JP2006063032A - External preparation for skin useful for preventing sebum shininess - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a means for controlling aesthetic loss of appearance caused by excessive secretion of lipid. <P>SOLUTION: The external preparation for skin comprises (1) a dibasic acid ester, (2) spherical powder which may be subjected to surface treatment and (3) a carboxyvinyl polymer which may be modified with an alkyl group and/or its salt. The dibasic acid ester is preferably diethoxyethyl adipate, the spherical powder is preferably one or more kinds selected from silica, nylon, acrylic resin powder, calcium silicate, magnesium silicate and calcium carbonate. The external preparation for skin is preferably a gel-like cosmetic as a dosage form and preferably a cosmetic for preventing shininess by sebum. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable for preventing secreted sebum from being exposed to a site where sebum secretion is significant.

  The changes in dietary habits over the last 20 years have been remarkable, and such changes are starting to affect every part of social life. In particular, the rapid increase in lipid intake accompanying the westernization of dietary content has led to the spread of adult diseases such as hyperlipidemia. Even if such a disease does not occur, such changes in dietary habits have a great influence on various physiological aspects. Such influence extends to the field of external preparations for skin such as cosmetics. That is, conventionally, the main purpose of cosmetics has been moisturizing, but with the rapid increase in lipid intake as described above, countermeasures against excessive secretion of lipids have come to occupy an important position. Specific examples include cosmetics that are applied to the forehead and nasal muscles where lipid secretion is active on the face and the like for the purpose of excessive secretion of lipids, so-called T-zone cosmetics. Examples of such a cosmetic for the T zone include a two-layer cosmetic containing silica and a cosmetic obtained by molding silica together with silicone (see, for example, Patent Document 1 and Patent Document 2). However, the use of such cosmetics promotes the temporary adsorption of lipids to the contained silica, etc., and can temporarily cope with it, but the sebum adsorption amount on silica reaches saturation. Then, only the part is wetted with lipids, and the color and the like change remarkably, so the effect must be questioned. In particular, such a cosmetic disintegration due to lipids has a major disadvantage of the aesthetic loss of its appearance. Therefore, it can be said that such a countermeasure may increase the disadvantages caused by excessive secretion of lipids. That is, it can be said that development of a means for suppressing the aesthetic loss of appearance caused by excessive lipid secretion is desired.

  On the other hand, 1) an ester of dibasic acid and 2) a surface-treated, spherical powder and 3) an alkyl-modified carboxyvinyl polymer, which are constituents of the external preparation for skin of the present invention Examples of the external preparation for skin containing a dibasic acid ester and a spherical powder among the salts thereof include, for example, sunscreen cosmetics and stick cleansing materials. (For example, refer patent document 3, patent document 4, patent document 5), As a skin external preparation containing a dibasic acid and a carboxy vinyl polymer, a gel-like cleaning material, a cleansing material, etc. exist. (For example, refer to Patent Document 6 and Patent Document 7) Further, as a skin external preparation containing a spherical powder and a carboxyvinyl polymer, there are pre-shave cosmetics and anti-wrinkle cosmetics. (For example, refer to Patent Document 8 and Patent Document 9) However, a skin external preparation containing all these three components is not known at all. It was not speculated that an external preparation could be obtained.

JP 2003-277229 A JP 2003-309500 A Special table 2003-500343 gazette Special table 2003-531160 gazette Japanese National Patent Publication No. 10-505062 JP-A-7-267815 Japanese Patent Laid-Open No. 7-196444 JP 2003-34627 A JP 2002-326923 A

  The present invention has been made under such circumstances, and an object of the present invention is to provide means for suppressing the aesthetic loss of appearance caused by excessive secretion of lipids.

In view of such circumstances, the present inventors have sought for means for suppressing the aesthetic loss of appearance caused by excessive secretion of lipids, and as a result of intensive research efforts, 1) esters of dibasic acids and 2) surfaces A spherical powder that may be treated, and 3) a skin external preparation containing a dibasic acid ester and a spherical powder among carboxyvinyl polymers and / or salts thereof that may be alkyl-modified, It has been found that it has such a property, and has come to complete the invention. That is, the present invention is as follows.
(1) 1) an ester of dibasic acid, 2) a surface-treated, spherical powder, and 3) an alkyl-modified, carboxyvinyl polymer and / or a salt thereof. An external preparation for skin.
(2) The external preparation for skin according to (1), wherein the dibasic acid ester is diethoxyethyl adipate.
(3) The spherical powder is one or more selected from silica, nylon, acrylic resin powder, calcium silicate, magnesium silicate and calcium carbonate, (1) or The external preparation for skin according to (2).
(4) The external preparation for skin according to any one of (1) to (3), which is a gel cosmetic.
(5) The external preparation for skin according to any one of (1) to (4), which is a cosmetic for preventing shine due to sebum.
(6) The external preparation for skin according to any one of (1) to (5), which is a cosmetic to be administered to the T zone.
(7) The external preparation for skin according to any one of (1) to (6), characterized in that a packaging form indicates that it has an anti-shine effect due to sebum.

