulfate, sodium N-acyl glutamate such as sodium N-lauroyl glutamate, sodium N-palmitoyl glutamate, and N-lauroyl. N-acyl sarcosine sodium, such as sarcosine sodium, N-myristoyl sarcosine sodium, N-methyl-N-acyl taurine sodium, N-methyl-N-acylalanine sodium, such as N-lauroylmethyl taurine sodium, N-myristoyl methyl taurine sodium Sodium laurylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, α-o Sodium fins sulfonate, lauryl POE (polyoxyethylene) sulfate, sodium lauryl POE acetate, sodium lauryl POE phosphate, sodium stearyl POE phosphate, sodium surfactin or the like is used.

  Nonionic surfactants include glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl laurate, sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester, lactose fatty acid ester, maltitol fatty acid ester, lactitol fatty acid ester, etc. Sugar alcohol fatty acid ester, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, myristic acid mono or diethanolamide, etc. Fatty acid ethanol amide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxy Propylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester or the like is used.

  Zwitterionic surfactants include alkyldimethylaminoacetic acid betaines such as lauryldimethylaminoacetic acid betaine, N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, and N-alkyl-N-carboxyl. Methyl ammonium betaine, 2-alkyl-1-hydroxyethyl imidazoline betaine sodium and the like are used.

  Further, the composition of the present invention includes 1-menthol, anethole, carvone, citral, benzaldehyde, cinnamic aldehyde, octanol, methyl salicylate, peppermint oil, spearmint oil and other fragrance ingredients, benzoic acid and its sodium salt, methylparaben, Parabens such as ethyl paraben, propyl paraben, and butyl paraben are used as preservatives, and pigments or colorants such as red No. 3, red No. 104, yellow No. 4, blue No. 1, green No. 3, mica titanium, and petiole, xylitol , Saccharin or its sodium salt, stevioside, glycyrrhizin, aspartame and other sweeteners can be incorporated.

  The pH of the composition of the present invention is not particularly limited as long as it is within the range of safety in the oral cavity and the human body, but preferably the pH when the composition is diluted 10 times with purified water is 4. It is 0.0-10.0, More preferably, it is 5.0-9.0. When the pH is less than 4.0, the tooth surface may be decalcified depending on the application time. When the pH exceeds 10.0, there is a concern such as mucosal detachment when touching the gingiva. As pH adjusters, hydrochloric acid, citric acid, malic acid, malonic acid, glycolic acid, phosphoric acid, sodium hydroxide, potassium hydroxide, sodium carbonate, sodium citrate, sodium hydrogen citrate, sodium phosphate, sodium hydrogen phosphate , Triethanolamine, triisopropanolamine, arginine and the like may be blended.

  The effect of the composition of the present invention is further enhanced by applying the composition of the present invention in combination with an application tool that is detachably attached to the tooth while retaining the composition of the present invention as a tool for retaining the composition on the tooth.

  The tooth whitening composition is applied in combination with a dedicated application tool as described above, but the application tool used in the present invention assists the reliable application and fixation of the tooth whitening composition to the teeth. In addition to preventing the tooth whitening composition from elution into the gingiva, tongue and oral mucosa, it prevents unpleasant feeling of use and the induction of saliva. In addition, tooth whitening due to saliva intrusion, occlusion, chewing and other physical stimuli It is used for the purpose of preventing dilution of the chemical composition and removal from the teeth. The material and shape of the application tool are not particularly limited as long as the above purpose can be achieved, but tape, sheet, film, mouth tray, mouthpiece, sponge, impression made of water-insoluble material. Tooth materials, pack materials, and tooth covers molded into dentitions are preferably used.

  The thickness of the application tool is preferably 0.01 to 5 mm, which does not give a sense of incongruity when applied to a tooth, and is preferably 0.01 to 2 mm for films and sheets.

  The material of the application tool is not particularly limited as long as it is excellent in safety applicable to the oral cavity, but polyethylene, polypropylene, polyester, polyurethane, rayon, pulp, cotton, silk, paper, vinyl acetate It is preferable to use one or more of resins, acrylic resins, silicone rubber, natural rubber, metal foil and the like. From the viewpoint of good fit and suppression of saliva secretion, it is preferable to use a thin plastic film or a woven or non-woven fabric made of synthetic or natural fibers. When used as a woven fabric or non-woven fabric, those composed of one or more of polyethylene, polypropylene, polyester, rayon, nylon, cotton, pulp, paper, silk are preferred because of the good feel when worn. 300 is preferred.

