JP2006320897A - 交差チャンネルを利用した流体混合装置 - Google Patents
交差チャンネルを利用した流体混合装置 Download PDFInfo
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- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
- B01F25/3142—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit the conduit having a plurality of openings in the axial direction or in the circumferential direction
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
- B01F25/3142—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit the conduit having a plurality of openings in the axial direction or in the circumferential direction
- B01F25/31422—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit the conduit having a plurality of openings in the axial direction or in the circumferential direction with a plurality of perforations in the axial direction only
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
- B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/812—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more alternative mixing receptacles, e.g. mixing in one receptacle and dispensing from another receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/712—Feed mechanisms for feeding fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/715—Feeding the components in several steps, e.g. successive steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
- B01F35/81—Forming mixtures with changing ratios or gradients
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- General Physics & Mathematics (AREA)
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
【解決手段】一つの層に平行に配置されて、その上流側から均等配分された希釈液が流入される複数の第1チャンネルと、第1チャンネルが形成された層と隣接した層に第1チャンネルと交差するように形成されて、その上流側から均等配分された試料液が流入される複数の第2チャンネルと、各第1チャンネルに対して第2チャンネルが交差される複数の交差点のうち少なくとも一つの交差点に形成されて、所定量の試料液を第2チャンネルから当該第1チャンネルに流入させるビアホールと、を備え、第1チャンネルごとに異なる濃度を有する溶液を排出させる交差チャンネルを利用した流体混合装置である。
【選択図】図1
Description
21 第2チャンネル、
25 ビアホール。
Claims (17)
- 試料液及び希釈液を混合して多様な濃度を有する溶液を提供する流体混合装置において、
一つの層に平行に配置されて、その上流側から均等配分された希釈液が流入される複数の第1チャンネルと、
前記第1チャンネルが形成された層と隣接した層に、前記第1チャンネルと交差するように形成されて、その上流側から均等配分された試料液が流入される複数の第2チャンネルと、
前記各第1チャンネルに対して前記第2チャンネルが交差される複数の交差点のうち少なくとも一つの交差点に形成されて、所定量の試料液を第2チャンネルから当該第1チャンネルに流入させるビアホールと、を備え、
前記ビアホールを通じてそれぞれの第1チャンネルに流入される試料液の量により相異なる濃度の溶液を提供することを特徴とする交差チャンネルを利用した流体混合装置。 - それぞれの第1チャンネルに連結されたビアホールの断面積の和は、前記第1チャンネルに流入される試料液の量に比例するように形成されたことを特徴とする請求項1に記載の流体混合装置。
- 前記複数の第2チャンネルは、その内部の圧力がほぼ同じであることを特徴とする請求項1に記載の流体混合装置。
- 前記複数の第2チャンネルは、それぞれに形成されたビアホールの数が同じであることを特徴とする請求項3に記載の流体混合装置。
- 前記ビアホール数は、2つであることを特徴とする請求項4に記載の流体混合装置。
- 前記複数の第2チャンネルは、それぞれに形成されたビアホールの断面積の和がほぼ同じであることを特徴とする請求項3に記載の流体混合装置。
- 前記複数の第1チャンネルは、前記第2チャンネルと交差する希釈チャンネル部の下流に、各チャンネルが反復的に屈折された混合チャンネル部を備えることを特徴とする請求項1に記載の流体混合装置。
- 前記複数の第1チャンネルのうち、n番目のチャンネルに流入される試料液の総流量が前記希釈液の流量のXn倍であるとき、前記n番目の第1チャンネルの濃度、Yn(ここで、Yn=Xn/(1+Xn))は、自然数であるnに対して所定の関数関係を有することを特徴とする請求項1に記載の流体混合装置。
- 前記所定の関数は、指数関数であることを特徴とする請求項8に記載の流体混合装置。
- 試料液及び希釈液を混合して多様な濃度を有する溶液を提供する流体混合装置において、
その上面に希釈液注入部から分岐された複数の第1チャンネルからなる希釈チャンネル部と、前記希釈チャンネル部の下流側から延びて反復的に屈折された混合チャンネル部が形成された第1プレートと、
前記第1プレートの上側に備えられるものであって、その上面に試料液注入部から分岐された複数の第2チャンネルからなり、前記希釈チャンネル部の上側で第1チャンネルと交差するように配置された試料液チャンネル部、及び前記第1チャンネルのそれぞれに対して交差する第2チャンネルのうち、少なくとも一つの交差点に対応するチャンネルの溝底面から底端面部まで貫通するビアホールが形成された第2プレートと、
前記第2プレートの上面を覆うものであって、前記希釈液注入部及び試料液注入部とそれぞれ連通される第1開口部及び第2開口部が形成されたカバーと、を備え、
前記試料液チャンネル部からビアホールを通じてそれぞれの第1チャンネルに流入される試料液の量により相異なる濃度の溶液を提供することを特徴とする交差チャンネルを利用した流体混合装置。 - それぞれの第1チャンネルに連結されたビアホールの断面積の和は、前記第1チャンネルに流入される試料液の量に比例するように形成されたことを特徴とする請求項10に記載の流体混合装置。
- 前記試料液チャンネル部は、複数の第2チャンネルの内部の圧力がほぼ同じであることを特徴とする請求項10に記載の流体混合装置。
- 前記複数の第2チャンネルは、それぞれに形成されたビアホールの数が同じであることを特徴とする請求項12に記載の流体混合装置。
- 前記ビアホール数は、2つであることを特徴とする請求項13に記載の流体混合装置。
- 前記複数の第2チャンネルは、それぞれに形成されたビアホールの断面積の和がほぼ同じであることを特徴とする請求項12に記載の流体混合装置。
- 前記複数の第1チャンネルのうち、n番目のチャンネルに流入される試料液の総流量が前記希釈液流量のXn倍であるとき、前記n番目の第1チャンネルの濃度、Yn(ここで、Yn=Xn/(1+Xn))は自然数であるnに対して所定の関数関係を有することを特徴とする請求項10に記載の流体混合装置。
- 前記所定の関数は、指数関数であることを特徴とする請求項16に記載の流体混合装置。
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KR1020050041765A KR100695151B1 (ko) | 2005-05-18 | 2005-05-18 | 교차 채널을 이용한 유체 혼합 장치 |
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JP4228003B2 JP4228003B2 (ja) | 2009-02-25 |
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US (1) | US7736050B2 (ja) |
