JP2006517940A5 - - Google Patents

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Publication number
JP2006517940A5
JP2006517940A5 JP2006501857A JP2006501857A JP2006517940A5 JP 2006517940 A5 JP2006517940 A5 JP 2006517940A5 JP 2006501857 A JP2006501857 A JP 2006501857A JP 2006501857 A JP2006501857 A JP 2006501857A JP 2006517940 A5 JP2006517940 A5 JP 2006517940A5
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JP
Japan
Prior art keywords
enantiomers
enantiomer
side effects
doses
hyperalgesia
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006501857A
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English (en)
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JP2006517940A (ja
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Publication date
Priority claimed from GBGB0303615.9A external-priority patent/GB0303615D0/en
Application filed filed Critical
Publication of JP2006517940A publication Critical patent/JP2006517940A/ja
Publication of JP2006517940A5 publication Critical patent/JP2006517940A5/ja
Pending legal-status Critical Current

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Description

得られた結果は、式Ｉの化合物の２つのエナンチオマーにおける抗痛覚過敏活性の明らかな差異を示し、Ｒ−エナンチオマーがＳ−エナンチオマーより大きな効果と有効性を示し、Ｒ−エナンチオマーの作用期間はより長い。さらに、Ｓ−エナンチオマーは痛覚過敏症を回復する投与量で副作用を産生し、一方、Ｒ−エナンチオマーの最高投与量で比較的穏やかな副作用が観察される。
JP2006501857A 2003-02-17 2004-02-16 神経障害性疼痛におけるｒ−１０−ヒドロキシ−１０，１１−ジヒドロ−カルバマゼピンの使用 Pending JP2006517940A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0303615.9A GB0303615D0 (en) 2003-02-17 2003-02-17 Use of organic compounds
PCT/EP2004/001451 WO2004071513A1 (en) 2003-02-17 2004-02-16 Use of r-10-hydroxy-10, 11-dihydro-carbamazepine in neuropathic pain

Publications (2)

Publication Number Publication Date
JP2006517940A JP2006517940A (ja) 2006-08-03
JP2006517940A5 true JP2006517940A5 (ja) 2007-04-12

Family

ID=9953162

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006501857A Pending JP2006517940A (ja) 2003-02-17 2004-02-16 神経障害性疼痛におけるｒ−１０−ヒドロキシ−１０，１１−ジヒドロ−カルバマゼピンの使用

Country Status (11)

Country Link
US (3) US20060166967A1 (ja)
EP (1) EP1596865A1 (ja)
JP (1) JP2006517940A (ja)
CN (1) CN1750826A (ja)
AU (1) AU2004212327A1 (ja)
BR (1) BRPI0407529A (ja)
CA (1) CA2516265A1 (ja)
GB (1) GB0303615D0 (ja)
MX (1) MXPA05008711A (ja)
PL (1) PL376755A1 (ja)
WO (1) WO2004071513A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2384755A1 (en) * 2005-05-06 2011-11-09 Bial-Portela & CA, S.A. Eslicarbazepine acetate and methods of use
US20060252745A1 (en) 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0517740D0 (en) * 2005-08-31 2005-10-12 Novartis Ag Organic compounds
GB0603008D0 (en) * 2006-02-14 2006-03-29 Portela & Ca Sa Method
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
WO2011017319A1 (en) * 2009-08-03 2011-02-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating disorders associated with protein polymerization
US9072772B2 (en) 2009-11-05 2015-07-07 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating disorders associated with protein aggregation
US8809617B2 (en) 2009-11-05 2014-08-19 The University of Pittsburgh—Of the Commonwealth System of Higher Education Automated high-content live animal drug screening using C. elegans

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH505101A (de) * 1969-03-31 1971-03-31 Ciba Geigy Ag Verfahren zur Herstellung von neuen Azepinderivaten
EP0435826A1 (de) * 1989-12-27 1991-07-03 Ciba-Geigy Ag Intravenöse Lösungen für Status Epilepticus
US5534495A (en) * 1993-05-25 1996-07-09 Advanced Peptides And Biotechnology Sciences Treatment of non-HIV neuropathic pain syndromes
US5688830A (en) * 1996-01-25 1997-11-18 Syntex (U.S.A.) Inc. Treatment of neuropathic pain
GB0112812D0 (en) * 2001-05-25 2001-07-18 Portela & Ca Sa Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom
MXPA04004470A (es) * 2001-11-12 2005-05-16 Novartis Ag Monohidroxicarbamazepina para utilizarse en la preparacion de un medicamento para el tratamiento de un trastorno afectivo y de la atencion y dolor neuropatico.
AU2003266965A1 (en) * 2002-08-06 2004-02-25 Novartis Ag Use of carboxamides for the treatment of tinnitus
GB0223224D0 (en) * 2002-10-07 2002-11-13 Novartis Ag Organic compounds

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