JP2006241031A5 - - Google Patents

Description

In the external preparation for skin such as cosmetics, essence dosage form of a high viscosity and viscosity 10000MPascal · sec or more, precisely at the site to be administered, it is possible to administer the external preparation for skin in reluctant wide, with very useful dosage form It can be said that there is. This can be said to be more remarkable in types of cosmetics such as quasi-drugs that have clearer efficacy and effects. In such an essence dosage form, it can be said that a particularly big problem is a decrease in viscosity over time. In particular, in the presence of pyrrolidone carboxylic acid or a salt thereof, a thickener such as carboxyvinyl polymer is difficult to form a crosslinked structure, so that the stability of these components is maintained while maintaining the above-mentioned viscosity stably. It was very difficult to maintain. The pyrrolidone carboxylic acid or a salt thereof has good compatibility with the skin, and, in a wide decorative good areas in order to have a good water retention properties, that has been used as a moisturizer (e.g., see Patent Document 1, Patent Document 2 ) is such disadvantage because the formulation may dosage form that has become what was very limited (e.g., see Patent Document 3, Patent Document 4).

On the other hand, carrageenan is a raw material used as a gelling / thickening agent in the field of external preparations for skin, such as cosmetics, and in the field of food. However, it is disclosed that these components and pyrrolidonecarboxylic acid are conceptually combined. Tei Ru (e.g., Patent Document 5, refer to Patent Document 6) is not actually a combination example which contains, in its viscosity stabilizing effect was not known.

In view of such a situation, the present inventors have intensively researched and sought for an external preparation for essence dosage form having excellent viscosity stability while containing pyrrolidonecarboxylic acid and / or a salt thereof. As a result, it was found that a skin external preparation containing 1) carrageenan 0.5 to 2% by mass and 2) 0.1 to 10% by mass of pyrrolidonecarboxylic acid and / or a salt thereof has such characteristics. The present invention has been completed. That is, the present invention is as follows.
(1) 1) It contains 0.5 to 2% by mass of carrageenan, 2) 0.1 to 10% by mass of pyrrolidonecarboxylic acid and / or its salt, and has a viscosity of 10,000 mPascal · second or more. , Skin preparation for essence dosage form
(2) The external preparation for skin according to (1), wherein the pH is 7 or less.
(3) The external preparation for skin according to (1) or (2) , which is a cosmetic .

(4) External preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing the essential components. The topical skin preparation of the present invention can be applied without particular limitation as long as it is externally administered to the skin. Examples thereof include cosmetics (including quasi-drugs), pharmaceutical compositions for external use on skin, and miscellaneous goods. Of these, cosmetics are particularly preferred. The dosage form of the external preparation for skin, the viscosity is highly viscous dosage form is at least 10000MPascal · sec, ie include dosage forms are said to normally essence dosage form. This is because by taking such a dosage form, it is possible to accurately administer the active ingredient to a local site where the effect of the active ingredient is necessary, and to limit the administration range. At this time, the pH is preferably 7 or less which is close to that of the skin.

In accordance with the formulation shown below, a cosmetic, which is an external preparation for skin of the present invention, was prepared. That is, the components of A and B are heated to 80 ° C. and mixed well, and then gradually added to B under stirring, and then cooled with stirring to obtain an essence dosage form (viscosity: 27000 mPascal · second; B type). Viscometer No. 4 rotor, 20 ° C., pH 6.55) cosmetic 1 was obtained. In this, Carrageenan was replaced with Comparative Example 1 (viscosity: 26500 mPascal · sec, pH 6.45) substituted with gum arabic, 20% carboxyvinyl polymer (neutralized by adding 1 ml of 10% aqueous potassium hydroxide solution after addition). Example 2 (viscosity 23500 mPascal · second, pH 8.45) and Comparative Example 3 (viscosity 21000 mPascal · second, pH 6.65) substituted with xanthan gum were also prepared in the same manner.

Claims (3)

An essence agent comprising 1) 0.5 to 2% by mass of carrageenan, 2) 0.1 to 10% by mass of pyrrolidonecarboxylic acid and / or a salt thereof, and having a viscosity of 10,000 mPascal · sec or more. the form of the external preparation for skin. The skin external preparation according to claim 1, wherein the pH is 7 or less. The external preparation for skin according to claim 1 or 2, which is a cosmetic.