JP2006022051A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a cosmetic that has preventing or ameliorating effect on chapped skin and slight skin irritation. <P>SOLUTION: The cosmetic comprises (A) at least one or more kinds selected from nicotinic acid, a nicotinic acid derivative, nicotinic alcohol, a nicotinic alcohol salt, (B) at least one or more kinds selected from the group consisting of a monosaccharide and an oligosaccharide and (C) one or more kinds selected from the group consisting of water-soluble film-forming polymers. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a cosmetic, and more particularly to a cosmetic that is excellent in rough skin improvement and has low irritation.

In order to prevent or improve rough skin, keratinocyte lipid synthesis promoters such as nicotinic acid, nicotinic acid derivatives, nicotinic alcohol, and nicotinic alcohol salts have been formulated.
However, for example, nicotinic acid, nicotinic acid derivatives, nicotinic alcohol, nicotinic alcohol salts, and the like may give a sense of irritation to sensitive skin such as atopic dermatitis. It could not be added to cosmetics for healthy skin, or only at low concentrations.

  The present inventors have completed the present invention as a result of diligent research in view of the above circumstances, and the purpose of the present invention is makeup that is excellent in preventing or improving rough skin and has little irritation to the skin. In providing a fee.

  The object described above is (A) at least one selected from nicotinic acid, nicotinic acid derivatives, nicotinic alcohol, and nicotinic alcohol salt, and (B) at least one selected from the group consisting of monosaccharides and oligosaccharides. This is achieved by a cosmetic comprising (C) one or more selected from the group consisting of water-soluble film-forming polymers.

  The cosmetic of the present invention is a cosmetic that is excellent in preventing or improving rough skin and has little irritation to the skin.

  Hereinafter, embodiments of the present invention will be described in detail.

  The nicotinamide, nicotinic acid derivative, nicotinic alcohol, and nicotinic alcohol salt used as the component (A) in the present invention are substances known as cosmetic raw materials.

  Specific examples of nicotinic acid derivatives include methyl nicotinic acid, ethyl nicotinic acid, benzyl nicotinic acid, nicotinamide, citric acid nicamethate, tocopherol nicotinate, quinolinic acid, pyridine 3,5-dicarboxylic acid, nicotinamide adenine dinucleotide phosphorus Examples include acids and nicotinic acid mononucleotides.

  The content of the component (A) used in the present invention is preferably from 0.01 to 10.0% by mass (hereinafter abbreviated as%), particularly preferably from 0.1 to 8 based on the total amount of the cosmetic. 0.0%. If it is 0.01% or more, the rough skin improvement and prevention effect is particularly excellent, and if it is 10.0% or less, the skin irritation reducing effect due to the synergistic effect with other components (B) and (C) is particularly high. This is remarkable and is advantageous in terms of cost.

  The monosaccharide or oligosaccharide used as the component (B) in the present invention is also a known substance as a cosmetic raw material.

  Specific examples of the component (B) include raffinose, maltitol, sorbitol, trehalose, β-lactose, glucose and the like.

  The content of the entire component (B) used in the present invention is preferably 0.01 to 20.0%, more preferably 0.1 to 10.0%, particularly preferably 0, based on the total amount of the cosmetic. .1 to 5.0%. When the content is 0.01% or more, the effect of improving and preventing rough skin and the effect of reducing irritation caused by the component (A) are particularly excellent, and 20.0% or less is advantageous in terms of cost.

  The water-soluble film-forming polymer used as the component (C) in the present invention is also a known substance as a cosmetic raw material.

  Specific examples of the component (C) include carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, gum arabic, alginic acid or a salt thereof, carrageenan, agar, guar gum, quince seed, tamarind gum, dextrin, dextran, starch, locust bean gum, Karaya gum, tragacanth gum, pectin, quince, chitosan, xanthan gum, gellan gum, hyaluronic acid or salts thereof, pullulan, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, cationized cellulose, polyacrylamide, polyvinyl Alcohol, polyvinyl pyrrolidone, etc. can be mentioned, combining one or more It can be used.

  Among these, it is preferable to use a combination of one or more selected from the group consisting of carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, carrageenan, xanthan gum, hyaluronic acid or salts thereof, methylcellulose, and polyacrylamide.

