JP2007077157A5 - - Google Patents
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- Publication number
- JP2007077157A5 JP2007077157A5 JP2006273447A JP2006273447A JP2007077157A5 JP 2007077157 A5 JP2007077157 A5 JP 2007077157A5 JP 2006273447 A JP2006273447 A JP 2006273447A JP 2006273447 A JP2006273447 A JP 2006273447A JP 2007077157 A5 JP2007077157 A5 JP 2007077157A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- trifluoromethyl
- alkylcarbonyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 C 1 -C 4 alkyl Chemical group 0.000 claims 34
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 229940100198 alkylating agent Drugs 0.000 claims 4
- 239000002168 alkylating agent Substances 0.000 claims 4
- 230000000259 anti-tumor effect Effects 0.000 claims 4
- 231100000433 cytotoxic Toxicity 0.000 claims 4
- 230000001472 cytotoxic effect Effects 0.000 claims 4
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 3
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000000018 nitroso group Chemical group N(=O)* 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 3
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 claims 3
- 125000005951 trifluoromethanesulfonyloxy group Chemical group 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 229920002554 vinyl polymer Polymers 0.000 claims 3
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000012954 diazonium Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- 0 *c1c(*)nc(N)nc1OCc1ccccc1 Chemical compound *c1c(*)nc(N)nc1OCc1ccccc1 0.000 description 5
- ZHTBAYPUCDCQPX-UHFFFAOYSA-N Nc(nc1OCc2ccccc2)nc2c1nn[nH]2 Chemical compound Nc(nc1OCc2ccccc2)nc2c1nn[nH]2 ZHTBAYPUCDCQPX-UHFFFAOYSA-N 0.000 description 3
- FXXUYUZEWHFQJZ-UHFFFAOYSA-N Nc1nc(N)nc(OCc2ccccc2)n1 Chemical compound Nc1nc(N)nc(OCc2ccccc2)n1 FXXUYUZEWHFQJZ-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/283,953 US5525606A (en) | 1994-08-01 | 1994-08-01 | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50669496A Division JP3981407B2 (ja) | 1994-08-01 | 1995-07-31 | 置換された０▲上６▼−ベンジルグアニン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007077157A JP2007077157A (ja) | 2007-03-29 |
| JP2007077157A5 true JP2007077157A5 (cg-RX-API-DMAC7.html) | 2007-06-21 |
Family
ID=23088285
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50669496A Expired - Lifetime JP3981407B2 (ja) | 1994-08-01 | 1995-07-31 | 置換された０▲上６▼−ベンジルグアニン |
| JP2006273447A Pending JP2007077157A (ja) | 1994-08-01 | 2006-10-04 | ６（４）−ベンジルオキシピリミジンおよび他の化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50669496A Expired - Lifetime JP3981407B2 (ja) | 1994-08-01 | 1995-07-31 | 置換された０▲上６▼−ベンジルグアニン |
Country Status (10)
| Country | Link |
|---|---|
| US (8) | US5525606A (cg-RX-API-DMAC7.html) |
| EP (3) | EP1142893B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP3981407B2 (cg-RX-API-DMAC7.html) |
| AT (2) | ATE286054T1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2632452A1 (cg-RX-API-DMAC7.html) |
| DE (2) | DE69523462T2 (cg-RX-API-DMAC7.html) |
| DK (2) | DK1142893T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2233513T3 (cg-RX-API-DMAC7.html) |
| PT (2) | PT1142893E (cg-RX-API-DMAC7.html) |
| WO (1) | WO1996004281A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6043228A (en) * | 1993-06-08 | 2000-03-28 | Cancer Research Campaign Technology Limited | O6 -substituted guanine derivatives, a process for their preparation and their use in treating tumor cells |
| US5929046A (en) * | 1994-06-08 | 1999-07-27 | Cancer Research Campaign Technology Limited | Pyrimidine and purine derivatives and their use in treating tumour cells |
| US5525606A (en) * | 1994-08-01 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
| US6794390B2 (en) * | 1996-08-02 | 2004-09-21 | Cv Therapeutics, Inc. | Purine inhibitors of cyclin dependent kinase 2 & ikappabalpha |
| DE19653646A1 (de) * | 1996-12-20 | 1998-06-25 | Hoechst Ag | Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung |
| ATE311884T1 (de) * | 1997-07-12 | 2005-12-15 | Cancer Rec Tech Ltd | Cyclin-abhängige-kinase inhibierende purinderivate |
