JP2006255290A - Surfactant, deodorizer, deodorization material, and deodorization method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a surfactant which suppresses the cause of a gastric ulcer or the like by blocking urease activity, and a deodorizer, a deodorization material, and a deodorization method capable of preventing a malodor generated from human waste or the like and performing deodorization. <P>SOLUTION: The deodorizer contains the surfactant capable of blocking the urease activity. For the deodorization material, the surfactant capable of blocking the urease activity is contained in a water absorbent. In the deodorization method, the surfactant capable of blocking the urease activity is used. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a surfactant, a deodorant, a deodorant material, and a technique relating to a method for deodorizing malodorous components that can inhibit urease activity, and in particular, a technique for deodorizing malodor such as human and pet human waste and the urease activity. The present invention relates to a technique for suppressing the cause of gastric ulcer and the like by inhibiting.

In recent years, various odors in the living environment have become a problem. In particular, the odor of ammonia generated from human and indoor pet urine is an irritating odor, so a method to effectively reduce the odor of ammonia is desired. There wasn't.

Zinc chloride, which is a typical urease inhibitor, is known to be mutagenic and is positive in micronucleus and Ames tests, so it is considered undesirable to use a large amount. .
Similarly, even if bacteria that generate malodors are sterilized using antibacterial agents or the activity of the bacteria is suppressed, the activity of the existing enzymes and malodor cannot be suppressed.

Many surfactants are known to inhibit enzyme activity by denaturing proteases or amylases. However, it is known that a specific surfactant hardly affects the enzyme activity of urease, but rather stabilizes the enzyme activity over a long period of time (see, for example, Patent Document 1).
Japanese Patent Laid-Open No. 11-253199

Recently, Helicobacter pylori has been shown to cause gastritis and duodenal ulcer. Helicobacter pylori has strong urease activity, and it can grow in the stomach by decomposing urea present in the stomach into ammonia to neutralize gastric acid, and ammonia also damages the stomach mucous membrane It is believed that. From such a background, it has been proposed and used to use urease activity inhibitors as therapeutic agents, but the effect is not sufficient, and the development of effective therapeutic agents has been desired. (For example, see Patent Document 2)
JP 2004-75694 A

The present invention provides a surfactant that suppresses the cause of gastric ulcer and the like by inhibiting urease activity, and further provides a deodorant, a deodorant material, and a deodorization method that can prevent and deodorize bad odor generated from human urine and the like. Objective.

  As a result of intensive studies to solve the above problems, the present inventors have found a surfactant capable of inhibiting urease activity that is excellent in suppressing causes such as gastric ulcer and the like, and an interface capable of inhibiting urease activity. The inventors have found a deodorizing material and a deodorizing method that can be deodorized by using a deodorant characterized by containing an activator, and have completed the present invention.

That is, the present invention
(1) a surfactant capable of inhibiting urease activity;
(2) The surfactant according to (1), wherein the surfactant is an anionic surfactant,
(3) The surfactant according to (2), wherein the anionic surfactant is a sulfonic acid type or sulfate type surfactant,
(4) The surfactant of (3) above, wherein the sulfonic acid type or sulfate ester type surfactant is polystyrene sulfonic acid,
(5) a deodorant containing a surfactant capable of inhibiting the urease activity of any one of (1) to (4),
(6) A deodorizing material comprising a water-absorbing material containing a surfactant capable of inhibiting the urease activity of any one of (1) to (4),
(7) The deodorizing material according to (6), wherein the water absorbing material is a water absorbing resin and / or a water absorbing pulp,
(8) A deodorizing method using a surfactant capable of inhibiting the urease activity according to any one of (1) to (4),
Is to provide.

The present invention can provide a surfactant that inhibits the cause of gastric ulcer and the like by inhibiting urease activity. In addition, a deodorant, a deodorant material, and a deodorization method capable of deodorizing can be provided by preventing generation of malodor due to ammonia or the like generated from human waste.

The surfactant that can inhibit urease activity may be any surfactant that can inhibit urease activity, and specifically, a hydrophobic atomic group (for example, a C 8-20 paraffin chain and its derivatives). ) And a hydrophilic atomic group (for example, anionic group, cationic group, etc.), and an appropriate balance (HLB: Hydrophobic Lipophile Balance) is established between the two atomic groups. And can inhibit urease activity. A plurality of hydrophobic atomic groups may be connected by a covalent bond to form a dimer, trimer, oligomer, polymer, or a derivative thereof. More specifically, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, and radically polymerizable surfactants may be mentioned, and at least one selected from these groups Can be used.

