JP2005535691A - 加齢性黄斑変性を有する患者における視力の保護のための酢酸アネコルタブの使用 - Google Patents
加齢性黄斑変性を有する患者における視力の保護のための酢酸アネコルタブの使用 Download PDFInfo
- Publication number
- JP2005535691A JP2005535691A JP2004526013A JP2004526013A JP2005535691A JP 2005535691 A JP2005535691 A JP 2005535691A JP 2004526013 A JP2004526013 A JP 2004526013A JP 2004526013 A JP2004526013 A JP 2004526013A JP 2005535691 A JP2005535691 A JP 2005535691A
- Authority
- JP
- Japan
- Prior art keywords
- acetate
- anecoltab
- patients
- treatment
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000004438 eyesight Effects 0.000 title claims abstract description 26
- 206010064930 age-related macular degeneration Diseases 0.000 title claims abstract description 23
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 title claims description 51
- 208000002780 macular degeneration Diseases 0.000 title abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 21
- 230000004393 visual impairment Effects 0.000 claims abstract description 21
- YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 201000004569 Blindness Diseases 0.000 claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 12
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- 231100000673 dose–response relationship Toxicity 0.000 description 2
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- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
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- 238000002428 photodynamic therapy Methods 0.000 description 2
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- 206010055665 Corneal neovascularisation Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015946 Eye irritation Diseases 0.000 description 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 description 1
- 102100033417 Glucocorticoid receptor Human genes 0.000 description 1
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- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 229960001232 anecortave Drugs 0.000 description 1
- 230000000964 angiostatic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000001772 anti-angiogenic effect Effects 0.000 description 1
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- 238000001727 in vivo Methods 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 229960004657 indocyanine green Drugs 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
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- 238000011105 stabilization Methods 0.000 description 1
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- 150000003431 steroids Chemical class 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
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- 238000002562 urinalysis Methods 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40122002P | 2002-08-05 | 2002-08-05 | |
| PCT/US2003/020154 WO2004012742A1 (en) | 2002-08-05 | 2003-06-26 | Use of anecortave acetate for the protection of visual acuity in patients with age related macular degeneration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005535691A true JP2005535691A (ja) | 2005-11-24 |
| JP2005535691A5 JP2005535691A5 (https=) | 2006-03-23 |
Family
ID=31495940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004526013A Pending JP2005535691A (ja) | 2002-08-05 | 2003-06-26 | 加齢性黄斑変性を有する患者における視力の保護のための酢酸アネコルタブの使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20040127472A1 (https=) |
| EP (1) | EP1539182A4 (https=) |
| JP (1) | JP2005535691A (https=) |
| KR (1) | KR20050026510A (https=) |
| CN (1) | CN1674913A (https=) |
| AR (1) | AR040599A1 (https=) |
| AU (1) | AU2003281817A1 (https=) |
| BR (1) | BR0313546A (https=) |
| CA (1) | CA2494211A1 (https=) |
| DE (1) | DE03742226T1 (https=) |
| ES (1) | ES2244361T1 (https=) |
| MX (1) | MXPA05000773A (https=) |
| PL (1) | PL375024A1 (https=) |
| RU (1) | RU2322239C2 (https=) |
| TW (1) | TW200410699A (https=) |
| WO (1) | WO2004012742A1 (https=) |
| ZA (1) | ZA200500731B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040127472A1 (en) * | 2002-08-05 | 2004-07-01 | Jerdan Janice A. | Use of anecortave acetate for the protection of visual acuity in patients with age related macular degeneration |
| MXPA05008396A (es) * | 2003-02-20 | 2006-03-30 | Alcon Inc | Formulaciones de glucocorticoides para tratar angiogenesis ocular patologica. |
| AU2004249256A1 (en) * | 2003-06-20 | 2004-12-29 | Alcon, Inc. | Treatment of AMD with combination of ingredients |
| CA2539023A1 (en) * | 2003-09-23 | 2005-04-14 | Alcon Inc. | Triamcinolone acetonide and anecortave acetate formulations for injection |
| US7257366B2 (en) * | 2003-11-26 | 2007-08-14 | Osmosis Llc | System and method for teaching a new language |
| WO2005110374A1 (en) * | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Intraocular drug delivery systems containing a therapeutic component, a cyclodextrin, and a polymeric component |
