JP2006241030A - External preparation for skin in form of essence - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an external preparation for skin, containing a glycoside of hydroquinone including arbutin, a glycoside of ascorbic acid including ascorbic acid-2-glucoside, sulfated trehalose or the like, and their salts in a high concentration, given by using a measure of increasing viscosity stability. <P>SOLUTION: This external preparation for skin contains (1) carrageenan in an amount of 0.5-2 mass%, (2) one, two, or more kinds selected from the glycoside of the ascorbic acid, the glycoside of the hydroquinone, and their salts in an amount of 1-10 mass%, and (3) the sulfated trehalose and/or its salt in an amount of 0.1-10 mass%. The ascorbic acid-2-glucoside is preferably used as the glycoside of the ascorbic acid and hydroquinone glucoside (arbutin) or hydroquinone maltoside is preferably used as the glycoside of the hydroquinone. The external preparation for skin is preferably used as a cosmetic. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable for cosmetics (including quasi-drugs) in an essence dosage form.

  In skin external preparations such as cosmetics, an essence dosage form having a viscosity of 10000 mPascal · second or more is an extremely useful dosage form because the external preparation for skin can be administered without accurately spreading to the site to be administered. I can say that. This can be said to be more remarkable in types of cosmetics such as quasi-drugs that have clearer efficacy and effects. In such an essence dosage form, it can be said that a particularly big problem is a decrease in viscosity over time. In particular, in hydroquinone glycosides, ascorbic acid glycosides, sulfated trehalose or salts thereof, the stable pH range is different from the thickening range of carboxyvinyl polymer. It was very difficult to maintain the stability of the ingredients. In particular, the content of these components was particularly high in the form of a high concentration blending of 1% by mass or more.

  The technology of using hydroquinone glycoside and carrageenan in combination with an external preparation for skin already exists (see, for example, Patent Document 1, Patent Document 2, and Patent Document 3), but only a thickener such as an essence system. Thus, it was not known at all how to use the system in such a way that the viscosity of the system is maintained. This is presumably because the glycoside of ascorbic acid is known to reduce the viscosity of the thickener over time. Although the technique which uses ascorbic acid and carrageenan together with a skin external preparation already existed (for example, refer patent document 4 and patent document 5), in this case, in order to maintain stability, carrageenan alone is not enough. There was recognition, and an acrylic thickener was used in combination. A technique for combining carrageenan and trehalose into a skin external preparation is already known (see, for example, Patent Document 6 and Patent Document 7), but a technique for combining sulfated trehalose and carrageenan was not known at all. . Accordingly, 1) carrageenan 0.5 to 2% by mass, 2) 1 to 10% by mass of one or more selected from glycosides of ascorbic acid, glycosides of hydroquinone and salts thereof, 3) No external preparation for skin containing sulfated trehalose and / or its salt of 0.1 to 10% by mass is known at all, and it is also completely known that such a system is excellent in long-term stability of viscosity. There wasn't. Furthermore, as a secondary effect, it has not been known at all that the prognosis of pigmentation caused by light irradiation is extremely improved by adopting such a configuration.

  Usually, in the essence dosage form skin external preparation, as the component for maintaining the viscosity, a carboxyvinyl polymer which may be alkyl-modified and / or a salt thereof is used. This is a component with extremely good viscosity stability over time in the field of topical skin preparations, but even if such a component is used, the hydroquinone glycoside, ascorbic acid glycoside, sulfuric acid In an essence dosage form containing chlorinated trehalose or a salt thereof, it is said that the effect is not exhibited.

  As the thickener other than the carboxyvinyl polymer and / or salt thereof which may be alkyl-modified, in the field of external preparation for skin, xanthan gum, carboxymethylcellulose and / or salt thereof, locust bean gum, gum arabic Polyacrylic acid and / or a salt thereof, polyvinyl alcohol and the like are known, and any of these is said to decrease in viscosity over time in the presence of the above components.

JP 2002-226355 A JP 2002-047123 A JP 2001-342125 A JP 2004-315421 A JP 2003-012498 A JP-A-10-279466 JP-A-10-182408

  The present invention has been made under such circumstances, and high concentrations of hydroquinone glycosides such as arbutin, ascorbic acid glycosides such as ascorbic acid-2-glucoside, sulfated trehalose and the like and salts thereof. An object of the present invention is to provide a means for enhancing the viscosity stability of the external preparation for skin contained in the above.

