JP2006176431A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic excellent in the effects of preventing or ameliorating skin aging, especially having marked quick-acting tendency and sustainability. <P>SOLUTION: The cosmetic contains (A) an acylated oligopeptide and (B) a plant( extract ) belonging to the genus Pueraria of Leguminosae. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a cosmetic excellent in aging prevention / improvement effects, and more particularly to a cosmetic excellent in immediate effect and sustainability of aging prevention / improvement effects.

  In recent years, various external preparations for preventing and improving aging have been proposed in combination with raising awareness of anti-aging.

  As this type of skin external preparation, for example, hydroxypurine or an acylated derivative thereof or a salt thereof, and an acylated derivative of an oligopeptide, preventing and improving skin aging symptoms such as wrinkles and reduction in acupuncture Have been proposed (see, for example, Patent Document 1).

Further, a breast augmentation promoter containing a root of a genus Kudu and a processed product thereof has been proposed (see, for example, Patent Document 2), and an external skin for anti-aging comprising an extract of Pueraria Mirifica as an anti-aging component. An agent has been proposed (see, for example, Patent Document 3).
JP 2004-43366 A JP 2000-302667 A JP 2001-220340 A

However, these external preparations for skin are not only insufficient in preventing and improving aging, but are particularly insufficient in immediate effect and sustainability, and need to be used for a long period of time.
For example, in Patent Document 1, emulsions, lotions, oil-in-water creams, and water-in-oil emollient creams are used for one month by a panelist, and changes in the skin condition before and after use are observed and evaluated.

In Patent Document 2, a coating agent is continuously applied to a rat every 6 hours for 1 week, and after a certain period, the rat mammary cells are taken out and examined for cell proliferation.
Furthermore, Patent Document 3 evaluates the wrinkle improving effect after applying the test cream to the face after washing the face twice a day in the morning and night for 12 weeks.

  An object of the present invention is to solve such drawbacks of the prior art, to provide a remarkable anti-aging / improving effect, and to provide an anti-aging / improving cosmetic material that has remarkable immediate effect and durability. .

  As a result of diligent research to solve the above problems, the present inventors have included an acylated oligopeptide and a plant belonging to the genus Leguminosae in a short time (approx. 1 hour) after application (application). It has been found that a cosmetic can be provided while exhibiting a remarkable effect (afterwards) and the effect is maintained (for example, even after 24 hours), and has completed the present invention.

  That is, claim 1 of the present invention includes a cosmetic comprising (A) an acylated oligopeptide and (B) a plant belonging to the genus Leguminosae.

  The second aspect of the present invention includes the cosmetic according to the first aspect, wherein the component (A) is palmitoyl pentapeptide.

  The third aspect of the present invention includes the cosmetic according to the first or second aspect, wherein the component (B) is a root mass powder of Pueraria mirifica.

  Claim 4 of the present invention contains the cosmetic according to any one of claims 1 to 3, wherein the amino acid sequence of the peptide of component (A) is represented by lysine-threonine-threonine-lysine-serine. .

  A fifth aspect of the present invention includes the cosmetic according to any one of the first to fourth aspects, wherein the particle size of the component (B) is 150 μm or less.

  A sixth aspect of the present invention includes the cosmetic according to any one of the first to fifth aspects, wherein the content of the component (A) is 0.000001 to 0.003% by weight.

  The seventh aspect of the present invention includes the cosmetic according to any one of the first to sixth aspects, wherein the content of the component (B) is 0.01 to 20% by weight.

  The eighth aspect of the present invention includes the cosmetic according to any one of the first to seventh aspects, which is used for reducing wrinkles and sagging of the face, and for lifting and lifting the beam.

  A ninth aspect of the present invention includes the cosmetic according to any one of the first to seventh aspects, which is used for giving a bust to the bust and for bust-up.

  A tenth aspect of the present invention includes the cosmetic according to any one of the first to seventh aspects, which is used for giving a hip to a hip and raising the hip.

  The cosmetic composition of the present invention contains an acylated oligopeptide and a plant belonging to the genus Leguminosae, so that it has a surprising immediate effect as compared with the case of the acylated oligopeptide alone or the plant alone belonging to the genus Legumes. Exhibits sex and sustainability.

  Therefore, since the immediate effect and sustainability of conventional cosmetics are not sufficient, it is necessary to continue the use for a long period of time, and since the effect cannot be confirmed in a short period of time, the use is interrupted or frustrated. There were many cases, but the cosmetics of the present invention show a remarkable effect even 1 hour after use, so there is no such interruption or frustration.

  The cosmetic of the present invention is characterized in that it contains (A) an acylated oligopeptide and (B) a plant belonging to the genus Leguminosae.

  The acylated oligopeptide (A) used in the present invention is preferably an acylated derivative of an oligopeptide in which 2 to 6 amino acids selected from lysine, threonine, serine, glycine, histidine and the like are bound, Among them, palmitoyl pentapeptide is preferable, and palmitoyl-lysine-threonine-threonine-lysine-serine is particularly preferable.

  (A) The content of the acylated oligopeptide is preferably 0.000001 to 0.003% by weight, more preferably 0.00001 to 0.0005% by weight. If the content is less than 0.000001% by weight, the effect of using the component (A) together cannot be obtained, and for example, there is a tendency that a sufficient improvement effect of wrinkles, sagging, texture, and beam cannot be obtained. On the other hand, even if it exceeds 0.003% by weight, the effect does not change so much and it is uneconomical.