EP (1) | EP1724007B1 (ja) |
JP (1) | JP4228003B2 (ja) |
KR (1) | KR100695151B1 (ja) |
DE (1) | DE602006015389D1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US8986546B2 (en) | 2011-03-18 | 2015-03-24 | Kobe Steel, Ltd. | Flow channel structure, and mixing method, extraction method, and reaction method for fluids |
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EP2291509B1 (en) * | 2008-05-16 | 2023-11-15 | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids |
US11118150B2 (en) | 2011-10-20 | 2021-09-14 | Research Foundation Of The City University Of New York | Layered microfluidic array |
US10233482B2 (en) * | 2014-09-10 | 2019-03-19 | The United States Of America, As Represented By The Secretary Of Agriculture | Micro-fluidic mixer and method of determining pathogen inactivation via antimicrobial solutions |
US9802176B2 (en) * | 2015-03-24 | 2017-10-31 | Saudi Arabian Oil Company | Method for mixing in a hydrocarbon conversion process |
CN105842041B (zh) * | 2016-05-11 | 2018-05-04 | 张兆军 | 粮仓分样器 |
KR20230062842A (ko) | 2020-09-08 | 2023-05-09 | 썬플라워 테라퓨틱스, 피비씨 | 유체 이송 및 분배 매니폴드 |
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US1319572A (en) * | 1919-10-21 | Aie-filter | ||
US4516632A (en) * | 1982-08-31 | 1985-05-14 | The United States Of America As Represented By The United States Deparment Of Energy | Microchannel crossflow fluid heat exchanger and method for its fabrication |
US5534328A (en) * | 1993-12-02 | 1996-07-09 | E. I. Du Pont De Nemours And Company | Integrated chemical processing apparatus and processes for the preparation thereof |
DE19540292C1 (de) * | 1995-10-28 | 1997-01-30 | Karlsruhe Forschzent | Statischer Mikrovermischer |
DE19541266A1 (de) * | 1995-11-06 | 1997-05-07 | Bayer Ag | Verfahren und Vorrichtung zur Durchführung chemischer Reaktionen mittels eines Mikrostruktur-Lamellenmischers |
DE19703779C2 (de) * | 1997-02-01 | 2003-06-05 | Karlsruhe Forschzent | Verfahren und Vorrichtung zur Herstellung eines dispersen Gemisches |
US5869004A (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
US6167910B1 (en) | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
DE19927554C2 (de) | 1999-06-16 | 2002-12-19 | Inst Mikrotechnik Mainz Gmbh | Mikromischer |
JP2001293345A (ja) | 2000-04-12 | 2001-10-23 | Sunstar Inc | 多層チャンネル構造体 |
US20010042712A1 (en) | 2000-05-24 | 2001-11-22 | Battrell C. Frederick | Microfluidic concentration gradient loop |
US7318912B2 (en) * | 2001-06-07 | 2008-01-15 | Nanostream, Inc. | Microfluidic systems and methods for combining discrete fluid volumes |
EP1412065A2 (en) * | 2001-07-27 | 2004-04-28 | President And Fellows Of Harvard College | Laminar mixing apparatus and methods |
WO2003015890A1 (en) * | 2001-08-20 | 2003-02-27 | President And Fellows Of Harvard College | Fluidic arrays and method of using |
KR100473364B1 (ko) | 2001-10-17 | 2005-03-08 | 주식회사 디지탈바이오테크놀러지 | 미세 채널을 이용하여 유체를 혼합하는 미세 채널 장치 및그 방법 |
DE20218972U1 (de) | 2002-12-07 | 2003-02-13 | Ehrfeld Mikrotechnik AG, 55234 Wendelsheim | Statischer Laminationsmikrovermischer |
TWI230683B (en) * | 2004-04-19 | 2005-04-11 | Jing-Tang Yang | The micromixer with overlapping-crisscross entrance |
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- 2005-05-18 KR KR1020050041765A patent/KR100695151B1/ko active IP Right Grant
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- 2006-05-10 DE DE602006015389T patent/DE602006015389D1/de active Active
- 2006-05-10 EP EP06009691A patent/EP1724007B1/en active Active
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US8986546B2 (en) | 2011-03-18 | 2015-03-24 | Kobe Steel, Ltd. | Flow channel structure, and mixing method, extraction method, and reaction method for fluids |
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DE602006015389D1 (de) | 2010-08-26 |
KR20060119154A (ko) | 2006-11-24 |
EP1724007B1 (en) | 2010-07-14 |
EP1724007A2 (en) | 2006-11-22 |
JP4228003B2 (ja) | 2009-02-25 |
KR100695151B1 (ko) | 2007-03-14 |
US7736050B2 (en) | 2010-06-15 |
US20060262642A1 (en) | 2006-11-23 |
EP1724007A3 (en) | 2007-05-23 |
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