JP2006104156A - Hypotensive composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a hypotensive composition or a hypotensive agent exerting excellent hypotensive activity, high in safety and effectively exhibiting effect by its oral administration. <P>SOLUTION: This hypotensive composition or the hypotensive agent contains (I) γ-aminobutyric acid and (II) adenosine as synergistically active ingredients. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a blood pressure lowering composition or a blood pressure lowering agent that exhibits an excellent blood pressure lowering action to improve a hypertension state. Furthermore, the present invention relates to a drug for improving hypertension, a food, and a beverage containing the blood pressure lowering composition or blood pressure lowering agent.

  In Japan, hypertension is steadily increasing year by year with the aging of society and the Western diet. Since hypertensive diseases cause strokes, heart diseases, and the like, substances having an effect of improving hypertension have attracted attention, and their commercialization has been studied.

Until now, the hypertension improving agent which uses sputum as an active ingredient is known (refer patent document 1). Moreover, (gamma) -aminobutyric acid has been identified as a hypotensive substance (refer nonpatent literature 1). However, the details of their actions have not been fully clarified.
Japanese Patent Publication No. 03-031170 Yasuhiro Kohama et al: Isolation and Identification of Hypotensive Principles in Red-Mold Rice Chem. Pharm. Bull. 35 (6), 2484-2489, (1987).

  The main object of the present invention is to provide an antihypertensive composition or an antihypertensive agent that exhibits an excellent antihypertensive action, is highly safe, and exhibits an effective action when taken orally. Furthermore, the main purpose is to provide an effective usage form thereof.

  As a result of intensive studies aimed at solving the above problems, the present inventors have found that adenosine and γ-aminobutyric acid act synergistically to produce a significant blood pressure lowering effect, and Through repeated studies, the present invention has been completed.

  That is, the present invention provides an antihypertensive composition or antihypertensive agent containing γ-aminobutyric acid and adenosine as a synergistic active ingredient, and an antihypertensive agent containing the antihypertensive composition or antihypertensive agent. It relates to medicines, foods and beverages.

  Item 1: A blood pressure lowering composition comprising (I) adenosine and (II) γ-aminobutyric acid as synergistic active ingredients.

  Item 2: The composition for lowering blood pressure according to Item 1, comprising (I) and (II) in a weight ratio of 1: 0.1 to 1:10.

  Item 3: An antihypertensive agent comprising (I) adenosine and (II) γ-aminobutyric acid as synergistic active ingredients.

  Item 4: The antihypertensive agent according to Item 3, comprising (I) and (II) in a weight ratio of 1: 0.1 to 1:10.

Item 5: A hypertension-improving pharmaceutical composition comprising the blood pressure lowering composition according to item 1 or the blood pressure lowering agent according to item 3.
Preferably, a composition for lowering blood pressure or an antihypertensive agent containing (I) adenosine and (II) γ-aminobutyric acid in a ratio of 1: 0.1 to 1:10 by weight as a synergistic active ingredient A pharmaceutical composition for improving hypertension.

Item 6: An antihypertensive food comprising the blood pressure lowering composition according to item 1 or the blood pressure lowering agent according to item 3.
Preferably, a composition for lowering blood pressure or an antihypertensive agent containing (I) adenosine and (II) γ-aminobutyric acid in a ratio of 1: 0.1 to 1:10 by weight as a synergistic active ingredient It is a food for improving hypertension.

Item 7: A hypertension-improving beverage comprising the blood pressure lowering composition according to Item 1 or the blood pressure lowering agent according to Item 3.
Preferably, a composition for lowering blood pressure or an antihypertensive agent containing (I) adenosine and (II) γ-aminobutyric acid in a ratio of 1: 0.1 to 1:10 by weight as a synergistic active ingredient It is a drink for improving hypertension.