In view of such circumstances, the present inventors contain hydroquinone glycosides such as arbutin, ascorbic acid glycosides such as ascorbic acid-2-glucoside, sulfated trehalose and the like and salts thereof in high concentration. As a result of intensive research efforts to find a means to increase viscosity stability in the topical skin preparation, 1) carrageenan 0.5-2% by mass, 2) glycoside of ascorbic acid, glycoside of hydroquinone And a skin external preparation containing 1 to 10% by mass of one or two or more selected from the salts thereof and 3) 0.1 to 10% by mass of sulfated trehalose and / or a salt thereof. The present invention has been found to have excellent characteristics, and the present invention has been completed. That is, the present invention is as follows.
(1) 1) Carrageenan 0.5-2% by mass, 2) 1 to 10% by mass of one or more selected from glycosides of ascorbic acid, glycosides of hydroquinone and salts thereof 3) A skin external preparation characterized by containing 0.1 to 10% by mass of sulfated trehalose and / or a salt thereof.
(2) The external preparation for skin according to (1), wherein the glycoside of ascorbic acid is ascorbic acid-2-glucoside.
(3) The skin external preparation according to (1) or (2), wherein the glycoside of hydroquinone is hydroquinone glucoside (arbutin) or hydroquinone maltoside.
(4) The skin external preparation according to any one of (1) to (3), which is a cosmetic.
(5) The external preparation for skin according to (4), wherein the cosmetic is a quasi-drug having an indication that it has a whitening effect.
(6) The external preparation for skin according to any one of (1) to (5), wherein the viscosity is 10,000 mPascal · second or more.
(7) The external preparation for skin according to any one of (1) to (6), wherein the pH is 7 or less.
(8) The external preparation for skin according to any one of (1) to (7), which is an essence dosage form.

  According to the present invention, a hydroquinone glycoside such as arbutin, an ascorbic acid glycoside such as ascorbic acid-2-glucoside, a sulfated trehalose or the like or a salt thereof at a high concentration, the viscosity is stable. A means for enhancing the performance can be provided.

(1) Carrageenan which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing carrageenan as an essential component. Carrageenan is a polysaccharide based on red algae such as the genus Tunomata, and has galactose as a main constituent monosaccharide and a sulfate group. Carrageenan has long been used in cosmetics as a thickener. Carrageenan as a cosmetic raw material is sold by various manufacturers. For example, “Delta Gel C80”, “Delta Gel C200”, “Delta Gel S80”, “Delta Gel S200” of Nippon Biocon Co., Ltd., “Carrageenan” of Nippon Carrageenan Industry Co., Ltd. (Registered Trademark) FA "and the like can be preferably exemplified, and any of these can be used, and particularly preferred is" CGPam (Registered Trademark) FA "sold by Dainippon Pharmaceutical Co., Ltd. This is because this product is particularly excellent in stability improvement effect. In the external preparation for skin of the present invention, such a component has an action of maintaining the viscosity of the system for a long period of time. In order to exert such an action, the carrageenan is preferably contained in an amount of 0.5 to 2% by mass, more preferably 0.8 to 1.5% by mass, based on the total amount of the external preparation for skin. This is for realizing an appropriate viscosity and for realizing the stabilizing action. Moreover, it is also for maintaining the stability of the hydroquinones which are the essential components.

(2) Ascorbic acid glycosides, hydroquinone derivatives and salts thereof as essential components of the skin external preparation of the present invention The skin external preparation of the present invention contains ascorbic acid glycoside and hydroquinone glycoside as essential components. It is characterized by containing 1 to 10% by mass, more preferably 2 to 5% by mass, of one or more selected from the body and salts thereof. Examples of the sugar residue of these glycosides include glucose residue, arabinose residue, galactose residue, rhamnose residue, maltose residue and the like, among which glucose residue and maltose residue are particularly preferable. Examples of preferred specific compounds include hydroquinone glucoside (arbutin), hydroquinone maltoside, ascorbic acid-2-glucoside, and salts thereof. Such salt is not particularly limited as long as it is used in a skin external preparation, for example, alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium and magnesium, ammonium salts, Preferred examples include organic amine salts such as triethanolamine salt and triethylamine salt, and basic amino acid salts such as lysine salt and arginine salt. Since such components have a melanin production inhibitory action, an active oxygen scavenging action, and the like, the skin beautifying effect and the whitening effect can be imparted to the skin external preparation of the present invention by utilizing such action in the above-described content.