  In the present invention, the surfactant capable of inhibiting urease activity is obtained by dissolving reagents having the composition shown in Table 1 in distilled water, and the concentration of urease (derived from Jack Bean) in artificial urine adjusted to pH 5 is 1 mg / L. The inoculated sample was used as a reference solution. To this reference solution, 100 ml of each of the flasks containing no surfactant (blank) and inoculated so that the surfactant concentration was 100 mg / L was poured into each Erlenmeyer flask. Sealed with a rubber stopper and allowed to stand at 30 ° C for 1 day, then the ammonia concentration in artificial urine (JIS K0102 compliant indophenol blue absorptiometry) was measured, and those with lower ammonia concentration than the blank inhibited urease activity A surfactant that can be used.

Examples of the anionic surfactant include sulfonic acid type or sulfate ester type surfactants, carboxylic acid type or carboxylic acid ester type surfactants, phosphoric acid type or phosphate ester type surfactants, etc. At least one selected from the group of can be used. Of these, sulfonic acid type or sulfate ester type surfactants are preferred. Furthermore, a sulfonic acid type surfactant is preferable.

As sulfonic acid type surfactants, di-2-ethylhexylsulfosuccinic acid, 2-ethylhexyldiphenyl ether disulfonic acid, dodecylsulfonic acid, dodecanesulfonic acid, n-hexylbenzenesulfonic acid, octadecanesulfonic acid, tetrapropylenebenzenesulfonic acid, direct Chain or branched dodecylbenzene sulfonic acid, polynaphthylmethane sulfonic acid, lignin sulfonic acid, N-methyl-N-acyl tauric acid, styrene sulfonic acid, polystyrene sulfonic acid, etc., and its ammonium, calcium, sodium, potassium, etc. Examples thereof include salts, and at least one selected from these groups can be used.

Examples of the sulfate ester type surfactant include dodecyl sulfate ester, dodecyl benzene sulfate ester, octadecyl sulfate ester, and ammonium, calcium, sodium, and potassium salts thereof, and at least one selected from these groups is used. be able to.

  Among these surfactants, polystyrene sulfonic acid is particularly preferable because of its excellent safety.

As the cationic surfactant, acetates of primary and secondary amines, modified products of epichlorohydrin, and the like can be used. The primary and secondary amines are represented by the general formulas R ¹ NH ₂ and R ² R ³ NH, and R ¹ , R ² , and R ³ are the same or different, each having 1 to 30 carbon atoms or cyclic It is a hydrocarbon group. Examples of R ¹ , R ² and R ³ include methyl, ethyl, propyl, isopropyl, allyl, butyl, isobutyl, s-butyl, t-butyl, hexyl, cyclohexyl, octyl, 2-ethylhexyl, nonyl, decyl, lauryl, Substituents such as myristyl, palmityl, stearyl, oleyl, phenyl, naphthyl, dehydroabietyl can be exemplified.

Examples of other cationic surfactants include tetraalkylammonium chloride, trialkylbenzylammonium chloride, rosinamine acetate and epichlorohydrin modified products, monooxyethylene alkylamine and polyoxyethylene alkylamine. it can. In the present invention, one of the cationic low molecular surfactants can be used alone, or two or more of them can be used in combination.

    Examples of amphoteric surfactants include betaine surfactants, amino acid surfactants, imidazoline surfactants, and amine oxide surfactants.

Examples of the nonionic surfactant include polyoxyalkylene alkyl phenyl ether, polyoxyalkylene alkyl ether, polyoxyalkylene fatty acid ester, polyoxypropylene polyoxyethylene glycol glycerin fatty acid ester, sorbitan fatty acid ester, polyethylene glycol fatty acid ester, Examples include oxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, pentaerythritol fatty acid ester, propylene glycol fatty acid ester, fatty acid diethanolamide, and polyoxypropylene polyoxyethylene glycol. In the present invention, one of the nonionic surfactants can be used alone, or two or more thereof can be used in combination.

  The radical polymerizable surfactant is generally called a reactive emulsifier, and is a compound having a hydrophobic group, a hydrophilic group and a carbon-carbon double bond in the molecule. Examples of the compound having a carbon-carbon double bond include a functional group of (meth) allyl group, 1-propenyl group, 2-methyl-1-propenyl group, isopropenyl group, vinyl group, and (meth) acryloyl group. Are included.

    As these radically polymerizable surfactants, those usually applicable to emulsion polymerization can be used and are not particularly limited, but specific examples include, for example, one or more of the above functional groups in the molecule. Polyoxyalkylene alkyl ether, polyoxyalkylene aralkyl ether, polyoxyalkylene phenyl ether, polyoxyalkylene monostyryl phenyl ether, polyoxyalkylene distyryl phenyl ether, and their sulfonates, sulfate esters, phosphate esters and Sulfosuccinic acid ester salts, aliphatic carboxylates and aromatic carboxylates of polyoxyalkylene alkyl ethers or polyoxyalkylene phenyl ethers having one or more of the above functional groups in the molecule, acidic phosphoric acid (meth) acrylic acid ester Tellurium compounds, rosin-glycidyl (meth) acrylate compounds, and alkyl diphenyl ether disulfonic acid compounds such as hexyl diphenyl ether disulfonic acid, decyl diphenyl ether disulfonic acid, dodecyl diphenyl ether disulfonic acid, hexadecyl diphenyl ether disulfonic acid and their sodium salts, Examples thereof include alkali metal salts such as potassium salts and ammonium salts. In the present invention, one kind of the surfactant having a polymerizable group can be used alone, or two or more kinds thereof can be used in combination.