Item 8: The food for improving hypertension according to Item 6, comprising (I) adenosine and (II) γ-aminobutyric acid in the form of a component contained in a natural product extract.
Specifically, as a synergistic active ingredient, a composition for lowering blood pressure containing (I) adenosine and (II) γ-aminobutyric acid in the form of ingredients contained in a natural product extract is contained. Contains a blood pressure-lowering agent containing (I) adenosine and (II) γ-aminobutyric acid in the form of ingredients contained in natural product extracts as a food for improving hypertension or a synergistic active ingredient It is a food for improving hypertension.
Preferably, as a synergistic active ingredient, (I) adenosine and (II) γ-aminobutyric acid in a weight ratio of 1: 0.1 to 1:10, the ingredient contained in the natural product extract The antihypertensive food containing the blood pressure lowering composition contained in the form of, or as a synergistic active ingredient, (I) adenosine and (II) γ-aminobutyric acid in a weight ratio of 1: 0.1. It is a food for improving hypertension containing an antihypertensive agent contained in the form of a component contained in a natural product extract at a ratio of ˜1: 10.

  Item 9: The food for improving hypertension according to Item 8, wherein the natural product is red yeast rice.

Item 10: The hypertension-improving beverage according to Item 7, comprising (I) adenosine and (II) γ-aminobutyric acid in the form of a component contained in a natural product extract.
Specifically, as a synergistic active ingredient, a composition for lowering blood pressure containing (I) adenosine and (II) γ-aminobutyric acid in the form of ingredients contained in a natural product extract is contained. Contains a blood pressure lowering agent containing (I) adenosine and (II) γ-aminobutyric acid in the form of a component contained in a natural product extract as an antihypertensive beverage or a synergistic active ingredient It is a drink for improving hypertension.
Preferably, as a synergistic active ingredient, (I) adenosine and (II) γ-aminobutyric acid in a weight ratio of 1: 0.1 to 1:10 are contained in the natural product extract The antihypertensive beverage containing the blood pressure lowering composition contained in the form of, or as a synergistic active ingredient, (I) adenosine and (II) γ-aminobutyric acid in a weight ratio of 1: 0.1. It is a drink for improving hypertension containing an antihypertensive agent contained in the form of a component contained in a natural product extract at a ratio of ˜1: 10.

  Item 11: The beverage for improving hypertension according to Item 10, wherein the natural product is red yeast rice.

  Hereinafter, the present invention will be described in more detail.

Composition for lowering blood pressure The composition for lowering blood pressure of the present invention contains two components, adenosine and γ-aminobutyric acid, as active ingredients. Adenosine and γ-aminobutyric acid act synergistically to produce an excellent blood pressure lowering effect.

  The content ratio of adenosine and γ-aminobutyric acid is not particularly limited as long as it has a synergistic effect, but is preferably about 1: 0.1 to 1:10 by weight. Preferably, it is about 1: 0.2 to 1: 2, more preferably about 1: 0.5 to 1: 1.

  The blood pressure lowering composition of the present invention is prepared by mixing two components of adenosine and γ-aminobutyric acid, or by mixing the two components with other appropriate components. The composition may be obtained by synthesizing or extracting each of adenosine and γ-aminobutyric acid from a natural product and mixing them. Moreover, the extract or extract obtained by extracting from the natural product containing 2 components, or those preparations may be sufficient. Preferably, in the blood pressure lowering composition of the present invention, adenosine and γ-aminobutyric acid are contained in the form of components contained in a natural product extract. The kind of synthesis method in the case of synthesizing adenosine and / or γ-aminobutyric acid is not particularly limited. The type of natural product obtained by extracting adenosine and / or γ-aminobutyric acid from the natural product is not particularly limited, but the natural product includes, for example, red yeast rice. Also, the extraction method is not particularly limited, and examples include a method of extracting water or hydrous alcohol as an extraction solvent.

  In the composition for lowering blood pressure of the present invention, other components can be appropriately blended as long as the effects of the present invention are not impaired. The blood pressure lowering composition of the present invention can be appropriately prepared and used in an appropriate form, for example, a liquid form, a powder form, a granule form, a paste form, etc., according to a known method.

