JP2006265128A - Peel assisting pasting material and method for use of peel assisting pasting material - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a peel assisting pasting material capable of safely discarding an adhesive sheet by peeling the adhesive sheet from the surface of an adherend without touching the adhesive layer of the adhesive sheet. <P>SOLUTION: The peel assisting pasting material has the 1st adhesive layer on at least a part of a surface of a sheet substrate and the 2nd adhesive layer on the remaining area of the surface. The 1st adhesive layer and the 2nd adhesive layer account for essentially the whole area of the surface of the sheet substrate. The 1st adhesive layer contains a reactive compound reacting with a legally restricted drug and eliminates the drug effect. The size of the 1st adhesive layer and that of the 2nd adhesive layer are larger than the size of the adhesive sheet to be applied to the adherend. The adhesive sheet can be peeled off from the adherend surface by using the pasting material. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a peeling auxiliary patch capable of peeling and removing a pressure-sensitive adhesive sheet adhered to an adherend surface, and a method for using the same. For example, a patch preparation adhered to an adherend surface is used as the patch preparation. The present invention relates to a peeling assisting patch suitable for use in order to peel from a surface to be adhered without touching a transdermal absorbable drug-containing adhesive layer and to safely dispose of the same, and to a method for using the same.

  As is well known, one of the dosage forms for administering medical drugs to humans and animals is the skin patch type patch preparation, which is easy to handle and applicable drugs have expanded. In recent years, it has attracted attention.

  This patch preparation is a preparation in which a pressure-sensitive adhesive layer containing a transdermally absorbable drug is provided on one side of a sheet-like or film-like support, and the pressure-sensitive adhesive layer usually protects the pressure-sensitive adhesive layer. The separator for this is laminated | stacked.

  When a transdermally absorbable drug is administered to a patient using such a patch preparation, the above-mentioned separator is peeled to expose the adhesive layer, and the exposed adhesive layer is adhered to the patient's skin. From such a patch preparation affixed to the skin surface by such a simple operation, the percutaneously absorbable drug can be administered to the patient stably and continuously during the application.

  Currently, the transdermally absorbable drugs for the patch preparations include angina pectoris such as isosorbide nitrate and nitroglycerin, antihypertensives such as tulobuterol, anesthetics such as lidocaine, hormonal drugs such as estradiol, and morphine. Specific therapeutic drugs such as narcotic analgesics such as fentanyl and various steroids and non-steroids are beginning to be used. These specific therapies are drugs that must be strictly prevented from being absorbed by non-patients. In other words, the doses of these various therapeutic drugs must be strictly prescribed for patients, and it is dangerous for persons other than patients to absorb them. However, strict attention is needed.

  Thus, the drug contained in the therapeutic patch preparation is a pharmaceutical product, and the type, content, and application time of the drug are prescribed for each preparation. Therefore, it is necessary to peel off the patch preparation affixed to the adherend surface after a predetermined time has elapsed or to replace it with a new patch preparation. In the exfoliation or renewal operation of this patch preparation, when the retouching operator touches the adhesive layer of the patch preparation, various drugs remaining in the adhesive layer may be absorbed into the worker's body. is there.

  When peeling off general poultices, the peripheral part of the poultice is turned up with fingers, the turned up part is pinched with fingers, peeled off from the adherend surface, and then folded and discarded . However, if the same operation is performed in the case of a patch preparation for administering a specific medicine, the adhesive layer of the patch preparation is touched with the fingertip, and the transdermally absorbable drug remaining in the adhesive layer is removed from the fingertip. It will be absorbed.

  A release film called a separator is attached to the patch preparation. The separator is peeled off to expose the adhesive layer, and is applied to the skin surface. Currently, this separator has a cut line called a back split. The patch preparation can be applied without touching the adhesive layer. However, it is difficult to peel off the patch preparation without touching the pressure-sensitive adhesive layer.

  In order to carry out the replacement work so that the finger does not touch the adhesive layer of the patch preparation, for example, work using gloves or tweezers is partly performed. However, since the work to peel off the patch preparation is a work that depends on the sensation of the fingertips, it is difficult to work with gloves and tweezers, and when using tweezers, There are times when it pokes.

  As described above, when the exfoliation work of the patch preparation is performed by the patient himself or by a person other than the patient, such as a family member or a nurse, not only is there discomfort, but there is a risk of drug poisoning.

  On the other hand, conventionally, a patch preparation having a shape that can be easily peeled off from the adherend surface has been proposed. The patch preparation has a non-adhesive part formed on a part of the adhesive layer, and it is described that the non-adhesive part can be used as a handle to facilitate the peeling operation (patent) Reference 1).

