JP2006520801A5 - - Google Patents

Info

Publication number

JP2006520801A5

JP2006520801A5 JP2006507423A JP2006507423A JP2006520801A5 JP 2006520801 A5 JP2006520801 A5 JP 2006520801A5 JP 2006507423 A JP2006507423 A JP 2006507423A JP 2006507423 A JP2006507423 A JP 2006507423A JP 2006520801 A5 JP2006520801 A5 JP 2006520801A5

Authority

JP

Japan

Prior art keywords

composition

group

mixtures

local anesthetic

shear

Prior art date

2004-03-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 57
• 238000000034 method Methods 0.000 claims 22
• 239000003589 local anesthetic agent Substances 0.000 claims 14
• -1 propivacaine Chemical compound 0.000 claims 12
• 150000003839 salts Chemical class 0.000 claims 10
• 125000005908 glyceryl ester group Chemical group 0.000 claims 8
• DUXYWXYOBMKGIN-UHFFFAOYSA-N trimyristin Chemical compound CCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC DUXYWXYOBMKGIN-UHFFFAOYSA-N 0.000 claims 8
• DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims 8
• 150000004676 glycans Chemical class 0.000 claims 7
• 229920001282 polysaccharide Polymers 0.000 claims 7
• 239000005017 polysaccharide Substances 0.000 claims 7
• 150000003180 prostaglandins Chemical class 0.000 claims 7
• 230000002227 vasoactive effect Effects 0.000 claims 7
• OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical group O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims 6
• 125000001931 aliphatic group Chemical group 0.000 claims 5
• 229920000642 polymer Polymers 0.000 claims 5
• RXBQNMWIQKOSCS-UHFFFAOYSA-N (7,7-dimethyl-4-bicyclo[3.1.1]hept-3-enyl)methanol Chemical compound C1C2C(C)(C)C1CC=C2CO RXBQNMWIQKOSCS-UHFFFAOYSA-N 0.000 claims 4
• LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 4
• 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 claims 4
• RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 claims 4
• NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 4
• 229920002125 Sokalan® Polymers 0.000 claims 4
• BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 claims 4
• PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 claims 4
• 150000001298 alcohols Chemical class 0.000 claims 4
• 229960003150 bupivacaine Drugs 0.000 claims 4
• 239000003995 emulsifying agent Substances 0.000 claims 4
• 229960004194 lidocaine Drugs 0.000 claims 4
• RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims 4
• 239000003961 penetration enhancing agent Substances 0.000 claims 4
• 239000002562 thickening agent Substances 0.000 claims 4
• 229940113164 trimyristin Drugs 0.000 claims 4
• PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 claims 4
• 229940117972 triolein Drugs 0.000 claims 4
• 150000002148 esters Chemical class 0.000 claims 3
• BUJAGSGYPOAWEI-SECBINFHSA-N (2r)-2-amino-n-(2,6-dimethylphenyl)propanamide Chemical compound C[C@@H](N)C(=O)NC1=C(C)C=CC=C1C BUJAGSGYPOAWEI-SECBINFHSA-N 0.000 claims 2
• RXYQCXVUMLSFHM-CKCSCOOESA-N 19-hydroxy-PGA2 Chemical compound CC(O)CCC[C@H](O)\C=C\[C@H]1C=CC(=O)[C@@H]1C\C=C/CCCC(O)=O RXYQCXVUMLSFHM-CKCSCOOESA-N 0.000 claims 2
• PPYRMVKHPFIXEU-BAKUXOMWSA-N 19-hydroxy-PGB2 Chemical compound CC(O)CCC[C@H](O)\C=C\C1=C(C\C=C/CCCC(O)=O)C(=O)CC1 PPYRMVKHPFIXEU-BAKUXOMWSA-N 0.000 claims 2
• VTUSIVBDOCDNHS-UHFFFAOYSA-N Etidocaine Chemical compound CCCN(CC)C(CC)C(=O)NC1=C(C)C=CC=C1C VTUSIVBDOCDNHS-UHFFFAOYSA-N 0.000 claims 2
• 229920000926 Galactomannan Polymers 0.000 claims 2
• 229920002907 Guar gum Polymers 0.000 claims 2
• RXBQNMWIQKOSCS-RKDXNWHRSA-N Myrtenol Natural products C1[C@H]2C(C)(C)[C@@H]1CC=C2CO RXBQNMWIQKOSCS-RKDXNWHRSA-N 0.000 claims 2
• FQYUMYWMJTYZTK-UHFFFAOYSA-N Phenyl glycidyl ether Chemical compound C1OC1COC1=CC=CC=C1 FQYUMYWMJTYZTK-UHFFFAOYSA-N 0.000 claims 2
• 125000005907 alkyl ester group Chemical group 0.000 claims 2
• OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims 2
• 239000007853 buffer solution Substances 0.000 claims 2
• 229960001747 cinchocaine Drugs 0.000 claims 2
• PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 claims 2
• XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 2
• HSMMSDWNEJLVRY-INIZCTEOSA-N dodecyl (2s)-2-(dimethylamino)propanoate Chemical group CCCCCCCCCCCCOC(=O)[C@H](C)N(C)C HSMMSDWNEJLVRY-INIZCTEOSA-N 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 229960003976 etidocaine Drugs 0.000 claims 2
• 239000003205 fragrance Substances 0.000 claims 2
• 239000000665 guar gum Substances 0.000 claims 2
• 229960002154 guar gum Drugs 0.000 claims 2
• 235000010417 guar gum Nutrition 0.000 claims 2
• XPXMKIXDFWLRAA-UHFFFAOYSA-N hydrazinide Chemical compound [NH-]N XPXMKIXDFWLRAA-UHFFFAOYSA-N 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 229960002409 mepivacaine Drugs 0.000 claims 2
• INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 claims 2
• 229920005862 polyol Polymers 0.000 claims 2
• 150000003077 polyols Chemical class 0.000 claims 2
• 229920000136 polysorbate Polymers 0.000 claims 2
• 206010036596 premature ejaculation Diseases 0.000 claims 2
• 239000003755 preservative agent Substances 0.000 claims 2
• 230000002335 preservative effect Effects 0.000 claims 2
• GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 claims 2
• 150000003445 sucroses Chemical class 0.000 claims 2
• 229960002872 tocainide Drugs 0.000 claims 2
• 230000000699 topical effect Effects 0.000 claims 2
• 150000003626 triacylglycerols Chemical class 0.000 claims 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 229960005015 local anesthetics Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000008247 solid mixture Substances 0.000 claims 1