JP4874577B2 - Topical skin preparation - Google Patents
Topical skin preparation Download PDFInfo
- Publication number
- JP4874577B2 JP4874577B2 JP2005170797A JP2005170797A JP4874577B2 JP 4874577 B2 JP4874577 B2 JP 4874577B2 JP 2005170797 A JP2005170797 A JP 2005170797A JP 2005170797 A JP2005170797 A JP 2005170797A JP 4874577 B2 JP4874577 B2 JP 4874577B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- mass
- external preparation
- salt
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002360 preparation method Methods 0.000 title claims description 65
- 230000000699 topical effect Effects 0.000 title claims description 4
- -1 poly glucosyl methacrylate Chemical compound 0.000 claims description 51
- 150000003839 salts Chemical class 0.000 claims description 45
- 150000001720 carbohydrates Chemical class 0.000 claims description 29
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 22
- 150000001413 amino acids Chemical class 0.000 claims description 21
- CSHZYWUPJWVTMQ-UHFFFAOYSA-N 4-n-Butylresorcinol Chemical compound CCCCC1=CC=C(O)C=C1O CSHZYWUPJWVTMQ-UHFFFAOYSA-N 0.000 claims description 19
- 235000000346 sugar Nutrition 0.000 claims description 17
- 244000005700 microbiome Species 0.000 claims description 16
- 238000011109 contamination Methods 0.000 claims description 15
- 241000588724 Escherichia coli Species 0.000 claims description 13
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 13
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 12
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 11
- 239000004471 Glycine Substances 0.000 claims description 11
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 11
- 241000191967 Staphylococcus aureus Species 0.000 claims description 11
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims description 11
- 229960002591 hydroxyproline Drugs 0.000 claims description 11
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 8
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 7
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 7
- 229920000578 graft copolymer Polymers 0.000 claims description 7
- 239000004475 Arginine Substances 0.000 claims description 6
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004472 Lysine Substances 0.000 claims description 6
- 150000007513 acids Chemical class 0.000 claims description 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 6
- UITSPQLTFPTHJZ-XTLGRWLVSA-N 2-[[(2r,6r)-3,4,5-tris(2-hydroxyethoxy)-6-methoxyoxan-2-yl]methoxy]ethanol Chemical compound CO[C@@H]1O[C@H](COCCO)C(OCCO)C(OCCO)C1OCCO UITSPQLTFPTHJZ-XTLGRWLVSA-N 0.000 claims description 4
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229920000881 Modified starch Polymers 0.000 claims 1
- 125000003071 maltose group Chemical group 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 22
- 229940024606 amino acid Drugs 0.000 description 20
- 235000001014 amino acid Nutrition 0.000 description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 19
- 239000006210 lotion Substances 0.000 description 19
- 230000002421 anti-septic effect Effects 0.000 description 15
- 239000007864 aqueous solution Substances 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical class CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 12
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 12
- 239000004359 castor oil Substances 0.000 description 12
- 235000019438 castor oil Nutrition 0.000 description 12
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 12
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 12
- 235000011187 glycerol Nutrition 0.000 description 11
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000000194 fatty acid Substances 0.000 description 10
- 229930195729 fatty acid Natural products 0.000 description 10
- 229960002449 glycine Drugs 0.000 description 10
- 230000003020 moisturizing effect Effects 0.000 description 10
- 229920001296 polysiloxane Polymers 0.000 description 10
- 229960001153 serine Drugs 0.000 description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 8
- 239000006096 absorbing agent Substances 0.000 description 7
- 239000003755 preservative agent Substances 0.000 description 7
- 230000002335 preservative effect Effects 0.000 description 7
- 229940067596 butylparaben Drugs 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 6
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 6
- 229960002216 methylparaben Drugs 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 229960003121 arginine Drugs 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 229960003646 lysine Drugs 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 5
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000004166 Lanolin Substances 0.000 description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 229940039717 lanolin Drugs 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 159000000000 sodium salts Chemical class 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- ZQQPUAADEQJOSG-UHFFFAOYSA-N [Na].C(CCC)C1=C(C=C(O)C=C1)O Chemical compound [Na].C(CCC)C1=C(C=C(O)C=C1)O ZQQPUAADEQJOSG-UHFFFAOYSA-N 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 3
- 150000003863 ammonium salts Chemical class 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical group CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000001447 alkali salts Chemical class 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- 229960000735 docosanol Drugs 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 229920001542 oligosaccharide Polymers 0.000 description 2
- 150000002482 oligosaccharides Chemical class 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- 229960001755 resorcinol Drugs 0.000 description 2
- 238000007788 roughening Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- 229960002703 undecylenic acid Drugs 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- BJDAUCLANVMIOB-UHFFFAOYSA-N (3-decanoyloxy-2,2-dimethylpropyl) decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCC BJDAUCLANVMIOB-UHFFFAOYSA-N 0.000 description 1
- HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 description 1
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- NRWMBHYHFFGEEC-KTKRTIGZSA-N (9Z)-1-O-octadec-9-enyl glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCCOCC(O)CO NRWMBHYHFFGEEC-KTKRTIGZSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- XLTMWFMRJZDFFD-UHFFFAOYSA-N 1-[(2-chloro-4-nitrophenyl)diazenyl]naphthalen-2-ol Chemical compound OC1=CC=C2C=CC=CC2=C1N=NC1=CC=C([N+]([O-])=O)C=C1Cl XLTMWFMRJZDFFD-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- RKJGFHYCZPZJPE-UHFFFAOYSA-N 2,2-bis(16-methylheptadecanoyloxymethyl)butyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C RKJGFHYCZPZJPE-UHFFFAOYSA-N 0.000 description 1
- XFOQWQKDSMIPHT-UHFFFAOYSA-N 2,3-dichloro-6-(trifluoromethyl)pyridine Chemical compound FC(F)(F)C1=CC=C(Cl)C(Cl)=N1 XFOQWQKDSMIPHT-UHFFFAOYSA-N 0.000 description 1
- WZJUBBHODHNQPW-UHFFFAOYSA-N 2,4,6,8-tetramethyl-1,3,5,7,2$l^{3},4$l^{3},6$l^{3},8$l^{3}-tetraoxatetrasilocane Chemical compound C[Si]1O[Si](C)O[Si](C)O[Si](C)O1 WZJUBBHODHNQPW-UHFFFAOYSA-N 0.000 description 1
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
- MUHFRORXWCGZGE-KTKRTIGZSA-N 2-hydroxyethyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCO MUHFRORXWCGZGE-KTKRTIGZSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- NRWMBHYHFFGEEC-MDZDMXLPSA-N 3-[(e)-octadec-9-enoxy]propane-1,2-diol Chemical compound CCCCCCCC\C=C\CCCCCCCCOCC(O)CO NRWMBHYHFFGEEC-MDZDMXLPSA-N 0.000 description 1
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 229910000497 Amalgam Inorganic materials 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 208000033830 Hot Flashes Diseases 0.000 description 1
- 206010060800 Hot flush Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- ZRMFNFGXKKFXKS-UHFFFAOYSA-N OCC(CO)(CO)CO.CCCCC Chemical compound OCC(CO)(CO)CO.CCCCC ZRMFNFGXKKFXKS-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- DJWYOLJPSHDSAL-UHFFFAOYSA-N Pantethine Natural products OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO DJWYOLJPSHDSAL-UHFFFAOYSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 229920002845 Poly(methacrylic acid) Chemical group 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 229920002359 Tetronic® Polymers 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003756 Vitamin B7 Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- UDRYFKCHZFVZGJ-UHFFFAOYSA-N [5-hexadecanoyloxy-4-(hexadecanoyloxymethyl)-6-methylpyridin-3-yl]methyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC1=CN=C(C)C(OC(=O)CCCCCCCCCCCCCCC)=C1COC(=O)CCCCCCCCCCCCCCC UDRYFKCHZFVZGJ-UHFFFAOYSA-N 0.000 description 1