JP 7-309747 A

  However, the patch preparation disclosed in Patent Document 1 is in a state in which the non-adhesive part is lifted from the skin surface without adhering to the skin, and therefore, the non-adhesive part is caught on clothing or the like during the application, and the Not only does it create a pleasant feeling, but in some cases, there is a risk that a part or all of it will be peeled off. As described above, the patch preparation disclosed in Patent Document 1 is an alternative to the previous patch preparation because the patchability is sacrificed as a result of placing importance on the peelability and is not satisfactory as a patch preparation. It is not. Therefore, the problem accompanying the peeling work of the patch preparation still remains, and the solution is desired.

  This invention is made | formed in view of the said conventional situation, Comprising: The subject can peel an adhesive sheet from a to-be-adhered surface, without touching the adhesive layer of an adhesive sheet, and can discard it safely. It is in providing the peeling auxiliary | assistant adhesive material and its usage.

In order to solve the above-mentioned problems, the present inventors have intensively conducted experiments and studies, and as a result, have completed the present invention.
That is, in the peeling auxiliary patch of the present invention, the first adhesive layer is provided on at least a part of one side of the sheet-like substrate, and the second adhesive layer is provided on the remaining region of the one side. The first adhesive layer and the second adhesive layer occupy substantially the entire area of one side of the sheet-like base material, and the first adhesive layer reacts with a legally regulated drug and has a medicinal effect. A patch containing a reactive compound to be eliminated, the size of the first adhesive layer and the size of the second adhesive layer being larger than the size of the pressure-sensitive adhesive sheet to be adhered to the adherend surface, The pressure-sensitive adhesive sheet can be peeled off from the adherend surface.

  Here, the reactive compound has at least two functional groups in one molecular unit constituting the reactive compound, and the functional group is at least one selected from the group consisting of an isocyanate group and a glycidyl group. Preferably there is.

  The sheet-like base material may be formed with a fold line that can be easily folded on the first adhesive layer and the second adhesive layer side.

In the peeling auxiliary patch of the present invention, it is preferable that a separator is provided on the surfaces of the first adhesive layer and the second adhesive layer.
Further, the separator may be split at least in one place.
The separator may have a fold line that can be easily folded at a position corresponding to the fold line formed on the sheet-like substrate.

  In the present invention, the first adhesive layer, the second adhesive layer, the sheet-like base material, and / or the separator may be colored.

  Moreover, it is preferable that the adhesive force with respect to the back surface of the said adhesive sheet of said 2nd adhesive layer is a peeling auxiliary patch material larger than the adhesive force with respect to the adhesion surface of the said adhesive sheet.

  In addition, the sheet-like base material can be roughened on the surface on which the first adhesive layer and the second adhesive layer are provided.

  The pressure-sensitive adhesive sheet may be a patch preparation provided with a transdermally absorbable drug-containing pressure-sensitive adhesive layer.

  In the present invention, via the portion where the sheet-like base material and the first adhesive layer are laminated and / or via the portion where the sheet-like base material and the second adhesive layer are laminated. It is preferable that the adhesive sheet can be visually confirmed. In addition, the sheet-like substrate can be substantially transparent.

  The method of using the peeling assisting adhesive material of the present invention is a peeling aid for disposing of the pressure-sensitive adhesive sheet adhered to the adherend surface by peeling off from the adherend surface using any of the above-mentioned peeling assisting adhesive materials. A method of using the adhesive material, the step of aligning the second adhesive layer surface of the peeling assisting adhesive material so as to overlap the adhesive sheet attached to the adherend surface; and A step of affixing the second adhesive layer surface on the pressure-sensitive adhesive sheet; a step of peeling and removing the peeling auxiliary adhesive material together with the pressure-sensitive adhesive sheet; and the pressure-sensitive adhesive sheet by folding the peeling auxiliary adhesive material. A step of covering the pressure-sensitive adhesive layer surface with the first adhesive layer surface, a step of reacting the reactive compound contained in the first adhesive layer and the medicinal component of the pressure-sensitive adhesive layer to deactivate the medicinal effect, It is characterized by having.

  Here, in the step of sticking the second adhesive layer surface of the peeling assisting adhesive material on the pressure-sensitive adhesive sheet, after removing a part of the separator laminated on the peeling assisting adhesive material and partially attaching it Then, at least a part of the remaining separator can be removed, and the peeling auxiliary patch can be stuck on the adhesive sheet.

