JP2006254885A - Food and drink for amelioration and prophylaxis of pollinosis - Google Patents

Food and drink for amelioration and prophylaxis of pollinosis Download PDF

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JP2006254885A
JP2006254885A JP2005116234A JP2005116234A JP2006254885A JP 2006254885 A JP2006254885 A JP 2006254885A JP 2005116234 A JP2005116234 A JP 2005116234A JP 2005116234 A JP2005116234 A JP 2005116234A JP 2006254885 A JP2006254885 A JP 2006254885A
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shrimp
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hay fever
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Nagayo Kazami
修代 風見
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Abstract

<P>PROBLEM TO BE SOLVED: To provide a safe and lightly ingestible food and drink carrying out amelioration and prophylaxis of symptoms of pollinosis without adverse effects, etc. <P>SOLUTION: The food and drink is composed of a pink shrimp, a soup stock-containing Miso and water. That is, about 200 ml of the pink shrimp Miso soup is continuously drunk in the morning, in the afternoon and at night. Thereby, the ingestion can lightly be carried out without the adverse effects, etc. The amelioration and prophylaxis of the pollinosis are carried out with the safe and easily drinkable shrimp Miso soup. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

本発明は花粉症の治療に効果がある飲食物に関するものである。  The present invention relates to foods and drinks effective for treating hay fever.

近年、花粉症患者が増加し社会問題になっている。しかし花粉症の原因は花粉だけでなく、大気汚染、食事の変化、ストレスや生活環境の変化が関係していると言われる。  In recent years, the number of hay fever patients has increased and has become a social problem. However, it is said that the cause of hay fever is not only pollen but also air pollution, dietary changes, stress and changes in living environment.

花粉症は、吸入された花粉が鼻粘膜上に沈着し、粘液層で花粉からアレルゲンが遊離する。生体外異物と認識されて、IgE抗体が産生される。肥満細胞や好塩其球表面にIgE抗体が結合する(感作の成立) 新たに花粉の吸入、アレルゲンの遊離。肥満細胞からのケミカルメディエーターの放出。  In hay fever, inhaled pollen deposits on the nasal mucosa and allergens are released from the pollen in the mucus layer. It is recognized as a foreign substance and an IgE antibody is produced. IgE antibody binds to the surface of mast cells and eosinophils (establishment of sensitization) New inhalation of pollen and release of allergen. Release of chemical mediators from mast cells.

ケミカルメディエーターは、ヒスタミンや好酸球遊走因子、好中球遊走因子などがある。肥満細胞の活性化後、細胞内で酵素的に生合成され、アラキドン酸代謝産物であるプロスタグランジン、ロイコトリエンや血小板活性化因子などがある。  Chemical mediators include histamine, eosinophil migration factor, and neutrophil migration factor. After activation of mast cells, there are prostaglandins, leukotrienes and platelet activating factors which are biosynthesized enzymatically in the cells and are arachidonic acid metabolites.

ロイコトリエンB4は多核白血球の血管内皮細胞への粘着を促進するとともにその遊走亢進作用をもち、さらに集積した白血球を活性化して、活性酸素やリソゾーム酵素などを放出し、炎症を促す。血小板活性化因子はマクロファージ好酸球、血小板など炎症担当細胞の細胞膜リン脂質からも生成される。  Leukotriene B4 promotes adhesion of polynuclear leukocytes to vascular endothelial cells and has an effect of promoting migration thereof, and further activates accumulated leukocytes to release active oxygen, lysosomal enzymes and the like, thereby promoting inflammation. Platelet-activating factor is also generated from plasma membrane phospholipids of cells responsible for inflammation such as macrophage eosinophils and platelets.

炎症担当細胞から各種のケミカルメディエーターが放出され連鎖的に炎症をひき起こし、ロイコトリエンなどによってくしゃみ、鼻水、鼻詰まりや眼のかゆみ、流涙などの症状が現れる。  Various chemical mediators are released from the cells in charge of inflammation, causing chain inflammation, and symptoms such as sneezing, runny nose, nasal congestion, itchy eyes, and tearing appear due to leukotrienes.

従来の花粉症の治療には、1)花粉の防除、2)減感作療法3)薬物療法などがある。  Conventional hay fever treatment includes 1) pollen control, 2) desensitization therapy, and 3) drug therapy.

花粉の防除は、外出時にマスクや眼鏡をつけ、帰宅後すぐに洗顔、洗眼、うがい、できたら鼻洗をする方法である。  Pollen control is a method of putting on a mask or glasses when going out, washing the face, washing eyes, gargles, and nasal washing as soon as possible.

減感作療法は、抗原を少量から皮膚に注射していき患者が大量の抗原に耐えられるようにする方法で2,3年注射を続ける方法である。  Desensitization therapy is a method in which injection is continued for a few years by injecting antigen into the skin from a small amount so that the patient can tolerate a large amount of antigen.

