JP2006525811A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006525811A5 JP2006525811A5 JP2006514886A JP2006514886A JP2006525811A5 JP 2006525811 A5 JP2006525811 A5 JP 2006525811A5 JP 2006514886 A JP2006514886 A JP 2006514886A JP 2006514886 A JP2006514886 A JP 2006514886A JP 2006525811 A5 JP2006525811 A5 JP 2006525811A5
- Authority
- JP
- Japan
- Prior art keywords
- sirna
- sequence
- nucleotides
- nucleotide sequence
- target gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims 53
- 239000002773 nucleotide Substances 0.000 claims 50
- 125000003729 nucleotide group Chemical group 0.000 claims 50
- 238000000034 method Methods 0.000 claims 42
- 108020004459 Small interfering RNA Proteins 0.000 claims 34
- 239000004055 small Interfering RNA Substances 0.000 claims 34
- 210000003527 eukaryotic cell Anatomy 0.000 claims 21
- 230000000692 anti-sense effect Effects 0.000 claims 17
- 108091081021 Sense strand Proteins 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108091035707 Consensus sequence Proteins 0.000 claims 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 230000003828 downregulation Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000030279 gene silencing Effects 0.000 claims 2
- 230000009368 gene silencing by RNA Effects 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47139203P | 2003-05-16 | 2003-05-16 | |
| US51522303P | 2003-10-27 | 2003-10-27 | |
| PCT/US2004/015439 WO2005018534A2 (en) | 2003-05-16 | 2004-05-17 | Methods and compositions for rna interference |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010202235A Division JP2011004763A (ja) | 2003-05-16 | 2010-09-09 | Ｒｎａ干渉の方法と組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006525811A JP2006525811A (ja) | 2006-11-16 |
| JP2006525811A5 true JP2006525811A5 (https=) | 2007-07-05 |
Family
ID=34221197
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006514886A Pending JP2006525811A (ja) | 2003-05-16 | 2004-05-17 | Ｒｎａ干渉の方法と組成物 |
| JP2010202235A Pending JP2011004763A (ja) | 2003-05-16 | 2010-09-09 | Ｒｎａ干渉の方法と組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010202235A Pending JP2011004763A (ja) | 2003-05-16 | 2010-09-09 | Ｒｎａ干渉の方法と組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8609830B2 (https=) |
| EP (1) | EP1628993A4 (https=) |
| JP (2) | JP2006525811A (https=) |
| CA (1) | CA2525619A1 (https=) |
| WO (1) | WO2005018534A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040219565A1 (en) | 2002-10-21 | 2004-11-04 | Sakari Kauppinen | Oligonucleotides useful for detecting and analyzing nucleic acids of interest |
| US8447526B2 (en) | 2005-05-23 | 2013-05-21 | Microsoft Corporation | Methods and computer systems for analyzing high-throughput assays |
| US8014957B2 (en) | 2005-12-15 | 2011-09-06 | Fred Hutchinson Cancer Research Center | Genes associated with progression and response in chronic myeloid leukemia and uses thereof |
| JP2010525826A (ja) * | 2007-05-03 | 2010-07-29 | ロゼッタ インファーマティックス エルエルシー | 癌を治療するためのｍｉｒ３４治療剤を含む組成物 |
| EP2581081A3 (en) | 2007-06-01 | 2013-07-31 | The Trustees Of Princeton University | Treatment of viral infections by modulation of host cell metabolic pathways |
| US20110294870A1 (en) * | 2008-12-04 | 2011-12-01 | Opko Curna, Llc | Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene |
| US20130131148A1 (en) * | 2010-04-12 | 2013-05-23 | Noam Shomron | Micro-rna for cancer diagnosis, prognosis and therapy |
| DE102011009470A1 (de) * | 2011-01-21 | 2012-08-09 | Friedrich-Schiller-Universität Jena | Biologisch wirksame Nukleotid-Moleküle zur gezielten Abtötung von Zellen, Verwendung derselben sowie Applikationskit |
