JP2006117657A - Shininess depressant - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a shininess depressant which is highly safe, can be taken or administered daily, and is effective in depressing the shininess of the skin. <P>SOLUTION: The invention relates to the shininess depressant comprising a heat treated product or an extract of Momordica charantia which has a neutral-fat reducing effect in the blood and is used as an active ingredient for a shininess depressant. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a shine inhibitor that effectively suppresses skin shine. Furthermore, this invention relates to the foodstuff or pharmaceutical composition containing the said karikari inhibitor.

  Sebum secreted from the sebaceous glands of the skin plays a role of imparting smoothness to the skin and suppressing the entry of foreign matter from outside the body and the release of moisture from the skin. However, if sebum is excessively secreted, sebum causes shininess on the skin, which causes cosmetic problems such as stickiness and makeup collapse. Furthermore, it is known that skin shine caused by excessive secretion of sebum promotes the growth of microorganisms and pathogens and causes various skin abnormalities.

  As means for suppressing such skin shine, conventionally, cosmetics suitable for suppressing skin shine have been proposed (see, for example, Patent Document 1). However, all the conventional shine prevention means are used by being applied transdermally, and there is no known component that can suppress skin shine by daily use in the form of food or the like. .

By the way, it has been reported that pulverized bittern and its extract have an effect of improving lipid metabolism (see Patent Document 2). However, the dried powder of bitter gourd, which is simply crushed and dried, can reduce the amount of neutral fat in the liver, but does not have the effect of reducing the amount of blood neutral fat that causes skin shine. (See paragraphs 0036 and 0046 of Patent Document 2). Moreover, it is not known how the heat-treated product of bitter gourd affects skin shine.
JP 2002-187811 A JP 2002-278804 A

  Accordingly, an object of the present invention is to provide a shining inhibitor that is highly safe and can be ingested or administered on a daily basis and is effective in suppressing skin shine. Furthermore, an object of the present invention is to provide foods and pharmaceuticals containing the shine inhibitor.

  The present inventors have intensively studied to solve the above-mentioned problems. As a result, the heat treatment of bitter gourd, especially the bitter gourd heat obtained by drying the bitter gourd, has the effect of suppressing skin shine. Found that there is. The present invention has been developed through further studies based on such findings.

That is, the present invention provides the following inventions:
Item 1. A shine control agent comprising a heat-treated bitter gourd or an extract thereof as an active ingredient.
Item 2. Item 2. The shine inhibitor according to item 1, wherein the heat-treated bitter gourd is obtained by drying and heating the bitter gourd.
Item 3. Item 3. A food for suppressing shine, comprising the shine control agent according to Item 1 or 2.
Item 4. Item 4. The food for suppressing shininess according to Item 3, which is in the form of powder, tablet, capsule, syrup, jelly, or beverage.
Item 5. Item 5. The food for suppressing shine according to item 3 or 4, which is displayed to be used for suppressing shine.
Item 6. A food product containing a bitter gourd heat-treated product or an extract thereof, which is used to suppress shine.
Item 7. Item 7. The food according to Item 6, which is in the form of a powder, tablet, capsule, syrup, jelly, or beverage.
Item 8. Item 3. A medicinal or quasi-drug for shining suppression containing the shining inhibitor according to Item 1 or 2.

  The present invention is described in detail below.

  As for the shine inhibitor of this invention, a bittern heat-processed material is used as an active ingredient.

Nigauri is a plant belonging to the family Cucurbitaceae and is known as the scientific name Momordica charantia L. It is native to tropical Asia and is cultivated in Okinawa and Kyushu regions in Japan. Nigari is also known as bitter gourd or pickle. The bitter gourd used in the present invention may be a wild species or an improved variety.

  As a raw material of the bitter gourd heat-treated product which is the active ingredient of the present invention, the fruit portion of bitter gourd is used. The fruit part includes fruit skin, fruit pulp, fruit juice, cotton, seeds, etc., but any of these parts may be used as the raw material for the bitter melon heat-treated product. Preferably, it is an edible part obtained by removing seeds and cotton from the fruit part, and more preferably pulp.