- RJDOZRNNYVAULJ-UHFFFAOYSA-L [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[F-].[F-].[Mg++].[Mg++].[Mg++].[Al+3].[Si+4].[Si+4].[Si+4].[K+] Chemical compound [O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[F-].[F-].[Mg++].[Mg++].[Mg++].[Al+3].[Si+4].[Si+4].[Si+4].[K+] RJDOZRNNYVAULJ-UHFFFAOYSA-L 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229960003767 alanine Drugs 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 150000001483 arginine derivatives Chemical class 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 description 1
- 150000007514 bases Chemical class 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229940066595 beta tocopherol Drugs 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 125000006267 biphenyl group Chemical group 0.000 description 1
- 229940073609 bismuth oxychloride Drugs 0.000 description 1
- 235000012745 brilliant blue FCF Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 150000001719 carbohydrate derivatives Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- JBTHDAVBDKKSRW-UHFFFAOYSA-N chembl1552233 Chemical compound CC1=CC(C)=CC=C1N=NC1=C(O)C=CC2=CC=CC=C12 JBTHDAVBDKKSRW-UHFFFAOYSA-N 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 229910000428 cobalt oxide Inorganic materials 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(ii) oxide Chemical compound [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 229940031578 diisopropyl adipate Drugs 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 229940113120 dipropylene glycol Drugs 0.000 description 1
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 231100000507 endocrine disrupting Toxicity 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- TUKWPCXMNZAXLO-UHFFFAOYSA-N ethyl 2-nonylsulfanyl-4-oxo-1h-pyrimidine-6-carboxylate Chemical compound CCCCCCCCCSC1=NC(=O)C=C(C(=O)OCC)N1 TUKWPCXMNZAXLO-UHFFFAOYSA-N 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 235000010382 gamma-tocopherol Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229960002743 glutamine Drugs 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- TXGJTWACJNYNOJ-UHFFFAOYSA-N hexane-2,4-diol Chemical compound CCC(O)CC(C)O TXGJTWACJNYNOJ-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 1
- LDHBWEYLDHLIBQ-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide;hydrate Chemical compound O.[OH-].[O-2].[Fe+3] LDHBWEYLDHLIBQ-UHFFFAOYSA-M 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000012182 japan wax Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- BWOROQSFKKODDR-UHFFFAOYSA-N oxobismuth;hydrochloride Chemical compound Cl.[Bi]=O BWOROQSFKKODDR-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960000903 pantethine Drugs 0.000 description 1
- 235000008975 pantethine Nutrition 0.000 description 1
- 239000011581 pantethine Substances 0.000 description 1
- DJWYOLJPSHDSAL-ROUUACIJSA-N pantethine Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO DJWYOLJPSHDSAL-ROUUACIJSA-N 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229960005190 phenylalanine Drugs 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000307 polymer substrate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
- 229940116985 potassium lauryl sulfate Drugs 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229940093625 propylene glycol monostearate Drugs 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- NRWMBHYHFFGEEC-UHFFFAOYSA-N selachyl alcohol Natural products CCCCCCCCC=CCCCCCCCCOCC(O)CO NRWMBHYHFFGEEC-UHFFFAOYSA-N 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940082004 sodium laurate Drugs 0.000 description 1
- 229940045870 sodium palmitate Drugs 0.000 description 1
- GGXKEBACDBNFAF-UHFFFAOYSA-M sodium;hexadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCC([O-])=O GGXKEBACDBNFAF-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- PDSVZUAJOIQXRK-UHFFFAOYSA-N trimethyl(octadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)C PDSVZUAJOIQXRK-UHFFFAOYSA-N 0.000 description 1
- 229940118594 trimethylolpropane triisostearate Drugs 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 150000003698 vitamin B derivatives Chemical class 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
Description
本発明は、皮膚外用剤に関し、更に詳細には、黄色ブドウ球菌、大腸菌及び酵母の汚染に対して対抗性を有する皮膚外用剤に関する。
The present invention relates to an external preparation for skin, and more particularly, to an external preparation for skin having resistance to contamination of Staphylococcus aureus, Escherichia coli and yeast .
化粧料などの皮膚外用剤に於いて、防腐力を保持することは重要なことである。これは、皮膚外用剤に於いては、製造時にはクリーンに製造され、例えば黄色ブドウ球菌、大腸菌又は酵母などの微生物の混入が存しなくとも、販売後の使用状況により、使用者を介して微生物が混入する可能性が非常に高いためである。通常は、この様な微生物の混入に際しても、皮膚外用剤中で微生物が死滅するように、パラベンなどの防腐剤を配合して、防腐力を持たせることが一般的に行われている。その反面、この様な防腐剤の代表たるパラベンに於いては、ブチルパラベンに於ける内分泌物かく乱作用を有する疑い、パラベン全体に於ける一過性の刺激発現可能性の高さなど、パラベンの使用に制限すべき状況が存することがある。加えて、新しく開発された皮膚外用剤用の種々の成分の中には、微生物の生育を促進しがちな成分が存し、皮膚外用剤に於ける防腐力の維持はこの意味で年々困難性を高めている。特に、黄色ブドウ球菌、大腸菌或いは酵母は、防腐剤への対抗性が高く、しかも病原性が存する場合があるので、これらの菌に対する防腐力の維持は大きな課題となっている。 In skin preparations such as cosmetics, it is important to maintain antiseptic power. In skin external preparations, it is manufactured cleanly at the time of manufacture. For example, even if there is no contamination with microorganisms such as Staphylococcus aureus, Escherichia coli or yeast, the microorganisms are passed through the user depending on the use situation after sales. This is because the possibility of contamination is very high. Usually, even when such microorganisms are mixed, a preservative such as paraben is added so as to have antiseptic power so that the microorganisms are killed in the external preparation for skin. On the other hand, parabens, which are representative of such preservatives, are suspected of having endocrine disrupting effects in butylparaben, and there is a high possibility of transient stimulation in the entire paraben. There may be circumstances that should be restricted to use. In addition, among the various newly developed ingredients for external preparations for skin, there are ingredients that tend to promote the growth of microorganisms, and in this sense, maintaining antiseptic power in external preparations for skin has become difficult year by year. Is increasing. In particular, Staphylococcus aureus, Escherichia coli, or yeast has a high resistance to preservatives and may have pathogenicity. Therefore, maintaining the antiseptic power against these bacteria is a major issue.
パラベン以外の防腐力の向上手段としては、グルコピラノシルグリセロール、1,2−ペンタンジオール、ウンデシレン酸モノグリセリド、ヒドロキシアパタイトなどが知られているが、黄色ブドウ球菌、大腸菌又は酵母に対する防腐作用は優れているとは言い難い(例えば、特許文献1、特許文献2、特許文献3、特許文献4を参照)。 As means for improving the antiseptic power other than parabens, glucopyranosylglycerol, 1,2-pentanediol, undecylenic acid monoglyceride, hydroxyapatite and the like are known, but the antiseptic action against S. aureus, Escherichia coli or yeast is excellent. (For example, see Patent Document 1, Patent Document 2, Patent Document 3, and Patent Document 4).
ところで、マルチトース、メチルグルセス、ポリグルコシルエチルメタクリレート又はデンプン・ポリアクリル酸ナトリウムグラフト重合体等の糖類或いはその誘導体は、皮膚外用剤に於いては、保湿作用、肌荒れ改善作用などの作用を有することが知られている(例えば、特許文献5、特許文献6、特許文献7を参照)。 By the way, saccharides such as maltose, methylgluces, polyglucosylethyl methacrylate or starch / sodium polyacrylate graft polymer or derivatives thereof are known to have effects such as moisturizing action and skin roughening action in external preparations for skin. (See, for example, Patent Document 5, Patent Document 6, and Patent Document 7).
また、皮膚外用剤に於いて、リジン、アルギニン、セリン、グリシン或いはヒドロキシプロリン等のアミノ酸類は、肌を柔軟にせしめ、保湿性向上させる作用を有することが知られている(例えば、特許文献8、特許文献9を参照)。
Further, in the external preparation for skin, lysine, arginine, serine, amino acids such as glycine or hydroxyproline, flexibly allowed the skin, that are known to have an effect of moisturizing improved (e.g., Patent Document 8 , See Patent Document 9 ).
さらに、4−n−ブチルレゾルシノール又はその塩については、メラニン産生抑制作用(例えば、特許文献10参照)、雲脂抑制作用(例えば、特許文献11参照)、ニキビ抑制作用(例えば、特許文献12参照)、赤外線防護剤との併用による、日焼けと火照りの改善作用(例えば、特許文献13参照)、放射線照射後の瘢痕生成の抑制作用(例えば、特許文献14参照)、活性酸素消去作用(例えば、特許文献15参照)、抗掻痒作用(例えば、特許文献16参照)等が知られている。 Furthermore, about 4-n-butylresorcinol or its salt, melanin production inhibitory action (for example, refer patent document 10), cloud fat suppression action (for example, refer patent document 11), acne suppression action (for example, refer patent document 12) ), An effect of improving sunburn and hot flash (for example, see Patent Document 13), an effect of suppressing scar formation after radiation irradiation (for example, see Patent Document 14), an active oxygen scavenging action (for example, Patent Document 15), anti-pruritic action (for example, see Patent Document 16) and the like are known.
