JP2006298889A - External aqueous composition for skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an external aqueous composition which is used for the skins, has an excellent skin-bleaching effect, excellent ageing-preventing effects (active oxygen-controlling effect, peroxidized lipid-controlling effect, collagen and elastin production-promoting effect, and the like), an excellent effect for improving wrinkles, and a good effect for holding young beautiful skins, and exhibits excellent functional characteristics, when coated on the skins. <P>SOLUTION: This stable external aqueous composition for the skins contains an ascorbic acid derivative in an amount of 5 to 30 wt.% based on the total amount of the composition, and furthermore contains an α-hydroxy acid. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention is excellent in skin whitening effect and anti-aging effect (active oxygen suppression effect, lipid peroxide suppression effect, collagen / elastin production promotion effect, etc.), and has an excellent effect in improving wrinkles that have been made, It is an aqueous composition for external use on skin, which is excellent in sensory characteristics when applied to the skin, and is formulated with an ascorbic acid derivative and an α-hydroxy acid.

  Conventionally, it is well known that ascorbic acid is a powder and has very good solubility in water. However, it is also well known that ascorbic acid dissolved in water loses its effectiveness in a very short time due to the influence of oxygen in the water. Ascorbic acid may be used as a component with a high whitening effect as a blending component of cosmetics and the like, but because it has poor underwater stability as described above, it can be used in the form of powder or tablet, but it is so-called It is very difficult to use it in a real product as a cosmetic. Therefore, as a component that is applied to the skin and has a whitening effect and an anti-aging effect (active oxygen suppression effect, lipid peroxide suppression effect, collagen / elastin production promotion effect, etc.), it has high stability and skin effect. Ascorbic acid derivatives are widely used as an external skin composition for cosmetics and the like, but the concentration of the ascorbic acid derivative in water is around 5% due to solubility and other problems. Due to problems such as precipitation, the skin whitening effect and anti-aging effect (active oxygen inhibitory effect, lipid peroxide inhibitory effect, collagen / elastin production promoting effect, etc.) are still unsatisfactory.

  In addition, it promotes the production of collagen, elastin, hyaluronic acid, etc. by the proliferation of glandular fibroblasts in the dermis and promotes the improvement of wrinkles. As is known, coexistence in an aqueous solution with an ascorbic acid derivative is considered to be difficult due to stability problems due to conflicting pH values.

  However, for many women, it is the ultimate ideal to have white skin and to keep youthful skin without wrinkles forever. To maintain beautiful skin and enjoy everyday life with confidence and fun. Has an excellent whitening effect, anti-aging effect (reactive oxygen suppression effect, lipid peroxide suppression effect, collagen / elastin production promotion effect, etc.), and an aqueous composition for external use for skin that is excellent in improving wrinkles. It has been.

  Therefore, the object of the present invention is excellent in the skin whitening effect, anti-aging effect (active oxygen suppression effect, lipid peroxide suppression effect, collagen / elastin production promotion effect, etc.), and has a youthful wrinkle improving effect. An object of the present invention is to provide an aqueous composition for external use having the effect of maintaining beautiful skin.

  In view of such circumstances, the present inventor has excellent whitening effect, anti-aging effect (active oxygen suppression effect, lipid peroxide suppression effect, collagen / elastin production promotion effect, etc.), and has an effect of improving wrinkles. As a result of diligent examination of the aqueous composition for use, the ascorbic acid derivative is blended in an amount of 5 to 30% by weight based on the total weight of the composition, and the α-hydroxy acid is blended together and the stability is excellent in these effects. The present invention has been completed.

  That is, the present invention contains 5 to 30% by weight of ascorbic acid derivative based on the total weight of the composition, which has been considered difficult until now, and at the same time α-hydroxy acid. It is an aqueous | water-based composition for external use of the skin characterized by containing.