| US6060458A (en) * | 1998-02-13 | 2000-05-09 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use |
| US6677345B1 (en) * | 1998-03-28 | 2004-01-13 | Cancer Research Campaign Technology Limited | Cyclin dependent kinase inhibitors |
| GB9806739D0 (en) * | 1998-03-28 | 1998-05-27 | Univ Newcastle Ventures Ltd | Cyclin dependent kinase inhibitors |
| US6303607B1 (en) * | 1998-09-10 | 2001-10-16 | Cv Therapeutics, Inc. | Method for administering a sustained release ranolanolazine formulation |
| KR100368515B1 (ko) * | 1999-02-03 | 2003-01-24 | 주식회사 엘지생명과학 | 싸이클린 의존 키나아제 저해제 및 그의 제조 방법 |
| WO2008109417A1 (en) * | 2007-03-02 | 2008-09-12 | Case Western Reserve University | Mgmt inhibitor combinations for the treatment of neoplastic disorders |
| US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| AU2002216650A1 (en) | 2000-10-31 | 2002-05-15 | Lynn Bonham | Triazine derivatives as lpaat-b inhibitors and uses thereof |
| GB0101686D0 (en) * | 2001-01-23 | 2001-03-07 | Cancer Res Campaign Tech | Cyclin dependent kinase inhibitors |
| JP4443215B2 (ja) * | 2001-02-08 | 2010-03-31 | メモリ ファーマセチカル コーポレーション | ホスホジエステラーゼ４阻害剤としてのトリフルオロメチルプリン |
| EP1554572B1 (en) | 2001-07-25 | 2009-10-14 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| US20070129334A1 (en) * | 2001-10-30 | 2007-06-07 | Conforma Therapeutics Corporation | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 |
| EP2336133A1 (en) * | 2001-10-30 | 2011-06-22 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
| WO2004014911A1 (en) * | 2002-08-08 | 2004-02-19 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
| EP1529049B1 (en) * | 2002-08-08 | 2009-11-18 | Memory Pharmaceuticals Corporation | Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors |
| GB0219746D0 (en) | 2002-08-23 | 2002-10-02 | Inst Of Ex Botany Ascr | Azapurine derivatives |
| DE10307928A1 (de) * | 2003-02-25 | 2004-09-16 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Verwendung von 1-(2-Chlorethyl)-1-nitroso-3-(2-hydroxyethyl)-urea zur Behandlung von Pankreaskarzinomen, Weichteilsarkomen, Hodentumoren, Lymphomen, Thymomen, Wilms Tumoren, Nierenkarzinomen, Melanomen, Lungentumoren, intracerebralen Metastasen, Tumoren im Kopf- und Halsbereich, und Mamma-Karzinomen |
| MXPA06002997A (es) | 2003-09-18 | 2007-02-08 | Conforma Therapeutics Corp | Novedosos compuestos heterociclicos como inhibidores- hsp90. |
| US20070155752A1 (en) * | 2004-01-06 | 2007-07-05 | Government of the United States of America, | 2-Amino-o4-substituted pteridines and their use as inactivators of o6-alkylguanine-dna alkyltransferase |
| EP1746889B1 (en) * | 2004-05-12 | 2009-07-22 | Bayer CropScience AG | Plant growth regulation |
| US7825096B2 (en) * | 2004-09-08 | 2010-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs |
| AU2005282562A1 (en) * | 2004-09-08 | 2006-03-16 | Government Of The United States Of America Represented By The Secretary, Department Of Health And Human Services | Beta-glucuronidase cleavable prodrugs of O6-alkylguanine-DNA alkyltransferase inactivators |
| CN100386115C (zh) * | 2004-10-14 | 2008-05-07 | 孔庆忠 | 一种抗癌药物组合物 |
| GB0502573D0 (en) * | 2005-02-08 | 2005-03-16 | Topotarget As | Therapeutic compounds |
| BRPI0609509A2 (pt) | 2005-03-30 | 2010-04-13 | Conforma Therapeutics Corp | composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável |
| US8178314B2 (en) * | 2005-04-27 | 2012-05-15 | Covalys Biosciences Ag | Pyrimidines reacting with O6-alkylguanine-DNA alkyltransferase fusion protein and method for detecting protein |
| CN102379684B (zh) | 2005-04-28 | 2014-11-19 | 普罗透斯数字保健公司 | 药物信息系统 |
| ES2577514T3 (es) * | 2005-08-22 | 2016-07-15 | The Regents Of The University Of California | Antagonistas de TLR |
| WO2007035963A2 (en) * | 2005-09-23 | 2007-03-29 | Conforma Therapeutics Corporation | Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors |
| CA2653941C (en) * | 2006-05-31 | 2013-01-08 | The Regents Of The University Of California | Substituted amino purine derivatives and uses thereof |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| SI2510946T1 (sl) | 2007-02-07 | 2015-12-31 | The Regents Of The University Of California | Konjugati sintetičnih agonistov TLR in njihove uporabe |