  The bitter gourd heat-treated product can be obtained by chopping or crushing bitter cucumber as necessary and heating it at 40 to 120 ° C. for about 1 to 60 minutes. Although it does not restrict | limit especially as a heating method, Preferably the method of roasting is mentioned.

  The bitter gourd heat-treated product is preferably obtained by heating the bitter gourd after drying. Hereinafter, a method for preparing a bitter gourd heat-treated product by drying and heating the bitter gourd will be described. In the preparation of such a bitter gourd heat-treated product, the bitter gourd is subjected to a step of drying the bitter gourd prior to the heat treatment of the bitter gourd, and it is desirable to cut or crush the bitter gourd into an appropriate size before the drying step. From the viewpoint of efficiently performing drying and heating, it is desirable to chop the bitter gourd into 1 to 20 mm, preferably about 5 to 8 mm. Drying of bitter melon may be carried out until the weight after drying of bitter melon is reduced to 1 to 20%, preferably about 5 to 12% of the weight before drying. The drying method and conditions are not particularly limited, and a drying method known or commonly used in the art may be employed. Specific examples of the drying method include a method of drying by applying hot air of about 40 to 120 ° C. and a method of drying for 1 to 5 days, preferably about 3 days in the sun. The dried bittern is then subjected to a heat treatment (for example, roasting treatment). About heating conditions, it adjusts suitably according to heating temperature and heating time. About heating temperature, what is necessary is just to set to 40-120 degreeC normally, Preferably it is 60-120 degreeC. Further, the heating time varies depending on the heating temperature and cannot be defined uniformly, but is usually 1 to 60 minutes, preferably about 3 to 15 minutes. Although it does not restrict | limit especially about a heating method, The method to fry on the said temperature conditions is mentioned as an example of a suitable heating method. The said heat processing can be implemented using a roasting machine etc., for example. By performing such heat treatment, a bitter gourd heat-treated product is prepared. The bitter gourd heat-treated product is usually reduced to a weight of about 1 to 10%, preferably about 5 to 7% of the weight of the bitter melon before drying.

  In the present invention, the bittern heat-treated product obtained by the above method can be used as it is as the active ingredient of the shine inhibitor, but an extract of the bittern-heat-treated product may also be used.

An extract of the bitter melon heat-treated product can be obtained by extracting the bitter melon heat-treated product with an extraction solvent at room temperature or under heating. Examples of the extraction solvent include water; an organic solvent; or a mixed solution of water and an organic solvent. Examples of the organic solvent used for extraction include methanol, ethanol, isopropanol, propylene glycol, 1,3-butylene glycol, acetone, ethyl acetate, chloroform, pentane, hexane, heptane and the like alone or in combination of two or more. Can be mentioned. As extraction solvent, preferably water;
A lower alcohol such as methanol, ethanol, isopropanol; or a mixed solution of water and lower alcohol, more preferably water, ethanol, or a mixed solution of water and ethanol (5 to 50% by weight ethanol aqueous solution); particularly preferably water. Can be mentioned. In addition, warm water and hot water are contained in said water.

  The extract of the bitter cucumber heat-treated product used for the shine inhibitor may be the same as the extract obtained by the above-described extraction process, or the solid product may be removed from the extract. Good. Moreover, what was further concentrated by vacuum distillation etc. as needed, and what was dried by drying processes, such as vacuum drying and freeze-drying, may be used.

  The intake or dose of the tekari inhibitor of the present invention varies depending on the age and sex of the subject, expected effects, etc., and cannot be defined uniformly, but as an example of the intake or dose per day for an adult, Examples of the amount of the karikari inhibitor (converted to the dry weight of the bitter gourd heat-treated product) are 0.1 to 4 g, preferably 0.3 to 2 g, and more preferably 0.7 to 2 g.

  The shine control agent of the present invention can be blended in foods and provided as a food product for skin shine control, or prepared in the form of an internal medicine or quasi-drug, or a drug for skin shine control or It can also be provided as a quasi-drug.