  The blood pressure lowering composition of the present invention can be used as a food composition or a pharmaceutical composition. Moreover, it can also be added to a pharmaceutical composition, a foodstuff, a drink, etc., and can also be used as an additive. It can also be used as a reagent composition.

  When ingested, the composition for lowering blood pressure of the present invention exhibits an excellent blood pressure lowering action and improves a hypertensive state.

  The intake of the composition for lowering blood pressure of the present invention can be appropriately set according to conditions such as the hypertension state to be improved and the age, sex and the like of the application target. Usually, adenosine and γ-aminobutyric acid are added. The combined intake is about 0.5 mg to 5 g / day, desirably about 1 mg to 100 mg / day.

Antihypertensive agent The antihypertensive agent of the present invention contains two components, adenosine and γ-aminobutyric acid, as active ingredients. Adenosine and γ-aminobutyric acid act synergistically to produce an excellent blood pressure lowering effect.

  The content ratio of adenosine and γ-aminobutyric acid is not particularly limited as long as it has a synergistic effect, but is preferably about 1: 0.1 to 1:10 by weight. Preferably, it is about 1: 0.2 to 1: 2, more preferably about 1: 0.5 to 1: 1.

  The antihypertensive agent of the present invention is produced by appropriately preparing or formulating a mixture of two components of adenosine and γ-aminobutyric acid or a mixture of the two components and other appropriate components. The mixture may be obtained by synthesizing or extracting each of adenosine and γ-aminobutyric acid from a natural product and mixing them. Moreover, the extract obtained by extracting from the natural product containing 2 components, or its preparation may be sufficient. Preferably, in the antihypertensive agent of the present invention, adenosine and γ-aminobutyric acid are contained in the form of components contained in a natural product extract. The kind of synthesis method in the case of synthesizing adenosine and / or γ-aminobutyric acid is not particularly limited. The type of natural product when adenosine and / or γ-aminobutyric acid is extracted from the natural product is not particularly limited, but the natural product includes, for example, red yeast rice. Also, the extraction method is not particularly limited, and examples include a method of extracting water or hydrous alcohol as an extraction solvent.

  The blood pressure lowering agent of the present invention can be appropriately mixed with other components as long as the effects of the present invention are not impaired. In addition, the antihypertensive agent of the present invention can be used in an appropriate form, for example, powder, granule, tablet, capsule, paste, solvent, etc., by itself or in combination with various excipients and carriers according to known methods. It can be prepared and used.

  The antihypertensive agent of the present invention can itself be used as a food, beverage or medicine. Specifically, it can be used as a drink or an oral preparation. Further, it can be added to a pharmaceutical composition, food, beverage or the like and used as an additive. It can also be used as a research / test reagent.

  When taken, the antihypertensive agent of the present invention exhibits an excellent antihypertensive action and improves a hypertensive state.

  The intake or dosage of the antihypertensive agent of the present invention can be appropriately set according to conditions such as the hypertension state to be improved and the age, sex, etc. of the application target, but usually adenosine and γ-aminobutyric acid The combined intake is about 0.5 mg to 5 g / day, desirably about 1 mg to 100 mg / day.

Pharmaceutical composition for improving hypertension The antihypertensive composition or antihypertensive agent of the present invention is used as a pharmaceutical composition for improving hypertension or a pharmaceutical composition having an antihypertensive effect in combination with a pharmaceutically acceptable carrier. be able to.

  The pharmaceutical composition of the present invention can be prepared in various forms, for example, powders, granules, tablets, capsules, pastes, solvents and the like.

  In addition to the antihypertensive composition or antihypertensive agent of the present invention, the pharmaceutical composition of the present invention can further contain components for improving hypertension or lowering blood pressure.

  Furthermore, in the pharmaceutical composition of the present invention, components that are usually blended in the pharmaceutical composition, for example, various nutrients, preservatives, emulsifiers, solubilizers, and the like are appropriately blended within a range that does not impair the effects of the present invention. Can do.