  Further, in the step of covering with the first adhesive layer surface, while removing or removing the remaining separator during the adhesion, the auxiliary adhesive material is folded and the first adhesive layer and the adhesive layer are laminated and adhered. can do.

  By using the peeling auxiliary patch of the present invention, the peeling operation of the adhesive sheet, for example, the peeling operation of the patch preparation or the like can be performed without touching the adhesive layer containing the specific therapeutic agent etc. Thereafter, the entire surface of the pressure-sensitive adhesive layer such as a patch preparation can be covered and the medicinal effect can be surely deactivated, so that the pressure-sensitive adhesive sheet can be safely discarded.

BEST MODE FOR CARRYING OUT THE INVENTION

The present invention will be described below.
In the peeling auxiliary patch of the present invention, the first adhesive layer is provided on at least a part of one side of the sheet-like base material, and the second adhesive layer is provided on the remaining region of the one side. The first adhesive layer and the second adhesive layer occupy substantially the entire area of one side of the sheet-like substrate. The size of the first adhesive layer is a size that can cover the entire pressure-sensitive adhesive layer of the pressure-sensitive adhesive sheet adhered to the adherend surface, and the size of the second adhesive layer is the size of the pressure-sensitive adhesive sheet. It is a size that can be covered.

  Here, the substantially entire region has an adhesive layer (a first adhesive layer and a second adhesive layer) on almost the entire surface of one side, but a small area portion compared to the area of the adhesive layer is, for example, so-called As for a part such as a dry edge (for example, 5 mm or less), it means that a part where the second adhesive layer is not provided and the sheet-like base material is exposed may be present. However, for example, an adhesive layer is provided in such a form that a portion provided with a second adhesive layer can be overlaid on at least four corners of a rectangular pressure-sensitive adhesive sheet adhered to the adherend surface. Preferably it is. The exfoliation auxiliary patch of the present invention has a function capable of exfoliating the pressure-sensitive adhesive sheet from the adherend surface.

  The first adhesive layer provided on at least a part of one side of the sheet-like substrate contains a reactive compound that reacts with legally regulated drugs and the like to lose its medicinal effect, and removes the adhesive sheet from the adhesion surface. After peeling, it is overlaid so as to cover the entire surface of the pressure-sensitive adhesive layer.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. However, the present invention is not limited to these embodiments. In addition, the same reference number is attached | subjected about the same component, and these description is abbreviate | omitted.

  The structure of the peeling assistance sticking material which concerns on the 1st Embodiment of this invention to (a)-(c) of FIG. 1 is shown. FIG. 1 (a) is a plan view of the peeling assisting patch as viewed from the adhesive layer side, and FIG. 1 (b) is an adhesive sheet with the adhesive layer on top of the second adhesive layer. FIG. 1C is a diagram showing a state where the peeling assisting adhesive material of FIG. 1B is bent so that the adhesive sheet is on the inside.

  The peeling assisting patch according to the present embodiment has a first half of one side of a sheet-like substrate 1 (see FIG. 1 (c)) having a sufficient size that can be wrapped as it is without folding the adhesive sheet. The adhesive layer 3 is formed, and the second adhesive layer 2 is formed in the other half. In addition, a fold line 4a that is easily foldable on the adhesive layer side is provided in the approximate center of the peeling assisting adhesive material.

  Here, although the material which comprises the sheet-like base material 1 of a peeling auxiliary | assistant patch is not specifically limited, Plasticizer etc. including the chemical | medical agent contained in adhesive layers, such as a 1st adhesive layer and a 2nd adhesive layer It is preferable to use a material that does not cause a decrease in content due to permeation and disappearance of components such as additives, that is, a material that prevents permeation of the adhesive layer-containing component. Suitable materials for such a sheet-like substrate include polyesters such as polyethylene terephthalate, polyamides such as nylon, polyolefins such as polyethylene and polypropylene, polyvinyl chloride, plasticized polyvinyl chloride, and plasticized vinyl acetate-vinyl chloride. Examples include polymers, polyvinylidene chloride, ethylene-vinyl acetate copolymers, cellulose acetate, ethyl cellulose, ethylene-ethyl acrylate copolymers, polytetrafluoroethylene, polyurethane, ionomer resins, and metal foils such as aluminum foil. Further, the sheet-like substrate may be a single layer film or a laminate film.