しかしながら、糖類もしくは該糖類の誘導体及び/又はその塩と、アミノ酸及び/又はその塩と、4−n−ブチルレゾルシノール及び/又はその塩を含有する皮膚外用剤が、パラベンフリーで優れた防腐力を有することは知られていなかった。
However, the sugar acids are properly and derivatives and / or salts thereof saccharide, an amino acid and / or its salts, skin external preparation containing a 4-n-butyl resorcinol and / or its salts, was excellent Paraben-free It was not known to have preservative power.
本発明は、上記の様な状況下為されたものであり、パラベン等の防腐剤を含有しなくても優れた防腐力を有する皮膚外用剤を提供することを課題とする。 The present invention has been made under the circumstances as described above, and an object of the present invention is to provide an external preparation for skin having an excellent antiseptic power without containing an antiseptic such as paraben.
本発明者らは、糖類又はその誘導体とアミノ酸を組み合わせて皮膚外用剤に配合した場合は、パラベンの防腐力が著しく低下することを見出している。そして、この様な糖類又はその誘導体とアミノ酸とを含有する皮膚外用剤に於いて、防腐力を維持する手段を求めて、鋭意研究努力を重ねた結果、4−n−ブチルレゾルシノール及び/又はその塩を含有せしめることにより、優れた防腐力を有する皮膚外用剤となることを見出し、発明を完成させるに至った。 The present inventors have found that when a saccharide or derivative thereof and an amino acid are combined in an external preparation for skin, the antiseptic power of paraben is significantly reduced. And in the skin external preparation containing such saccharides or a derivative thereof and an amino acid, as a result of earnest research efforts seeking a means for maintaining antiseptic power, 4-n-butylresorcinol and / or its It has been found that by containing a salt, it becomes a skin external preparation having an excellent antiseptic power, and the present invention has been completed.
即ち、本発明は以下に示すとおりである。
(1)1)糖類及び/又はその塩もしくは該糖類の誘導体及び/又はその塩を0.1〜10質量%、2)アミノ酸及び/又はその塩を0.001〜1質量%、並びに3)4−n−ブチルレゾルシノール及び/又はその塩を0.01〜5質量%含有することを特徴とする、皮膚外用剤。
(2)糖類及び/又はその塩もしくは該糖類の誘導体及び/又はその塩がグルコシル基又はポリグルコシル骨格を有することを特徴とする、(1)に記載の皮膚外用剤。
(3)糖類及び/又はその塩もしくは該糖類の誘導体及び/又はその塩が、マルチトース、メチルグルセス、ポリグルコシルエチルメタクリレート及びデンプン・ポリアクリル酸ナトリウムグラフト重合体並びにそれらの塩から選択される1種又は2種以上であることを特徴とする、(1)に記載の皮膚外用剤。
(4)アミノ酸が、リジン、アルギニン、セリン、グリシン及びヒドロキシプロリンから選択される1種又は2種以上であることを特徴とする、(1)〜(3)の何れかに記載の皮膚外用剤。
(5)ブチルパラベンを含有しないことを特徴とする、(1)〜(4)の何れかに記載の皮膚外用剤。
(6)パラベンを含有しないことを特徴とする、(1)〜(4)の何れかに記載の皮膚外用剤。
(7)黄色ブドウ球菌、大腸菌及び酵母の汚染に対して対抗性を有することを特徴とする、(1)〜(6)の何れかに記載の皮膚外用剤。
(8)黄色ブドウ球菌、大腸菌及び酵母の汚染に対する対抗性が、皮膚外用剤に前記微生物を植えつけた場合に於いて、前記微生物が1週間以内にコロニーを作ることなく死滅することで定義されることを特徴とする、(7)に記載の皮膚外用剤。
That is, the present invention is as follows.
(1) 1) Saccharide and / or salt thereof or derivative and / or salt thereof of 0.1 to 10% by mass, 2) Amino acid and / or salt thereof of 0.001 to 1% by mass, and 3) A skin external preparation characterized by containing 0.01 to 5% by mass of 4-n-butylresorcinol and / or a salt thereof.
(2) The external preparation for skin according to (1), wherein the saccharide and / or salt thereof or a derivative of the saccharide and / or salt thereof has a glucosyl group or a polyglucosyl skeleton.
(3) A saccharide and / or a salt thereof or a derivative of the saccharide and / or a salt thereof selected from maltose, methylgluces, polyglucosylethyl methacrylate, starch / sodium polyacrylate graft polymer, and salts thereof The skin external preparation according to (1), characterized in that there are two or more kinds.
(4) The skin external preparation according to any one of (1) to (3), wherein the amino acid is one or more selected from lysine, arginine, serine, glycine and hydroxyproline. .
(5) The external preparation for skin according to any one of (1) to (4), which does not contain butylparaben.
(6) The external preparation for skin according to any one of (1) to (4), which does not contain paraben.
(7) The external preparation for skin according to any one of (1) to (6), which has a resistance to contamination by Staphylococcus aureus, Escherichia coli and yeast.
(8) Resistance to Staphylococcus aureus, Escherichia coli, and yeast contamination is defined by the fact that the microorganisms die without forming colonies within one week when the microorganisms are planted in a topical skin preparation. The external preparation for skin according to (7), wherein
即ち、本発明は以下に示すとおりである。
(1)1)糖類、もしくはメチルグルセス、ポリグルコシルエチルメタクリレート、デンプン・ポリアクリル酸ナトリウムグラフト重合体及びヒドロキシプロピルセルロースから選択される1種又は2種以上の糖類の誘導体及び/又はその塩0.1〜10質量%と、2)アミノ酸及び/又はその塩0.001〜1質量%と、3)4−n−ブチルレゾルシノール及び/又はその塩0.01〜5質量%とを含有し、パラベンを含有しないことを特徴とする、黄色ブドウ球菌、大腸菌及び酵母の汚染に対して対抗性を有する皮膚外用剤。
(2)糖類がマルチトースまたは異性化糖であることを特徴とする、(1)に記載の皮膚外用剤。
(3)アミノ酸が、リジン、アルギニン、セリン、グリシン及びヒドロキシプロリンから選択される1種又は2種以上であることを特徴とする、(1)又は(2)に記載の皮膚外用剤。
(4)黄色ブドウ球菌、大腸菌及び酵母の汚染に対する対抗性が、皮膚外用剤に前記微生物を植えつけた場合に於いて、前記微生物が1週間以内にコロニーを作ることなく死滅することで定義されることを特徴とする、(1)〜(3)の何れかに記載の皮膚外用剤。
That is, the present invention is as follows.
(1) 1) sugar acids, it is also properly methyl gluceth, poly glucosyl methacrylate, one or more saccharides derivatives and / or salts thereof selected from starch sodium polyacrylate graft polymer and hydroxypropyl cellulose 0 . And 1 to 10 mass%, 2) amino acids and / or salts thereof 0. And 001-1 wt%, 3) 4-n- butyl-resorcinol and / or a salt thereof 0. A skin external preparation having resistance against contamination of Staphylococcus aureus, Escherichia coli and yeast, characterized by containing 01 to 5% by mass and not containing parabens .
(2), wherein the sugar compound is multitose or isomerized sugar, skin external preparation as described in (1).
(3) The skin external preparation according to (1) or (2) , wherein the amino acid is one or more selected from lysine, arginine, serine, glycine and hydroxyproline.
(4) The resistance to Staphylococcus aureus, Escherichia coli and yeast contamination is defined by the fact that the microorganisms die without forming colonies within one week when the microorganisms are planted in a topical skin preparation. The external preparation for skin according to any one of ( 1) to (3), wherein
(1)本発明の皮膚外用剤の必須成分である糖類及び/又はその塩もしくは該糖類の誘導体及び/又はその塩
本発明の皮膚外用剤は、糖類及び/又はその塩もしくは該糖類の誘導体及び/又はその塩を必須成分として含有することを特徴とする。本発明にいう「糖類」とは、単糖もしくは多糖類(オリゴ糖を含む)をいい、かかる糖類の「誘導体」とは、これらの糖類又は多糖類の水酸基を介して糖類に分類されないモエティーが結合した化合物をいう。本発明においては、糖類又はその誘導体は、皮膚保湿作用を有するものであることが好ましい。
(1) Saccharide and / or a salt thereof or a derivative of the saccharide and / or a salt thereof, which are essential components of the external preparation for skin of the present invention, a saccharide and / or a salt thereof or a derivative of the saccharide and And / or a salt thereof as an essential component. “Saccharides” as used in the present invention refers to monosaccharides or polysaccharides (including oligosaccharides), and “derivatives” of such saccharides are those that are not classified into saccharides via the hydroxyl groups of these saccharides or polysaccharides. Refers to the bound compound. In the present invention, it is preferable that the saccharide or its derivative has a skin moisturizing action.
