JP2006525994A - 非膵島組織における調節された膵ホルモンの産生を誘導する方法 - Google Patents

非膵島組織における調節された膵ホルモンの産生を誘導する方法 Download PDF

Info

Publication number
JP2006525994A
JP2006525994A JP2006506631A JP2006506631A JP2006525994A JP 2006525994 A JP2006525994 A JP 2006525994A JP 2006506631 A JP2006506631 A JP 2006506631A JP 2006506631 A JP2006506631 A JP 2006506631A JP 2006525994 A JP2006525994 A JP 2006525994A
Authority
JP
Japan
Prior art keywords
pdx
cell
cells
expression
pancreatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006506631A
Other languages
English (en)
Japanese (ja)
Inventor
サラ ファーバー，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2006525994A publication Critical patent/JP2006525994A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Microbiology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006506631A 2003-05-12 2004-05-12 非膵島組織における調節された膵ホルモンの産生を誘導する方法 Pending JP2006525994A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46971503P 2003-05-12 2003-05-12
PCT/IB2004/001973 WO2004098646A1 (en) 2003-05-12 2004-05-12 Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010261850A Division JP2011068660A (ja) 2003-05-12 2010-11-24 非膵島組織における調節された膵ホルモンの産生を誘導する方法

Publications (1)

Publication Number Publication Date
JP2006525994A true JP2006525994A (ja) 2006-11-16

Family

ID=33435254

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006506631A Pending JP2006525994A (ja) 2003-05-12 2004-05-12 非膵島組織における調節された膵ホルモンの産生を誘導する方法
JP2010261850A Pending JP2011068660A (ja) 2003-05-12 2010-11-24 非膵島組織における調節された膵ホルモンの産生を誘導する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010261850A Pending JP2011068660A (ja) 2003-05-12 2010-11-24 非膵島組織における調節された膵ホルモンの産生を誘導する方法

Country Status (4)

Country Link
EP (1) EP1624898A1 (enrdf_load_stackoverflow)
JP (2) JP2006525994A (enrdf_load_stackoverflow)
AU (1) AU2004236573B2 (enrdf_load_stackoverflow)
WO (1) WO2004098646A1 (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019530439A (ja) * 2016-08-29 2019-10-24 ハッケンサック ユニヴァーシティ メディカル センター ヒトにおける血小板様細胞を含有する血液の血小板に富む画分の幹細胞性により成体細胞を再プログラミングするための組成物および方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US8778899B2 (en) 1999-06-01 2014-07-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
DE602006020071D1 (de) 2005-12-21 2011-03-24 Univ Catholique Louvain Isolierte leberstammzellen
AU2007299649B2 (en) * 2006-09-22 2012-11-15 Baylor Research Institute In vivo transformation of pancreatic acinar cells into insulin-producing cells
EP2968472A1 (en) * 2013-03-15 2016-01-20 Université de Genève Use of insulin signaling antagonists, optionally in combination of transfection of non-beta cells, for inducing insulin production
MX2015017235A (es) 2013-06-13 2017-05-04 Orgenesis Ltd Poblaciones celulares, metodos de transdiferenciacion y metodos de uso de los mismos.
US20160129047A1 (en) 2013-07-05 2016-05-12 Université Catholique de Louvain Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
US9957287B2 (en) 2016-05-26 2018-05-01 Cornell University Methods and compositions to treat type-1 and type-2 diabetes
CA3033750A1 (en) 2016-08-29 2018-03-08 Hackensack University Medical Center Compositions and methods for programming adult cells with platelet rich fraction of blood containing platelet-like cells
SG11201911256UA (en) 2017-05-08 2020-01-30 Orgenesis Ltd Transdifferentiated cell populations and methods of use thereof
WO2019022780A1 (en) * 2017-07-27 2019-01-31 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College FUNCTIONAL PANCREATIC CELLS FROM FÉLINSPREADING ADIPOSE TISSUE
CN112899351B (zh) * 2021-02-03 2022-08-26 东华大学 一种双重荧光定量pcr检测pdx模型小鼠细胞浸润状态试剂盒