  In the present invention, it is preferable that the pressure-sensitive adhesive sheet can be visually observed through the sheet-like base material or through the portion where the sheet-like base material and the adhesive layer are laminated. In the present invention, the visible light transmittance of the portion where the sheet-like base material and the first adhesive layer or the second adhesive layer are laminated is 10% or more as measured based on Japanese Industrial Standard JIS K7105. It is preferable. Moreover, it is preferable that a sheet-like base material is substantially transparent. Here, “substantially transparent” means that both transparent and colored and transparent can be visually confirmed through the sheet-like substrate. In this case, for example, the visible light transmittance of the sheet-like substrate is preferably 30% or more as measured based on Japanese Industrial Standard JIS K7105.

  Moreover, the sheet-like base material may be colored, or may be printed with characters, symbols, designs, and the like. For example, a display may be attached so that it can be identified at a glance that it is a peeling assisting patch used to recover the patch preparation.

  The thickness of the sheet-like substrate is not particularly limited, but when peeling the pressure-sensitive adhesive sheet, considering that the thicker one is easier in handling and easier processing when putting a fold line, It is preferably 15 μm or more, more preferably 20 μm or more, particularly preferably 50 μm or more, and preferably 200 μm or less, more preferably 100 μm or less.

  In order to improve the anchoring property (adhesive force) between the sheet-like substrate and the adhesive layer, this sheet-like substrate is further laminated with a porous film and adhered to the porous film side of this laminate film. It is preferable to form a layer. As this porous film, paper, woven fabric, non-woven fabric, a resin film subjected to mechanical perforation treatment, a resin film subjected to chemical mechanical roughening and perforation treatment, or the like can be used.

  The adhesive used for the second adhesive layer 2 is an acrylic pressure-sensitive adhesive that has been used in the past, has adhesiveness at room temperature, and does not cause adverse effects such as skin irritation when in contact with the skin. Natural rubber adhesives, silicone adhesives, synthetic rubber adhesives, vinyl ester adhesives, vinyl ether adhesives, and other medical adhesives are preferred. Furthermore, by blending a liquid plastic component that is compatible with these pressure-sensitive adhesives and making them compatible with the pressure-sensitive adhesive, the adhesive layer is plasticized, and when the adhesive layer is applied to the skin surface, It is preferable to provide an adhesive layer having a composition that gives a soft feel and can reduce skin irritation even during peeling. The liquid plastic component is not particularly limited as long as it is liquid at room temperature and is compatible with the adhesive used. Specific examples include fatty acid esters, fatty acids, liquid surfactants, hydrocarbons, etc. Among these, those that are liquid at room temperature are used. These may be used alone or in combination of two or more.

  The first adhesive layer 3 contains a reactive compound. The first adhesive layer 3 is laminated and adhered so as to cover the entire surface of the pressure-sensitive adhesive layer 5 of the pressure-sensitive adhesive sheet after the pressure-sensitive adhesive sheet adhered to the surface to be adhered is peeled off from the surface to be adhered. The reactive compound contained in the first adhesive layer 3 reacts with the medicinal component of the pressure-sensitive adhesive to lose its medicinal effect and can be inactivated. In the present invention, the reactive compound is preferably a polyfunctional compound having at least two functional groups in one molecule constituting the reactive compound. Examples of such functional groups include isocyanate groups and glycidyl groups. Two or more functional groups contained in one molecule of the reactive compound may be the same functional group or different functional groups. When a polyfunctional reactive compound is added to the drug component, a complex compound is generated, and extraction with a liquid or the like becomes impossible. Therefore, after the reaction between the drug component and the reactive compound, the effect of the drug can be surely inactivated, so that even if the drug is, for example, a narcotic, it may be impossible to extract and recover the drug. it can.

  The first adhesive layer 3 contains a non-functional pressure-sensitive adhesive that does not react with the reactive compound. Examples of such non-functional pressure-sensitive adhesives include conventionally used acrylic pressure-sensitive adhesives, rubber-based pressure-sensitive adhesives, SIS-based pressure-sensitive adhesives, and silicone-based pressure-sensitive adhesives. Moreover, as long as it does not react with a reactive compound in the 1st contact bonding layer 3, what is normally used for the adhesive within the range which does not impair the effect of this invention can be included suitably, for example, A liquid plastic component as described in the second adhesive layer 2 can also be blended.

  Each of the first adhesive layer 3 and the second adhesive layer 2 may be formed using a pressure-sensitive adhesive for the adhesive layer or the like on one half of the area of one side of the sheet-like substrate 1 or wavy. It may be provided in a shape such as a line shape or a dot shape.

  The thicknesses of the first adhesive layer and the second adhesive layer are preferably 20 μm to 200 μm, more preferably 40 μm, considering the adhesiveness to the support and skin surface of the pressure-sensitive adhesive sheet and handleability, respectively. ~ 150 μm.