  The content of the entire component (C) used in the present invention is preferably 0.001 to 10.0%, more preferably 0.1 to 5.0%, particularly preferably 0, based on the total amount of the cosmetic. 0.1-1.0%. This is because at 0.001% or more, the effect of improving and preventing skin roughness and the effect of reducing irritation caused by the component (A) are particularly excellent, and 10.0% or less is advantageous in terms of cost.

  The content ratio of the component (A) and the component (B) is easy to form an occlusive composite film, can sufficiently exert the effect of preventing or improving the rough skin of the component (A), and the stimulation caused by the component (A) (A) :( B) = 3: 1 to 1:10 is preferable and 2: 1 to 1: 8 is more preferable in that the effect of reducing the property is excellent.

  Further, the combined content of the component (B) and the component (C) is preferably 1.0 to 5.0% based on the total amount of the cosmetic.

  The cosmetic of the present invention has the above-described components as essential components, but other components such as an anionic surfactant and an amphoteric surfactant are included in the composition as long as the object of the present invention is not impaired. Agent, nonionic surfactant, sticky agent, oil agent, powder (dye, resin, pigment), preservative, fragrance, moisturizer, physiologically active ingredient, salt, solvent, antioxidant, chelating agent, pearlizing agent Ingredients such as a neutralizer, a pH adjuster, an insect repellent, and an enzyme can be appropriately blended.

  Specific examples of other blending components are shown below, but are not limited thereto.

  Examples of the anionic surfactant include linear or branched fatty acid salts, α-acyl sulfonates, alkyl sulfonates, alkyl allyl sulfonates, alkyl naphthalene sulfonates, alkyl sulfates, alkyl ether sulfates, Alkylamide sulfate, polyoxyethylene alkyl ether sulfate, polyoxyethylene alkylamide ether sulfate, alkyl phosphate, alkylamide phosphate, alkyloylalkyl taurine salt, N-acyl amino acid salt, sulfosuccinate, Examples thereof include fluoroalkyl phosphate esters.

  Examples of amphoteric surfactants include glycine type, aminopropionic acid type, carboxybetaine type, sulfobetaine type, sulfonic acid type, sulfuric acid type, and phosphoric acid type.

  Nonionic surfactants include fatty acid alkanolamide, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkyl ester, sucrose fatty acid ester, polyglycerin fatty acid ester, alkyl An amine oxide etc. are mentioned.

  Examples of the oil agent include volatile and non-volatile oil agents, solvents, and resins that are usually used in cosmetics, and may be in the form of liquid, paste, or solid at room temperature. Examples of oils include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol, octyldodecanol, fatty acids such as isostearic acid, undecylenic acid, oleic acid, myristyl myristate, hexyl laurate, myristine Octyldodecyl acid, decyl oleate, isopropyl myristate, hexyl decyl dimethyloctanoate, glyceryl monostearate, glyceryl trioctanoate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, cholesteryl stearate, Cholesterol esters such as cholesteryl oleate and branched fatty acid cholesteryl, hydrocarbons such as liquid paraffin, petroleum jelly and squalane, lanoli Waxes such as reduced lanolin, carnauba wax, mink oil, cacao butter, palm oil, palm kernel oil, camellia oil, sesame oil, castor oil, olive oil, dimethylpolysiloxane, cyclic dimethylpolysiloxane, methylphenylpolysiloxane, etc. Silicone oil etc. are mentioned.

  Examples of powders include red No. 201, yellow No. 4, blue No. 1, black No. 401 and other dyes, yellow No. 4 Al lake, yellow No. 203 Ba lake and other lake dyes, nylon powder, silk powder and silicone powder. , Cellulose powder, silicone elastomer spherical powder, resin such as polyethylene powder, yellow iron oxide, red iron oxide, chromium oxide, carbon black, colored pigments such as ultramarine and bitumen, white pigments such as zinc oxide and titanium oxide, talc, Body pigments such as mica, sericite and kaolin, pigments such as pearl pigments such as titanium mica, metal salts such as barium sulfate, calcium carbonate, magnesium carbonate and magnesium silicate, inorganic powders such as silica and alumina, bentonite, smectite, Examples thereof include boron nitride. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, indeterminate, flake-like, spindle-like, etc.).

  Examples of the physiologically active ingredient include substances that impart some physiological activity to the skin when applied to the skin. For example, anti-aging agents, UV protection agents, squeeze agents, antioxidants, moisturizers, blood circulation promoters, antibacterial agents, bactericides, desiccants, cooling agents, warming agents, vitamins, amino acids, wound healing promoters , Stimulation mitigating agents, analgesics, cell activators, enzyme components and the like.