薬物療法は、抗アレルギー剤、抗ヒスタミン剤などが知られている。
斎藤洋三著(花粉症の科学)化学同人発行1994年P,107
As drug therapy, antiallergic agents, antihistamines and the like are known.
Published by Yozo Saito (Science of hay fever)

しかしながら、マスクや眼鏡などだけでは花粉を防ぐことができず、減感作療法では注射を続けるのに時間がかかることや有効性が明らかではない。また薬物療法には眠気などの副作用が心配されるため、安全で効果的な花粉症を改善できる食品が期待される。  However, pollen cannot be prevented only with a mask, glasses, etc., and it is not clear that desensitization therapy takes time to continue injection and its effectiveness. Moreover, since side effects such as drowsiness are worried about drug therapy, food that can improve hay fever safely and effectively is expected.

そこで本発明は、手軽に摂取でき、副作用などがなく安全で花粉症の症状を改善及び予防する飲食物を提供することを目的とする。  Accordingly, an object of the present invention is to provide a food and drink that can be easily taken, has no side effects, and is safe and improves and prevents the symptoms of hay fever.

本発明者は20年以上花粉症に悩まされていた。偶然飲んでいた甘エビとだし入り味噌と水分から成る飲食物、すなわちエビ味噌汁によって花粉症を改善及び予防できることを見出し、エビ味噌汁を1回約200ml朝、昼、夜に飲用し続けることで手軽に摂取でき副作用などがなく安全で飲み易い花粉症を改善及び予防する飲食物を得ることができる。  The inventor has been suffering from hay fever for over 20 years. We found that food and drink consisting of sweet shrimp, dashi miso and water that had been drunk accidentally, that is, shrimp miso soup can improve and prevent hay fever, and it is easy to continue to drink shrimp miso soup once in the morning, noon and night It is possible to obtain a food and drink that improves and prevents hay fever that is safe and easy to drink without side effects.

本発明のエビ味噌汁はこれに限定されない。だし入り味噌の代わりにカツオエキスとコンブエキスと味噌を使用できる。又は市販のカツオだしとコンブだしと味噌でもよい。エビは甘エビなどの有頭エビを使用する。エビは頭部だけでも使用できる。エビは生だけではなく乾燥エビでもよい。又は乾燥エビを粉末状にしてもよい。エビから抽出したエビエキスも使用できる。  The shrimp miso soup of the present invention is not limited to this. Skipjack extract, kombu extract and miso can be used instead of miso with miso. Or commercially available bonito stock, kombu stock and miso. Shrimp use headed shrimp such as sweet shrimp. Shrimp can be used only on the head. Shrimp may be not only raw but also dried. Alternatively, dried shrimp may be powdered. Shrimp extract extracted from shrimp can also be used.

本発明はエビ味噌汁であるがその形態はこれに限定されない。エビとだし入り味噌を粉末状にし水分で溶解したり、エビ味噌汁をゼリー状に加工したり、エビ味噌汁を濃縮しソフトカプセルに加工するなどが可能である。  Although this invention is shrimp miso soup, the form is not limited to this. Shrimp and dashi miso can be powdered and dissolved with water, shrimp miso soup can be processed into jelly, and shrimp miso soup can be concentrated and processed into soft capsules.

本発明のエビ味噌汁は花粉症の改善効果が高く、安全で摂取し易いので子供から妊婦の方まで、安心して飲用できる。速効性があり、また持続性や予防にも優れた効果を表した。  The shrimp miso soup of the present invention has a high effect of improving hay fever, and is safe and easy to take, so it can be drunk with peace of mind from children to pregnant women. It was fast-acting and also exhibited excellent effects on sustainability and prevention.

本発明は水約400mlに対し、甘エビ約200g、だし入り味噌約40gから作る。甘エビは頭と身に分ける。鍋に水を入れ沸騰させ先にエビの頭を入れ、次にエビの身を入れ約10分程度煮る。これにだし入り味噌を溶かし入れエビ味噌汁が完成される。  The present invention is made from about 200 g of sweet shrimp and about 40 g of miso soup with about 400 ml of water. Sweet shrimp is divided into a head and a body. Put water in a pan and boil, put the shrimp head first, then put the shrimp meat and simmer for about 10 minutes. The soup stock is melted and the shrimp miso soup is completed.

本発明のエビ味噌汁を花粉症の時期は1回約200mlを朝、昼、夜に飲用し続ける事で花粉症を改善できる。花粉症がない時期でもエビ味噌汁を1日1回約200ml飲用し続ける事で予防もできる。  The shrimp miso soup of the present invention can be improved in hay fever by continuing to drink about 200 ml at a time in the morning, noon and night. Even when there is no hay fever, it can be prevented by continuing to drink about 200 ml of shrimp miso soup once a day.