  The administration method of the pharmaceutical composition of the present invention is preferably oral administration, and the pharmaceutical composition of the present invention can be suitably used as an oral preparation for improving hypertension.

  When ingested or administered, the pharmaceutical composition for improving hypertension of the present invention exhibits an excellent blood pressure lowering action and improves the hypertensive state.

  The intake or dose of the pharmaceutical composition of the present invention can be appropriately set according to conditions such as the hypertension state to be improved and the age and sex of the application target.

Food for improving hypertension The composition for decreasing blood pressure or the blood pressure-lowering agent of the present invention can be used in the form of food by being incorporated in various foods.

  The food containing the blood pressure lowering composition or blood pressure lowering agent of the present invention is a food having a blood pressure lowering action or a food having an antihypertensive action, and is a health food or special purpose food, more specifically, a health functional food. It can be suitably used as a food for specified health use or a food with a nutritional function.

  The kind of the food of the present invention is not particularly limited, and for example, it can be used as bread, biscuits, cookies, cereals, candy, miso and the like.

  In the food of the present invention, other ingredients usually used in food within the range of not impairing the effects of the present invention, such as various nutrients, animal and plant ingredients, excipients, sweeteners, flavoring agents, coloring agents, preservatives, etc. Can be appropriately blended.

  When the food of the present invention is ingested or taken orally, it exhibits an excellent blood pressure lowering effect and improves the hypertensive state.

  The intake of the food of the present invention can be appropriately set according to conditions such as the hypertension state to be improved and the age and sex of the application target.

Beverage for improving hypertension The composition for lowering blood pressure or the blood pressure-lowering agent of the present invention can be used in the form of a beverage by being contained in various beverages.

  The beverage containing the antihypertensive composition or antihypertensive agent of the present invention is a beverage having a blood pressure lowering effect or a beverage having an antihypertensive effect, and is a health food or special purpose food, more specifically, a health functional food. It can be suitably used as a food for specified health use or a food with nutritional function.

  The kind of beverage of the present invention is not particularly limited, and can be used as, for example, various soft drinks, energy drinks, soups, juices, and the like.

  In the beverage of the present invention, other components usually used in beverages can be blended within a range not impairing the effects of the present invention. Examples of other components include various nutrients, animal and plant components, sweeteners, flavoring agents, coloring agents, and preservatives.

  When ingested, the beverage of the present invention exhibits an excellent blood pressure lowering effect and improves the hypertensive state.

  The intake of the beverage of the present invention can be appropriately set according to conditions such as the hypertension state to be improved and the age and sex of the application target.

  When ingested, the blood pressure lowering composition or blood pressure lowering agent of the present invention exhibits an excellent blood pressure lowering effect and effectively improves the hypertensive state.

  The antihypertensive composition or antihypertensive agent of the present invention contains adenosine and γ-aminobutyric acid as active ingredients, and exhibits a remarkable antihypertensive action due to the synergistic action of the two ingredients. Moreover, since the two components act synergistically, the amount of the single component is reduced, the action is gentle, and the safety is high. As described above, the antihypertensive composition or antihypertensive agent of the present invention exhibits an excellent blood pressure lowering action, and has a remarkable effect of gently achieving improvement of the hypertensive state.

  The pharmaceutical composition, food or beverage containing the blood pressure lowering composition or blood pressure lowering agent of the present invention also exhibits an excellent blood pressure lowering action and exhibits a remarkable effect of gently improving the hypertension state.

  EXAMPLES Hereinafter, although an Example and an experiment example are given and this invention is demonstrated, this invention is not limited to these examples.