  The adhesive strength of the second adhesive layer is greater than the adhesive strength of the pressure-sensitive adhesive sheet to be peeled to the adherend surface. The adhesive force of the first adhesive layer may be an adhesive force that can maintain the adhesion of the adhesive sheet to the adhesive layer. In use, considering that the second adhesive layer contacts not only the support surface of the adhesive sheet but also the adherend surface, the adhesive force of the second adhesive layer is peeled off from the adherent surface of the adhesive sheet. However, it is preferable to set as small as possible. In this case, when the adherend surface is human skin or the like, it is preferable to set in a range where the skin irritation is small, but there are individual differences in the state of the skin surface such as the dry state of the skin. A preferable adhesive strength of the second adhesive layer is 0.1 to 0.6 N / cm, more preferably 0.2 to 0.4 N / cm, as measured by Japanese Industrial Standard JIS Z-0237. However, the test plate is made of phenol resin having a width of 35 mm, a length of 150 mm, and a thickness of 2 mm.

  Although the shape of a sheet-like base material is not specifically limited, It is preferable to design according to the shape of the patch preparation which it is going to peel. In the embodiment shown in (a) to (c) of FIG. 1, the shape of the sheet-like substrate is rectangular, and the shape of half of the sheet-like substrate is similar to the shape of the pressure-sensitive adhesive sheet, and these shapes Is almost similar.

  Moreover, the dimension of a sheet-like base material is a magnitude | size which can cover the adhesive layer of the adhesive sheet in which the 1st adhesive layer is affixed on the to-be-adhered body, and a 2nd adhesive layer is an adhesive sheet. What is necessary is just a magnitude | size which can cover a support body. The dimension setting of the second adhesive layer is to prevent the operator's finger from touching the pressure-sensitive adhesive layer of the pressure-sensitive adhesive sheet, for example, the drug-containing pressure-sensitive adhesive layer of the patch preparation, during the peeling operation. The dimension setting of the first adhesive layer is to maximize the contact area so as to sufficiently react with the medicinal component of the adhesive of the adhesive sheet. In the embodiment shown in FIGS. 1A to 1C, the sheet-like base material 1 has a half size larger than that of the pressure-sensitive adhesive sheet, and the sheet-like base material 1 is folded in half. It is the size which can wrap an adhesive sheet.

  Another object of the peeling assisting patch of the present invention is to allow safe disposal of adhesive sheets such as patch preparations after peeling. In consideration of such disposal, it is desirable that the half size of the sheet-like substrate is set to an area that is 1.2 times or more that of the pressure-sensitive adhesive sheet. For example, when the pressure-sensitive adhesive sheet is a patch preparation, the size of the pressure-sensitive adhesive sheet is often set to a large or small number of standard dimensions. Therefore, it is possible to set quantitatively so that the area becomes 1.2 times or more based on each fixed dimension.

  The peeling auxiliary patch is a pressure-sensitive adhesive sheet on the back surface (on the support surface) of the pressure-sensitive adhesive sheet in which the second adhesive layer 2 provided on a part of one surface is adhered to the surface to be adhered. After being laminated and pasted so as to cover the whole, it is peeled off. When the peeling auxiliary patch after peeling is viewed from the pressure-sensitive adhesive layer 5 side of the pressure-sensitive adhesive sheet, it is as shown in FIG. If the adhesive sheet affixed on the second adhesive layer 2 of the peeling assisting patch is set to an appropriate range in the adhesive strength of the second adhesive layer 2 of the peeling assisting patch, the peeling assisting patch Are peeled off together when peeled off from the adherend surface. That is, as described above, the adhesive force of the second adhesive layer 2 to the back surface of the pressure-sensitive adhesive sheet (support 4 in FIG. 2) needs to be larger than the adhesive force of the pressure-sensitive adhesive sheet to the adherent surface of the pressure-sensitive adhesive layer 5. It is. Further, as shown in FIG. 1 (b), since a part of the second adhesive layer 2 of the peeling assisting adhesive material is affixed to the adherend surface, when the adherend surface is skin or the like, the skin It is preferable that the adhesive strength does not damage the keratin.