| WO2008137207A2 (en) * | 2007-05-02 | 2008-11-13 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Inactivators of o6-alkylguanine-dna alkyltransferase |
| US8542442B2 (en) | 2007-05-07 | 2013-09-24 | Centre Suisse d'Electronique et de Microtechnique SA—Recherche et Developpement | Isotropic zero-order diffractive filter |
| EA201001264A1 (ru) * | 2008-02-07 | 2011-04-29 | Дзе Регентс Оф Дзе Юниверсити Оф Калифорния | Способ лечения заболеваний мочевого пузыря с помощью активатора tlr7 |
| WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
| EP2396328A2 (en) * | 2009-02-11 | 2011-12-21 | The Regents of The University of California | Toll-like receptor modulators and treatment of diseases |
| NZ616673A (en) | 2009-02-20 | 2014-08-29 | To Bbb Holding B V | Glutathione-based drug delivery system |
| CN110075069A (zh) | 2009-05-06 | 2019-08-02 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用 |
| US20120270812A1 (en) * | 2009-08-24 | 2012-10-25 | Duke University | Compositions, methods, and kits for determining an alkyl transferase |
| CN101850504B (zh) * | 2010-05-06 | 2011-11-16 | 陕西理工学院 | 一种用两个步进电机控制主轴运动的振动制孔装置 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| GB201106814D0 (en) * | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
| SI2718270T1 (sl) | 2011-06-10 | 2022-11-30 | Merck Patent Gmbh | Sestavki in postopki za proizvodnjo pirimidinskih in piridinskih spojin z BTK inhibitorno aktivnostjo |
| US20130236504A1 (en) * | 2012-03-06 | 2013-09-12 | Medical University Of South Carolina | Delivery System for Enhancing Drug Efficacy |
| US9775835B2 (en) | 2012-08-06 | 2017-10-03 | Sirga Advanced Biopharma, Inc. | Small molecule inhibitors of viral protein interactions with human t-RNA |
| WO2016040419A1 (en) * | 2014-09-11 | 2016-03-17 | Bristol-Myers Squibb Company | Thioether triazolopyridine and triazolopyrmidine inhibitors of myeloperoxidase |
| US11697851B2 (en) | 2016-05-24 | 2023-07-11 | The Regents Of The University Of California | Early ovarian cancer detection diagnostic test based on mRNA isoforms |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| IL64501A (en) * | 1980-12-22 | 1985-07-31 | Astra Laekemedel Ab | 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use |
| US5260291A (en) | 1981-08-24 | 1993-11-09 | Cancer Research Campaign Technology Limited | Tetrazine derivatives |
| US5731304A (en) * | 1982-08-23 | 1998-03-24 | Cancer Research Campaign Technology | Potentiation of temozolomide in human tumour cells |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| DE3485225D1 (de) * | 1983-08-18 | 1991-12-05 | Beecham Group Plc | Antivirale guanin-derivate. |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| EP0184473A1 (en) * | 1984-10-26 | 1986-06-11 | Merck & Co. Inc. | Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives |
| US4801710A (en) * | 1984-10-26 | 1989-01-31 | Merck & Co., Inc. | Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives |
| US4751221A (en) * | 1985-10-18 | 1988-06-14 | Sloan-Kettering Institute For Cancer Research | 2-fluoro-arabinofuranosyl purine nucleosides |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4965270A (en) * | 1987-05-30 | 1990-10-23 | Beecham Group P.L.C. | Purine derivatives |
| US5723609A (en) * | 1988-03-30 | 1998-03-03 | E. R. Squibb & Sons, Inc. | Bis (hydroxymethyl) cyclobutyl purines |
| US5352669A (en) * | 1990-03-13 | 1994-10-04 | The Of The United States Of America As Represented By The Department Of Health And Human Services | O6 -benzylated guanine, guanosine and 2'-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity |
| US5691307A (en) * | 1990-03-13 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | O6 -substituted guanine compositions and methods for depleting O6 |
| US5091430A (en) * | 1990-03-13 | 1992-02-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | O6 -substituted guanine compounds and methods for depleting O6 -alkylguanine-DNA alkyltransferase levels |
| CA2059663C (en) * | 1990-06-29 | 1996-11-12 | David Bertland Farmer | Emulsion polymerisation |