The cosmetic of the present invention can be produced according to a conventional method. The cosmetics of the present invention include basic cosmetics, makeup cosmetics, body cosmetics and the like. The dosage form can also be arbitrarily selected according to the purpose. That is, liquid, cream, gel, emulsion, sheet, aerosol and the like can be mentioned. The cosmetics of the present invention are not limited to general cosmetics, and include quasi drugs, designated quasi drugs, topical drugs and the like.

Examples 1-6, Comparative Examples 1-6 [lotion]
Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples. Moreover, the evaluation method of the rough skin improvement effect and irritation | stimulation reduction effect about the cosmetics obtained by the Example and the comparative example is shown below. In addition, all content is mass%. The present invention is not limited to these examples.
[Rough skin improvement effect]
Cosmetics of each composition shown in Table 1 were prepared by a conventional method. Targeting 10 sensitive skin panelists who feel rough skin on the outer side of the lower limbs, the control is applied to the lower limbs of one leg, and the cosmetics of each of the examples and comparative examples are applied to the lower limbs of the other leg. It was applied twice a day and used continuously for one week. According to the evaluation criteria shown in Table 2, the paneler himself evaluates the rough skin improvement degree of each Example / Comparative Example when compared to the rough skin improvement degree of the control application side, and the evaluation result with the total score of all the panelists did. Therefore, it shows that it is excellent in the rough skin improvement effect with respect to control, so that a score is high. The results are shown in Table 3.
[Irritation evaluation by sensitive skin panelists]
In addition, the irritation | stimulation evaluation in an Example was evaluated by the questionnaire response of 20 same sensitive skin panelers in the above-mentioned test.

The evaluation criteria are as follows.
Evaluation is based on the total score of 20 people, and the results are shown in Table 3.
[Irritation]
++++: I feel a lot of irritation (3)
++: I feel a sense of irritation (Score 2)
+: Slightly irritating (score 1)
-: I do not feel irritation (rating 0)

Examples 7-9
Hereinafter, cosmetics (Example 7: lotion, Example 8: emulsion, Example 9: cream) having the compositions shown in Tables 4 to 6 were prepared by a conventional method.

When evaluated in the same manner as in Examples 1 to 6, all the cosmetics were cosmetics that were excellent in preventing or improving rough skin and having little irritation to the skin.
Example 7 [skin lotion]

Example 8 [Emulsion]

Example 9 [Cream]

  In addition, the fragrance | flavor in the said Example used the following fragrance | flavor prescription.

  The cosmetic of the present invention is a cosmetic that is excellent in preventing or improving rough skin and has little irritation to the skin.

Claims (4)

(A) at least one or more selected from nicotinic acid, nicotinic acid derivatives, nicotinic alcohol, and nicotinic alcohol salt; and (B) at least one or more selected from the group consisting of monosaccharides and oligosaccharides; And 1) at least one selected from the group consisting of water-soluble film-forming polymers. The nicotinic acid derivative of (A) is methyl nicotinic acid, ethyl nicotinic acid, benzyl nicotinic acid, nicotinic acid amide, citric acid nicamethate, nicotinic acid tocopherol, quinolinic acid, pyridine 3,5-dicarboxylic acid, nicotinamide adenine dinucleotide phosphorus The cosmetic according to claim 1, which is an acid or nicotinic acid mononucleotide. The cosmetic according to claim 1 or 2, wherein the monosaccharide or oligosaccharide of (B) is raffinose, maltitol, sorbitol, trehalose, β-lactose, or glucose. The water-soluble film-forming polymer (C) is a carboxyvinyl polymer, an alkyl-modified carboxyvinyl polymer, gum arabic, alginic acid or a salt thereof, carrageenan, agar, guar gum, quince seed, tamarind gum, dextrin, dextran, starch, Locust bean gum, Karaya gum, tragacanth gum, pectin, quince, chitosan, xanthan gum, gellan gum, hyaluronic acid or its salts, pullulan, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, cationized cellulose, polyacryl One or more selected from the group consisting of acid amide, polyvinyl alcohol, and polyvinylpyrrolidone The cosmetic according to any one of claims 1 to 4, characterized in Rukoto.