Examples and experimental examples

Materials and Methods Test article A red yeast rice drink was produced as follows. After inoculating Monascus pilosus IFO4520 in steamed and sterilized steamed rice and aerobically cultivating for 9 days at 30 ° C, heat treatment inactivates the koji mold and enzyme, and further dried the koji mold obtained in 13 times the amount Extraction was carried out for 2 hours with moderate circulation in warm water (50 ° C.) to obtain a concentrated red yeast rice extract. The obtained red yeast rice extract was used as a main ingredient (3.5% of the whole), and flavorants, acidulants, caramels and sweeteners were used as auxiliary ingredients and added to and dissolved in water to produce a red yeast rice drink. The adenosine and γ-aminobutyric acid contents of this drink were analyzed by high performance liquid chromatography for adenosine, and amino acid analysis for γ-aminobutyric acid. As a result, the adenosine content was 1.8 mg / 100 ml, The content was 2.4 mg / 100 ml.
Adenosine (SIGMA) was purchased and dissolved in water for injection (Otsuka Pharmaceutical Factory). Similarly, γ-aminobutyric acid (GABA) (SIGMA) was purchased and dissolved in water for injection (Otsuka Pharmaceutical Factory).

2. Animals used Spontaneously hypertensive rats (SHR) (Japan SLC Co., Ltd.) were selected from animals that had no abnormalities in the general state after preliminary breeding. In Experiment 1, the body weight was 275 to 334 g (14 weeks old). In Experiment 2, animals weighing 271 to 338 g (14 weeks old) and in Experiment 3 animals weighing 286 to 319 g (14 weeks old) were used. For the feed, solid feed (Lab MR Stock, Nippon Agricultural Industry Co., Ltd.) was freely ingested except during the basic feed period. Drinking water was ingested freely with a water bottle.
The breeding and experimentation were all carried out in accordance with the guidelines of the Japanese Pharmacological Society and the “Guidelines for Animal Experiment Management” of the New Drug Development Laboratory and Central Research Laboratory.

3. Feed composition (basic feed)
The basic feed was a semi-purified feed prepared according to the composition of Tsuji et al. (Home Economics Journal, 44, 109-114, (1993)) according to the AIN composition, and 1% sodium chloride was added. The basic feeds are casein (pure chemical), lard (pure chemical), mineral MIX (Clea Japan), vitamin MIX (Clea Japan), choline chloride (Pure Chemical), cellulose (Asahi Kasei), sodium chloride (Wako Pure Chemical) and Prepared with sucrose (TTGH granulated sugar, Toyo Sugar).

4). Test method The systolic blood pressure (SBP) and heart rate (HR) of the animals were measured before the test feed intake, 5, 10 and 15 days later, with the non-animal non-blood pressure sphygmomanometer (MK-2000, Muromachi Kikai ( )). The red yeast rice drink was orally administered once a day for 15 days from the day after the start of basic feed intake. Adenosine, GABA, GABA + adenosine were repeatedly administered once a day for 15 days from the day following the start of basic feed intake. Blood pressure was measured 2 hours after administration of the test substance.

5. Dosage and group composition In the experiment (experiment 1) that examined the blood pressure lowering effect of red yeast rice drink and adenosine, the control group to which water for injection was orally administered, red yeast rice drink 5 mL / kg, and adenosine 0.09, 0.3 and 0.9 mg / kg A total of 5 groups (5 mL / kg) were used, and 8 animals per group were used. Since 5 mL of red yeast rice drink contains 0.09 mg of adenosine, the group of red yeast rice drink and adenosine 0.09 mg / kg was orally administered with the same amount of adenosine.

  In the experiment (experiment 2) in which the blood pressure lowering effect of red yeast rice drink and GABA was examined, a control group orally administered with water for injection, red blood sugar drink 5 mL / kg, and GABA 0.12, 0.40 and 1.20 mg / kg (5 mL / kg) ) For a total of 5 groups, 6 per group. Since 5 mL of red yeast rice drink contains 0.12 mg of GABA, the group of red yeast drink and GABA 0.12 mg / kg was orally administered with the same amount of GABA.

In an experiment (experiment 3) that examined the blood pressure lowering effect of red yeast rice drink and adenosine + GABA,
The control group to which water for injection was orally administered, a red yeast drink 5 mL / kg, and GABA 0.12 mg / kg + adenosine 0.09 mg / kg (5 mL / kg) were made into a total of 3 groups, and 8 animals per group were used. Since 5 mL of red yeast rice drink contains 0.12 mg GABA and 0.09 mg adenosine, the group of red yeast drink and GABA + adenosine orally administered the same amounts of GABA and adenosine.