(3) Sulfated trehalose which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing sulfated trehalose and / or a salt thereof as an essential component. Such sulfated trehalose is prepared by dissolving trehalose in pyridine and adding Pyridine Sulfur Trioxide Complex (Pyr · SO3: Tokyo Kasei) at room temperature, followed by reaction at room temperature for several minutes at 60 ° C. for 1 hour. Dilute with water, adjust the pH to neutral with saturated aqueous barium hydroxide solution, dry under reduced pressure, add a small amount of water to the resulting concentrate, and remove the precipitate of barium sulfate by centrifugation. Can be produced by purifying the supernatant with a cation exchange column [Amberlite IRA-120 (Na +) (organo)]. Some are sold as raw materials and can be purchased and used.

  In the external preparation for skin of the present invention, such sulfated trehalose and / or a salt thereof enhances skin water retention, improves the skin barrier function, suppresses inflammatory factors, and exhibits an action of suppressing inflammation. In the skin external preparation of the present invention, such sulfated trehalose and its salt can contain only one species, or can contain two or more species in combination. In order to express such an action clearly, the sulfated trehalose and / or salt thereof is contained in a total amount of 1 to 5% by mass, more preferably 2 to 4% by mass, based on the total amount of the external preparation for skin. It is preferable to do.

(4) Skin external preparation of this invention The skin external preparation of this invention contains the said essential component, It is characterized by the above-mentioned. The topical skin preparation of the present invention can be applied without particular limitation as long as it is externally administered to the skin. Examples thereof include cosmetics (including quasi-drugs), pharmaceutical compositions for external use on skin, and miscellaneous goods. Among these, cosmetics are particularly preferable, and quasi drugs are particularly preferable. This is because the action of ascorbic acid glycoside and hydroquinone glycoside, which are essential components, is clear and relaxed. As described above, when the external preparation for skin of the present invention is implemented as a quasi-drug, it is a quasi-drug, a glycoside of ascorbic acid that is an essential component of the external preparation for skin of the present invention, The main effects of hydroquinone glycosides, such as having a whitening action, and if you feel abnormalities in the skin during use, immediately stop using it and see a doctor, etc. It is preferable to display the above precautions in a printed form somewhere on the product because the correct usage can be promoted. By observing such a correct usage mode, safety and effects can be enhanced. The dosage form of such a preparation is preferably a high-viscosity dosage form having a viscosity of 10,000 mPascal · second or more, and a dosage form generally referred to as an essence dosage form. This is because by taking such a dosage form, it is possible to accurately administer the active ingredient to a local site where the effect of the active ingredient is necessary, and to limit the administration range. At this time, the pH is preferably 7 or less which is close to that of the skin.

  In the external preparation for skin of the present invention, in addition to the above-mentioned essential components, any formulation component that is usually used in external preparations for skin can be contained. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oils such as hardened oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpoly Loxane, linear polysiloxane such as diphenylpolysiloxane, cyclic polysiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oil such as modified polysiloxane such as fluorine-modified polysiloxane, anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, chloride Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (eg, glyceryl monostearate), propylene glycol fatty acid esters (eg, propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid ester and alkyl glucoside, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene Polyols such as recall, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol, pyrrolidone carboxylic acid Moisturizing ingredients such as sodium, lactic acid, sodium lactate, guar gum, quince seed, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl guar gum, Carboxymethyl guar gum, dextran, locust bean gum, succinoglucan, caronic acid, chitin, chitosan, carboxymethyl chitin, agar, polyvinyl alcohol Thickener such as coal, polyvinylpyrrolidone, carboxyvinyl polymer, sodium polyacrylate, polyethylene glycol, bentonite, etc., surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silica Powders such as acid (silica), aluminum oxide, barium sulfate, inorganic pigments of which the surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide The surface may be treated, pearl agents such as titanium mica, fish phosphorus foil, bismuth oxychloride, red 202, red 228, red 226, yellow 4, which may be raked, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow Organic powders such as No. 04, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, Paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2'-hydroxy-5 ' -T-octylphenyl) benzotriazole, UV absorbers such as 4-methoxy-4'-t-butyldibenzoylmethane, lower alcohols such as ethanol and isopropanol, vitamin A or a derivative thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or its derivatives Vitamin B such as body, vitamin B12, vitamin B15 or derivatives thereof, α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate such as vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrrolo Preferred examples include vitamins such as quinoline quinone. Of these, particularly preferred are one or two selected from 1,2-pentanediol, isoprene glycol, 1,2-hexanediol, 2,4-hexylene glycol, and 1,2-octanediol. That's it. Since these polyhydric alcohols have antibacterial properties, by containing them, the content of components such as parabens that sometimes cause transient stimulation can be reduced. The preferable content of such components is 1 to 10% by mass, more preferably 2 to 5% by mass. A form containing such a mass ratio and containing no parabens is a particularly preferred form. Further, the external preparation for skin of the present invention can contain a thickener other than carrageenan, for example, a salt of carboxyvinyl polymer which may be alkyl-modified or xanthan gum. By containing these, carrageenan. As the thickener, a form containing only carrageenan is particularly preferable. The external preparation for skin of the present invention can be produced by treating such optional components and essential components according to a conventional method.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