(1) Dibasic acid ester which is an essential component of the skin external preparation of this invention The skin external preparation of this invention contains dibasic acid ester as an essential component, It is characterized by the above-mentioned. Preferred examples of the dibasic acid constituting the dibasic acid ester include those having 2 to 8 carbon atoms, such as adipic acid, succinic acid, sebacic acid, and oxalic acid. Moreover, as an aliphatic group which comprises an ester part, a C1-C4 thing is preferable and can also have an alkoxy group in a side chain. As such an aliphatic group, for example, an ethyl group, an isopropyl group, an ethoxyethyl group and the like can be particularly preferably exemplified. Specific examples of preferred esters include diethoxyethyl adipate, diethyl succinate, diisopropyl adipate, diisopropyl sebacate, diethyl sebacate and the like. These can be produced by condensing an acid chloride and an alcohol in the presence of an alkali. However, since a commercially available product already exists, such a commercially available product can be purchased and used. In the external preparation for skin of the present invention, such a component is compatible with sebum, reduces the surface tension of sebum, and exerts an action of uniformly dispersing on the skin. For this reason, since unevenness of sebum wetting is less likely to occur, the optical effect of this sebum can be made inconspicuous by the light diffusion effect of the spherical powder. In order to exhibit such an effect, the dibasic acid ester can contain only one species, or can contain two or more species in combination. The preferable content of such components in the external preparation for skin of the present invention is 1 to 40% by mass, and more preferably 2 to 25% by mass, based on the total amount of external preparation for skin. This is because if the amount is too small, the sebum dispersing action may not be exhibited. If the amount is too large, the viscosity becomes too low as a physical property, and the usability may be impaired.

(2) Spherical powder that may be surface-treated, which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention contains spherical powder that may be surface-treated as an essential component It is characterized by containing. The spherical powder is preferably a true sphere, but a sphere having a fluctuation of about 10% with respect to the average diameter can also be used and belongs to the technical scope of the present invention. Further, as the constituent material, a material having high light diffusibility is preferable, for example, acrylic resin powder such as anhydrous silicic acid, alumina, calcium silicate, magnesium silicate, magnesium carbonate, calcium carbonate, methyl methacrylate, nylon powder, etc. Can be preferably exemplified. The acrylic resin powder may be hollow or solid. Further, the surface of the spherical powder may be treated. As such a surface treatment, any treatment that is usually performed on powders for external preparations for skin can be applied without any particular limitation. Examples of such surface treatment include dimethicone baking treatment, hydrogenmethylpolysiloxane baking treatment, silylation treatment with a silylating agent, phospholipid coating treatment, acylamino acid salt coating treatment, metal soap coating treatment, perfluoroalkyl phosphoric acid. A salt coating treatment can be preferably exemplified. In such processing. The amount of the treatment agent is preferably 1 to 10% by mass with respect to the total amount of the powder.

  In the external preparation for skin of the present invention, such powder has an action of making the sensation of sebum inconspicuous due to its light diffusion effect. In order to exhibit such an effect, such powder can contain only one species or a combination of two or more species. The preferable content of the spherical powder in the external preparation for skin of the present invention is 0.01 to 20% by mass, more preferably 0.1 to 15% by mass, based on the total amount of the external preparation for skin. It is. This is because if the amount is too small, the above-mentioned effect may not be achieved, and if the amount is too large, the degree of freedom of the system is lost and the stability may be impaired.