6). Statistical processing The results were expressed as mean values and standard errors. The significant difference test between the two groups was performed using the Student's t-test when F> 0.05 and the Aspin-Welch t-test when P <0.05. There was a significant difference.

Experiment 1: Blood pressure lowering action of adenosine Blood pressure when preparing red yeast rice drink containing adenosine and γ-aminobutyric acid and using adenosine alone and in combination with γ-aminobutyric acid in the form of red yeast rice drink The descent action was compared.

  The obtained results are shown in FIG.

  In the control group (group in which water for injection was orally administered), the systolic blood pressure increased compared to the value before 5 days after ingestion of the basic feed, and remained constant until 15 days thereafter. Sockeye drink (SS-BL) (5ml / kg) did not show an increase in systolic blood pressure, and although it was mild until 15 days later, the systolic blood pressure decreased. Adenosine 0.09 mg / kg showed no change in systolic blood pressure after 5 days, but increased after 10 and 15 days. Red blood sugar drink (5 ml / kg) and adenosine 0.09 mg / kg showed effective low values in all after 5, 10 and 15 days against systolic blood pressure in the control group. At higher doses of 0.3 mg / kg and 0.9 mg / kg, systolic blood pressure was lower than 0.09 mg / kg. However, with the exception of a transient decline after 5 days at 0.9 mg / kg, both did not fall below the systolic blood pressure of the red yeast drink, and after 15 days there was a significant difference from the red yeast drink. .

  In this way, 1-fold (0.09 mg / kg), 3.3-fold (0.3 mg / kg), and 10-fold (0.9 mg / kg) adenosine contained in red yeast rice drink were administered to rats alone. As a result, 1-dose amount of adenosine was about 33% lowering blood pressure than red yeast rice drink, and 3.3-fold and 10-fold amount lowering blood pressure about 60% of red yeast rice drink.

Experiment 2: Hypotensive action of γ-aminobutyric acid (GABA) A red yeast drink containing adenosine and γ-aminobutyric acid was prepared, and when using γ-aminobutyric acid alone, The blood pressure lowering effect when combined was compared.

  The obtained results are shown in FIG.

  In the control group (group in which water for injection was orally administered), systolic blood pressure increased compared to the value before ingestion 5 days after ingestion of the basic feed, and increased at a substantially constant rate until 15 days thereafter. Sockeye drink (SS-BL) (5 ml / kg) showed a drop in blood pressure after 5 days, and then increased slightly, but remained at a lower value than before ingestion. γ-aminobutyric acid 0.12 mg / kg increased systolic blood pressure compared to before intake, but was lower than that of the control group in all 5, 10, and 15 days. At higher doses of γ-aminobutyric acid 0.40 mg / kg and 1.20 mg / kg, systolic blood pressure was even lower than 0.12 mg / kg, but both did not fall below the systolic blood pressure of red yeast drink. After 15 days, a significant difference was observed with the red yeast rice drink.

  Single amount (0.12 mg / kg), 3.3 times (0.4 mg / kg), and 10 times (1.2 mg / kg) of γ-aminobutyric acid contained in red yeast rice drink alone for rats As a result of administration, a 1-fold amount of γ-aminobutyric acid had a blood pressure lowering effect of about 44%, and a 3.3-fold amount and a 10-fold amount of γ-aminobutyric acid had a blood pressure lowering effect of about 70% of a red yeast drink.

Experiment 3: Blood pressure lowering action of adenosine + γ-aminobutyric acid (GABA) Comparison of blood pressure lowering action when adenosine and γ-aminobutyric acid are used in combination with adenosine and γ-aminobutyric acid drink did.

  The obtained results are shown in FIG.

