JP2007069208A - 弱酸性および/または弱塩基性化合物の結晶化方法 - Google Patents

弱酸性および/または弱塩基性化合物の結晶化方法 Download PDF

Info

Publication number
JP2007069208A
JP2007069208A JP2006233790A JP2006233790A JP2007069208A JP 2007069208 A JP2007069208 A JP 2007069208A JP 2006233790 A JP2006233790 A JP 2006233790A JP 2006233790 A JP2006233790 A JP 2006233790A JP 2007069208 A JP2007069208 A JP 2007069208A
Authority
JP
Japan
Prior art keywords
compound
value
solution
solubility
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006233790A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007069208A5 (https=
Inventor
Lei Du-Cuny
ライ・ドゥ−クニィ
Manfred Kansy
マンフレット・カンジィ
Joerg Huwyler
ヤェーク・フビイラー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2007069208A publication Critical patent/JP2007069208A/ja
Publication of JP2007069208A5 publication Critical patent/JP2007069208A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/005Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054Use of anti-solvent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of Non-Electrical Variables (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006233790A 2005-08-30 2006-08-30 弱酸性および/または弱塩基性化合物の結晶化方法 Pending JP2007069208A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05018750A EP1759749A1 (en) 2005-08-30 2005-08-30 Method for crystallization of a weakly acidic and/or weakly basic compound

Publications (2)

Publication Number Publication Date
JP2007069208A true JP2007069208A (ja) 2007-03-22
JP2007069208A5 JP2007069208A5 (https=) 2009-10-08

Family

ID=35686493

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006233790A Pending JP2007069208A (ja) 2005-08-30 2006-08-30 弱酸性および/または弱塩基性化合物の結晶化方法

Country Status (7)

Country Link
US (1) US7381265B2 (https=)
EP (1) EP1759749A1 (https=)
JP (1) JP2007069208A (https=)
CN (1) CN1923328B (https=)
CA (1) CA2551485C (https=)
ES (1) ES2608600T3 (https=)
SG (1) SG130091A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110024354A1 (en) * 2009-07-30 2011-02-03 General Electric Company Desalination system and method
CN116850633A (zh) * 2023-08-18 2023-10-10 青海利亚达化工有限公司 一种制备晶种的装置及方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0824795A (ja) * 1994-07-18 1996-01-30 Toshiba Corp 郵便物区分装置
JP2002255928A (ja) * 2001-02-28 2002-09-11 Mitsubishi Chemicals Corp 高純度ホモシスチン誘導体の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093089A (en) * 1990-07-16 1992-03-03 Chemetics International Company Ltd. Process for the separation of sulphate
CN1212324C (zh) * 2002-06-10 2005-07-27 上海医药工业研究院 结晶头孢硫脒及其制备方法和用途
CN1651341A (zh) * 2004-02-06 2005-08-10 中南大学 硫酸盐体系中多金属离子溶液的深度净化方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0824795A (ja) * 1994-07-18 1996-01-30 Toshiba Corp 郵便物区分装置
JP2002255928A (ja) * 2001-02-28 2002-09-11 Mitsubishi Chemicals Corp 高純度ホモシスチン誘導体の製造方法

Also Published As

Publication number Publication date
CN1923328A (zh) 2007-03-07
EP1759749A1 (en) 2007-03-07
SG130091A1 (en) 2007-03-20
US7381265B2 (en) 2008-06-03
CA2551485A1 (en) 2007-02-28
ES2608600T3 (es) 2017-04-12
CA2551485C (en) 2012-12-18
CN1923328B (zh) 2010-09-01
US20070044705A1 (en) 2007-03-01

Similar Documents

Publication Publication Date Title
Sou et al. Automated assays for thermodynamic (equilibrium) solubility determination
Brandel et al. Measuring induction times and crystal nucleation rates
Avdeef Suggested improvements for measurement of equilibrium solubility-pH of ionizable drugs
Bergström et al. Perspectives in solubility measurement and interpretation
Avdeef et al. pH-metric solubility.: 3. Dissolution titration template method for solubility determination
Veseli et al. A review of methods for solubility determination in biopharmaceutical drug characterization
Park et al. Determination of solubility of polymorphs using differential scanning calorimetry
Loftsson et al. Determination of aqueous solubility by heating and equilibration: a technical note
Comer et al. The intrinsic aqueous solubility of indomethacin
Chavan et al. Evaluation of the inhibitory potential of HPMC, PVP and HPC polymers on nucleation and crystal growth
Stuart et al. Chasing equilibrium: measuring the intrinsic solubility of weak acids and bases
Box et al. Equilibrium versus kinetic measurements of aqueous solubility, and the ability of compounds to supersaturate in solution—a validation study
Baka et al. Study of equilibrium solubility measurement by saturation shake-flask method using hydrochlorothiazide as model compound
Yang et al. Solubility of Form α and Form γ of Glycine in Aqueous Solutions
Zhang et al. Nucleation kinetics of lovastatin in different solvents from metastable zone widths
Qu et al. Solubility and stability of anhydrate/hydrate in solvent mixtures
Pataki et al. In-line monitoring of carvedilol crystallization using Raman spectroscopy
Luo et al. Antisolvent crystallization of biapenem: estimation of growth and nucleation kinetics
Apley et al. Determination of thermodynamic solubility of active pharmaceutical ingredients for veterinary species: A new USP general chapter
Ziegenheim et al. The kinetics of the precipitation of gypsum, CaSO4· 2H2O, over a wide range of reactant concentrations
O’Mahony et al. Measuring the solubility of a quickly transforming metastable polymorph of carbamazepine
Semjonov et al. The formation and physical stability of two-phase solid dispersion systems of indomethacin in supercooled molten mixtures with different matrix formers
Ma et al. Thermodynamic and Kinetic Investigation on the Crucial Factors Affecting Adefovir Dipivoxil-Saccharin Cocrystallization: Ma et al.
Lange et al. Predicting the effect of pH on stability and solubility of polymorphs, hydrates, and cocrystals
Schram et al. Understanding crystal growth kinetics in the absence and presence of a polymer using a rotating disk apparatus

Legal Events

Date Code Title Description
A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20070420

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20070420

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090821

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090821

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20120209

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20120323

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120330

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20120323

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120629

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120704

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20121120