JP2005539062A - 化合物、組成物および方法 - Google Patents
化合物、組成物および方法 Download PDFInfo
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- JP2005539062A JP2005539062A JP2004536213A JP2004536213A JP2005539062A JP 2005539062 A JP2005539062 A JP 2005539062A JP 2004536213 A JP2004536213 A JP 2004536213A JP 2004536213 A JP2004536213 A JP 2004536213A JP 2005539062 A JP2005539062 A JP 2005539062A
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- Prior art keywords
- optionally substituted
- alkyl
- compound
- hydrogen
- heteroaryl
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- C07—ORGANIC CHEMISTRY
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- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41074302P | 2002-09-13 | 2002-09-13 | |
| PCT/US2003/028696 WO2004024086A2 (en) | 2002-09-13 | 2003-09-11 | Compounds, compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005539062A true JP2005539062A (ja) | 2005-12-22 |
| JP2005539062A5 JP2005539062A5 (https=) | 2006-10-12 |
Family
ID=31994196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004536213A Pending JP2005539062A (ja) | 2002-09-13 | 2003-09-11 | 化合物、組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080312310A1 (https=) |
| EP (1) | EP1554265A4 (https=) |
| JP (1) | JP2005539062A (https=) |
| AU (1) | AU2003267169A1 (https=) |
| WO (1) | WO2004024086A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003234733B2 (en) | 2002-04-17 | 2009-01-29 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| RS50670B (sr) | 2004-05-21 | 2010-06-30 | Novartis Vaccines And Diagnostics Inc. | Supstitucionisani derivati hinolina kao mitotički kinezinski inhibitori |
| KR101170925B1 (ko) | 2004-06-18 | 2012-08-07 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 암 치료용 키네신 방추 단백질 (ksp) 억제제로서의n-(1-(1-벤질-4-페닐-1h-이미다졸-2-일)-2,2-디메틸프로필)벤자미드 유도체 및 관련 화합물 |
| CN101027309B (zh) | 2004-08-18 | 2010-10-27 | 阿斯利康(瑞典)有限公司 | 所选择的稠合嘧啶酮的对映体和在治疗和预防癌症中的用途 |
| JP2008517057A (ja) | 2004-10-19 | 2008-05-22 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | インドールおよびベンゾイミダゾール誘導体 |
| AU2007323998B2 (en) | 2006-11-13 | 2011-09-22 | Novartis Ag | Substituted pyrazole and triazole compounds as KSP inhibitors |
| AU2008205169B2 (en) | 2007-01-05 | 2012-02-02 | Novartis Ag | Imidazole derivatives as kinesin spindle protein inhibitors (Eg-5) |
| US8912244B2 (en) * | 2012-03-09 | 2014-12-16 | Protocol Environmental Solutions Inc. | Non-film forming compositions and methods of protecting cured concrete and cementitious materials |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP0046953B1 (de) * | 1980-08-30 | 1989-12-06 | Hoechst Aktiengesellschaft | Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung |
| US4434296A (en) * | 1982-05-17 | 1984-02-28 | The Upjohn Company | Process for preparing intermediates for antiatherosclerotic compounds |
| US4482558A (en) * | 1982-06-18 | 1984-11-13 | Pfizer Inc. | Antifungal amide and urea derivatives of (3-amino-2-aryl-2-hydroxyprop-1-yl)-1H-1,2,4-triazoles |
| JPS62201882A (ja) * | 1985-11-18 | 1987-09-05 | Yamanouchi Pharmaceut Co Ltd | イソフラボン誘導体 |
| IN164232B (https=) * | 1986-04-11 | 1989-02-04 | Hoechst India | |
| IL85554A0 (en) * | 1987-03-02 | 1988-08-31 | Takeda Chemical Industries Ltd | Chromone derivatives |
| JPH0753725B2 (ja) * | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
| USH1427H (en) * | 1988-04-06 | 1995-04-04 | Briet; Phillipe | Substituted flavonoid compounds, their salts, their manufacture and their use in combination with interleukin-2 |
| US5304548A (en) * | 1988-08-16 | 1994-04-19 | The Upjohn Company | Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol |
| US5180717A (en) * | 1988-08-16 | 1993-01-19 | The Upjohn Company | Bivalent ligands effective for blocking ACAT enzyme for lowering plasma triglycerides and for elevating HDL cholesterol |
| US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
