JP2006514681A5 - - Google Patents
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- Publication number
- JP2006514681A5 JP2006514681A5 JP2004572190A JP2004572190A JP2006514681A5 JP 2006514681 A5 JP2006514681 A5 JP 2006514681A5 JP 2004572190 A JP2004572190 A JP 2004572190A JP 2004572190 A JP2004572190 A JP 2004572190A JP 2006514681 A5 JP2006514681 A5 JP 2006514681A5
- Authority
- JP
- Japan
- Prior art keywords
- epothilone
- pharmaceutical composition
- concentration
- intravenous infusion
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XOZIUKBZLSUILX-UKMAFROXSA-N Epothilone D Chemical compound O1C(=O)C[C@@H](O)C(C)(C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)CCC\C(C)=C/C[C@@H]1C(\C)=C\C1=CSC(C)=N1 XOZIUKBZLSUILX-UKMAFROXSA-N 0.000 claims 9
- XOZIUKBZLSUILX-SDMHVBBESA-N Epothilone D Natural products O=C1[C@H](C)[C@@H](O)[C@@H](C)CCC/C(/C)=C/C[C@@H](/C(=C\c2nc(C)sc2)/C)OC(=O)C[C@H](O)C1(C)C XOZIUKBZLSUILX-SDMHVBBESA-N 0.000 claims 9
- 229930013353 epothilone D Natural products 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 238000001802 infusion Methods 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 3
- 230000000259 anti-tumor Effects 0.000 claims 2
- 238000010253 intravenous injection Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38216602P | 2002-05-20 | 2002-05-20 | |
PCT/US2003/017921 WO2004103267A2 (en) | 2002-05-20 | 2003-05-20 | Methods to administer epothilone d |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006514681A JP2006514681A (ja) | 2006-05-11 |
JP2006514681A5 true JP2006514681A5 (US07794700-20100914-C00125.png) | 2006-07-13 |
Family
ID=33476529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004572190A Pending JP2006514681A (ja) | 2002-05-20 | 2003-05-20 | エポチロンdの投与方法 |
Country Status (7)
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU756699B2 (en) * | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
US8618085B2 (en) * | 2000-04-28 | 2013-12-31 | Koasn Biosciences Incorporated | Therapeutic formulations of desoxyepothilones |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
AU2003260002B2 (en) * | 2002-08-23 | 2010-03-18 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
WO2005020989A1 (en) * | 2003-09-02 | 2005-03-10 | Novartis Ag | Cancer treatment with epothilones |
US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
JP2008536479A (ja) | 2005-02-11 | 2008-09-11 | ユニバーシティ オブ サザン カリフォルニア | ジスルフィド架橋を有するタンパク質の発現法 |
WO2007130501A2 (en) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Combination therapy for treatment of cancer |
US9175390B2 (en) * | 2008-04-25 | 2015-11-03 | Asm International N.V. | Synthesis and use of precursors for ALD of tellurium and selenium thin films |
US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
CN102687243B (zh) | 2009-10-26 | 2016-05-11 | Asm国际公司 | 用于含va族元素的薄膜ald的前体的合成和使用 |
AU2011255647A1 (en) | 2010-05-18 | 2012-11-15 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3737518B2 (ja) * | 1996-03-12 | 2006-01-18 | ピージー−ティーエックスエル カンパニー, エル.ピー. | 水溶性パクリタキセルプロドラッグ |
AU756699B2 (en) * | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
EP1042327B1 (en) * | 1997-12-04 | 2003-09-17 | Bristol-Myers Squibb Company | A process for the reduction of oxiranyl epothilones to olefinic epothilones |
US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
US6302838B1 (en) * | 1998-02-25 | 2001-10-16 | Novartis Ag | Cancer treatment with epothilones |
WO2000031247A2 (en) * | 1998-11-20 | 2000-06-02 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
US6664288B1 (en) * | 1999-04-14 | 2003-12-16 | Dana Farber Cancer Institute, Inc. | Method and composition for the treatment of cancer |
EP1259490A2 (en) * | 2000-03-01 | 2002-11-27 | Sloan Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
ES2254493T3 (es) * | 2000-04-28 | 2006-06-16 | Kosan Biosciences, Inc. | Produccion heterologa de policetidos. |
WO2002008440A2 (en) * | 2000-07-25 | 2002-01-31 | Kosan Biosciences, Inc. | Fermentation process for epothilones |
-
2003
- 2003-05-20 US US10/442,820 patent/US20040072882A1/en not_active Abandoned
- 2003-05-20 AU AU2003296878A patent/AU2003296878A1/en not_active Abandoned
- 2003-05-20 EP EP03817031A patent/EP1575556A2/en not_active Withdrawn
- 2003-05-20 CN CNA03815062XA patent/CN101389334A/zh active Pending
- 2003-05-20 KR KR1020047018759A patent/KR20050043796A/ko not_active Application Discontinuation
- 2003-05-20 WO PCT/US2003/017921 patent/WO2004103267A2/en active Application Filing
- 2003-05-20 JP JP2004572190A patent/JP2006514681A/ja active Pending