  Examples of the above-mentioned food for suppressing skin shine are preferably health functional foods (nutrient functional foods and foods for specified health), so-called health foods, dietary supplements or special-purpose foods (foods for sick people, etc.). it can. Examples of forms include powders, tablets, capsules, syrups, jelly, and the like. In addition, since the extract of a bitter melon heat-processed product obtained using water as an extraction solvent can be drunk as it is, it is good also considering this extract itself, its concentrated liquid, or a dilution liquid as a drink form foodstuff.

  What is necessary is just to set suitably the ratio of the shining inhibitor mix | blended in the said food for skin shine control according to the intake of the said agent per day, the form of food, the effect expected, etc.

  Further, the shape of the pharmaceutical or quasi-drug for suppressing skin shine is not particularly limited as long as the effect of the present invention is not hindered. Examples of the form of the pharmaceutical or quasi drug include tablets, powders, granules, capsules, pills, troches, liquids, extracts and the like. The medicinal product or quasi-drug is formulated with a pharmaceutically acceptable base or carrier, and if necessary, a binder, a disintegrant, a lubricant, a wetting agent, a buffering agent, a preservative. In addition, pharmaceutically acceptable additives such as fragrances may optionally be contained.

  The ratio of the shinkari inhibitor contained in the above-mentioned medicinal or quasi-drug for skin shine is the dose per day, the age and sex of the subject, the form of the drug or quasi-drug, expectation It can set suitably according to the effect etc. which are carried out.

  The shine control agent of the present invention can suppress skin shine caused by excessive secretion of sebum by oral ingestion or application. In particular, the shininess inhibitor of the present invention can effectively suppress shininess on the face where excessive secretion of sebum is likely to occur, and thus can be suitably used as a cosmetic means.

  According to the shine inhibitor of the present invention, it is possible to effectively suppress skin shine caused by excessive secretion of sebum, and thus it is possible to maintain a healthy skin that is unlikely to cause stickiness and makeup collapse.

  Further, the shine inhibitor of the present invention is prepared with bitter gourd which has been conventionally used as a raw material for foods, so it is highly safe and can be ingested or administered on a daily basis as a food or an internal medicine. .

  Furthermore, the bittersweet heat-treated product obtained by drying bittern after drying does not have the bitterness peculiar to bitter gourd and does not adversely affect the taste. It can be used without being limited to the shape of the composition, and can provide a wide variety of means for suppressing skin shine.

EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated, this invention is not limited to these Examples.
Example 1
The following test was conducted to evaluate the shine prevention effect of the bitter gourd heat-treated product.
<Preparation of heat-treated bitter gourd>
After removing seeds and cotton from the fruit part of bitter gourd, it was chopped to about 5-8 mm. 1000 g of chopped bitter gourd was dried with hot air at 40 to 120 ° C. until the weight reached 120 g. Next, using a direct-fire roasting machine, the iron plate temperature was gradually raised from 70 ° C. to 110 ° C. for 15 minutes and fried to obtain 60 g of a bitter gourd heat-treated product.

The soy-boiled heat-treated product thus obtained is added to hot water immediately after boiling, and left to stand for 1 minute. The extract from which the residue was removed was used as a test sample.
<Measurement of amount of sebum secreted in forehead>
The amount of sebum secreted in the forehead was measured by a subject who took the test sample under the conditions shown in Table 1 below. Specifically, first of all, oil blotting paper (trade name “Maketo Planet Oil Blotting Paper”
Using Orbit Co., Ltd., 100% natural hemp), the subject's forehead sebum was sufficiently absorbed. Immediately thereafter, about 300 g of grilled meat was ingested. Two hours after the disclosure of the grilled meat intake, the oil on the left half of the subject's left forehead was sufficiently sucked up using oil blotting paper. Furthermore, 4 hours after the disclosure of the grilled meat intake, the oil on the right half of the forehead of the subject was sufficiently sucked up again using oil blotting paper. According to the following formula, the amount of sebum after 2 and 4 hours of ingestion of yakiniku was calculated.
Evaluation criteria for the degree of shine on the face
Score 0: No shine Rating 1: A slight amount of shine is found in part of the face 2: A shine is clearly recognized in part of the face 3: A shine is clearly recognized in the whole face (degree of shine) Judgment)
◎: Average score of subjects is less than 1 ○: Average score of subjects is 1 or more and less than 2 ×: Average score of subjects is 2 or more