  (B) The plant belonging to the genus Leguminosae used in the present invention is preferably Pueraria mirifica, a powder obtained by drying the root mass, stem, and leaves and then pulverizing them, water, hot water, alcohol Those extracted with a solvent such as are preferably used. In particular, root mass powder is preferred. The smaller the particle diameter of the powder, the more preferable, for example, 150 μm or less is preferable. When the particle diameter exceeds 150 μm, for example, a rough feeling is produced when applied to the skin, which is not preferable.

  (B) Content of the plant which belongs to the leguminous genus Kudu is 0.01 to 20 weight% in solid content, More preferably, it is 0.10 to 5 weight%. If the content is less than 0.01% by weight, the effect of using the component (B) in combination cannot be obtained. For example, a sufficient improvement effect of wrinkles, sagging and texture cannot be obtained. There is a tendency that the effect of improving is not obtained. On the other hand, if the amount exceeds 20% by weight, the effect does not change so much, but it is uneconomical.

  In addition to the above components (A) and (B), the cosmetic of the present invention, if necessary, an anti-inflammatory agent such as stearyl glycyrrhetinate, a sebum secretion inhibitor such as vitamin B group, a cell activator such as allantoin, Antioxidants such as vitamin E, humectants such as glycerin and sorbitol, UV inhibitors such as titanium oxide and benzophenone, whitening agents such as ascorbic acid, antifungal agents such as parabens, other stabilizers, pigments, and fragrances And various other additives can be contained.

  The shape of the cosmetic of the present invention may be any of lotion, milky lotion, gel, cream, paste and the like, but cream is particularly preferable.

The cosmetic of the present invention, for example, reduces swelling and wrinkles when applied to the face, improves texture, lifts with a beam, and reduces sagging when applied to a bust. Improve the texture, give the beam a plump feeling and bust up, and when applied to the hips, reduce sagging, improve the texture, give the beam a plump feeling and hip up The effect of preventing aging is surprising, and surprisingly, these anti-aging / improving effects have outstanding immediate effects and sustainability that could not be predicted by conventional cosmetics of the same kind.
For example, a remarkable improvement effect can be realized in 1 hour after application (application), and the effect is sustained (for example, hardly decreases even after 24 hours).

  EXAMPLES Hereinafter, although an Example and a comparative example are given and this invention is demonstrated further in detail, this does not limit at all.

Example 1, Comparative Examples 1-2
A cream was prepared with the ingredients and formulations shown in Table 1. As the component (A), palmitoyl pentapeptide (trade name MATRIXYL, manufactured by Croda Japan Co., Ltd.) is used, and as the component (B), the root mass powder of Pueraria Mirifica (Thailand, importer: Seiko Pharmaceutical Co., Ltd.) Company) was pulverized with an electric mill and then passed through a 100 mesh (150 μm) sieve. The root mass powder of (B) Pueraria mirifica was added to the oil phase component, and (A) palmitoyl pentapeptide was added to the aqueous phase component and uniformly mixed and emulsified.

The effects of the creams obtained in Example 1 and Comparative Examples 1 and 2 were evaluated by the following methods.
That is, 30 female panelists aged 25 to 60 years old apply the appropriate amount of the above cream to their face (face), bust, and hips after washing in the morning. It was evaluated according to the criteria. The results are shown in Table 2.

〔Evaluation methods〕
For the face (face), “wrinkle, sagging, texture, beam, plump”, and for the bust and hip, “sag, texture, beam, plump, up” were evaluated according to the following criteria.

5: The improvement effect is extremely remarkable.
4: The improvement effect is remarkable.
3: The improvement effect is normal.
2: Not much improvement effect is observed.
1: The improvement effect is not recognized.

As is clear from the results in Table 2 above, the cosmetic composition of the present invention has a remarkable anti-aging / improvement effect in any part of the face, bust, and hip, and is prominent one hour after application (application). An effect has appeared and the effect persists after 24 hours.
The cosmetic of the present invention has a repeat rate of 100% for obtaining a sample even after the test is completed, and the magnitude of the effect can be seen from such a high repeater rate.

As described above, the cosmetic of the present invention reduces wrinkles and sagging, improves texture, gives a feeling of elasticity and plumpness, for example, when applied to the face, bust, and hips, lift-up and bust, respectively. The anti-aging / improvement effect of raising and hip-up is remarkable. In addition, these anti-aging effects have tremendous immediate effects, so you can continue using them while feeling the effects without stopping or frustrating on the way, and they are also excellent in sustainability. ing.

Claims (10)

  A cosmetic comprising (A) an acylated oligopeptide and (B) a plant belonging to the genus Leguminosae.   The cosmetic according to claim 1, wherein component (A) is palmitoyl pentapeptide.   The cosmetic according to claim 1 or 2, wherein the component (B) is a powder of the root mass of Pueraria mirifica.   The cosmetic according to any one of claims 1 to 3, wherein the amino acid sequence of the peptide of component (A) is represented by lysine-threonine-threonine-lysine-serine.   The cosmetic according to any one of claims 1 to 4, wherein the particle diameter of the component (B) is 150 µm or less.   The cosmetic according to any one of claims 1 to 5, wherein the content of the component (A) is 0.000001 to 0.003% by weight.   The cosmetic according to any one of claims 1 to 6, wherein the content of the component (B) is 0.01 to 20% by weight.   The cosmetic according to any one of claims 1 to 7, wherein the cosmetic is used for reducing wrinkles and sagging on the face, and for raising and lifting a beam.   The cosmetic according to any one of claims 1 to 7, wherein the cosmetic is used to give a bust to the bust and to bust up. The cosmetic according to any one of claims 1 to 7, wherein the cosmetic is used for giving a hip to the hip and raising the hip.