  In addition, by adhering a water-impermeable film such as polyethylene, polypropylene, or polyester to one side or both sides of a woven fabric or non-woven fabric or between two woven or non-woven fabrics, the formulation can be adsorbed excessively or the non-woven fabric It is possible to prevent permeation and elution into the oral cavity, or conversely, saliva permeates through the nonwoven fabric and enters the preparation. In addition, plastics such as silicone rubber and natural rubber, and thermoplastic resins such as vinyl acetate resin and acrylic resin in the mouth tray, mouthpiece, and tooth cover are easily deformed according to the dentition and have good fit to teeth. It is preferable because of its superiority.

  The application frequency and time of the tooth whitening set of the present invention are appropriately selected, but are usually 1 to 6 times, particularly 1 to 3 times a day. The application time is 1 minute to 6 hours, particularly 1 minute to 2 hours, but it can also be applied while sleeping.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

<Preparation of formulation>
After weighing each raw material, the pressure was reduced by about 93.3 kPa from normal pressure, mixed at about 80 ° C., and if necessary, a fragrance was added at 40 ° C. or lower and mixed under reduced pressure to prepare a preparation.

<Preparation of set for teeth whitening>
The composition was sandwiched between various sheet materials and a facing film coated with silicone on the surface, and spread so that the total thickness was 1 mm to prepare a set for teeth whitening.
In Examples 1 to 11 and Comparative Examples 1 to 6 shown in Tables 1 to 3 below, a nonwoven fabric sheet composed of three layers of 0.5 mm PP (polypropylene) / PE (polyethylene) film / rayon + PP (7/3) The composition was sandwiched between a PP film and a facing film coated with silicone on the surface, and spread so that the total thickness was 1 mm to prepare a sheet preparation.

<Evaluation of whitening effect and sustainability of whitening effect>
The tooth whitening set (10 mm × 10 mm) produced by the above method was applied in advance to the extracted human anterior tooth whose color difference (L0, a0, b0) was measured, and left in a constant temperature bath at 37 ° C. After 5 minutes, the sheet was removed and the sheet was peeled off. The gel adhering to the teeth was wiped with a tissue, washed lightly, and the color difference (L1, a1, b1) was measured. Thereafter, it was immersed in artificial saliva and left in a constant temperature bath at 37 ° C. After 3 hours, the color difference (L1, a1, b1) was taken out and measured. The color difference was measured using a spectrocolorimeter (Minolta, CM-2022).
Then, the whitening effect immediately after the treatment and the change in color ΔE after 3 hours as the persistence of the whitening effect are calculated by the following formulas based on the pre-treatment, respectively. Evaluated.
ΔE = ((L1-L0) ² + (a1-a0) ² + (b1-b0) ² ) ^1/2

Evaluation criteria <immediately after treatment><after 3 hours>
ΔE value is 5 or more: ◎ ΔE value is 4 or more: ◎
ΔE value of 4 or more and less than 5: ○ ΔE value of 3 or more and less than 4: ○
ΔE value of 3 or more and less than 4: ΔE value of 2 or more and less than 3: Δ
ΔE value is less than 3: × ΔE value is less than 2: ×

<Tooth adhesion, mucous membrane irritation>
Cut the tooth whitening set prepared by the above method into the same shape using a tooth shape designed to cover the lip and tongue surfaces of the left and right third to third teeth of the upper and lower jaws, and apply them to the upper and lower jaws A possible tooth whitening set was prepared. The tooth whitening set was affixed to the upper and lower jaws for 5 minutes, and the adhesion to the teeth and the oral mucosal irritation at the time of wearing were evaluated according to the following criteria. It was conducted by 10 panelists.