  A cosmetic (quasi-drug), which is an external preparation for skin of the present invention, was prepared according to the formulation shown below. That is, after the components of A and B are heated to 80 ° C. and mixed well, b is gradually added to B with stirring, and then the mixture is cooled with stirring to obtain an essence form (viscosity: 32000 mPascal · second; B type viscosity A total of No. 4 rotor, 20 ° C., pH 6.45) was obtained. In this, Carrageenan was replaced with Comparative Example 1 (viscosity: 25500 mPascal · sec, pH 6.35) substituted with gum arabic, 20% carboxyvinyl polymer (neutralized by adding 1 ml of 10% aqueous potassium hydroxide solution after addition). Example 2 (viscosity 24500 mPascal · second, pH 8.5) and Comparative Example 3 (viscosity 20000 mPascal · second, pH 6.35) substituted with xanthan gum were also prepared in the same manner.

Icarrageenan 1% by mass
("Ceepe gum (registered trademark) FA")
1,3-butanediol 5% by mass
Glycerin 3% by mass
1,2-hexanediol 3% by mass
Ethanol 5% by mass
Loarbutin 3% by mass
Sulfated trehalose sodium 3% by mass
10% aqueous citric acid solution 0.1% by mass
Sodium citrate 0.1% by mass
Phenoxyethanol 0.5% by mass
76.3% by mass of water

  The cosmetic 1 and Comparative Examples 1 to 3 produced as described above were subjected to a storage test for 1 month at 5 ° C, 20 ° C and 40 ° C. Table 1 shows the results of measuring the viscosity at a constant weight of 20 ° C. after completion of the storage test. This shows that the external preparation for skin of the present invention is excellent in stability.

  According to the tanning model, using cosmetic 1, comparative examples 1 to 3 manufactured as described above, comparative example 4 in which arbutin in cosmetic 1 was replaced with water, and comparative example 5 in which sulfated trehalose was replaced with water. A recovery experiment from the effects of sunburn was conducted. That is, seven sites of 2 cm × 4 cm were provided on the back of the three panelists, and this site was irradiated with ultraviolet rays 2.5 times the MED (minimum erythema amount). Five minutes after irradiation, 0.04 ml of the sample was applied. Nothing was applied to one part of the control. At 24 hours after irradiation, the color difference from the non-irradiated site was measured with a color difference meter to confirm the degree of erythema. Thereafter, the specimen was applied to the site once a day for 30 consecutive days, and the color difference was measured again 32 days after the irradiation to measure the degree of pigmentation. The results are shown in Tables 2 and 3. From this, it can be seen that the external preparation for skin of the present invention is excellent in the action of rapidly eliminating inflammation and suppressing subsequent pigmentation.

  Similarly to cosmetic 1, cosmetics 2 to 5, which are external preparations for skin of the present invention, were produced according to the following prescription and subjected to a storage test. The results are shown in Table 4. From this, it can be seen that all the samples have excellent stability. The pH of cosmetic 2 was 6.43, cosmetic 3 was 6.31, cosmetic 4 was 6.38, and cosmetic 5 was 6.47.