| US5703075A (en) * | 1988-12-21 | 1997-12-30 | Pharmacia & Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
| US5082849A (en) * | 1989-07-13 | 1992-01-21 | Huang Fu Chich | Quinolinyl-benzopyran derivatives as antagonists of leukotriene D4 |
| US4977162A (en) * | 1989-07-13 | 1990-12-11 | Rorer Pharmaceutical Corporation | Quinolinyl-chromone derivatives and use for treatment of hypersensitive ailments |
| US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
| US5215989A (en) * | 1989-12-08 | 1993-06-01 | Merck & Co., Inc. | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents |
| AU650036B2 (en) * | 1990-07-25 | 1994-06-09 | Teijin Limited | Benzopyran derivative, production thereof, and pharmaceutical composition containing the same |
| US5605896A (en) * | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
| JPH09509428A (ja) * | 1994-02-23 | 1997-09-22 | カイロン コーポレイション | 薬理学的に活性な薬剤の血清半減期を増加させるための方法および組成物 |
| WO1995034547A1 (en) * | 1994-06-10 | 1995-12-21 | Smithkline Beecham Plc | C-4 amide substituted compounds and their use as therapeutic agents |
| US5607928A (en) * | 1994-08-05 | 1997-03-04 | Zeneca Limited | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives |
| US5602171A (en) * | 1995-06-07 | 1997-02-11 | Sugen Inc. | Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof |
| US6028088A (en) * | 1998-10-30 | 2000-02-22 | The University Of Mississippi | Flavonoid derivatives |
| US6087385A (en) * | 1998-10-30 | 2000-07-11 | University Of Mississippi | Flavonoid derivatives |
| DE19858341A1 (de) * | 1998-12-17 | 2000-06-21 | Merck Patent Gmbh | Chromanderivate |
| JP4831906B2 (ja) * | 1999-08-27 | 2011-12-07 | ケモセントリックス, インコーポレイテッド | Cxcr3機能を調節するための複素環式化合物および方法 |
| GB9920912D0 (en) * | 1999-09-03 | 1999-11-10 | Indena Spa | Novel derivatives of flavones,xanthones and coumarins |
| AU780846B2 (en) * | 1999-09-16 | 2005-04-21 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| US6545004B1 (en) * | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6559145B2 (en) * | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| US6903121B1 (en) * | 2000-08-17 | 2005-06-07 | Allergan, Inc. | Treatment of tumors with acetylenes disubstituted with a phenyl or heteroaromatic group and a substituted chromanyl, thiochromanyl or tetrahydroquinolinyl group in combination with other anti-tumor agents |
| MXPA03005152A (es) * | 2000-12-11 | 2004-10-14 | Tularik Inc | Antogonista de cxcr3. |
| JP2003286301A (ja) * | 2002-01-22 | 2003-10-10 | Omron Corp | 2段階硬化型樹脂組成物、微細賦形成形物およびその製造方法、ならびに精密機器 |
| AU2003234733B2 (en) * | 2002-04-17 | 2009-01-29 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| JP2005533119A (ja) * | 2002-07-17 | 2005-11-04 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、及び方法 |
| WO2004014388A1 (en) * | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | 6,6-fused heteroaryl derivatives as matrix metalloproteinase inhibitors |
| JP2007507539A (ja) * | 2003-10-06 | 2007-03-29 | サイトキネティクス・インコーポレーテッド | 化合物、組成物及び方法 |
| WO2005040163A1 (en) * | 2003-10-28 | 2005-05-06 | Dr. Reddy's Laboratories Ltd | Heterocyclic compounds that block the effects of advanced glycation end products (age) |
-
2003
- 2003-09-11 EP EP03749642A patent/EP1554265A4/en not_active Withdrawn
- 2003-09-11 AU AU2003267169A patent/AU2003267169A1/en not_active Abandoned
- 2003-09-11 WO PCT/US2003/028696 patent/WO2004024086A2/en not_active Ceased
- 2003-09-11 JP JP2004536213A patent/JP2005539062A/ja active Pending
-
2007
- 2007-09-27 US US11/862,993 patent/US20080312310A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080312310A1 (en) | 2008-12-18 |
| EP1554265A4 (en) | 2008-05-07 |
| WO2004024086A3 (en) | 2004-07-22 |
| AU2003267169A8 (en) | 2004-04-30 |
| WO2004024086A2 (en) | 2004-03-25 |
| AU2003267169A1 (en) | 2004-04-30 |
| EP1554265A2 (en) | 2005-07-20 |
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