<Result>
The obtained results are shown in Table 2. In Table 2, the sebum secretion reduction rate means the ratio (%) of the sebum amount reduced with respect to the control sebum amount. As a result, it was confirmed that by taking the extract of the bitter gourd heat treatment, facial shine was suppressed, and the amount of sebum secreted in the forehead was also reduced. In particular, from the results of Test Example 2, it was confirmed that the amount of sebum secretion was effectively suppressed and shine was suppressed by daily ingestion of the extract of the bitter gourd heat-treated product.

  From the above results, the heat-treated bitter gourd or its extract has the effect of suppressing the increase in the amount of neutral fat in the blood, and it can be improved to a constitution with less skin shine by taking this continuously. Became clear.

Example 2 (Capsule)
5 g of gelatin heated to 40-60 ° C. was gradually added with stirring to dissolve the mixture. The mixed solution was degassed under reduced pressure, and then appropriate amounts of titanium oxide and pigment were added and further mixed. Thereafter, it is filled into a capsule-type bottle and dried until the water content is 15 to 18% by weight. The body part of the capsule is filled with 200 mg of bitter gourd prepared by the method described in Example 1, The cap part was combined and the capsule containing a bittern heat processing thing was prepared.

Example 3 (Microcapsule)
To 100 g of purified water heated to 40 ° C., 5 g of gelatin was gradually added with stirring, and mixed and dissolved. Thereafter, 200 mg of bitter gourd heat-treated product prepared by the method described in Example 1, titanium oxide, glycerin, and dye were added in appropriate amounts and mixed to obtain capsules. The capsule was then cooled, dehydrated until the water content was 15-18% by weight, and further dried until the water content was 8.2-16% by weight. Then, it filtered and the microcapsule containing a bittern heat processing thing was prepared.

Example 4 (Cookies)
First, 80 g of sugar (granulated sugar) was gradually added to 70 g of unsalted butter while stirring. After adding 1 broken egg to this, 2 g of bittern heat-treated product prepared by the method described in Example 1 was added and further stirred. In a sufficiently mixed stage, 200 g of weak flour that was evenly sieved was added and stirred at a low speed, and then a lump. This was laid down in a low temperature room for about 30 minutes, then uniformly spread to a thickness of about 1 cm, and extracted with a circular mold having a diameter of 5 cm. Next, the cut cookie dough was arranged on a top plate and heated in an oven preheated at 170 ° C. for 12 to 15 minutes to obtain a cookie containing a bittersweet heat-treated product.

Example 5 (soft drink)
A soft drink having the following composition was prepared.
(weight%)
Extract from heat-treated bittern (prepared by the method described in Example 1) 0.5
Fructose dextrose liquid sugar 6.0
Sodium citrate 0.6
L-ascorbic acid 3.0
Appropriate amount of water
Total 100% by weight
Example 6 (Jelly)
According to a conventional method, a jelly having the following composition was prepared.

(weight%)
Extract from heat-treated bittern (prepared by the method described in Example 1) 0.5
Gelatin 1.1
Sugar 22.0
L-tartaric acid 0.1
Sodium citrate 0.1
Citric acid 0.1
Appropriate amount of water
Total 100% by weight

Claims (4)

A shine control agent comprising a heat-treated bitter gourd or an extract thereof as an active ingredient. The shining inhibitor according to claim 1, wherein the bitter gourd heat-treated product is obtained by drying and heating the bitter gourd. A food for suppressing shine, comprising the shine control agent according to claim 1. A pharmaceutical or quasi-drug for shining suppression containing the shining inhibitor according to claim 1 or 2.