| WO2012143427A1 (en) * | 2011-04-19 | 2012-10-26 | Santaris Pharma A/S | Anti polyomavirus compounds |
| CN110225770B (zh) | 2016-12-14 | 2022-04-26 | 杨森生物科技公司 | 结合cd8a的纤连蛋白iii型结构域 |
| EP3554535A4 (en) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | PD-L1 BINDING FIBRONECTIN TYPE III DOMAINS |
| EP3554561B1 (en) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Cd137 binding fibronectin type iii domains |
| US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
| WO2021076543A1 (en) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Epcam binding fibronectin type iii domains |
| CN119119240A (zh) | 2019-10-14 | 2024-12-13 | Aro生物疗法公司 | 结合cd71的纤维粘连蛋白iii型结构域 |
| CA3214552A1 (en) | 2021-04-14 | 2022-10-20 | Russell C. Addis | Cd71 binding fibronectin type iii domains |
| EP4323008A4 (en) | 2021-04-14 | 2026-02-25 | Aro Biotherapeutics Company | FN3-ARNSI DOMAIN CONJUGATES AND THEIR USES |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
| AU672760B2 (en) | 1991-09-24 | 1996-10-17 | Keygene N.V. | Selective restriction fragment amplification: a general method for DNA fingerprinting |
| US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
| US6165709A (en) | 1997-02-28 | 2000-12-26 | Fred Hutchinson Cancer Research Center | Methods for drug target screening |
| WO1998041531A2 (en) | 1997-03-20 | 1998-09-24 | University Of Washington | Solvent for biopolymer synthesis, solvent microdroplets and methods of use |
| US6028189A (en) | 1997-03-20 | 2000-02-22 | University Of Washington | Solvent for oligonucleotide synthesis and methods of use |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| CN100351562C (zh) * | 1998-01-13 | 2007-11-28 | 特里·谢弗 | 具有浮动保持环的阀组件 |
| US5965352A (en) | 1998-05-08 | 1999-10-12 | Rosetta Inpharmatics, Inc. | Methods for identifying pathways of drug action |
| US6324479B1 (en) | 1998-05-08 | 2001-11-27 | Rosetta Impharmatics, Inc. | Methods of determining protein activity levels using gene expression profiles |
| US6218122B1 (en) | 1998-06-19 | 2001-04-17 | Rosetta Inpharmatics, Inc. | Methods of monitoring disease states and therapies using gene expression profiles |
| US6132969A (en) | 1998-06-19 | 2000-10-17 | Rosetta Inpharmatics, Inc. | Methods for testing biological network models |
| US6203987B1 (en) | 1998-10-27 | 2001-03-20 | Rosetta Inpharmatics, Inc. | Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns |
| US6950752B1 (en) | 1998-10-27 | 2005-09-27 | Rosetta Inpharmatics Llc | Methods for removing artifact from biological profiles |
| US6801859B1 (en) | 1998-12-23 | 2004-10-05 | Rosetta Inpharmatics Llc | Methods of characterizing drug activities using consensus profiles |
| US6351712B1 (en) | 1998-12-28 | 2002-02-26 | Rosetta Inpharmatics, Inc. | Statistical combining of cell expression profiles |
| US6132997A (en) | 1999-05-28 | 2000-10-17 | Agilent Technologies | Method for linear mRNA amplification |
| US20020016216A1 (en) | 1999-06-08 | 2002-02-07 | Kenji Kobayashi | Golf club |
| US7013221B1 (en) | 1999-07-16 | 2006-03-14 | Rosetta Inpharmatics Llc | Iterative probe design and detailed expression profiling with flexible in-situ synthesis arrays |
| US6271002B1 (en) | 1999-10-04 | 2001-08-07 | Rosetta Inpharmatics, Inc. | RNA amplification method |
| ES2336887T5 (es) | 2000-03-30 | 2019-03-06 | Whitehead Inst Biomedical Res | Mediadores de interferencia por ARN específicos de secuencias de ARN |
| US7807447B1 (en) | 2000-08-25 | 2010-10-05 | Merck Sharp & Dohme Corp. | Compositions and methods for exon profiling |