(1)本発明の皮膚外用剤の必須成分である糖類、もしくは糖類の誘導体及び/又はその塩
本発明の皮膚外用剤は、糖類、もしくは後記する糖類の誘導体及び/又はその塩を必須
成分として含有することを特徴とする。本発明にいう「糖類」とは、単糖もしくは多糖類(オリゴ糖を含む)をいう。本発明においては、糖類又はその誘導体は、皮膚保湿作用を有するものであることが好ましい。
(1) a sugar compound is an essential component of the skin external preparation of the present invention, or skin external preparation of the derivatives and / or salts thereof present invention sugar acids are sugar acids, also properly derivatives of later-described saccharide and / or a It contains a salt as an essential component. The “saccharide” as used in the present invention refers to a monosaccharide or polysaccharide (including oligosaccharides) . In the present invention, it is preferable that the saccharide or its derivative has a skin moisturizing action.
糖類に分類されないモエティーとしては、アルキルオキシ基、カルボキシル基、アルキルオキシカルボニル基を有していてもよいアルキル基若しくはアルケニル基、ポリオキシエチレン鎖、ポリ(メタ)アクリル酸鎖、ポリオキシプロピレン鎖等のポリマー基体等が好適に例示できる。 Moieties that are not classified as sugars include alkyloxy groups, carboxyl groups, alkyl groups or alkenyl groups that may have an alkyloxycarbonyl group, polyoxyethylene chains, poly (meth) acrylic acid chains, polyoxypropylene chains, etc. The polymer substrate of FIG.
前記した糖類の誘導体としては、メチルグルセス、ポリグルコシルエチルメタクリレート、デンプン・ポリアクリル酸ナトリウムグラフト重合体、及びヒドロキシプロピルセルロースが挙げられる。メチルグルセスは、メチルグルコシドに酸化エチレンを付加した化合物であり、酸化エチレンの平均付加モル数が5〜25のものが好ましい。具体的には、平均付加モル数がそれぞれ10又は20であるメチルグルセス−10及びメチルグルセス−20が挙げられる。
It is a derivative of the above saccharides, methyl gluceth, poly glucosyl methacrylate click relays DOO, de Npun-sodium polyacrylate graft polymers, and hydroxypropyl cellulose. Methyl gluces is a compound obtained by adding ethylene oxide to methyl glucoside, and those having an average addition mole number of ethylene oxide of 5 to 25 are preferable. Specific examples include methyl gluces-10 and methyl gluces-20, each having an average added mole number of 10 or 20.
上記のような糖類又はその誘導体は、糖鎖に由来する水分保持性により、優れた皮膚保湿作用を有するが、糖鎖の資化性により皮膚外用剤の防腐力を著しく低下せしめる。特に、アミノ酸が共存する場合には、窒素供給源も確保されるので、この傾向は著しい。 The saccharides as described above or derivatives thereof have an excellent skin moisturizing action due to the moisture retention derived from the sugar chain, but significantly reduce the antiseptic power of the external preparation for skin due to the utilization of the sugar chain. In particular, when amino acids coexist, this tendency is remarkable because a nitrogen supply source is also secured.
本発明の皮膚外用剤に於いては、かかる糖類又はその誘導体は唯一種を含有せしめることも出来るし、2種以上を組み合わせて含有せしめることも出来る。又、塩としては、ナトリウム塩、カリウム塩等のアルカリ金属塩、カルシウム、マグネシウム等のアルカリ土類金属塩、アンモニウム塩、トリエタノールアミン塩、トリエチルアミン塩等の有機アミン塩類等が好ましく例示できる。前記の様な皮膚保湿作用を発現せしめるためには、かかる糖類又はその誘導体を、皮膚外用剤全量に対して、総量で0.1〜10質量%、より好ましくは、0.2〜5質量%含有せしめることが好ましい。下限値を下回ると前記作用を発現しない場合が存し、上限値を上回っても効果が頭打ちになる場合が存するからである。 In the external preparation for skin of the present invention, such saccharides or derivatives thereof can contain only one species or can contain two or more species in combination. Preferred examples of the salt include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium and magnesium, and organic amine salts such as ammonium salt, triethanolamine salt and triethylamine salt. In order to express the skin moisturizing action as described above, the saccharide or derivative thereof is 0.1 to 10% by mass, more preferably 0.2 to 5% by mass, based on the total amount of the external preparation for skin. It is preferable to make it contain. This is because if the lower limit value is not reached, the above-mentioned action may not be exhibited, and if the upper limit value is exceeded, the effect may reach its peak.
(2)本発明の皮膚外用剤の必須成分であるアミノ酸及び/又はその塩
本発明の皮膚外用剤は、必須成分としてアミノ酸及び/又はその塩を含有することを特徴とする。アミノ酸としては、通常皮膚外用剤で知られているものであれば特段の限定無く適用でき、例えば、ロイシン、イソロイシン、グルタミン、グルタミン酸、トリプトファン、リジン、アルギニン、セリン、グリシン、ヒドロキシプロリン、フェニルアラニン、アラニン等が好ましく例示でき、リジン、アルギニン、セリン、グリシン及びヒドロキシプロリンが特に好ましく例示できる。アミノ酸はL−体、D−体及びDL−体のいずれでもよいが、L−体が好ましい。
(2) Amino acid and / or salt thereof which is an essential component of the external preparation for skin of the present invention is characterized by containing an amino acid and / or a salt thereof as an essential component. The amino acid, as long as it is known in normal skin external agent applicable particular limitation without, for example, leucine, isoleucine, glutamine, glutamic acid, tryptophan, lysine, arginine, serine, glycine, hydroxyproline, phenylalanine, Alanine and the like can be preferably exemplified, and lysine, arginine, serine, glycine and hydroxyproline can be particularly preferably exemplified. The amino acid may be any of the L-form, D-form and DL-form, but the L-form is preferred.
本発明の皮膚外用剤では、かかるアミノ酸は唯一種を含有することも出来るし、2種以上を組み合わせて含有させることも出来る。又、塩としてはナトリウム塩、カリウム塩等のアルカリ金属塩、カルシウム、マグネシウム等のアルカリ土類金属塩、アンモニウム塩、トリエタノールアミン塩、トリエチルアミン塩等の有機アミン塩類等のアルカリ塩、クエン酸塩、酒石酸塩などの有機酸塩、リン酸塩、塩酸塩、硫酸塩、硝酸塩などの鉱酸塩などが好ましく例示できる。 In the external preparation for skin of the present invention, such amino acids can contain only one species, or two or more can be contained in combination. Further, as salts, alkali salts such as sodium salts and potassium salts, alkaline earth metal salts such as calcium and magnesium, alkali salts such as ammonium salts, organic ethanol salts such as triethanolamine salts and triethylamine salts, and citrate salts Preferred examples include organic acid salts such as tartrate, mineral acid salts such as phosphate, hydrochloride, sulfate and nitrate.
これらのアミノ酸及び/又はその塩は、皮膚保湿作用を発現するとともに、肌荒れなどの改善を促進する作用を有する。 These amino acids and / or salts thereof have a skin moisturizing action and an action of promoting improvement such as rough skin.
本発明の皮膚外用剤に於いて、かかるアミノ酸の好ましい含有量は、0.001〜1質量%、より好ましくは、0.005〜0.5質量%である。これは下限値を下回ると皮膚保湿効果を奏さない場合が存し、上限値を上回っても効果が頭打ちになる場合が存するからである。 In the skin external preparation of the present invention, the preferred content of such amino acids is 0.001 to 1% by mass, more preferably 0.005 to 0.5% by mass. This is because the skin moisturizing effect may not be achieved if the lower limit is not reached, and the effect may reach its peak even if the upper limit is exceeded.
(3)本発明の皮膚外用剤の必須成分である4−n−ブチルレゾルシノール及び/又はその塩
本発明の皮膚外用剤は、4−n−ブチルレゾルシノール及び/又はその塩を必須成分として、0.01〜5質量%、より好ましくは、0.05〜1質量%を含有することを特徴とする。かかる4−n−ブチルレゾルシノールは、常法に従って製造することが出来、例えば、Lille,J.;Bitter,L.A.;Peiner,V. Trudy−Nauchono−Issledovatel’skii Institut Slantsev (1969), No.18, 127−34に記載された方法に従うことができる。
即ち、レゾルシンとブタン酸を塩化亜鉛の存在下で縮合し、亜鉛アマルガム/塩酸で還元する方法や、レゾルシンとn−ブチルアルコールとを200〜400℃の高温下で縮合させる方法が例示できる。
(3) 4-n-Butylresorcinol and / or its salt which is an essential component of the skin external preparation of this invention The skin external preparation of this invention has 4-n-butylresorcinol and / or its salt as an essential component, 0 0.01 to 5% by mass, and more preferably 0.05 to 1% by mass. Such 4-n-butylresorcinol can be prepared according to conventional methods, for example, see Lille, J. et al. Bitter, L .; A. Peiner, V .; Trudy-Nauchono-Issledovatel'skii Institute Sltsev (1969), No. 1 18, 127-34 can be followed.