  In order to peel the pressure-sensitive adhesive sheet from the adherend surface using this form of the peeling auxiliary patch, the second adhesive layer 2 is applied to the adherend surface so that the entire surface of the pressure-sensitive adhesive sheet support 6 is covered. The peeling operation should be performed. Here, it is not necessary to adhere to the adherend up to the first adhesive layer surface of the peeling assisting adhesive material. That is, it suffices if the peeling auxiliary patch material can be pasted so as to cover the entire pressure sensitive adhesive sheet, and it is not necessary to stick the remaining half of the first adhesive layer 3 that does not contribute to the sticking of the pressure sensitive adhesive sheet. The remaining portion may be gripped with a finger or the like to perform a peeling operation, or part of the second adhesive layer 2 may be peeled off from the adherend surface and the peeled portion may be peeled off with a finger or the like. You may grab it and pull it off.

  In this way, the peeling assisting adhesive material can be peeled off from the adherend surface together with the adhesive sheet, and after peeling, the peeling assisting adhesive material is applied at the fold line 4a at the center of the peeling assisting adhesive which is easy to bend. When folded in two, the state shown in FIG. Here, the sealing portion 7 is formed by sealing at the peripheral portion of the pressure-sensitive adhesive sheet, and the whole surface of the pressure-sensitive adhesive layer is brought into contact with and adhered to the first adhesive layer 3 of the peeling assisting adhesive material in a state where the pressure-sensitive adhesive sheet is not folded. It is wrapped inside the peeling aid patch. Moreover, if the fold line 4a is attached | subjected to the peeling auxiliary | assistant adhesive material in this way, it can fold to the contact bonding layer side easily. Moreover, since the sealing portion 7 is formed by bonding the first adhesive layer 3 and the second adhesive layer 2, a strong sealing is realized. If the pressure-sensitive adhesive sheet is peeled and discarded using the peeling auxiliary patch of this embodiment, it can be safely discarded without touching the pressure-sensitive adhesive layer of the pressure-sensitive adhesive sheet. In addition, since the reactive compound contained in the first adhesive layer 3 reacts with the medicinal component of the adhesive to lose its medicinal effect, it is not necessary to pay attention to handling of the adhesive sheet after completion of the reaction.

  If the pressure-sensitive adhesive sheet can be visually observed through the portion where the sheet-like base material of the peeling auxiliary patch and the first adhesive layer and / or the second adhesive layer are laminated, the entire surface of the pressure-sensitive adhesive sheet support is covered. Thus, it is convenient because it can be easily confirmed with the eyes when it is stacked so as to cover the entire surface of the pressure-sensitive adhesive layer.

  Thus, for example, even if the adhesive sheet is a patch preparation comprising a transdermally absorbable drug-containing adhesive layer, it can be safely discarded without touching the drug-containing adhesive layer with hands, fingers, etc. . In addition, if the adhesive sheet enclosed inside in the state which folded the peeling auxiliary | assistant adhesive material can be visually recognized, since the state of an adhesive sheet can be confirmed, it can handle more safely.

  FIG. 2 shows a cross-sectional view of the state where the peeling assisting adhesive material shown in FIG. A pressure-sensitive adhesive sheet having a pressure-sensitive adhesive layer 5 on a support 6 inside a peeling auxiliary patch having a first adhesive layer 3 and a second adhesive layer 2 on one side of a sheet-like substrate 1 is a pressure-sensitive adhesive. The layer 5 and the first adhesive layer 3 are included in contact with each other.

  In the present invention, it is preferable that a separator is overlapped on the surface of the adhesive layer in order to protect the surface of the adhesive layer until the peeling auxiliary patch material is used. FIG. 3 is a plan view of a peeling assisting patch having a separator on the surface of the adhesive layer as seen from the separator side. As shown in FIG. 3, the separator 8 is preferably formed with a back split 4 b. In the case where the pressure-sensitive adhesive sheet is peeled off from the adherend surface using the peeling assisting patch having such a separator 8, for example, first, the right half region where the second adhesive layer 2 of the peeling assisting patch is provided. Is overlapped so as to cover the entire surface of the pressure-sensitive adhesive sheet, and the right end portion of the back-separated separator 8 (separator covering a quarter region of the peeling assisting adhesive material) is removed so that the second adhesive layer 2 is half of the pressure-sensitive adhesive sheet. Paste to cover the area. Thereafter, if the central separator 8 is removed and the second adhesive layer 2 is applied, the adhesive layer 2 can be applied so that almost half of the peel-removal adhesive material, that is, the second adhesive layer covers the entire surface of the adhesive sheet. it can. The leftmost separator 8 (the separator that covers the first adhesive layer region on the left half of the peeling assisting adhesive) is left on during the peeling operation, and the separator is removed when the peeling operation is completed. Alternatively, while removing the separator, or after removing the separator, the separator may be folded at the fold line 4a and discarded with the adhesive sheet embedded therein.