Adhesion to teeth 5 points: It is fixed perfectly.
4 points: fixed and does not shift or move 3 points: slightly shifted but not worried 2 points: shifted and worried 1 point: oral mucosal irritation that cannot be fixed 5 points: no irritation at all 4 points: Slight irritation but no problem Level 3 points: Slight irritation and slight irritation after sheet peeling.
2 points: I feel strong stimulation 1 point: I feel the stimulation remarkably and it is difficult to wear for 5 minutes

The above-mentioned tooth adhesion and oral mucosal irritation were evaluated according to the following criteria by calculating the average value of 10 panelists for each evaluation item.
◎: 4.5 or more and 5 or less ○: 4 or more and less than 4.5 △: 3.5 or more and less than 4 × ×: less than 3.5

[Examples 1-11, Comparative Examples 1-6]
A tooth whitening set was prepared by the above method using the tooth whitening composition having the composition shown in Tables 1 to 3, and the above evaluation was performed. The results are shown in Tables 1-3.

The polyglycerin and polyvinylpyrrolidone used in each example are as follows.
Polyglycerin # 310:
Average polymerization degree n = 4 (containing glycerin: 7.4%, water: 5.1%, manufactured by Sakamoto Yakuhin)
Polyglycerin # 500 anhydride:
Average polymerization degree n = 6.5 (containing diglycerin: 3.6%, glycerin: 0.1%, manufactured by Sakamoto Yakuhin)
Polyglycerin # 500:
Average polymerization degree n = 6.5 (containing diglycerin: 3.2%, glycerin: 0.1%, water: 10.2%, manufactured by Sakamoto Yakuhin)
Polyglycerin # 750:
Average polymerization degree n = 10 (containing glycerin: 1.2%, water: 10.4%, manufactured by Sakamoto Yakuhin)
Polyvinylpyrrolidone K-90: K value = 90.1 (Kollidon 90F, manufactured by BASF)

  From the above results, by applying the tooth whitening composition of the present invention to the tooth surface, high whitening effect and persistence of the whitening effect can be obtained with a short time application, and good tooth adhesion can be obtained. It was confirmed that there was no mucous membrane irritation.

Example 12
The preparation (the following composition 1) prepared by the above-mentioned production method was coated on a polyethylene film (thickness 25 μm) so that the total thickness was about 1 mm, and evaluated according to the above-described test method and evaluation method. As a result, the whitening effect immediately after the treatment and after 3 hours was ◎, and the adhesion and oral mucosal irritation when applied to the tooth surface were both ◎.

<Composition 1>
Polyglycerin # 500 anhydride (Sakamoto Yakuhin Co., Ltd.) 85.8%
Carboxyvinyl polymer (NOVEON: Carbopol 980) 3.0%
Polyvinylpyrrolidone K-90 (BASF, Kollidon 90F) 5.0%
Ethyl acrylate / Methyl methacrylate / Methacrylated trimethylammonium ethyl copolymer (Degussa: Eudragit RSPO)
1.0%
Anhydrous zeolite (manufactured by Tosoh Corporation: Zeolum A4) 5.0%
Fragrance 0.1%
Methyl paraben 0.1%
Total 100.0%

Example 13
The preparation (following composition 2) prepared by the above-mentioned manufacturing method is applied to a polypropylene film (thickness: about 0.1 mm) so that the total thickness is about 1 mm, and evaluated according to the above-described test method and evaluation method. did. As a result, the whitening effect immediately after the treatment and after 3 hours was ◎, and the adhesion and oral mucosal irritation when applied to the tooth surface were both ◎.

<Composition 2>
Polyglycerin # 500 anhydride (Sakamoto Yakuhin Co., Ltd.) 84.8%
Carboxyvinyl polymer (NOVEON: Carbopol 980) 2.0%
Vinyl acetate-vinylpyrrolidone copolymer (BASF, VA-VP64) 3.0%
Anhydrous zeolite (manufactured by Tosoh Corporation: Zeolum A3) 8.0%
Ethyl acrylate / Methyl methacrylate / Methacrylated trimethylammonium ethyl copolymer (Degussa: Eudragit RSPO)
1.0%
Tocopherol acetate 1.0%
Methyl paraben 0.1%
Fragrance 0.1%
Total 100.0%

Example 14
The preparation prepared by the above manufacturing method (the following composition 3) was coated on a two-layer polypropylene / polyethylene film nonwoven fabric (thickness: about 0.2 mm) so that the total thickness was about 1 mm. Evaluation was performed according to the evaluation method. As a result, the whitening effect was ◎ immediately after treatment, ◯ after 3 hours, and the adhesion and oral mucosal irritation when applied to the tooth surface were both ◎.