That is, examples include a method of condensing resorcin and butanoic acid in the presence of zinc chloride and reducing with zinc amalgam / hydrochloric acid, and a method of condensing resorcin and n-butyl alcohol at a high temperature of 200 to 400 ° C.
このようにして得られた4−n−ブチルレゾルシノールは種々の塩基性化合物と反応させることにより塩とすることが出来る。このような塩としては、生理的に許容されるものであれば特段の限定はされず、例えば、ナトリウム塩、カリウム塩などのアルカリ金属塩、カルシウム塩、マグネシウム塩などのアルカリ土類金属塩、アンモニウム塩、トリエタノールアミン塩やトリエチルアミン塩等の有機アミン塩、リジン塩やアルギニン塩等の塩基性アミノ酸塩などが好ましく例示できる。これらの塩の内、特に好ましいものはアルカリ金属塩であり、中でもナトリウム塩が特に好ましい。 The 4-n-butylresorcinol thus obtained can be converted into a salt by reacting with various basic compounds. Such a salt is not particularly limited as long as it is physiologically acceptable, for example, an alkali metal salt such as sodium salt or potassium salt, an alkaline earth metal salt such as calcium salt or magnesium salt, Preferred examples include organic amine salts such as ammonium salts, triethanolamine salts and triethylamine salts, and basic amino acid salts such as lysine salts and arginine salts. Among these salts, alkali metal salts are particularly preferable, and sodium salts are particularly preferable.
本発明の皮膚外用剤に於いて、4−n−ブチルレゾルシノール又はその塩は1種を単独で含有させることもできるし、2種以上を組み合わせて含有させることもできる。かかる成分の含有量が、前記の量より、少なすぎると微生物に対する対抗性(防腐効果)を発揮しない場合があり、多すぎても効果が頭打ちになる場合がある。 In the external preparation for skin of the present invention, 4-n-butylresorcinol or a salt thereof can be contained alone or in combination of two or more. If the content of such a component is too smaller than the above-mentioned amount, the resistance to microorganisms (preservative effect) may not be exhibited, and if it is too much, the effect may reach its peak.
(4)本発明の皮膚外用剤
本発明の皮膚外用剤は、前記必須成分である、1)糖類、もしくはメチルグルセス、ポリグルコシルエチルメタクリレート、デンプン・ポリアクリル酸ナトリウムグラフト重合体及びヒドロキシプロピルセルロースから選択される1種又は2種以上の糖類の誘導体及び/又はその塩、2)アミノ酸及び/又はその塩、及び3)4−n−ブチルレゾルシノール及び/又はその塩を含有することを特徴とする。
本発明の皮膚外用剤は、かかる必須成分以外に、通常化粧料などの皮膚外用剤で使用される任意成分を含有することが出来る。この様な任意成分としては、例えば、マカデミアナッツ油、アボガド油、トウモロコシ油、オリーブ油、ナタネ油、ゴマ油、ヒマシ油、サフラワー油、綿実油、ホホバ油、ヤシ油、パーム油、液状ラノリン、硬化ヤシ油、硬化油、モクロウ、硬化ヒマシ油、ミツロウ、キャンデリラロウ、カルナウバロウ、イボタロウ、ラノリン、還元ラノリン、硬質ラノリン、ホホバロウ等のオイル、ワックス類;流動パラフィン、スクワラン、プリスタン、オゾケライト、パラフィン、セレシン、ワセリン、マイクロクリスタリンワックス等の炭化水素類;オレイン酸、イソステアリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン酸、ウンデシレン酸等の高級脂肪酸類;セチルアルコール、ステアリルアルコール、イソステアリルアルコール、ベヘニルアルコール、オクチルドデカノール、ミリスチルアルコール、セトステアリルアルコール等の高級アルコール等;イソオクタン酸セチル、ミリスチン酸イソプロピル、イソステアリン酸ヘキシルデシル、アジピン酸ジイソプロピル、セバチン酸ジ−2−エチルヘキシル、乳酸セチル、リンゴ酸ジイソステアリル、ジ−2−エチルヘキサン酸エチレングリコール、ジカプリン酸ネオペンチルグリコール、ジ−2−ヘプチルウンデカン酸グリセリン、トリ−2−エチルヘキサン酸グリセリン、トリ−2−エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ−2−エチルヘキサン酸ペンタンエリトリット等の合成エステル油類;ジメチルポリシロキサン、メチルフェニルポリシロキサン、ジフェニルポリシロキサン等の鎖状ポリシロキサン;オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサンシロキサン等の環状ポリシロキサン;アミノ変性ポリシロキサン、ポリエーテル変性ポリシロキサン、アルキル変性ポリシロキサン、フッ素変性ポリシロキサン等の変性ポリシロキサン等のシリコーン油等の油剤類;脂肪酸セッケン(ラウリン酸ナトリウム、パルミチン酸ナトリウム等)、ラウリル硫酸カリウム、アルキル硫酸トリエタノールアミンエーテル等のアニオン界面活性剤類;塩化ステアリルトリメチルアンモニウム、塩化ベンザルコニウム、ラウリルアミンオキサイド等のカチオン界面活性剤類;イミダゾリン系両性界面活性剤(2−ココイル−2−イミダゾリニウムヒドロキサイド−1−カルボキシエチロキシ2ナトリウム塩等)、ベタイン系界面活性剤(アルキルベタイン、アミドベタイン、スルホベタイン等)、アシルメチルタウリン等の両性界面活性剤類;ソルビタン脂肪酸エステル類(ソルビタンモノステアレート、セスキオレイン酸ソルビタン等)、グリセリン脂肪酸類(モノステアリン酸グリセリン等)、プロピレングリコール脂肪酸エステル類(モノステアリン酸プロピレングリコール等)、硬化ヒマシ油誘導体、グリセリンアルキルエーテル、POEソルビタン脂肪酸エステル類(POEソルビタンモノオレエート、モノステアリン酸ポリオキエチレンソルビタン等)、POEソルビット脂肪酸エステル類(POE−ソルビットモノラウレート等)、POEグリセリン脂肪酸エステル類(POE−グリセリンモノイソステアレート等)、POE脂肪酸エステル類(ポリエチレングリコールモノオレート、POEジステアレート等)、POEアルキルエーテル類(POE2−オクチルドデシルエーテル等)、POEアルキルフェニルエーテル類(POEノニルフェニルエーテル等)、プルロニック型類、POE・POPアルキルエーテル類(POE・POP2−デシルテトラデシルエーテル等)、テトロニック類、POEヒマシ油・硬化ヒマシ油誘導体(POEヒマシ油、POE硬化ヒマシ油等)、ショ糖脂肪酸エステル、アルキルグリセリルエーテル(グリセリンモノオレイルエーテル(セラキルアルコール)等)、アルキルグルコシド等の非イオン界面活性剤類;ポリエチレングリコール、グリセリン、1,3−ブチレングリコール、エリスリトール、ソルビトール、キシリトール、マルチトール、プロピレングリコール、ジプロピレングリコール、ジグリセリン、イソプレングリコール、1,3−ブタンジオール、1,2−ペンタンジオール、2,4−ヘキサンジオール、1,2−ヘキサンジオール、1,2−オクタンジオール等の多価アルコール類;ピロリドンカルボン酸ナトリウム、乳酸、乳酸ナトリウム等の保湿成分類;表面を処理されていても良い、マイカ、タルク、カオリン、合成雲母、炭酸カルシウム、炭酸マグネシウム、無水ケイ酸(シリカ)、酸化アルミニウム、硫酸バリウム等の粉体類;表面を処理されていても良い、ベンガラ、黄酸化鉄、黒酸化鉄、酸化コバルト、群青、紺青、酸化チタン、酸化亜鉛の無機顔料類;表面を処理されていても良い、雲母チタン、魚燐箔、オキシ塩化ビスマス等のパール剤類;レーキ化されていても良い赤色202号、赤色228号、赤色226号、黄色4号、青色404号、黄色5号、赤色505号、赤色230号、赤色223号、橙色201号、赤色213号、黄色204号、黄色203号、青色1号、緑色201号、紫色201号、赤色204号等の有機色素類;ポリエチレン末、ポリメタクリル酸メチル、ナイロン粉末、オルガノポリシロキサンエラストマー等の有機粉体類;パラアミノ安息香酸系紫外線吸収剤、アントラニル酸系紫外線吸収剤、サリチル酸系紫外線吸収剤、桂皮酸系紫外線吸収剤、ベンゾフェノン系紫外線吸収剤、糖系紫外線吸収剤、2−(2’−ヒドロキシ−5’−t−オクチルフェニル)ベンゾトリアゾール、4−メトキシ−4’−t−ブチルジベンゾイルメタン等の紫外線吸収剤類;エタノール、イソプロパノール等の低級アルコール類;ビタミンA又はその誘導体、ビタミンB 6 塩酸塩、ビタミンB 6 トリパルミテート、ビタミンB 6 ジオクタノエート、ビタミンB 2 又はその誘導体、ビタミンB 12 、ビタミンB 15 又はその誘導体等のビタミンB類、α−トコフェロール、β−トコフェロール、γ−トコフェロール、ビタミンEアセテート等のビタミンE類、ビタミンD類、ビタミンH、パントテン酸、パンテチン、ピロロキノリンキノン等のビタミン類等;フェノキシエタノール等の抗菌剤;アクリル酸−メタクリル酸アルキルコポリマー及び/又はその塩、カルボキシビニルポリマー及び/又はその塩、キサンタンガムやヒドロキシプロピルセルロース等の増粘剤;などが好ましく例示できる。
(4) Skin external preparation of the external preparation for skin of the Invention The present invention, the essential component, 1) sugar acids, methyl gluceth also is properly poly glucosyl methacrylate, starch sodium polyacrylate graft polymer and hydroxypropyl It contains one or more saccharide derivatives selected from cellulose and / or salts thereof, 2) amino acids and / or salts thereof, and 3) 4-n-butylresorcinol and / or salts thereof. And
The skin external preparation of this invention can contain the arbitrary components normally used with skin external preparations, such as cosmetics, besides this essential component. