CA2551485C - Method for crystallization of a weakly acidic and/or weakly basic compound - Google Patents

Method for crystallization of a weakly acidic and/or weakly basic compound Download PDF

Info

Publication number
CA2551485C
CA2551485C CA2551485A CA2551485A CA2551485C CA 2551485 C CA2551485 C CA 2551485C CA 2551485 A CA2551485 A CA 2551485A CA 2551485 A CA2551485 A CA 2551485A CA 2551485 C CA2551485 C CA 2551485C
Authority
CA
Canada
Prior art keywords
compound
value
solution
solubility
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2551485A
Other languages
English (en)
French (fr)
Other versions
CA2551485A1 (en
Inventor
Lei Du-Cuny
Manfred Kansy
Jorg Huwyler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2551485A1 publication Critical patent/CA2551485A1/en
Application granted granted Critical
Publication of CA2551485C publication Critical patent/CA2551485C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/005Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054Use of anti-solvent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of Non-Electrical Variables (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2551485A 2005-08-30 2006-07-06 Method for crystallization of a weakly acidic and/or weakly basic compound Expired - Fee Related CA2551485C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05018750A EP1759749A1 (en) 2005-08-30 2005-08-30 Method for crystallization of a weakly acidic and/or weakly basic compound
EP05018750.9 2005-08-30

Publications (2)

Publication Number Publication Date
CA2551485A1 CA2551485A1 (en) 2007-02-28
CA2551485C true CA2551485C (en) 2012-12-18

Family

ID=35686493

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2551485A Expired - Fee Related CA2551485C (en) 2005-08-30 2006-07-06 Method for crystallization of a weakly acidic and/or weakly basic compound

Country Status (7)

Country Link
US (1) US7381265B2 (https=)
EP (1) EP1759749A1 (https=)
JP (1) JP2007069208A (https=)
CN (1) CN1923328B (https=)
CA (1) CA2551485C (https=)
ES (1) ES2608600T3 (https=)
SG (1) SG130091A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110024354A1 (en) * 2009-07-30 2011-02-03 General Electric Company Desalination system and method
CN116850633A (zh) * 2023-08-18 2023-10-10 青海利亚达化工有限公司 一种制备晶种的装置及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093089A (en) * 1990-07-16 1992-03-03 Chemetics International Company Ltd. Process for the separation of sulphate
JPH0824795A (ja) * 1994-07-18 1996-01-30 Toshiba Corp 郵便物区分装置
JP3888071B2 (ja) * 2001-02-28 2007-02-28 三菱化学株式会社 高純度ホモシスチン誘導体の製造方法
CN1212324C (zh) * 2002-06-10 2005-07-27 上海医药工业研究院 结晶头孢硫脒及其制备方法和用途
CN1651341A (zh) * 2004-02-06 2005-08-10 中南大学 硫酸盐体系中多金属离子溶液的深度净化方法

Also Published As

Publication number Publication date
CN1923328A (zh) 2007-03-07
EP1759749A1 (en) 2007-03-07
SG130091A1 (en) 2007-03-20
JP2007069208A (ja) 2007-03-22
US7381265B2 (en) 2008-06-03
CA2551485A1 (en) 2007-02-28
ES2608600T3 (es) 2017-04-12
CN1923328B (zh) 2010-09-01
US20070044705A1 (en) 2007-03-01

Similar Documents

Publication Publication Date Title
Avdeef et al. pH-metric solubility.: 3. Dissolution titration template method for solubility determination
Mangin et al. Polymorphism in processes of crystallization in solution: a practical review
Bergström et al. Perspectives in solubility measurement and interpretation
Stuart et al. Chasing equilibrium: measuring the intrinsic solubility of weak acids and bases
Yan et al. Systematic study of barite nucleation and inhibition with various polymeric scale inhibitors by novel laser apparatus
US20020004244A1 (en) Measurement of solubility-pH profiles
Comer et al. The intrinsic aqueous solubility of indomethacin
Jiang et al. Concomitant polymorphism of o-aminobenzoic acid in antisolvent crystallization
Sun et al. Characterization of small molecule–protein interactions using SPR method
JP3631300B2 (ja) クレアチニン検定方法
Qu et al. Raman and ATR FTIR spectroscopy in reactive crystallization: Simultaneous monitoring of solute concentration and polymorphic state of the crystals
Tres et al. Mechanistic understanding of the phase behavior of supersaturated solutions of poorly water-soluble drugs
CA2551485C (en) Method for crystallization of a weakly acidic and/or weakly basic compound
Avdeef Disproportionation of pharmaceutical salts: pHmax and phase-solubility/pH variance
Companys et al. Determination of Zn2+ concentration with AGNES using different strategies to reduce the deposition time
Kathuria et al. A substituted benzothiazolinic merocyanine derivative as a reversible, selective, colorimetric and fluorescent probe for HSO4− in aqueous solution
EP1759750B1 (en) Method for crystallization of a weakly acidic and/or weakly basic compound
Sanvito et al. Fast iron speciation in seawater by catalytic competitive ligand equilibration-cathodic stripping voltammetry with tenfold sample size reduction
Kim et al. Solubility and prediction of the heat of solution of sodium naproxen in aqueous solutions
Costa-Neto et al. Flow injection turbidimetric determination of thiamine in pharmaceutical formulations using silicotungstic acid as precipitant reagent
US10184927B2 (en) Method for measuring polymer concentration in water systems
Du-Cuny et al. A potentiometric titration method for the crystallization of drug-like organic molecules
Narasimham et al. Kinetic and intrinsic solubility determination of some β-blockers and antidiabetics by potentiometry
Kitamura et al. Dependence of polymorphic transformation on anti-solvent composition and crystallization behavior of thiazole-derivative pharmaceutical
Lišková et al. Determination of dissociation constants of compounds with potential cognition enhancing activity by capillary zone electrophoresis

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20200831