| FR2676058B1 (fr) | 1991-04-30 | 1994-02-25 | Hoechst Lab | Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers. |
| NZ244306A (en) * | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
| DE4236237A1 (de) | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, ihre Herstellung und Verwendung als Arzneimittel |
| DE4311651A1 (de) * | 1993-04-08 | 1994-10-13 | Boehringer Ingelheim Int | Virus für den Transport von Fremd-DNA in höhere eukaryotische Zellen |
| AU697977B2 (en) | 1993-06-08 | 1998-10-22 | Cancer Research Technology Limited | O6-substituted guanine derivatives, a process for their preparation and their use in treating tumour cells |
| US6043228A (en) | 1993-06-08 | 2000-03-28 | Cancer Research Campaign Technology Limited | O6 -substituted guanine derivatives, a process for their preparation and their use in treating tumor cells |
| EP0647450A1 (en) | 1993-09-09 | 1995-04-12 | BEHRINGWERKE Aktiengesellschaft | Improved prodrugs for enzyme mediated activation |
| DK0648503T3 (da) | 1993-09-22 | 2000-10-02 | Hoechst Ag | Pro-prodrugs, deres fremstilling og anvendelse |
| US5929046A (en) | 1994-06-08 | 1999-07-27 | Cancer Research Campaign Technology Limited | Pyrimidine and purine derivatives and their use in treating tumour cells |
| US5525606A (en) | 1994-08-01 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines |
| EP0795334B1 (de) | 1996-03-12 | 2006-02-01 | Sanofi-Aventis Deutschland GmbH | Neuartige Prodrugs für die Therapie von Tumoren und entzündlichen Erkrankungen |
| US5965126A (en) | 1996-03-25 | 1999-10-12 | The Penn State Research Foundation | use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents |
| WO1999025386A1 (en) | 1997-11-13 | 1999-05-27 | Case Western Reserve University | delta-O6-METHYLGUANINE-DNA METHYLTRANSFERASE GENE TRANSFER FOR O6-BENZYLGUANINE AND (N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA) RESISTANCE |
-
1994
- 1994-08-01 US US08/283,953 patent/US5525606A/en not_active Expired - Lifetime
-
1995
- 1995-07-31 DK DK01108585T patent/DK1142893T3/da active
- 1995-07-31 EP EP01108585A patent/EP1142893B1/en not_active Expired - Lifetime
- 1995-07-31 CA CA002632452A patent/CA2632452A1/en not_active Abandoned
- 1995-07-31 DK DK95928237T patent/DK0775142T3/da active
- 1995-07-31 PT PT01108585T patent/PT1142893E/pt unknown
- 1995-07-31 AT AT01108585T patent/ATE286054T1/de not_active IP Right Cessation
- 1995-07-31 DE DE69523462T patent/DE69523462T2/de not_active Expired - Fee Related
- 1995-07-31 PT PT95928237T patent/PT775142E/pt unknown
- 1995-07-31 EP EP95928237A patent/EP0775142B1/en not_active Expired - Lifetime
- 1995-07-31 DE DE69533900T patent/DE69533900T2/de not_active Expired - Fee Related
- 1995-07-31 AT AT95928237T patent/ATE207490T1/de not_active IP Right Cessation
- 1995-07-31 US US08/849,223 patent/US5958932A/en not_active Expired - Fee Related
- 1995-07-31 WO PCT/US1995/009702 patent/WO1996004281A1/en not_active Ceased
- 1995-07-31 ES ES01108585T patent/ES2233513T3/es not_active Expired - Lifetime
- 1995-07-31 ES ES95928237T patent/ES2167451T3/es not_active Expired - Lifetime
- 1995-07-31 EP EP04030121A patent/EP1518854A1/en not_active Withdrawn
- 1995-07-31 JP JP50669496A patent/JP3981407B2/ja not_active Expired - Lifetime
- 1995-07-31 CA CA002195856A patent/CA2195856C/en not_active Expired - Fee Related
-
1996
- 1996-06-11 US US08/661,923 patent/US5753668A/en not_active Expired - Lifetime
-
1997
- 1997-09-11 US US08/927,846 patent/US5916894A/en not_active Expired - Fee Related
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1999
- 1999-05-25 US US09/318,238 patent/US6172070B1/en not_active Expired - Fee Related
- 1999-06-15 US US09/333,047 patent/US6333331B1/en not_active Expired - Fee Related
-
2000
- 2000-06-09 US US09/590,187 patent/US6303604B1/en not_active Expired - Fee Related
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2001
- 2001-08-14 US US09/928,410 patent/US6436945B2/en not_active Expired - Fee Related
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2006
- 2006-10-04 JP JP2006273447A patent/JP2007077157A/ja active Pending