(3) Alkyl-modified carboxyvinyl polymer and / or salt thereof which is an essential component of the skin external preparation of the present invention The skin external preparation of the present invention may be an alkyl-modified carboxyvinyl as an essential component. It contains a polymer and / or a salt thereof. Here, the carboxyvinyl polymer which may be alkyl-modified is a carboxyvinyl polymer obtained by polymerizing acrylic acid or methacrylic acid containing an alkyl having 10 to 30 carbon atoms as an ester as a constituent monomer. If desired, a crosslinking monomer such as divinyl ether can be incorporated into the constituent monomer to introduce a crosslinked structure. Such alkyl-modified carboxyvinyl polymer already has a commercially available product, and such a commercially available product can be purchased and used. Preferred examples of such commercially available products include “Carbopol 1392”, “Pemlen TR-1”, “Pemlen TR-2” and the like sold by Goodrich. Further, a normal carboxyvinyl polymer which is not alkyl-modified can be used in the same manner. Among these, “Carbopol 1392” having a crosslinked structure is particularly preferable. This is because the distribution of the spherical powder and the dibasic acid ester is particularly preferable when this powder is used, and the sebum feeling can be remarkably suppressed. Examples of such salts include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium and magnesium, organic amine salts such as ammonium salt, triethanolamine salt and triethylamine salt, lysine salt and arginine. Preferred examples include basic amino acid salts such as salts. In the external preparation for skin of the present invention, the alkyl-modified carboxyvinyl polymer and / or salt thereof may contain only one species or two or more species. In the external preparation for skin of the present invention, the preferable content of the alkyl-modified carboxyvinyl polymer and / or salt thereof is 0.05 to 2% by mass based on the total amount of the external preparation for skin. More preferably, it is 0.1-1 mass%. Such an ingredient has an action of causing an appropriate amount of an external preparation for skin to be present in the skin.

(4) External preparation for skin of the present invention The external preparation for skin of the present invention contains the essential components and is applied to the skin for external use. The topical skin preparation of the present invention can be used without particular limitation as long as it is externally administered to the skin, and examples thereof include cosmetics, skin external medicines, skin external goods and the like, but are particularly preferable. Those are cosmetics, and among them, cosmetics for preventing shine due to sebum are preferable, and such effects can be expressed particularly remarkably and applied to cosmetics to be administered to the so-called T zone of the forehead and nasal muscles. It is particularly preferred.

  The external preparation for skin of the present invention can contain, in addition to the essential components, optional components that are usually used in external preparations for skin within a range that does not impair the effects of the external preparation for skin of the present invention. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oils such as hardened oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohols such as myristyl alcohol, cetostearyl alcohol, etc., cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, cetyl lactate, ethylene glycol di-2-ethylhexanoate, neopentyl dicaprate Glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylolpropane, tetra-2-ethylhexanoic acid pentane erythritol, etc. Synthetic ester oils, chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, octamethylcyclotetrasilane Oils such as silicone oils such as cyclic polysiloxanes such as xane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc. , Fatty acid soap (sodium laurate, sodium palmitate, etc.), anionic surfactants such as potassium lauryl sulfate, alkylsulfuric triethanolamine ether, and cationic interfaces such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide Activators, imidazoline amphoteric surfactants (such as 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt), betaine surfactants Sex agents (alkyl betaines, amide betaines, sulfobetaines, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate) Propylene glycol fatty acid esters (such as propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ether, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbit Fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene) Glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonyl phenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2) -Decyltetradecyl ether, etc.), tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), nonionic surfactants such as sucrose fatty acid ester, alkyl glucoside, polyethylene glycol Glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-penta Polyhydric alcohols such as diol, 2,4-hexylene glycol, 1,2-hexanediol, 1,2-octanediol, moisturizing ingredients such as sodium pyrrolidonecarboxylate, lactic acid, sodium lactate, guar gum, quince seed, Carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin sulfate, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum , Keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, dextran, kerato sulfate, locust Bean gum, succinoglucan, caronic acid, chitin, chitosan, carboxymethylchitin, agar, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, polyacrylic acid sodium, polyethylene glycol, bentonite and other thickeners, surface treated Also good, powders such as mica, talc, kaolin, synthetic mica, surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic Pigments, surface may be treated, pearl agents such as titanium mica, fish phosphorous foil, bismuth oxychloride, red 202, red 228, red 226, yellow 4 may be raked , Blue 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red Organic dyes such as No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, etc., polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, etc. Powders, paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2'- Hydroxy-5'-t-octylphenyl) benzotriazole, ultraviolet absorbers such as 4-methoxy-4'-t-butyldibenzoylmethane, lower alcohols such as ethanol and isopropanol, vitamin A or its derivatives, vitamin B6 Hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, bitami B2 or derivatives thereof, vitamin B such as vitamin B12, vitamin B15 or derivatives thereof, α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate and other vitamin E, vitamin D, vitamin H, pantothenic acid, Preferred examples include vitamins such as pantethine and pyrroloquinoline quinone.