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. , hydrogenated oil, Japan wax, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, insect wax, lanolin, reduced lanolin, hard lanolin, oils such jojoba wax, waxes; liquidity paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, hydrocarbons such as microcrystalline wax; oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, higher fatty acids such as undecylenic acid; Se chill alcohol, stearyl alcohol, Isosuteari Alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, higher alcohols such as cetostearyl alcohol; Lee Sookutan cetyl, isopropyl myristate, isostearate hexyl decyl, diisopropyl adipate, sebacic di-2-ethylhexyl, cetyl lactate, malate Diisostearyl acid, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, synthetic ester oils such as tetra-2-ethylhexanoate pentane pentaerythritol; di methyl polysiloxane, methylphenyl Rokisan, linear polysiloxanes such as diphenyl polysiloxane; O Kuta tetramethyl cyclotetrasiloxane, decamethylcyclopentasiloxane, cyclic polysiloxanes such as dodeca methylcyclohexane siloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified poly siloxanes, oils such silicone oils of modified polysiloxanes and fluorine-modified polysiloxane; fatty acid soap (sodium laurate, sodium palmitate), potassium lauryl sulfate, an anionic surfactant such as alkyl sulfate, triethanolamine ether agents; salt stearyl trimethyl ammonium, benzalkonium chloride, cationic surfactants such as lauryl amine oxide; Lee Midazorin ampholytic surfactants (2-cocoyl-2-Imida Sledding pyridinium hydroxide-1-carboxylate et Ciro carboxymethyl disodium salt), betaine-based surfactants (alkyl betaines, amido betaines, sulfobetaine and the like), amphoteric surfactants such as acyl methyl taurine; Seo Rubitan fatty acid esters ( Sorbitan monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (such as glyceryl monostearate), propylene glycol fatty acid esters (such as propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ether, POE sorbitan fatty acid ester (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose fatty acid esters, (such as glycerin mono-oleyl ether (selachyl alcohol)) alkyl glyceryl ether, nonionic surfactants such as alkyl glucosides; Po triethylene glycol, glycerin, 1,3-Bed Glycol, erythritol Le, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,3-butanediol, 1,2-pentanediol, 2,4-hexanediol, 1,2 - hexanediol, 1,2 polyhydric alcohols octanediol; sodium pin Lori pyrrolidone carboxylic acid, lactic acid, moisturizing ingredients, such as sodium lactate; may be processed to the front surface, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide powder such as barium sulfate; may be processed to the front surface, red iron oxide, yellow iron oxide, black iron oxide, cobalt oxide, the processed front surface; ultramarine, iron blue, titanium oxide, inorganic pigments such zinc oxide Even though it may, mica titanium, Sakanarinhaku, pearl agent such as bismuth oxychloride; les over yellowing is good Red No. 202 even if the red No. 228, Red No. 226, Yellow No. 4, Blue No. 404, Organics such as yellow 5, red 505, red 230, red 223, orange 201, red 213, yellow 204, yellow 203, blue 1, green 201, purple 201, red 204 dyes; Po Riechiren powder, polymethyl methacrylate, nylon powder, organic powders such as organopolysiloxane elastomers; Pas Raamino benzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid ultraviolet absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4 Ultraviolet absorbers such as methoxy-4'-t-butyl dibenzoylmethane; ethanol, lower alcohols such as isopropanol; vitamin A or a derivative thereof, vitamin B 6 hydrochloride, vitamin B 6 tripalmitate, vitamin B 6 dioctanoate, vitamin B 2 or derivatives thereof, vitamin B such as vitamin B 12 , vitamin B 15 or derivatives thereof, α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E such as vitamin E acetate, vitamin D , vitamin H, pantothenic acid, pantethine, vitamins pyrroloquinoline quinone such like; full E Bruno carboxylate antimicrobial agents such as ethanol; a acrylic acid - alkyl copolymers and / or salts thereof methacrylic acid, carboxyvinyl polymers and / or salts thereof Xanthan gum or hydroxypropi Preferred examples include thickeners such as cellulose.
本発明の皮膚外用剤では、必須成分である4−n−ブチルレゾルシノール及び/又はその塩の作用により、優れた防腐効果を発現するため、使用に懸念のある防腐剤であるメチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベンなどのパラベンを含有しない。パラベンのみならず、エタノールを含有することなく防腐力を維持することも出来、アルコールフリーの皮膚外用剤が実現できる。本発明の皮膚外用剤は、この意味に於いても好ましい。
In the external preparation for skin of the present invention, an excellent antiseptic effect is expressed by the action of 4-n-butylresorcinol and / or a salt thereof, which are essential components, and therefore, methylparaben, ethylparaben, which are preservatives with concern for use, propyl paraben, containing no Parabe emissions, such as butyl paraben. Preservative power can be maintained without containing not only parabens but also ethanol, and an alcohol-free external preparation for skin can be realized. The external preparation for skin of the present invention, have preferred even in this sense.
本発明の皮膚外用剤の剤形としては、皮膚外用剤で知られている剤形であれば特段の限定無く適用することが出来、例えば、ローション、エッセンス、乳液、クリーム、ジェル等が好ましく例示できる。本発明の皮膚外用剤は、前記必須成分と任意成分とを剤型に応じて常法に従って処理することにより製造することが出来る。かくして得られる皮膚外用剤は、皮膚保湿性、肌荒れ改善作用に優れる、糖類又はその誘導体とアミノ酸とを含有しながら、抗微生物汚染性に優れる。 As the dosage form of the external preparation for skin of the present invention, any dosage form known as an external preparation for skin can be applied without particular limitation. For example, lotions, essences, emulsions, creams, gels and the like are preferably exemplified. can Ru. The external preparation for skin of the present invention can be produced by treating the essential components and optional components according to a conventional method according to the dosage form. Thus obtained external preparation for skin, skin moisturizing, excellent skin roughening improvement effects, while containing a saccharide or a derivative thereof and an amino acid, it is excellent in anti-microbial fouling.
本発明の皮膚外用剤の種類としては、皮膚に外用で適用されるものであれば特段の限定無く適用でき、例えば、医薬部外品を含む化粧料、皮膚外用医薬、皮膚外用雑貨などが好適に例示でき、医薬部外品を含む化粧料に適用されることが特に好ましい。 The type of the external preparation for skin of the present invention can be applied without particular limitation as long as it is externally applied to the skin. For example, cosmetics including quasi-drugs, external preparations for skin, sundries for skin use, etc. are suitable. It is particularly preferable to apply to cosmetics including quasi-drugs.
以下に、実施例を挙げて本発明について更に具体的に説明を加えるが、本発明がかかる実施例にのみ限定されないことは言うまでもない。
尚、下記の実施例において、アミノ酸はL−体である。
Hereinafter, the present invention will be described more specifically with reference to examples, but it goes without saying that the present invention is not limited to such examples.