Icarrageenan 1% by mass
("Ceepe gum (registered trademark) FA")
1,3-butanediol 5% by mass
Glycerin 3% by mass
Ingredients in Table 4 3% by mass
Ethanol 5% by mass
Loarbutin 3% by mass
Sulfated trehalose sodium 3% by mass
10% aqueous citric acid solution 0.1% by mass
Sodium citrate 0.1% by mass
Phenoxyethanol 0.5% by mass
76.3% by mass of water

  Similarly to cosmetic 1, cosmetic 6 as an external preparation for skin of the present invention was produced according to the following formulation, and a storage test was conducted. As a result, the viscosity before storage was 26500 mPascal · second, and after storage for 1 month, it was 5 ° C. (24000 mPascal · second), 20 ° C. (2500 mPascal · second), and 40 ° C. (20500 mPascal · second). The stability of the topical skin preparation was confirmed.

Icarrageenan 1% by mass
("Ceepe gum (registered trademark) FA")
1,3-butanediol 5% by mass
Glycerin 3% by mass
1,2-hexanediol 3% by mass
Ethanol 5% by mass
Loascorbic acid-2-glucoside 3% by mass
Sulfated trehalose sodium 3% by mass
10% aqueous citric acid solution 0.1% by mass
Sodium citrate 0.1% by mass
Phenoxyethanol 0.5% by mass
76.3% by mass of water

  Similarly to cosmetic 1, cosmetic 7 as an external preparation for skin of the present invention was produced according to the following formulation, and a storage test was conducted. As a result, the viscosity before storage was 28500 mPascal · second, and after storage for 1 month, it was 5 ° C. (26500 mPascal · second), 20 ° C. (27000 mPascal · second), and 40 ° C. (23500 mPascal · second). The stability of the topical skin preparation was confirmed.

Icarrageenan 1% by mass
("Ceepe gum (registered trademark) FA")
1,3-butanediol 5% by mass
Glycerin 3% by mass
1,2-hexanediol 3% by mass
Ethanol 5% by mass
Rohydroquinone maltoside 3% by mass
Sulfated trehalose sodium 3% by mass
10% aqueous citric acid solution 0.1% by mass
Sodium citrate 0.1% by mass
Phenoxyethanol 0.5% by mass
76.3% by mass of water

  Similarly to cosmetic 1, cosmetic 7 as an external preparation for skin of the present invention was produced according to the following formulation, and a storage test was conducted. As a result, the viscosity before storage was 26000 mPascal · second, and after storage for 1 month, it was 5 ° C. (21500 mPascal · second), 20 ° C. (18500 mPascal · second), and 40 ° C. (15500 mPascal · second). The stability of the topical skin preparation was confirmed. It has been found that it is preferable to use only carrageenan as the thickener.

Icarrageenan 1% by mass
("Ceepe gum (registered trademark) FA")
1,3-butanediol 5% by mass
Glycerin 3% by mass
1,2-hexanediol 3% by mass
Ethanol 5% by mass
Xanthan gum 0.1% by mass
Loarbutin 3% by mass
Sulfated trehalose sodium 3% by mass
10% aqueous citric acid solution 0.1% by mass
Sodium citrate 0.1% by mass
Phenoxyethanol 0.5% by mass
76.2% by mass of water

  The present invention can be applied to a stable cosmetic.

Claims (8)

1) Carrageenan 0.5 to 2% by mass, 2) 1 to 10% by mass of one or more selected from glycosides of ascorbic acid, glycosides of hydroquinone and salts thereof, and 3) A skin external preparation characterized by containing 0.1 to 10% by mass of sulfated trehalose and / or a salt thereof. The external preparation for skin according to claim 1, wherein the glycoside of ascorbic acid is ascorbic acid-2-glucoside. The skin external preparation according to claim 1 or 2, wherein the glycoside of hydroquinone is hydroquinone glucoside (arbutin) or hydroquinone maltoside. The external preparation for skin according to any one of claims 1 to 3, which is a cosmetic. The external preparation for skin according to claim 4, wherein the cosmetic is a quasi-drug having an indication that it has a whitening effect. The external preparation for skin according to any one of claims 1 to 5, wherein the viscosity is 10,000 mPascal · sec or more. The skin external preparation according to any one of claims 1 to 6, wherein the pH is 7 or less. It is an essence dosage form, The skin external preparation in any one of Claims 1-7 characterized by the above-mentioned.