  In the present invention, the separator 8 may be provided with a fold line instead of splitting. For example, if a fold line is attached to the center portion, the separator on the right side portion is first bent along the fold line. After exposing the second adhesive layer part and sticking it on the support of the pressure-sensitive adhesive sheet, after peeling off the peeling auxiliary patch together with the pressure-sensitive adhesive sheet from the adherend, the separator covering the surface of the first adhesive layer is removed. Then, it may be disposed on the pressure-sensitive adhesive layer.

  Examples of the separator 8 used in the present invention include paper whose surface is subjected to a peeling treatment, a plastic film, and the like. Specific examples include polyethylene-coated high-quality paper, polyolefin-coated glassine paper, polyethylene terephthalate film, and polypropylene film. The surface that comes into contact with the adhesive layer and the like is coated with silicone resin, fluororesin, Teflon resin, etc., and the release treatment is performed. It has been subjected.

  The thickness of the separator 8 is not particularly limited, but is preferably 10 μm or more and 100 μm or less, more preferably 15 μm or more and 75 μm or less in consideration of workability such as handleability and spine processing.

  As shown in FIG. 4, the peeling auxiliary patch of the present invention may be larger than twice the pressure-sensitive adhesive sheet to be peeled and collected. (A) of FIG. 4 is a figure which shows the peeling auxiliary | assistant adhesive material which concerns on the 2nd Embodiment of this invention, and is a figure which shows the state which accumulated the adhesive sheet on the 2nd contact bonding layer 2. FIG. Here, it is preferable that the second adhesive layer 2 is provided on the right side, the first adhesive layer 3 is provided in the center portion, and the second adhesive layer 2 is provided on the left side. In this way, if the adhesive layer is provided in such a configuration that is considerably larger than the size of the pressure-sensitive adhesive sheet, the second adhesive layer 2 is laminated on the pressure-sensitive adhesive sheet, and the right fold line is attached. When the sheet is bent and folded, the pressure-sensitive adhesive layer surface and the first adhesive layer 3 are brought into contact with each other, and when the sheet is further folded at the left folding line and folded into a belt shape, the sealing can be further completed.

  As shown in FIG. 4 (b), the peeling auxiliary patch of the form shown in FIG. 4 (a) is such that the first adhesive layer 3 is located at the right end and the second adhesive layer is at the center portion and the left end portion. May be located.

  According to the present invention, the peeling auxiliary patch having an adhesive layer exhibiting higher adhesive strength than the adhesive strength of the pressure-sensitive adhesive sheet attached to the adherend surface is stacked on the pressure-sensitive adhesive sheet to be peeled off. If it is pasted, and then an operation for grasping the peeling assisting patch and peeling it off from the adherend surface is performed, the pressure sensitive adhesive sheet can be easily peeled off from the adherend surface together with the stripping assisting patch. In addition, since the sheet-like base material of the peeling auxiliary patch is formed to have a size that can cover the entire pressure-sensitive adhesive sheet to be peeled, without touching the pressure-sensitive adhesive layer of the pressure-sensitive adhesive sheet during the peeling operation The peeling operation can be completed, and the peeled adhesive sheet can be safely discarded by wrapping it with a sheet-like substrate. In addition, it can react with drug components and the like to inactivate medicinal properties, and has excellent safety that does not allow extraction and recovery of drugs after peeling.

  With the use of the release-assisting patch of the present invention, it is possible to perform the peeling operation of the patch preparation without touching the adhesive layer containing the specific therapeutic agent, and it is possible to wrap the patch preparation after peeling. The patch preparation can be safely discarded. Therefore, the peeling auxiliary patch of the present invention is useful for peeling and discarding a patch preparation having a specific therapeutic agent-containing pressure-sensitive adhesive layer, and simultaneously improves work safety and efficiency in the treatment using the patch preparation. Can do.

