JP2006512897A5 - - Google Patents
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- JP2006512897A5 JP2006512897A5 JP2004524880A JP2004524880A JP2006512897A5 JP 2006512897 A5 JP2006512897 A5 JP 2006512897A5 JP 2004524880 A JP2004524880 A JP 2004524880A JP 2004524880 A JP2004524880 A JP 2004524880A JP 2006512897 A5 JP2006512897 A5 JP 2006512897A5
- Authority
- JP
- Japan
- Prior art keywords
- pth
- composition
- pthrp receptor
- individual
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 claims 39
- 102000006461 Parathyroid Hormone Receptors Human genes 0.000 claims 30
- 108010058828 Parathyroid Hormone Receptors Proteins 0.000 claims 30
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 16
- 239000000126 substance Substances 0.000 claims 14
- 210000000963 osteoblast Anatomy 0.000 claims 6
- 230000001737 promoting effect Effects 0.000 claims 6
- 238000000338 in vitro Methods 0.000 claims 5
- 238000012423 maintenance Methods 0.000 claims 5
- 239000000018 receptor agonist Substances 0.000 claims 5
- 229940044601 receptor agonist Drugs 0.000 claims 5
- 210000002536 stromal cell Anatomy 0.000 claims 5
- 210000001185 bone marrow Anatomy 0.000 claims 4
- 210000002865 immune cell Anatomy 0.000 claims 4
- 210000002751 lymph Anatomy 0.000 claims 4
- 230000035755 proliferation Effects 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 2
- 102000001759 Notch1 Receptor Human genes 0.000 claims 1
- 108010029755 Notch1 Receptor Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000003651 basophil Anatomy 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000006353 environmental stress Effects 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39880102P | 2002-07-25 | 2002-07-25 | |
| US60/398,801 | 2002-07-25 | ||
| PCT/US2003/023425 WO2004011484A2 (en) | 2002-07-25 | 2003-07-25 | Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006512897A JP2006512897A (ja) | 2006-04-20 |
| JP2006512897A5 true JP2006512897A5 (https=) | 2007-10-04 |
| JP4750416B2 JP4750416B2 (ja) | 2011-08-17 |
Family
ID=31188487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004524880A Expired - Fee Related JP4750416B2 (ja) | 2002-07-25 | 2003-07-25 | 副甲状腺ホルモン受容体の活性化と造血前駆細胞の増殖 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7429383B2 (https=) |
| EP (1) | EP1545603B1 (https=) |
| JP (1) | JP4750416B2 (https=) |
| AU (1) | AU2003256839B2 (https=) |
| CA (1) | CA2492295C (https=) |
| WO (1) | WO2004011484A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7635477B2 (en) * | 2002-07-25 | 2009-12-22 | The General Hospital Corporation | Parathyroid hormone receptor activation and stem and progenitor cell expansion |
| WO2004011484A2 (en) | 2002-07-25 | 2004-02-05 | The General Hospital Corporation | Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion |
| JP5500773B2 (ja) * | 2004-11-11 | 2014-05-21 | ザ ジェネラル ホスピタル コーポレーション | 副甲状腺ホルモン受容体の活性化並びに幹細胞及び前駆細胞の増殖 |
| US9394520B2 (en) | 2006-12-08 | 2016-07-19 | University Of Rochester | Expansion of hematopoietic stem cells |
| WO2008124166A2 (en) | 2007-04-09 | 2008-10-16 | The Board Of Trustees Of The University Of Arkansas | Fusion proteins of collagen-binding domain and parathyroid hormone |
| WO2011011675A1 (en) * | 2009-07-23 | 2011-01-27 | Zelos Therapeutics, Inc. | Pharmaceutically acceptable formulations/compositions for peptidyl drugs |
| WO2013120060A1 (en) | 2012-02-09 | 2013-08-15 | The Board Of Trustees Of The University Of Arkansas | Delivery of therapeutic agents by a collagen binding protein |
| ES2695161T3 (es) | 2011-12-14 | 2019-01-02 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| CA3028422A1 (en) * | 2016-06-23 | 2017-12-28 | Tithon Biotech, Inc. | Cells expressing parathyroid hormone 1 receptor and uses thereof |
| US11624060B2 (en) | 2017-02-10 | 2023-04-11 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
| US12403179B2 (en) | 2021-02-18 | 2025-09-02 | The Board Of Trustees Of The University Of Arkansas | Release of growth factors at wound healing stages |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5747456A (en) * | 1994-12-19 | 1998-05-05 | Beth Israel Deaconess Medical Center | Continuous low-dose administration of parathyroid hormone or its agonist |
| AU1558197A (en) * | 1996-02-01 | 1997-08-22 | Chugai Seiyaku Kabushiki Kaisha | Preventives and remedies for thrombocytopenia |
| JP4053107B2 (ja) * | 1996-02-01 | 2008-02-27 | 中外製薬株式会社 | 血小板減少症の予防剤および治療剤 |
| CA2369085A1 (en) * | 1999-05-14 | 2000-11-23 | City Of Hope | Ex vivo expansion of mammalian hematopoietic stem cells |
| AU6766100A (en) | 1999-08-13 | 2001-03-13 | University Of Rochester | Ex vivo generation of functional osteoclasts from bone marrow in a three-dimensional bioreactor |
| US6316410B1 (en) * | 1999-09-22 | 2001-11-13 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| WO2004011484A2 (en) | 2002-07-25 | 2004-02-05 | The General Hospital Corporation | Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion |
-
2003
- 2003-07-25 WO PCT/US2003/023425 patent/WO2004011484A2/en not_active Ceased
- 2003-07-25 US US10/521,971 patent/US7429383B2/en not_active Expired - Lifetime
- 2003-07-25 CA CA2492295A patent/CA2492295C/en not_active Expired - Fee Related
- 2003-07-25 EP EP03771904.4A patent/EP1545603B1/en not_active Expired - Lifetime
- 2003-07-25 JP JP2004524880A patent/JP4750416B2/ja not_active Expired - Fee Related
- 2003-07-25 AU AU2003256839A patent/AU2003256839B2/en not_active Ceased
-
2008
- 2008-08-28 US US12/200,419 patent/US7776334B2/en not_active Expired - Fee Related
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