<Composition 3>
Polyglycerin # 500 (Sakamoto Pharmaceutical Co., Ltd.) 72.2%
Xanthan gum (Dainippon Pharmaceutical Co., Ltd .: Monato Gum DA) 5.0%
Polyvinylpyrrolidone K-90 (manufactured by BASF, Kollidon 90F) 5.0%
Shellac 1.0%
Thickening silica 5.0%
Ethanol 10%
Tocopherol acetate 1.0%
Sodium lauryl sulfate 0.5%
Methyl paraben 0.1%
Propylparaben 0.1%
Fragrance 0.1%
Total 100.0%

Example 15
The preparation (following composition 4) prepared by the above-described production method was applied to a two-layer nonwoven fabric of polypropylene / polyethylene film (thickness: about 0.2 mm) so that the total thickness was about 1 mm. Evaluation was performed according to the evaluation method. As a result, the whitening effect immediately after the treatment and after 3 hours was ◎, and the adhesion and oral mucosal irritation when applied to the tooth surface were both ◎.

<Composition 4>
Polyglycerin # 500 (Sakamoto Yakuhin Co., Ltd.) 83.2%
Xanthan gum (Dainippon Pharmaceutical Co., Ltd .: Monato Gum DA) 5.0%
Polyvinylpyrrolidone K-90 (BASF, Kollidon 90F) 5.0%
Ethyl acrylate / Methyl methacrylate / Methacrylated trimethylammonium ethyl copolymer (Degussa: Eudragit RSPO)
1.0%
Smectite (Kunimine Industry Co., Ltd .: Smecton SA) 5.0%
Polyoxyethylene (10) oleyl ether 0.5%
Methyl paraben 0.1%
Propylparaben 0.1%
Fragrance 0.1%
Total 100.0%

Example 16
The total thickness of the preparation (composition 5 below) prepared by the above-described production method is about 3 layers of nonwoven fabric (thickness: about 0.2 mm) of PP + rayon (8/2) / PE film / PP + rayon (3/7). The coating was applied so that the thickness was 1 mm, and the evaluation was performed according to the test method and the evaluation method described above. As a result, the whitening effect was ◎ immediately after treatment, ◯ after 3 hours, and the adhesion and oral mucosal irritation when applied to the tooth surface were both ◎.

<Composition 5>
Polyglycerin # 500 (Sakamoto Yakuhin Co., Ltd.) 84.3%
Xanthan gum (Dainippon Pharmaceutical Co., Ltd .: Monato Gum DA) 5.0%
Polyvinylpyrrolidone K-90 (BASF, Kollidon 90F) 5.0%
Hydrophilic petrolatum (Nikko Pharmaceutical Co., Ltd.) 0.5%
1,3-butylene glycol 5.0%
Methyl paraben 0.1%
Fragrance 0.1%
Total 100.0%

For the above compositions 1 to 5,
(1) A mouthpiece made of ethylene vinyl acetate resin warmed with hot water and softened, chewed to fit into a tooth mold, and filled with about 3 g of a tooth whitening composition;
(2) a mouth tray made of silicone rubber filled with about 5 g of the present composition;
(3) Producing a non-woven mouth tray made of a three-layer nonwoven fabric of PP + rayon (8/2) / PE film / PP + rayon (3/7) filled with about 5 g of a tooth whitening composition into a tray shape When mounted in the oral cavity, it was confirmed that the applicability to teeth was good.

Claims (4)

  (A) 50 to 94% by mass of polyglycerol having an average degree of polymerization of 3 to 10, and 2 to 20% by mass of (B) thickener, and the mass ratio of the components (A) and (B) ( A) / (B) is 4 to 45, and includes a tooth whitening composition not containing a bleaching component, and an application tool that is detachably attached to a tooth while holding this composition. Tooth whitening set.   The set for tooth whitening according to claim 1, wherein the component (B) is at least one selected from xanthan gum, carboxyvinyl polymer, and polyvinylpyrrolidone.   The tooth whitening set according to claim 1 or 2, wherein the tooth whitening composition further contains at least one selected from a water-insoluble acrylic acid copolymer, cationized cellulose, shellac, and white petrolatum. The application tool is a tape, a sheet, a film, a mouth tray, a mouthpiece, a sponge, an impression material, a pack material, or a tooth cover molded into a dentition made of a water-insoluble material. Tooth whitening set described.