In the following Examples, the amino acid is L-form.
〔実施例1〕
以下に示す処方に従って、本発明の皮膚外用剤である、化粧水1を作製した。即ち、処方成分を80℃で加熱し、攪拌、可溶化し、攪拌下冷却して化粧水を得た。同様にして、4−n−ブチルレゾルシノールナトリウムをメチルパラベンに置換した比較例1の化粧水も作製した。
[Example 1]
In accordance with the formulation shown below, lotion 1 which is an external preparation for skin of the present invention was prepared. That is, the prescription ingredients were heated at 80 ° C., stirred and solubilized, and cooled with stirring to obtain a lotion. Similarly, the skin lotion of Comparative Example 1 in which 4-n-butylresorcinol sodium was substituted with methylparaben was also produced.
(化粧水1)
ポリエチレングリコール1500 0.5質量%
1,3−ブタンジオール 5 質量%
グリセリン 8 質量%
マルチトース 0.4質量%
ヒドロキシプロリン1%水溶液 0.2質量%
セリン1%水溶液 0.2質量%
グリシン1%水溶液 0.2質量%
異性化糖 0.1質量%
ポリオキシエチレン(60)硬化ヒマシ油 0.3質量%
メチルグルセス−20 0.5質量%
(「グルカムE−20」アマコール社製)
POP(23)POE(34)ステアリル 0.2質量%
4−n−ブチルレゾルシノール 0.3質量%
水 84.1質量%
(Lotion 1)
Polyethylene glycol 1500 0.5% by mass
1,3-butanediol 5% by mass
Glycerin 8% by mass
Multitose 0.4% by mass
Hydroxyproline 1% aqueous solution 0.2% by mass
Serine 1% aqueous solution 0.2% by mass
Glycine 1% aqueous solution 0.2% by mass
Isomerized sugar 0.1% by mass
Polyoxyethylene (60) hydrogenated castor oil 0.3% by mass
Methyl Gluces-20 0.5% by mass
("Gurucam E-20" manufactured by Amacall)
POP (23) POE (34) stearyl 0.2% by mass
4-n-butylresorcinol 0.3% by mass
84.1% by mass of water
〔試験例〕
上記化粧水1と比較例1の化粧水について微生物の汚染に対する対抗性(防腐効果)を調べた。これらの化粧水20mlを37℃で24時間予備培養後、各化粧水に、黄色ブドウ状球菌(Staphylococcus aureus IFO12732株)もしくは大腸菌(Escherichia coli IFO3972株)の菌体、又は酵母(Candida albicans IFO1594株)の分生子をPBSで1×106個/ml(終濃度)になるように調製した菌液を加え、これをトリプトソイ寒天(TSA)培地に20μl播種して、37℃で24〜48時間培養し、コロニー数をカウントした。結果を表1に示す。これより、本発明の皮膚外用剤は黄色ブドウ球菌、大腸菌及び酵母などの微生物の汚染に対する対抗性(防腐効果)に優れることがわかる。
[Test example]
With respect to the lotion 1 and the lotion of Comparative Example 1, the resistance (antiseptic effect) against microbial contamination was examined. After pre-culturing 20 ml of these lotions at 37 ° C. for 24 hours, each lotion contains cells of Staphylococcus aureus IFO12732 or Escherichia coli IFO3972 or yeast (Candida albicans IFO1594) Bacteria solution prepared to 1 × 10 6 cells / ml (final concentration) with PBS was added, 20 μl of this was seeded on tryptosoy agar (TSA) medium, and cultured at 37 ° C. for 24-48 hours. The number of colonies was counted. The results are shown in Table 1. From this, it can be seen that the external preparation for skin of the present invention is excellent in resistance (preservation effect) against contamination of microorganisms such as Staphylococcus aureus, Escherichia coli and yeast.
〔実施例2〕
以下に示す処方に従って、実施例1と同様にして、化粧水2と、化粧水2の4−n−ブチルレゾルシノールナトリウムをメチルパラベンに置換した比較例2の化粧水を作製し、微生物の汚染に対する対抗性(防腐効果)を調べた。結果を表2に示す。この結果も実施例1と同様であった。
[Example 2]
According to the formulation shown below, in the same manner as in Example 1, skin lotion 2 and the skin lotion of Comparative Example 2 in which 4-n-butylresorcinol sodium in the skin lotion 2 was replaced with methylparaben were prepared to counteract the contamination of microorganisms. The property (preservative effect) was examined. The results are shown in Table 2. This result was the same as in Example 1.
(化粧水2)
ポリエチレングリコール1500 0.5質量%
1,3−ブタンジオール 5 質量%
グリセリン 8 質量%
マルチトース 0.4質量%
ヒドロキシプロリン1%水溶液 0.2質量%
セリン1%水溶液 0.2質量%
グリシン1%水溶液 0.2質量%
ポリグルコシルエチルメタクリレート 0.1質量%
(大日精化株式会社製)
ポリオキシエチレン(60)硬化ヒマシ油 0.3質量%
デンプン・ポリアクリル酸ナトリウムグラフト重合体 0.5質量%
(三洋化成(株)製、サンフレッシュST−100)
POP(23)POE(34)ステアリル 0.2質量%
4−n−ブチルレゾルシノール 0.3質量%
水 84.1質量%
(Lotion 2)
Polyethylene glycol 1500 0.5% by mass
1,3-butanediol 5% by mass
Glycerin 8% by mass
Multitose 0.4% by mass
Hydroxyproline 1% aqueous solution 0.2% by mass
Serine 1% aqueous solution 0.2% by mass
Glycine 1% aqueous solution 0.2% by mass
Polyglucosylethyl methacrylate 0.1% by mass
(Daiichi Seika Co., Ltd.)
Polyoxyethylene (60) hydrogenated castor oil 0.3% by mass
0.5% by mass of starch / sodium polyacrylate graft polymer
(Manufactured by Sanyo Chemical Co., Ltd., Sunfresh ST-100)
POP (23) POE (34) stearyl 0.2% by mass
4-n-butylresorcinol 0.3% by mass
84.1% by mass of water
〔実施例3〕
以下に示す処方に従って、実施例1と同様にして、化粧水3と、化粧水3の4−n−ブチルレゾルシノールナトリウムをメチルパラベンに置換した比較例3の化粧水を作製し、微生物の汚染に対する対抗性(防腐効果)を調べた。結果を表3に示す。この結果も実施例1及び2と同様であった。
Example 3
According to the formulation shown below, in the same manner as in Example 1, the lotion 3 and the lotion of Comparative Example 3 in which 4-n-butylresorcinol sodium in the lotion 3 was replaced with methylparaben were prepared to counteract the contamination of microorganisms. The property (preservative effect) was examined. The results are shown in Table 3. This result was also the same as in Examples 1 and 2.
(化粧水3)
ポリエチレングリコール1500 0.5質量%
1,3−ブタンジオール 5 質量%
グリセリン 8 質量%
マルチトース 0.4質量%
ヒドロキシプロリン1%水溶液 0.2質量%
セリン1%水溶液 0.2質量%
グリシン1%水溶液 0.2質量%
ポリグルコシルエチルメタクリレート 0.1質量%
ポリオキシエチレン(60)硬化ヒマシ油 0.3質量%
メチルグルセス−20 0.5質量%
POP(23)POE(34)ステアリル 0.2質量%
4−n−ブチルレゾルシノール 0.3質量%
水 84.1質量%
(Lotion 3)
Polyethylene glycol 1500 0.5% by mass
1,3-butanediol 5% by mass
Glycerin 8% by mass
Multitose 0.4% by mass
Hydroxyproline 1% aqueous solution 0.2% by mass
Serine 1% aqueous solution 0.2% by mass
Glycine 1% aqueous solution 0.2% by mass
Polyglucosylethyl methacrylate 0.1% by mass
Polyoxyethylene (60) hydrogenated castor oil 0.3% by mass
Methyl Gluces-20 0.5% by mass
POP (23) POE (34) stearyl 0.2% by mass
4-n-butylresorcinol 0.3% by mass
84.1% by mass of water
〔実施例4〕
以下に示す処方に従って、実施例1と同様にして、化粧水4を作製し、微生物の汚染に対する対抗性(防腐効果)を調べた。黄色ブドウ球菌のコロニー数、大腸菌のコロニー数、酵母のコロニー数も何れも0であり、この結果も実施例1〜3と同様であった。
Example 4
In the same manner as in Example 1, a skin lotion 4 was prepared according to the formulation shown below, and the resistance (antiseptic effect) against microbial contamination was examined. The number of S. aureus colonies, the number of colonies of Escherichia coli, and the number of colonies of yeast were all 0, and the results were also the same as in Examples 1-3.