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003500457A (ja) * 1999-06-01 2003-01-07 サラ ファーバー， 非ランゲルハンス島組織における調節された膵臓ホルモンを誘導する方法
WO2003033697A1 (en) * 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells
JP2003304878A (ja) * 2002-04-17 2003-10-28 Susumu Kiyono インスリン産生細胞の誘導

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0206357D0 (en) * 2002-03-18 2002-05-01 Univ Bath Cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003500457A (ja) * 1999-06-01 2003-01-07 サラ ファーバー， 非ランゲルハンス島組織における調節された膵臓ホルモンを誘導する方法
WO2003033697A1 (en) * 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells
JP2003304878A (ja) * 2002-04-17 2003-10-28 Susumu Kiyono インスリン産生細胞の誘導

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6010028021, ＫＯＪＩＭＡ，Ｈ． ｅｔ ａｌ, "Ｃｏｍｂｉｎｅｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｐａｎｃｒｅａｔｉｃ ｄｕｏｄｅｎａｌ ｈｏｍｅｏｂｏｘ １ ａｎｄ ｉｓｌｅｔ ｆａｃｔｏｒ １ ｉｎｄｕｃｅｓ ｉｍｍａｔｕｒｅ ｅｎｔｅｒｏｃｙｔｅ", Ｄｉａｂｅｔｅｓ, 2002, Ｖｏｌ．５１， Ｎｏ．５, ｐ．１３９８−４０８ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019530439A (ja) * 2016-08-29 2019-10-24 ハッケンサック ユニヴァーシティ メディカル センター ヒトにおける血小板様細胞を含有する血液の血小板に富む画分の幹細胞性により成体細胞を再プログラミングするための組成物および方法
JP7219211B2 (ja) 2016-08-29 2023-02-07 ハッケンサック ユニヴァーシティ メディカル センター ヒトにおける血小板様細胞を含有する血液の血小板に富む画分の幹細胞性により成体細胞を再プログラミングするための組成物および方法

Also Published As

Publication number Publication date
AU2004236573A1 (en) 2004-11-18
WO2004098646B1 (en) 2005-04-28
JP2011068660A (ja) 2011-04-07
WO2004098646A1 (en) 2004-11-18
EP1624898A1 (en) 2006-02-15
AU2004236573B2 (en) 2009-10-22

Similar Documents

Publication Publication Date Title
JP2011068660A (ja) 非膵島組織における調節された膵ホルモンの産生を誘導する方法
US9481894B2 (en) Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US8119405B2 (en) Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
JP2003500457A5 (enrdf_load_stackoverflow)
KR102487883B1 (ko) 전환분화 방법 및 이의 사용 방법
KR102181336B1 (ko) 세포 집단, 이의 전환분화 방법 및 이용 방법
KR20080036015A (ko) 글루코오스 유도성 인슐린 발현 및 당뇨병 치료 방법
US20030157071A1 (en) Treatment or replacement therapy using transgenic stem cells delivered to the gut
Zhang et al. Genetically engineered K cells provide sufficient insulin to correct hyperglycemia in a nude murine model
JP2003531581A (ja) 黒色腫分化関連遺伝子−５およびプロモーターならびにこれらの使用
US20160083733A1 (en) Novel treatment of metabolic diseases
JP2004520006A (ja) ラットｐｅｇ−３プロモーターの領域を含んでなる核酸とその利用
AU2002344233A1 (en) Treatment or replacement therapy using transgenic stem cells delivered to the gut
AU2008200852A1 (en) Treatment or replacement therapy using transgenic stem cells delivered to the gut

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070511

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100524

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100823

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100830

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100916

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100927

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101022

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20101029

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20101124

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110221