  Examples of the water-absorbing material include water-absorbing polymer water-absorbing resin, water-absorbing pulp, pulp mold, paper, cloth, cellulose beads, porous beads, and silica gel.

Examples of the polymer water-absorbing resin include polyacrylate salts, copolymers of acrylic acid and sodium acrylate, starch and grafted acrylic acid, and the like.

The deodorizing material is a paper containing an absorbent material as a main raw material, a microorganism preparation having a deodorizing function in addition to the deodorizing agent of the present invention, and an additive such as an antibacterial agent and a fragrance as long as the effects of the present invention are not impaired. Diapers, cloth diapers, sanitary products, urine absorbing sheets for pets and the like can be mentioned.

  The microorganism preparation having deodorizing ability means that one or more microorganisms having deodorizing ability itself, the microorganism culture itself, the culture broth of the microorganism itself, the culture broth or culture of the microorganism were dried. Things etc. Among them, it is preferable that the entire slope does not turn red when it is cultured in a Christensen urea medium for 4 hours, that is, it is not strongly positive, more preferably weakly positive in Christensen urea medium, and more preferably Christensen urea. Those which are negative in the culture medium and do not promote the generation of ammonia by hydrolysis of urea are preferable, and it is preferable to contain microorganisms whose ammonia concentration in urine decreases with the growth and activity of microorganisms. Specific examples include microbial preparations OD-101, OD-106, OD-107, and OD-109 manufactured by Seiko PMC Corporation.

    As a deodorizing method using a surfactant capable of inhibiting urease activity, it is possible to deodorize by spraying a surfactant capable of inhibiting urease activity onto a deodorizing material or encapsulating it in a water absorbing material. Moreover, there is no restriction | limiting in particular also about the addition amount of surfactant which can inhibit urease activity, Although it can use by arbitrary addition amounts, 0.01-100g / sheet | sheet * 100g is preferable.

  Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. In addition, this invention is not limited to a following example.

Examples 1-10, Comparative Examples 1-6:
The deodorizing ability of the surfactant capable of inhibiting the urease activity of the present invention was evaluated by the amount of ammonia generated. In the evaluation, a reagent having the composition shown in Table 2 was dissolved in distilled water, and artificial urine prepared to pH 5 was inoculated so that the concentration of urease (from Jack Bean) was 1 mg / L. Example 6) was prepared by inoculating this reference solution so that the concentration of the surfactant capable of inhibiting urease activity was 100 mg / L, which was designated as test solutions 1 to 10 (Examples 1 to 10). Control solutions 1 to 5 (Comparative Examples 1 to 5) were similarly inoculated except that a surfactant that did not inhibit urease activity was used instead of the surfactant that could inhibit urease activity.

<Measurement method of ammonia generation amount>
100 ml each of test solutions 1 to 10, control solutions 1 to 5 and reference solution were poured into Erlenmeyer flasks, sealed with rubber stoppers, and allowed to stand at 30 ° C. for 1 day, then the ammonia concentration in artificial urine (according to JIS K0102 India) Phenol blue absorptiometry) was measured. The results are shown in Table 3.

In the reference solution (Comparative Example 6) and the control solutions 1 to 5 (Comparative Examples 1 to 5), ammonia was generated, but in the test solutions 1 to 10 (Examples 1 to 10), generation of ammonia was prevented and urease activity was increased. Obviously, it was inhibited. It is clear that a surfactant that can effectively inhibit urease activity as described above is effective for use as a therapeutic agent for gastric ulcer and the like.

Claims (8)

A surfactant capable of inhibiting urease activity. The surfactant according to claim 1, wherein the surfactant is an anionic surfactant. The surfactant according to claim 2, wherein the anionic surfactant is a sulfonic acid type or sulfate type surfactant. The surfactant according to claim 3, wherein the sulfonic acid type or sulfate ester type surfactant is polystyrene sulfonic acid. A deodorant comprising a surfactant capable of inhibiting the urease activity according to any one of claims 1 to 4. A deodorizing material comprising a water-absorbing material containing a surfactant capable of inhibiting the urease activity according to any one of claims 1 to 4. The deodorizing material according to claim 6, wherein the water absorbing material is a water absorbing resin and / or a water absorbing pulp. A deodorizing method comprising using a surfactant capable of inhibiting urease activity according to any one of claims 1 to 4.