| US20060182783A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Sustained release intraocular drug delivery systems |
| US20070059336A1 (en) * | 2004-04-30 | 2007-03-15 | Allergan, Inc. | Anti-angiogenic sustained release intraocular implants and related methods |
| US7261529B2 (en) * | 2005-09-07 | 2007-08-28 | Southwest Research Institute | Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents |
| US7758778B2 (en) * | 2005-09-07 | 2010-07-20 | Southwest Research Institute | Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents |
| US9693967B2 (en) * | 2005-09-07 | 2017-07-04 | Southwest Research Institute | Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates |
| US20070134244A1 (en) * | 2005-10-14 | 2007-06-14 | Alcon, Inc. | Combination treatment for pathologic ocular angiogenesis |
| MX2009006146A (es) * | 2006-12-18 | 2009-06-19 | Alcon Res Ltd | Dispositivos y metodos para la administracion de farmacos oftalmicos. |
| CN101759741B (zh) * | 2008-11-06 | 2013-01-09 | 天津金耀集团有限公司 | 一种化合物及其在制备治疗血管新生的药物中的应用 |
| CN101923856B (zh) | 2009-06-12 | 2012-06-06 | 华为技术有限公司 | 语音识别训练处理、控制方法及装置 |
| US20150037422A1 (en) * | 2012-02-22 | 2015-02-05 | Trustees Of Tufts College | Compositions and methods for ocular delivery of a therapeutic agent |
| RU2489146C1 (ru) * | 2012-07-11 | 2013-08-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт глазных болезней" Российской академии медицинских наук (ФГБУ "НИИГБ" РАМН) | Способ лечения "сухой" формы возрастной макулярной дегенерации |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4876250A (en) * | 1988-10-31 | 1989-10-24 | Alcon Laboratories, Inc. | Methods for controlling ocular hypertension with angiostatic steroids |
| RU2051651C1 (ru) * | 1988-07-07 | 1996-01-10 | Институт химии поверхности АН Украины | Основа для глазных капель |
| US5371078A (en) * | 1988-10-31 | 1994-12-06 | Alcon Laboratories, Inc. | Angiostatic steroids and methods and compositions for controlling ocular hypertension |
| US5770592A (en) * | 1991-11-22 | 1998-06-23 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization using angiostatic steroids |
| US5679666A (en) * | 1991-11-22 | 1997-10-21 | Alcon Laboratories, Inc. | Prevention and treatment of ocular neovascularization by treatment with angiostatic steroids |
| ATE283013T1 (de) * | 1999-10-21 | 2004-12-15 | Alcon Inc | Medikamentenzuführvorrichtung |
| US6416777B1 (en) * | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
| US20040127472A1 (en) * | 2002-08-05 | 2004-07-01 | Jerdan Janice A. | Use of anecortave acetate for the protection of visual acuity in patients with age related macular degeneration |
| US20070134244A1 (en) * | 2005-10-14 | 2007-06-14 | Alcon, Inc. | Combination treatment for pathologic ocular angiogenesis |
-
2003
- 2003-06-26 US US10/606,501 patent/US20040127472A1/en not_active Abandoned
- 2003-06-26 PL PL03375024A patent/PL375024A1/xx unknown
- 2003-06-26 JP JP2004526013A patent/JP2005535691A/ja active Pending
- 2003-06-26 MX MXPA05000773A patent/MXPA05000773A/es not_active Application Discontinuation
- 2003-06-26 US US10/521,707 patent/US20060166956A1/en not_active Abandoned
- 2003-06-26 DE DE03742226T patent/DE03742226T1/de active Pending
- 2003-06-26 KR KR1020057001248A patent/KR20050026510A/ko not_active Ceased
- 2003-06-26 ES ES03742226T patent/ES2244361T1/es active Pending
- 2003-06-26 WO PCT/US2003/020154 patent/WO2004012742A1/en not_active Ceased
- 2003-06-26 AU AU2003281817A patent/AU2003281817A1/en not_active Abandoned
- 2003-06-26 BR BR0313546-2A patent/BR0313546A/pt not_active IP Right Cessation
- 2003-06-26 RU RU2005106234/14A patent/RU2322239C2/ru not_active IP Right Cessation
- 2003-06-26 EP EP03742226A patent/EP1539182A4/en not_active Withdrawn
- 2003-06-26 CN CNA038188260A patent/CN1674913A/zh active Pending
- 2003-06-26 CA CA002494211A patent/CA2494211A1/en not_active Abandoned
- 2003-07-07 TW TW092118474A patent/TW200410699A/zh unknown
- 2003-07-17 AR AR20030102575A patent/AR040599A1/es unknown
-
2005
- 2005-01-25 ZA ZA200500731A patent/ZA200500731B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR040599A1 (es) | 2005-04-13 |
| BR0313546A (pt) | 2005-07-12 |
| ZA200500731B (en) | 2006-08-30 |
| RU2005106234A (ru) | 2005-08-10 |
| KR20050026510A (ko) | 2005-03-15 |
| US20060166956A1 (en) | 2006-07-27 |
| AU2003281817A1 (en) | 2004-02-23 |
| MXPA05000773A (es) | 2005-04-19 |
| CN1674913A (zh) | 2005-09-28 |
| TW200410699A (en) | 2004-07-01 |
| WO2004012742A1 (en) | 2004-02-12 |
| US20040127472A1 (en) | 2004-07-01 |
| PL375024A1 (en) | 2005-11-14 |
| DE03742226T1 (de) | 2006-03-09 |
| ES2244361T1 (es) | 2005-12-16 |
| CA2494211A1 (en) | 2004-02-12 |
| EP1539182A1 (en) | 2005-06-15 |
| EP1539182A4 (en) | 2010-01-20 |
| RU2322239C2 (ru) | 2008-04-20 |
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