本発明者は、平成12年7月から平成13年7月までの1年間継続してエビ味噌汁を1日約200ml飲用していた時、平成13年2月からの花粉症の時期に花粉症の症状を全く感じないほどの効果を発揮した。  The present inventor has been taking about 200 ml of shrimp miso soup for one year from July, 2000 to July, 2001, when hay fever has been occurring since February 2001. The effect of not feeling any of the symptoms.

本発明者は平成13年8月から平成16年1月まで約2年6ヶ月もの間エビ味噌汁の飲用を停止していたにもかかわらず、平成14年と平成15年の花粉症の時期にも全く花粉症の症状があらわれないので完治したものと実感した。  Although the present inventor stopped drinking shrimp miso soup for about 2 years and 6 months from August 2001 to January 2004, it was in the period of hay fever in 2002 and 2003. However, since I did not see any symptoms of hay fever, I realized that I was completely cured.

しかし、平成16年2月から花粉症のくしゃみ、鼻水、鼻詰まりを感じたので、エビ味噌汁約200mlを1日3回朝,昼,夜に飲用し、1週間程で花粉症の症状が改善できた。  However, since February 2004, I felt sneezing, runny nose and stuffy nose of hay fever. About 200 ml of shrimp miso soup was taken three times a day in the morning, noon, and night, and the symptoms of hay fever improved in about one week. did it.

本発明者は 寝る前に強い鼻詰まりを感じたので、エビ味噌汁約200mlを飲用し、約20分後に鼻詰まりが解消されたので速効性があると実感できた。またその効果は朝まで約8時間も続き、持続性も発揮した。  Since the present inventor felt a strong nasal congestion before going to bed, he drank about 200 ml of shrimp miso soup, and after about 20 minutes, the nasal congestion was resolved, so that he could feel that it was fast-acting. The effect lasted for about 8 hours until morning, and was also sustainable.

6歳の子供が鼻詰まりを感じ、エビ味噌汁を約180ml飲用し、やはり約20分後に鼻詰まりが解消され、朝まで効果が持続された。  A 6-year-old child felt stuffy nose and drank about 180 ml of shrimp miso soup. After about 20 minutes, the stuffy nose disappeared and the effect persisted until morning.

本発明者はエビ味噌汁が花粉症に大変効果があるので成分を文献で調べた結果、味噌には多くの生理機能があり、エビやカツオエキス、コンブエキスにも有効な成分が報告されていた。  The present inventor has studied the ingredients in the literature because shrimp miso soup is very effective for hay fever. As a result, miso has many physiological functions, and the shrimp, skipjack extract, and kombu extract have been reported to have effective ingredients. .

エビ味噌汁の味噌については、抗変異原性、抗酸化性、活性酸素ラジカル消去能、コレステロール低下、脂肪肝抑制作用、薬物代謝、酸素活性化作用、生体防御担当細胞活性化作用などの生理機能に関する研究が報告されている。  Regarding the miso of shrimp miso soup, it is related to physiological functions such as antimutagenicity, antioxidant property, reactive oxygen radical scavenging ability, cholesterol lowering, fatty liver inhibitory action, drug metabolism, oxygen activation action, cell defense responsible cell activation action Research has been reported.

カツオエキスに含まれるヒスチジン、アンセリン、カルノシンの生理作用が研究され、虚血性疾患、十二指腸潰瘍などの治療効果、副賢脂質ホルモン様の作用、抗炎症作用、殺菌効果、免疫調節作用、抗酸化作用、細胞内緩衝作用などがあるとされ実際の治療にも利用されている。  Physiological actions of histidine, anserine, and carnosine contained in skipjack extract are studied, therapeutic effects on ischemic diseases, duodenal ulcers, etc., adjuvant lipid hormone-like action, anti-inflammatory action, bactericidal effect, immunoregulatory action, antioxidant action It is said that it has an intracellular buffering action and is used for actual treatment.

魚油やDHA,EPAの摂取は急性、慢性、アレルギー性の炎症症状の軽減にも役立つことが知られている。この作用のメカニズムとしては、魚油のDHAやEPAが白血球膜リン脂質中のアラキドン酸を減少させたりして、アラキドン酸からの生成するロイコトリエンA4やB4などを少なくするとともに、白血球の働きを抑制することによるとされている。  It is known that intake of fish oil, DHA, and EPA can also help reduce acute, chronic, and allergic inflammatory symptoms. The mechanism of this action is that fish oil DHA and EPA reduce arachidonic acid in leukocyte membrane phospholipids, reduce leukotrienes A4 and B4 produced from arachidonic acid, and suppress the function of leukocytes. It is said that.