(化粧水4)
ポリエチレングリコール1500 0.5質量%
1,3−ブタンジオール 8 質量%
グリセリン 5 質量%
マルチトース 0.4質量%
ヒドロキシプロリン1%水溶液 0.2質量%
セリン1%水溶液 0.2質量%
グリシン1%水溶液 0.2質量%
異性化糖 0.1質量%
ポリオキシエチレン(60)硬化ヒマシ油 0.3質量%
メチルグルセス−20 0.5質量%
POP(23)POE(34)ステアリル 0.2質量%
4−n−ブチルレゾルシノール 0.1質量%
水 84.2質量%
(Lotion 4)
Polyethylene glycol 1500 0.5% by mass
1,3-butanediol 8% by mass
Glycerin 5% by mass
Multitose 0.4% by mass
Hydroxyproline 1% aqueous solution 0.2% by mass
Serine 1% aqueous solution 0.2% by mass
Glycine 1% aqueous solution 0.2% by mass
Isomerized sugar 0.1% by mass
Polyoxyethylene (60) hydrogenated castor oil 0.3% by mass
Methyl Gluces-20 0.5% by mass
POP (23) POE (34) stearyl 0.2% by mass
4-n-butylresorcinol 0.1% by mass
84.2% by mass of water
〔実施例5〕
下記に示す処方に従って、本発明の皮膚外用剤である乳液4を作製した。即ち、イ)、ロ)、ハ)をそれぞれ80℃に加熱し、イ)にロ)を加えてゲル化させ、これに攪拌下ハ)の成分を加え、乳化した後、ホモジナイザーで均一化処理し、攪拌冷却して乳液4を得た。このものの4−n−ブチルレゾルシノール0.3質量%を、ブチルパラベン0.1質量%とメチルパラベン0.2質量%に置換した比較例4、メチルパラベン0.3質量%に置換した比較例3も作製し、試験例1に準じて評価した。結果を表4に示す。これより、本発明の皮膚外用剤ではブチルパラベンを使用することなく、ブチルパラベンを配合した場合以上の微生物の汚染に対する対抗力(防腐力)を有することが判る。
Example 5
In accordance with the formulation shown below, emulsion 4 which is an external preparation for skin of the present invention was prepared. That is, a), b) and c) are heated to 80 ° C., respectively, and b) is added to a) to gel, and the ingredients of c) are added to the mixture with stirring and emulsified, and then homogenized with a homogenizer. The emulsion 4 was obtained by stirring and cooling. Comparative Example 4 in which 0.3% by mass of 4-n-butylresorcinol was substituted by 0.1% by mass of butylparaben and 0.2% by mass of methylparaben, and Comparative Example 3 in which 0.3% by mass of methylparaben was substituted were also produced. Then, it was evaluated according to Test Example 1. The results are shown in Table 4. From this, it can be seen that the external preparation for skin of the present invention has a resistance (preservative power) against the contamination of microorganisms more than when butylparaben is blended without using butylparaben.
(乳液4)
イ)
アクリル酸アルキル(炭素数10〜30)・アクリル酸コポリマー
(「ペムレンTR−2」:グッドリッチ社製) 0.4質量%
ポリエチレングリコール1500 0.5質量%
1,3−ブタンジオール 5 質量%
グリセリン 8 質量%
マルチトース 0.4質量%
ヒドロキシプロリン1%水溶液 0.2質量%
セリン1%水溶液 0.2質量%
グリシン1%水溶液 0.2質量%
異性化糖 0.1質量%
(「ペンタバイテイン」;ペンタファーム社社製)
ポリオキシエチレン(60)硬化ヒマシ油 0.3質量%
メチルグルセス−20 0.5質量%
POP(23)POE(34)ステアリル 0.2質量%
4−n−ブチルレゾルシノール 0.3質量%
水 77.2質量%
ロ)
10%水酸化カリウム水溶液 3 質量%
水 7 質量%
ハ)
流動パラフィン 5 質量%
ベヘニルアルコール 1 質量%
セラキルアルコール 0.5質量%
(Emulsion 4)
I)
Alkyl acrylate (10 to 30 carbon atoms) / acrylic acid copolymer ("Pemlen TR-2" manufactured by Goodrich) 0.4% by mass
Polyethylene glycol 1500 0.5% by mass
1,3-butanediol 5% by mass
Glycerin 8% by mass
Multitose 0.4% by mass
Hydroxyproline 1% aqueous solution 0.2% by mass
Serine 1% aqueous solution 0.2% by mass
Glycine 1% aqueous solution 0.2% by mass
Isomerized sugar 0.1% by mass
("Penta Bitein"; manufactured by Penta Farm)
Polyoxyethylene (60) hydrogenated castor oil 0.3% by mass
Methyl Gluces-20 0.5% by mass
POP (23) POE (34) stearyl 0.2% by mass
4-n-butylresorcinol 0.3% by mass
Water 77.2% by mass
B)
10% aqueous potassium hydroxide solution 3% by mass
7% by mass of water
C)
Liquid paraffin 5% by mass
Behenyl alcohol 1% by mass
Serakil alcohol 0.5% by mass
本発明は、皮膚外用医薬や化粧料等の皮膚外用剤に応用できる。 The present invention can be applied to external preparations for skin such as external preparations for skin and cosmetics.
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005170797A JP4874577B2 (en) | 2005-06-10 | 2005-06-10 | Topical skin preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005170797A JP4874577B2 (en) | 2005-06-10 | 2005-06-10 | Topical skin preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006342122A JP2006342122A (en) | 2006-12-21 |
JP4874577B2 true JP4874577B2 (en) | 2012-02-15 |
Family
ID=37639346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005170797A Active JP4874577B2 (en) | 2005-06-10 | 2005-06-10 | Topical skin preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP4874577B2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5015620B2 (en) * | 2007-01-30 | 2012-08-29 | 株式会社クラレ | Topical skin preparation |
JP5937384B2 (en) * | 2012-03-15 | 2016-06-22 | 株式会社 資生堂 | Translucent cosmetics |
DE102017114423A1 (en) * | 2017-06-28 | 2019-01-03 | Schülke & Mayr GmbH | Use of alkylresorcinols for improving the efficacy of cosmetic preservatives |
CN114727920A (en) * | 2019-11-20 | 2022-07-08 | 花王株式会社 | External preparation for skin |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6186940A (en) * | 1984-10-02 | 1986-05-02 | Kao Corp | Oil in water type emulsion composition |
JP4004182B2 (en) * | 1999-05-24 | 2007-11-07 | ポーラ化成工業株式会社 | Emulsified composition |
JP2004323401A (en) * | 2003-04-23 | 2004-11-18 | Mikimoto Pharmaceut Co Ltd | Skin care preparation for external use |
-
2005
- 2005-06-10 JP JP2005170797A patent/JP4874577B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2006342122A (en) | 2006-12-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4874577B2 (en) | Topical skin preparation | |
JP2007001947A (en) | Cosmetic composition | |
WO2012086760A1 (en) | Disinfectant | |
JP2000355515A (en) | Cosmetic composition | |
JP2008007414A (en) | External preparation for skin having antiseptic activity | |
JP5145221B2 (en) | Skin external preparation with excellent stability | |
JP2007332116A (en) | Skin care preparation containing colored aromatic quinone derivative | |
JP5231717B2 (en) | Topical skin preparation | |
JP6086706B2 (en) | Skin external composition having high UV absorption effect | |
JP2780803B2 (en) | External preparation for skin | |
JP2019210250A (en) | Preservative composition containing isopentyldiol | |
JP2007308381A5 (en) | ||
JP2007308381A (en) | External preparation for skin in water-in-oil type emulsion form | |
JP5165860B2 (en) | External preparation for skin containing 4-alkylresorcinol | |
JP2003252718A (en) | In vivo dihydroxyindole compound polymerization inhibitor | |
JP4808986B2 (en) | Essence dosage form topical skin preparation | |
JP5022568B2 (en) | Essence dosage form topical skin preparation | |
JP2006219450A (en) | Skin care preparation | |
JP4122272B2 (en) | Cosmetics for treatment of lips roughening | |
JP4147180B2 (en) | Gel-like skin external preparation | |
JP2007045768A (en) | Neutralized and stabilized skin care preparation | |
JP2005179318A (en) | Anti-inflammatory quasi drug for skin external use | |
JP4221310B2 (en) | Topical skin preparation | |
JP4801361B2 (en) | Essence dosage form topical skin preparation | |
JP4596463B2 (en) | Essence dosage form topical skin preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080515 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20110628 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110705 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110817 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20111108 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20111124 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20141202 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 4874577 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |