JP2006171005A - 試料溶液のpHを調節する方法 - Google Patents
試料溶液のpHを調節する方法 Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 47
- 239000012488 sample solution Substances 0.000 title claims abstract description 20
- 230000001105 regulatory effect Effects 0.000 title abstract description 6
- 238000005868 electrolysis reaction Methods 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 150000001875 compounds Chemical class 0.000 claims abstract description 19
- 230000033116 oxidation-reduction process Effects 0.000 claims abstract description 9
- 239000012528 membrane Substances 0.000 claims description 10
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 10
- 230000002378 acidificating effect Effects 0.000 claims description 9
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 6
- 150000002500 ions Chemical class 0.000 claims description 5
- 229910052697 platinum Inorganic materials 0.000 claims description 5
- 239000007789 gas Substances 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- 229910052763 palladium Inorganic materials 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract description 5
- 239000003792 electrolyte Substances 0.000 abstract description 4
- 239000000243 solution Substances 0.000 description 73
- 238000010979 pH adjustment Methods 0.000 description 13
- -1 PCR Chemical class 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 6
- 239000011259 mixed solution Substances 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 230000007935 neutral effect Effects 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000002032 lab-on-a-chip Methods 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 230000006037 cell lysis Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 229920000557 Nafion® Polymers 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- 229910021591 Copper(I) chloride Inorganic materials 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 150000001768 cations Chemical group 0.000 description 1
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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Abstract
【解決手段】アノードおよびカソードチャンバを備えた電気分解素子を備える微小流体素子を用い、アノードチャンバの流入口から水より標準酸化還元電位が低い化合物を含む溶液をアノードチャンバに流入させる工程、カソードチャンバの流入口から水より標準酸化還元電位が高い化合物を含む溶液をカソードチャンバに流入させる工程、アノードおよびカソードチャンバが備える電極に電圧を加え電気分解を行う工程、ならびにアノードおよびカソードチャンバ内の電解液を同じ体積で混合する工程を含み、アノードおよびカソードチャンバの体積は、アノードおよびカソードチャンバ内の電解液を混合して得られる試料溶液の、標的とするpHに従って所定の比率に調節されている、試料溶液のpH調節方法である。
【選択図】図1A
Description
本実施例では、電気分解はアノードチャンバ、カソードチャンバ、および前記アノードチャンバとカソードチャンバとの間に設置されている分割膜を有する電気分解素子を用いて試料溶液のpH調節を行った。電気分解を行った後で得られたアノードチャンバ溶液およびカソードチャンバ溶液を、ポンプを用いて同じ体積で混合した。その混合溶液のpHを測定した。
10a 白金電極、
10c 金電極、
20 アノードチャンバ、
30 カソードチャンバ、
40 マイクロポンプ。
Claims (6)
- アノードチャンバ、カソードチャンバ、および分割膜を備える電気分解素子を備える微小流体素子であって、前記分割膜は、前記アノードチャンバとカソードチャンバとの間に設置されており、前記アノードチャンバは、アノードチャンバ溶液が流入する流入口、アノードチャンバ溶液が流出する流出口、および電極を備え、前記カソードチャンバは、カソードチャンバ溶液が流入する流入口、カソードチャンバ溶液が流出する流出口、および電極を備える微小流体素子を用いて、試料溶液のpHを調節する方法であって、
(a)前記アノードチャンバの流入口を介して、水より標準酸化還元電位が低い化合物を含むアノードチャンバ溶液を前記アノードチャンバに流入させるステップと、
(b)前記カソードチャンバの流入口を介して、水より標準酸化還元電位が高い化合物を含むカソードチャンバ溶液を前記カソードチャンバに流入させるステップと、
(c)前記アノードチャンバおよび前記カソードチャンバに備わっている前記電極を介して電圧を印加し、前記アノードチャンバおよび前記カソードチャンバで電気分解を行うステップと、
(d)前記アノードチャンバ内の酸性の電気分解された溶液および前記カソードチャンバ内の塩基性の電気分解された溶液を同じ体積で混合するステップと、を含み、
前記アノードチャンバの体積および前記カソードチャンバの体積は、前記アノードチャンバ内の電気分解された溶液および前記カソードチャンバ内の電気分解された溶液を混合して得られる試料溶液の、標的となるpHに従って所定の比率に調節されていることを特徴とする、試料溶液のpHを調節する方法。 - 前記水より標準酸化還元電位が低い化合物は、NO3 −、F−、SO4 2−、PO4 3−、およびCO3 2−からなる群より選択される少なくとも一つのイオンを含むことを特徴とする、請求項1に記載の方法。
- 前記水より標準酸化還元電位が高い化合物は、Na+、K+、Ca2+、Mg2+、およびAl3+からなる群より選択される少なくとも一つのイオンを含むことを特徴とする、請求項1に記載の方法。
- 前記分割膜は、電流を通過させるが、前記アノードチャンバおよび前記カソードチャンバで電気分解によって発生したイオンおよび/または気体を通過させない特性を有することを特徴とする、請求項1に記載の方法。
- 前記電極は、白金、金、銅、およびパラジウムからなる群より選択される金属を含むことを特徴とする、請求項1に記載の方法。
- 前記電気分解素子は、前記アノードチャンバの流出口のマイクロチャンネル、および前記カソードチャンバの流出口のマイクロチャンネルが連結して形成されたマイクロチャンネルに設置されたポンプをさらに備えることを特徴とする、請求項1に記載の方法。
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Application Number | Priority Date | Filing Date | Title |
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KR1020040108035A KR100590573B1 (ko) | 2004-12-17 | 2004-12-17 | 전기분해 장치를 포함하는 미세유동장치를 이용한 pH조절 방법 |
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JP2006171005A true JP2006171005A (ja) | 2006-06-29 |
JP4094634B2 JP4094634B2 (ja) | 2008-06-04 |
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US (1) | US7914660B2 (ja) |
EP (1) | EP1672459B1 (ja) |
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KR (1) | KR100590573B1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006166916A (ja) * | 2004-12-17 | 2006-06-29 | Samsung Electronics Co Ltd | 細胞またはウイルス溶解用の電気分解素子を備える微小流体素子、およびそれを用いた細胞またはウイルスの溶解方法 |
US8293095B2 (en) | 2005-06-21 | 2012-10-23 | Samsung Electronics Co., Ltd. | Microfluidic device for electrically regulating the pH of a fluid therein and method of regulating the pH of a fluid in a microfluidic device using the same |
JP2018529981A (ja) * | 2015-08-07 | 2018-10-11 | フラウンホーファー・ユー・エス・エイ・インコーポレイテッドFraunhofer Usa, Inc. | 導電性ダイヤモンド電極で微量金属を検出するための装置および方法 |
US11440005B2 (en) | 2018-08-30 | 2022-09-13 | Lg Chem, Ltd. | Device comprising microbeads capable of adjusting pH of sample |
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Publication number | Priority date | Publication date | Assignee | Title |
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KR100657965B1 (ko) * | 2005-08-10 | 2006-12-14 | 삼성전자주식회사 | 유체의 pH를 전기화학적으로 조절하기 위한 미세유동장치및 그를 이용하여 pH를 조절하는 방법 |
KR100738084B1 (ko) * | 2005-12-21 | 2007-07-12 | 삼성전자주식회사 | 유체의 pH를 전기화학적으로 조절하기 위한 미세유동장치및 그를 이용하여 pH를 조절하는 방법 |
KR100738093B1 (ko) | 2006-01-05 | 2007-07-12 | 삼성전자주식회사 | pH 조절 장치 및 그를 이용한 pH 조절 방법 |
KR100723424B1 (ko) | 2006-04-07 | 2007-05-30 | 삼성전자주식회사 | 세포 또는 바이러스의 농축 및 용해용 미세유동장치 및방법 및 상기 미세유동장치의 제조 방법 |
TWI345058B (en) * | 2007-07-30 | 2011-07-11 | Benq Materials Corp | Micro flow device and method for generating a fluid with ph gradient |
US20090134041A1 (en) * | 2007-10-15 | 2009-05-28 | Transphorm, Inc. | Compact electric appliance providing hydrogen injection for improved performance of internal combustion engines |
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Cited By (4)
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JP2006166916A (ja) * | 2004-12-17 | 2006-06-29 | Samsung Electronics Co Ltd | 細胞またはウイルス溶解用の電気分解素子を備える微小流体素子、およびそれを用いた細胞またはウイルスの溶解方法 |
US8293095B2 (en) | 2005-06-21 | 2012-10-23 | Samsung Electronics Co., Ltd. | Microfluidic device for electrically regulating the pH of a fluid therein and method of regulating the pH of a fluid in a microfluidic device using the same |
JP2018529981A (ja) * | 2015-08-07 | 2018-10-11 | フラウンホーファー・ユー・エス・エイ・インコーポレイテッドFraunhofer Usa, Inc. | 導電性ダイヤモンド電極で微量金属を検出するための装置および方法 |
US11440005B2 (en) | 2018-08-30 | 2022-09-13 | Lg Chem, Ltd. | Device comprising microbeads capable of adjusting pH of sample |
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EP1672459A2 (en) | 2006-06-21 |
JP4094634B2 (ja) | 2008-06-04 |
US7914660B2 (en) | 2011-03-29 |
EP1672459A3 (en) | 2009-01-21 |
US20060169598A1 (en) | 2006-08-03 |
EP1672459B1 (en) | 2011-08-31 |
KR100590573B1 (ko) | 2006-06-19 |
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