コンブのうま味成分のグルタミン酸、甘エビに多く含まれる成分のグリシンは哺乳動物の脳神経系で作用する神経伝達物質である。脳の血流、酸素供給量の増加、脳細胞の代謝機能亢進に関与する。  Glutinic acid, a umami component of kombu, and glycine, a component abundant in sweet shrimp, are neurotransmitters that act in the mammalian brain nervous system. Involved in brain blood flow, increased oxygen supply, and increased metabolic function of brain cells.

エビ類に含まれるカルテノイド(アスタキサンチン)の生理機能、生物活性として、プロビタミンA活性(ビタミンAの前駆体としての働き)一重項酸素やフリーラジカルなどの活性酸素捕捉、消去活性、腫瘍細胞増殖阻害活性などが知られている。  Physiological function and biological activity of carotenoid (astaxanthin) contained in shrimps, provitamin A activity (acting as a precursor of vitamin A), capture of active oxygen such as singlet oxygen and free radicals, scavenging activity, tumor cell growth inhibition Activity is known.

アスタキサンチンは、ヘルパーT(Th)細胞のクローンであるTh1とTh2の両細胞によるIgMおよびIgGの産生を高めた。またアスタキサンチンは、ストレスに起因する多くの疾患の予防に対し有効な成分であるかもしれないとのことです。  Astaxanthin enhanced IgM and IgG production by both Th1 and Th2 cells, which are clones of helper T (Th) cells. Astaxanthin may also be an effective ingredient for the prevention of many diseases caused by stress.

発明の効果The invention's effect

以上のことから、本発明のエビ味噌汁は、相乗効果により神経系を調節しヒスタミンやロイコトリエンなどのケミカルメディエーターによる炎症を抑制し、人が本来備わっている生体機能を正常化し花粉症を根本的に改善できるものとおもわれる。従って本発明は副作用などがなく安全で花粉症を改善及び予防できる飲食物である。  From the above, the shrimp miso soup of the present invention regulates the nervous system by a synergistic effect, suppresses inflammation by chemical mediators such as histamine and leukotriene, normalizes the biological function inherent in humans, and fundamentally eliminates hay fever I think it can be improved. Therefore, the present invention is a food and drink that has no side effects and is safe and can improve and prevent hay fever.

花粉症改善だけでなく様々な疾患病などにも効果が期待でき、健康補助食品としても利用可能である。  It can be expected not only to improve hay fever but also to various diseases and can be used as a health supplement.

Claims (14)

エビとだし入り味噌と水分から成る花粉症を改善及び予防する飲食物。Food and drink to improve and prevent hay fever consisting of shrimp, dashi miso and water. エビと市販のカツオだしとコンブだしと味噌と水分から成る花粉症を改善及び予防する飲食物。Food and drink that improves and prevents hay fever consisting of shrimp, commercial bonito dashi, kombu dashi, miso and water. エビは甘エビとすることを特徴とする請求項1ないし請求項2いずれか記載の飲食物。The food or drink according to any one of claims 1 to 2, wherein the shrimp is sweet shrimp. エビはエビ頭部とすることを特徴とする請求項1,請求項2、請求項3いずれか記載の飲食物。The food or drink according to claim 1, wherein the shrimp is a shrimp head. 請求項1、請求項2、請求項3、請求項4いずれか記載のものを粉末状に加工した飲食物。A food or drink obtained by processing the powder according to claim 1, claim 2, claim 3, or claim 4 into a powder form. 請求項1、請求項2、請求項3、請求項4いずれか記載のものをゼリー状に加工した飲食物。A food or drink obtained by processing the product according to any one of claims 1, 2, 3, and 4 into a jelly shape. 請求項1、請求項2、請求項3、請求項4いずれか記載のものを濃縮しソフトカプセルに加工した飲食物。A food or drink obtained by concentrating and processing a soft capsule according to any one of claims 1, 2, 3, and 4. 甘エビを乾燥させたもの。Dried shrimp. エビ頭部を乾燥させたもの。A dried shrimp head. 甘エビ頭部を乾燥させたもの。A dried shrimp head. 請求項8、請求項9、請求項10いずれか記載のものを粉末状にし、だし紙パックに入れたもの。A powder according to any one of claims 8, 9, and 10 and put in a dashi paper pack. エビから抽出したエビエキス。Shrimp extract extracted from shrimp. エビは甘エビとすることを特徴とするエビエキス。A shrimp extract characterized by sweet shrimp. エビはエビ頭部とすることを特徴とするエビエキス。A shrimp extract characterized by the shrimp head.
JP2005116234A 2005-03-17 2005-03-17 Food and drink for amelioration and prophylaxis of pollinosis Pending JP2006254885A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107319404A (en) * 2017-08-10 2017-11-07 中国水产科学研究院东海水产研究所 A kind of processing method of prawn head food

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107319404A (en) * 2017-08-10 2017-11-07 中国水产科学研究院东海水产研究所 A kind of processing method of prawn head food

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