Embodiment of the present invention

  The aqueous skin composition for external use of the present invention has a range of 0.1 to 20% by weight of polyols and 0.01 to 1.0% by weight of HLB based on the total weight of the composition. 0 to 16.0 nonionic surfactant, 0.01 to 1.0% by weight α-hydroxy acid, 5 to 30% by weight ascorbic acid derivative and 1 to 94.5% by weight water. Is.

  The polyol used in the present invention is a polyhydric alcohol having high moisture retention on the skin, such as glycerin, diglycerin, 1,3 butylene glycol, propylene glycol, pentylene glycol, etc. It is highly probable. This is because, when the ascorbic acid derivative is in a high concentration, the skin external aqueous composition may be applied to the skin to cause moisture to evaporate and cause the skin to dry. In addition, said polyol is an example, and if it can mix | blend with what is water-soluble and has a high moisturizing effect, it will not be limited to the above. In order to increase the moisturizing effect, it is also effective to use polysaccharides such as mucopolysaccharides such as hyaluronic acid.

  In general, nonionic surfactants are used for dissolution, dispersion, emulsification, and the like. For the purpose of enhancing the solubility in the aqueous external composition, POE hydrogenated castor oil is used as a solubilizing nonionic surfactant. I use it. In general, POE hydrogenated castor oil is an active agent having high solubilization performance obtained by reacting hydrogenated castor oil with polyoxyethylene chains, and is also used as a solubilizer for injections. POE hydrogenated castor oil used in the present invention has an HLB range of about 10.0 to 16.0, preferably 12.0 to 14.0, and POE cured with 40 to 60 mol of polyoxyethylene added. Castor oil.

  The α-hydroxy acid used in the present invention is generally citric acid, malic acid, tartaric acid, etc. contained in fruits and the like, but the pH value of these aqueous solutions is on the acidic side, and the aqueous composition for external use of the skin of the present invention Since the product is on the alkali side, when a large amount of α-hydroxy acid is blended, the stability of the composition is affected, so the blending concentration is 0.01 to 1.0% by weight, preferably 0.01 to 0.5% by weight is appropriate. When the blending amount is 1.0% by weight or more, the dissolution stability of the ascorbic acid derivative is affected and precipitation may occur. In the present invention, since the amount of ascorbic acid derivative is as high as 30% by weight, the pH-dependent stability is particularly high, and it is contraindicated that the amount of α-hydroxy acid is too large. By blending the ingredients according to the above contents, whitening effect on skin, anti-aging effect (reactive oxygen suppression effect, lipid peroxide suppression effect, collagen / elastin production promotion effect) can be obtained at the same time. Thus, it is possible to obtain an aqueous external composition for skin that does not substantially irritate and has a mild effect on the skin.

  Examples of the aqueous skin composition for external use of the present invention are shown below. These examples are for explaining the present invention in more detail, and do not limit the scope of the present invention, and various modifications are possible. In the examples, [%] indicates weight%.

Example 1
Blending ingredients Blending ratio [%]
(1) Citric acid 0.002
(2) Glycolic acid 0.002
(3) Malic acid 0.002
(4) Tea extract 0.002
(5) Glucose 0.002
(6) Ascorbyl phosphate Na 20.000
(7) POE hydrogenated castor oil (60E0) 0.010
(8) Pentylene glycol 3.000
(9) Methylparaben 0.010
(10) Purified water 76.880
Total 100.000

Preparation method [1] The components of (1) to (6) and (10) are stirred and dissolved at room temperature.
[2] The components (7) to (9) are dissolved by heating at 60 ° C.
[3] [1] and [2] are mixed and dissolved at room temperature.

  A part of the obtained aqueous external composition for skin was taken out and confirmed to be stable at 5 ° C. cooling. As a result, even after 90 days, no precipitation occurred and the composition was stable.

Example 2
Tartaric acid instead of malic acid in Example 1, 1,3-butylene glycol instead of pentylene glycol, POE hydrogenated castor oil (50E0) instead of POE hydrogenated castor oil (50E0), the same properties, Stability was obtained.