| NZ523914A (en) | 2000-08-29 | 2004-02-27 | Mallinckrodt Baker Inc | Functionalized polymeric media for separation of analytes |
| WO2002044399A2 (en) | 2000-11-28 | 2002-06-06 | Rosetta Inpharmatics, Inc. | In vitro transcription method for rna amplification |
| CA2429814C (en) * | 2000-12-01 | 2014-02-18 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20020182590A1 (en) | 2001-05-25 | 2002-12-05 | Vanderbilt University | Determining protein function in cell culture using RNA interference |
| IL159756A0 (en) | 2001-07-12 | 2004-06-20 | Univ Massachusetts | IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING |
| US7418351B2 (en) | 2002-01-31 | 2008-08-26 | Rosetta Inpharmatics Llc | Methods for analysis of measurement errors in measured signals |
| US20040248299A1 (en) * | 2002-12-27 | 2004-12-09 | Sumedha Jayasena | RNA interference |
| US7996155B2 (en) | 2003-01-22 | 2011-08-09 | Microsoft Corporation | ANOVA method for data analysis |
| CN1926551B (zh) | 2003-10-27 | 2010-06-16 | 罗斯塔生化科技有限责任公司 | 用于基因沉默的siRNA的设计方法 |
-
2004
- 2004-05-17 WO PCT/US2004/015439 patent/WO2005018534A2/en not_active Ceased
- 2004-05-17 EP EP04776024A patent/EP1628993A4/en not_active Withdrawn
- 2004-05-17 JP JP2006514886A patent/JP2006525811A/ja active Pending
- 2004-05-17 US US10/557,219 patent/US8609830B2/en active Active
- 2004-05-17 CA CA002525619A patent/CA2525619A1/en not_active Abandoned
-
2010
- 2010-09-09 JP JP2010202235A patent/JP2011004763A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006525811A5 (https=) | ||
| Fernandes et al. | Aerobic exercise training promotes physiological cardiac remodeling involving a set of microRNAs | |
| Tan et al. | Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells | |
| US11193171B2 (en) | Diagnostic, prognostic and therapeutic uses of long noncoding RNAS for heart disease and regenerative medicine | |
| Danowski et al. | Decreased expression of miR-133a but not of miR-1 is associated with signs of heart failure in patients undergoing coronary bypass surgery | |
| Wang et al. | Role of microRNAs in cardiac hypertrophy and heart failure | |
| JP2011200238A5 (https=) | ||
| Pacholewska et al. | Novel equine tissue miRNAs and breed-related miRNA expressed in serum | |
| CN1890370A (zh) | RNAi潜能的预测方法 | |
| JP2012135301A5 (https=) | ||
| Hong et al. | Differential regulation of microRNA transcriptome in chicken lines resistant and susceptible to necrotic enteritis disease | |
| JP2010530239A5 (https=) | ||
| JP2011004763A (ja) | Ｒｎａ干渉の方法と組成物 | |
| Cheng et al. | LncRNA MALAT1 regulates proliferation and apoptosis of vascular smooth muscle cells by targeting miRNA-124-3p/PPARα axis. | |
| Miao et al. | Critical roles of microRNAs in the pathogenesis of systemic sclerosis: New advances, challenges and potential directions | |
| Latronico et al. | microRNAs in hypertrophy and heart failure | |
| Henshall | Manipulating microRNAs in murine models: targeting the multi-targeting in epilepsy | |
| Oladejo et al. | MicroRNAome: potential and veritable immunomolecular therapeutic and diagnostic baseline for lingering bovine endometritis | |
| JP2022163074A (ja) | 心肥大におけるマイクロＲＮＡ ｈｓａ－ｍｉＲ－６６５ | |
| CN104436195B (zh) | miR-155在制备防治急性肺损伤药物中的用途 | |
| WO2015085904A1 (zh) | 禽流感病毒miRNA及其鉴定、检测和应用 | |
| CN108977443A (zh) | 一种表达动脉粥样硬化炎症活动的环状rna及其应用 | |
| US9909127B2 (en) | Inhibitor for inhibiting avian influenza virus and a pharmaceutical composition containing the same | |
| JP7050277B2 (ja) | Ｒｎａ分子 | |
| CN111560437A (zh) | 用于预测口腔鳞癌的生物标志物及其在治疗中的应用 |