  In the control group (group in which water for injection was orally administered), systolic blood pressure increased compared to the value before ingestion 5 days after ingestion of the basic feed, and increased at a substantially constant rate until 15 days thereafter. Sockeye drink (SS-BL) (5 ml / kg) showed a slight decrease in blood pressure after 5 days and then increased slightly, but remained at a significantly lower value than the control group.

  In the group (GABA0.12mg / kg + adenosine 0.09mg / kg), which is the same amount of adenosine and γ-aminobutyric acid as the amount contained in the red yeast rice drink, the systolic blood pressure remained almost constant. Although the value was significantly lower than that of the red yeast rice drink 5 mg / kg, there was no statistically significant difference.

  As a result of co-administration of the same amount of adenosine and γ-aminobutyric acid as contained in a red yeast rice drink, the antihypertensive effect of 95% of the red yeast rice drink was shown.

  From the results of Experiments 1 to 3, administration of 1-fold adenosine and 1-fold γ-aminobutyric acid is more effective than administration of 10-fold adenosine or 10-fold γ-aminobutyric acid. Adenosine and γ-aminobutyric acid Was found to have a synergistic effect on blood pressure lowering action (see Table 1).

FIG. 1 is a drawing showing the experimental results regarding the blood pressure lowering effect of adenosine. SS-BL represents a red yeast rice drink. Each numerical value represents an average value ± standard error of 8 cases. ** p <0.01 indicates significant difference in t-test compared to control group. #p <0.05 and ## p <0.01 indicate that there is a significant difference in t-test compared to the adenosine 0.09 mg / kg group. $ p <0.05 indicates a significant difference in t-test compared to the adenosine 0.3 mg / kg group. & p <0.05 indicates a significant difference in t-test compared to the adenosine 0.9 mg / kg group. FIG. 2 is a drawing showing experimental results regarding the blood pressure lowering action of γ-aminobutyric acid. SS-BL represents a red yeast rice drink. Each numerical value represents the average value ± standard error of 6 cases. * p <0.05 and ** p <0.01 indicate that there is a significant difference in t-test compared to the control group. #p <0.05 and ## p <0.01 indicate that there is a significant difference in t-test compared to the GABA 0.12 mg / kg group. && p <0.01 indicates significant difference in t-test compared to GABA 0.40 mg / kg group. \ p <0.05 indicates a significant difference in t-test compared to the adenosine 1.20 mg / kg group. FIG. 3 is a drawing showing the experimental results regarding the blood pressure lowering effect by the combined use of adenosine and γ-aminobutyric acid. SS-BL represents a red yeast rice drink. Each numerical value represents an average value ± standard error of 8 cases. ** p <0.01 indicates significant difference in t-test compared to control group.

Claims (11)

A composition for lowering blood pressure, comprising (I) adenosine and (II) γ-aminobutyric acid as synergistic active ingredients. The composition for lowering blood pressure according to claim 1, comprising (I) and (II) in a weight ratio of 1: 0.1 to 1:10. An antihypertensive agent comprising (I) adenosine and (II) γ-aminobutyric acid as a synergistic active ingredient. The antihypertensive agent according to claim 3, comprising (I) and (II) in a weight ratio of 1: 0.1 to 1:10. A pharmaceutical composition for improving hypertension, comprising the blood pressure lowering composition according to claim 1 or the blood pressure lowering agent according to claim 3. A food for improving hypertension comprising the blood pressure lowering composition according to claim 1 or the blood pressure lowering agent according to claim 3. A hypertension-improving beverage comprising the blood pressure lowering composition according to claim 1 or the blood pressure lowering agent according to claim 3. The food for improving hypertension according to claim 6, comprising (I) adenosine and (II) γ-aminobutyric acid in the form of components contained in a natural product extract. The food for improving hypertension according to claim 8, wherein the natural product is red yeast rice. The beverage for improving hypertension according to claim 7, comprising (I) adenosine and (II) γ-aminobutyric acid in the form of components contained in the natural product extract. The beverage for improving hypertension according to claim 10, wherein the natural product is red yeast rice.

Images