Example 3
Blending ingredients Blending ratio [%]
(1) Hyaluronic acid Na 0.0500
(2) Citric acid 0.0025
(3) Lactic acid 0.0025
(4) Malic acid 0.0025
(5) Tea extract 0.0025
(6) Ascorbyl phosphate Na 10.00000
(7) POE hydrogenated castor oil (60E0) 0.0100
(8) Pentylene glycol 3.0000
(9) Methylparaben 0.1000
(10) Purified water 86.8300
Total 100.000

Preparation method [1] The components of (1) to (6) and (10) are stirred and dissolved at room temperature.
[2] The components (7) to (9) are dissolved by heating at 60 ° C.
[3] [1] and [2] are mixed and dissolved at room temperature.

  A part of the obtained aqueous external composition for skin was taken out and confirmed to be stable at 5 ° C. cooling. As a result, even after 90 days, no precipitation occurred and the composition was stable.

Example 4
Tartaric acid instead of tea extract in Example 3, 1,3 butylene glycol instead of pentylene glycol, POE hydrogenated castor oil (50E0) instead of POE hydrogenated castor oil (50E0), the same properties, Stability was obtained.

Example 5
Blending ingredients Blending ratio [%]
(1) Hyaluronic acid Na 0.05
(2) Citric acid 0.002
(3) Glycolic acid 0.002
(4) Lactic acid 0.002
(5) Malic acid 0.002
(6) Tartaric acid 0.002
(7) Tea extract 0.002
(8) Glucose 0.002
(9) Ascorbyl phosphate Na 30.000
(10) Glycerol 2.000
(11) POE hydrogenated castor oil (60E0) 0.010
(12) Pentylene glycol 3000
(13) Methylparaben 0.100
(14) Purified water 64.826
Total 100.000

Preparation method [1] The components of (1) to (10) and (14) are stirred and dissolved at room temperature.
[2] The components (11) to (13) are dissolved by heating at 60 ° C.
[3] [1] and [2] are mixed and dissolved at room temperature.

  A part of the obtained aqueous external composition for skin was taken out and confirmed to be stable at 5 ° C. cooling. As a result, even after 90 days, no precipitation occurred and the composition was stable.

Example 6
The same properties and stability were obtained by blending 1,3 butylene glycol in place of pentylene glycol in Example 5 and POE hydrogenated castor oil (50E0) in place of POE hydrogenated castor oil (60E0).

  The aqueous composition for external application of the skin of Example 1 of the present invention was applied for 30 days using an aqueous solution containing no ascorbic acid derivative as a control after producing melanin pigment by artificial ultraviolet irradiation using the inner side of the upper arm of a person. As a result, it was proved that the site where the aqueous composition for external application of Example 1 was applied clearly lost melanin quickly and had an excellent whitening effect.

  In the wrinkle improvement effect, it was confirmed that the wrinkle depth became shallow after 70 days of application. (Luminance shading method)

  Moreover, it was evaluation that it was excellent also in application | use usability and skin was moist.

The invention's effect

  According to the present invention, it has excellent whitening effect on skin and anti-aging effect (active oxygen suppression effect, lipid peroxide suppression effect, collagen / elastin production promotion effect, etc.), and has an excellent effect on improving wrinkles that have been made. Excellent sensory characteristics when applied to the skin, it will be a good news for the future aging society, and it can be applied to and provided in cosmetics that give dreams and hope to many women. it can.

Claims (3)

  Polyols and nonionic surfactants are essential components, and 0.1% to 20% by weight of polyols and 0.01% to 1.0% by weight of nonionic surfactants were dissolved based on the total weight of the composition. An aqueous composition for external application of skin containing a high-concentration ascorbic acid derivative, which is stabilized by adding an ascorbic acid derivative to an aqueous solution.   The aqueous skin composition for external use according to claim 1, wherein the content of the ascorbic acid derivative contained in the aqueous solution is 5% to 30% by weight based on the total weight of the composition.   The aqueous external composition for skin according to claim 1, wherein the α-hydroxy acid is composed of one kind or a mixture of two or more kinds and has a pH range of about 7.5 to 9.0.