It is a top view which shows the peeling auxiliary | assistant adhesive material which concerns on the 1st Embodiment of this invention, (a) is the figure which looked at this peeling auxiliary | assistant adhesive material from the contact bonding layer side, (b) has piled up an adhesive sheet further (C) is a figure which shows the state which folded the peeling assistance sticking material of (b) in half. It is sectional drawing of the state which piled up the adhesive sheet on the peeling assistance sticking material which concerns on the 1st Embodiment of this invention, and was folded in two. It is a top view when the thing of the state by which the separator was laminated | stacked on the contact bonding layer surface of the peeling auxiliary patch which concerns on the 1st Embodiment of this invention was seen from the separator side. (A) is a figure which shows the peeling auxiliary | assistant adhesive material which concerns on the 2nd Embodiment of this invention, is a figure which shows the state which accumulated the adhesive sheet, and (b) shows the deformation | transformation aspect of (a). FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Sheet-like base material 2 2nd contact bonding layer 3 1st contact bonding layer 4a Folding line 4b Back split 5 Adhesive layer 6 Support body 7 Sealing part 8 Separator

Claims (15)

  A first adhesive layer is provided on at least a part of one side of the sheet-like substrate, and a second adhesive layer is provided on the remaining area of the one side, and the first adhesive layer and the second adhesive are provided. And the first adhesive layer contains a reactive compound that reacts with a legally-regulated drug and loses its medicinal properties, and occupies substantially the whole area of one side of the sheet-like substrate. A size of one adhesive layer and a size of the second adhesive layer are each larger than the size of the pressure-sensitive adhesive sheet to be adhered to the adherend surface, and the pressure-sensitive adhesive sheet is peeled off from the adherend surface. A peeling-assisting patch, characterized in that it can be used.   2. The molecular component constituting the reactive compound has at least two functional groups, and the functional group is at least one selected from the group consisting of an isocyanate group and a glycidyl group. The peeling auxiliary patch as described.   The peeling assisting patch according to claim 1 or 2, wherein the sheet-like base material is formed with a fold line for easy folding on the first adhesive layer and the second adhesive layer side. .   The peeling auxiliary patch according to any one of claims 1 to 3, further comprising a separator on the surfaces of the first adhesive layer and the second adhesive layer.   The peeling assisting patch according to claim 4, wherein the separator is split at least at one place.   The peeling auxiliary patch according to claim 4, wherein the separator is formed with a fold line that is easily folded at a position corresponding to the fold line formed on the sheet-like base material.   The peeling aid according to any one of claims 1 to 6, wherein the first adhesive layer, the second adhesive layer, the sheet-like base material, and / or the separator are colored. Patch material.   8. The release assisting adhesive material according to claim 1, wherein the adhesive force of the second adhesive layer to the back surface of the pressure-sensitive adhesive sheet is greater than the adhesive force of the pressure-sensitive adhesive sheet to the adherend surface. The peeling auxiliary patch as described.   The peeling auxiliary sticking according to any one of claims 1 to 8, wherein the sheet-like base material has a roughened surface on the side where the first adhesive layer and the second adhesive layer are provided. Wood.   The peeling assisting patch according to any one of claims 1 to 9, wherein the adhesive sheet is a patch preparation provided with a transdermally absorbable drug-containing adhesive layer.   The pressure-sensitive adhesive sheet through a portion where the sheet-like base material and the first adhesive layer are laminated and / or via a portion where the sheet-like base material and the second adhesive layer are laminated. The peel assisting patch according to any one of claims 1 to 10, wherein the peeling assisting patch can be visually confirmed.   The peeling auxiliary patch according to claim 11, wherein the sheet-like substrate is substantially transparent. Use of a peeling assisting adhesive for removing and discarding an adhesive sheet adhered to an adherent surface from the adherend using the peeling assisting adhesive according to any one of claims 1 to 12. Is the way
A step of aligning the second adhesive layer surface of the peeling auxiliary patch so as to overlap the pressure-sensitive adhesive sheet adhered to the adherend surface;
A step of affixing the second adhesive layer surface of the peeling auxiliary patch on the pressure-sensitive adhesive sheet;
The step of peeling and removing the peeling auxiliary patch together with the pressure-sensitive adhesive sheet from the adherend surface;
Folding the peeling auxiliary patch and covering the adhesive layer surface of the adhesive sheet with the first adhesive layer surface;
Use of a peeling assisting patch comprising a step of reacting a reactive compound contained in the first adhesive layer with a medicinal component of the pressure-sensitive adhesive layer to deactivate the medicinal effect Method.   In the step of sticking the second adhesive layer surface of the peeling auxiliary patch on the pressure-sensitive adhesive sheet, after removing a part of the separator laminated on the peeling auxiliary patch and partially sticking, The method for using a peeling assisting patch according to claim 13, wherein at least a part of the separator is removed and the peeling assisting patch is pasted on the adhesive sheet.   In the step of covering with the surface of the first adhesive layer, after removing or removing the remaining separator during the sticking, the auxiliary adhesive is folded and the first adhesive layer and the pressure-sensitive adhesive layer are laminated and stuck. The method for using the peeling assisting patch according to claim 13 or 14, wherein:

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