  Among these optional components, polyhydric alcohols should be particularly limited in content. This is because polyhydric alcohol has a positive effect in terms of antiseptic power and at the same time has a negative effect in terms of prevention of shine, and when these balances are taken, it is set to about 1 to 7% by mass. It is preferable to do.

  The external preparation for skin of the present invention can be produced by treating such essential components and optional components according to a conventional method.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

According to the formulation shown below, a cosmetic for preventing shine caused by sebum (T zone cosmetic), which is an external preparation for skin of the present invention, was prepared. That is, the components of A, B, and C were each heated to 80 ° C., and added to C and dispersed, and then gradually added with B, neutralized, cooled with stirring, and T-zone cosmetic 1 was obtained. .
"Carbopol 1382" 1% aqueous solution 35% by mass
1,2-pentanediol 3% by mass
Phenoxyethanol 0.5% by mass
Xanthan gum 0.1% by mass
42.4% by weight of water
Diethoxyethyl adipate 15% by mass
2 Potassium hydroxide 10% aqueous solution 2% by mass
Ha spherical silica 1.8% by mass
Solid acrylic resin powder 0.2% by mass

<Test Example 1>
Similar to T-zone cosmetic 1, comparative example 1 in which carbopol 1382 of this product was replaced with xanthan gum, comparative example 2 in which diethoxyethyl adipate was replaced with ethanol, spherical silica and solid acrylic resin powder in mica The substituted comparative example 3 was created, and the sebum shine recovery inhibitory effect was examined. In order to suppress sebum shine, these cosmetics were applied, the foundation shown below was applied, a facial photograph was taken as an image, and a facial photograph was taken as an image two hours after makeup. Cut out the T zone from the captured image, subtract the T zone image after makeup from the T zone image before makeup, binarize it, measure the area of the black part, and divide by the area of the cut T zone Multiplying by 100, the shine rate was calculated. The results are shown in Table 1. From this, it can be seen that the cosmetic which is an external preparation for skin of the present invention has an excellent anti-shine effect.

  As shown below, the content of diethoxyethyl adipate in the T-zone cosmetic 1 was changed to examine the effect on the anti-shine effect. From this, it can be seen that the content of the dibasic acid ester is particularly preferably 2 to 25% by mass.

"Carbopol 1382" 1% aqueous solution 35% by mass
1,2-pentanediol 3% by mass
Phenoxyethanol 0.5% by mass
Xanthan gum 0.1% by mass
Water * Diethoxyethyl adipate listed in Table 2 * Potassium hydroxide 10% aqueous solution listed in Table 2 2% by mass
Ha spherical silica 1.8% by mass
Solid acrylic resin powder 0.2% by mass

  As shown below, the type of the dibasic acid ester of the T-zone cosmetic 1 was changed and examined. The results are shown in Table 3. From this, it can be seen that any dibasic acid ester exhibits the same effect. It can also be seen that particularly preferred is diethoxyethyl adipate.

"Carbopol 1382" 1% aqueous solution 35% by mass
1,2-pentanediol 3% by mass
Phenoxyethanol 0.5% by mass
Xanthan gum 0.1% by mass
42.4% by weight of water
Ingredients shown in Table 3 15% by mass
2 Potassium hydroxide 10% aqueous solution 2% by mass
Ha spherical silica 1.8% by mass
Solid acrylic resin powder 0.2% by mass

  The present invention can be applied to cosmetics for sebum control.

Claims (7)

It contains 1) an ester of a dibasic acid, 2) a surface-treated spherical powder, and 3) an alkyl-modified carboxyvinyl polymer and / or a salt thereof. , Topical skin preparation. The skin external preparation according to claim 1, wherein the dibasic acid ester is diethoxyethyl adipate. The spherical powder is one or more selected from silica, nylon, acrylic resin powder, calcium silicate, magnesium silicate, and calcium carbonate, according to claim 1 or 2. Topical skin preparation. It is a gel cosmetic, The skin external preparation of any one of Claims 1-3 characterized by the above-mentioned. The external preparation for skin according to any one of claims 1 to 4, which is a cosmetic for preventing shine due to sebum. The skin external preparation according to any one of claims 1 to 5, which is a cosmetic to be administered to the T zone. The external preparation for skin according to any one of claims 1 to 6, wherein the effect of preventing sebum has an effect of preventing shining is displayed in a packaging form.