JP2005535343A5 - - Google Patents
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- Publication number
- JP2005535343A5 JP2005535343A5 JP2004529314A JP2004529314A JP2005535343A5 JP 2005535343 A5 JP2005535343 A5 JP 2005535343A5 JP 2004529314 A JP2004529314 A JP 2004529314A JP 2004529314 A JP2004529314 A JP 2004529314A JP 2005535343 A5 JP2005535343 A5 JP 2005535343A5
- Authority
- JP
- Japan
- Prior art keywords
- ggta
- cells
- galactose
- gene
- porcine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims description 44
- 101150042360 GGTA1 gene Proteins 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 21
- 230000002950 deficient Effects 0.000 claims description 15
- 210000000287 oocyte Anatomy 0.000 claims description 10
- 230000001605 fetal effect Effects 0.000 claims description 8
- 101000856513 Homo sapiens Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase Proteins 0.000 claims description 5
- 102100025509 Inactive N-acetyllactosaminide alpha-1,3-galactosyltransferase Human genes 0.000 claims description 5
- 230000012173 estrus Effects 0.000 claims description 5
- 230000016087 ovulation Effects 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- 230000000295 complement effect Effects 0.000 claims description 4
- 108090001090 Lectins Proteins 0.000 claims description 2
- 102000004856 Lectins Human genes 0.000 claims description 2
- 239000002523 lectin Substances 0.000 claims description 2
- 210000002950 fibroblast Anatomy 0.000 claims 7
- 210000000056 organ Anatomy 0.000 claims 7
- 108700028369 Alleles Proteins 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- 241000282898 Sus scrofa Species 0.000 claims 5
- 239000011325 microbead Substances 0.000 claims 4
- 230000000779 depleting effect Effects 0.000 claims 3
- 244000309715 mini pig Species 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- QIGJYVCQYDKYDW-SDOYDPJRSA-N alpha-D-galactosyl-(1->3)-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@@H](O)[C@@H](CO)OC(O)[C@@H]1O QIGJYVCQYDKYDW-SDOYDPJRSA-N 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- FHIVAFMUCKRCQO-UHFFFAOYSA-N diazinon Chemical group CCOP(=S)(OCC)OC1=CC(C)=NC(C(C)C)=N1 FHIVAFMUCKRCQO-UHFFFAOYSA-N 0.000 claims 2
- 210000002257 embryonic structure Anatomy 0.000 claims 2
- 241000288906 Primates Species 0.000 claims 1
- 230000001745 anti-biotin effect Effects 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 108010008279 porcine alpha-1,3-galactosyltransferase 1 Proteins 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 description 8
- 238000010186 staining Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40340502P | 2002-08-14 | 2002-08-14 | |
| PCT/US2003/025199 WO2004016742A2 (en) | 2002-08-14 | 2003-08-13 | α(1,3)-GALACTOSYLTRANSFERASE NULL CELLS, METHODS OF SELECTING AND α(1,3)-GALACTOSYLTRANSFERASE NULL SWINE PRODUCED THEREFROM |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005535343A JP2005535343A (ja) | 2005-11-24 |
| JP2005535343A5 true JP2005535343A5 (https=) | 2006-08-31 |
Family
ID=31888232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004529314A Pending JP2005535343A (ja) | 2002-08-14 | 2003-08-13 | α（１，３）−ガラクトシルトランスフェラーゼ欠損細胞、選択する方法、およびそれらから作製されたα（１，３）−ガラクトシルトランスフェラーゼ欠損ブタ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7547522B2 (https=) |
| EP (1) | EP1534066A4 (https=) |
| JP (1) | JP2005535343A (https=) |
| AU (1) | AU2003265415A1 (https=) |
| CA (1) | CA2507486A1 (https=) |
| WO (1) | WO2004016742A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020012660A1 (en) * | 1999-03-04 | 2002-01-31 | Alan Colman | Method of preparing a somatic cells for nuclear transfer |
| DK1534819T3 (da) * | 2002-08-21 | 2010-04-19 | Revivicor Inc | Griselignende dyr, som mangler enhver ekspression af funktionel alfa-1,3-galactosyltransferase |
| US7468273B2 (en) * | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
| CA2528500A1 (en) | 2003-06-06 | 2004-12-16 | University Of Pittsburgh | Porcine cmp-n-acetylneuraminic acid hydroxylase gene |
| WO2005009134A1 (en) | 2003-07-21 | 2005-02-03 | Lifecell Corporation | ACELLULAR TISSUE MATRICES MADE FROM GALACTOSE α-1,3-GALACTOSE-DEFICIENT TISSUE |
| EP1685148A2 (en) | 2003-11-05 | 2006-08-02 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | PORCINE ISOGLOBOSIDE 3 SYNTHASE PROTEIN, cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION |
| US20070269412A1 (en) | 2003-12-02 | 2007-11-22 | Celavie Biosciences, Llc | Pluripotent cells |
| CN104721883A (zh) | 2004-03-17 | 2015-06-24 | 雷维维科公司 | 来源于缺乏任何功能性α1,3半乳糖基转移酶表达的动物的组织产品 |
| JP2006129736A (ja) * | 2004-11-02 | 2006-05-25 | Nippon Dobutsu Kogaku Kenkyusho:Kk | 異種移植用豚細胞、その選抜方法及び異種移植用豚 |
| CA2909775A1 (en) | 2005-08-09 | 2007-03-29 | Revivicor, Inc. | Transgenic ungulates expressing ctla4-ig and uses thereof |
| KR100943984B1 (ko) | 2007-11-23 | 2010-02-26 | 한국생명공학연구원 | 돼지 ＧＧＴＡ１ 유전자의 발현 억제를 위한 ｓｉＲＮＡ 및이를 포함하는 발현벡터 |
| WO2010019526A1 (en) * | 2008-08-14 | 2010-02-18 | Brent Lee | Dynamic filtration device using centrifugal force |
| US20100209399A1 (en) * | 2009-02-13 | 2010-08-19 | Celavie Biosciences, Llc | Brain-derived stem cells for repair of musculoskeletal system in vertebrate subjects |
| CA3104704A1 (en) | 2009-08-14 | 2011-02-17 | Revivicor, Inc. | Multi-transgenic pigs for diabetes treatment |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| CN103492576A (zh) | 2011-02-14 | 2014-01-01 | 雷维维科公司 | 用于血管化异种移植物及其衍生物的异种移植的遗传修饰的猪 |
| JP2014520533A (ja) * | 2011-06-30 | 2014-08-25 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー | Ｃｍｐ−ｎ−アセチルノイラミン酸ヒドロキシラーゼおよび／または糖タンパク質アルファ−１，３−ガラクトシルトランスフェラーゼを欠損する細胞 |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| EP3065790B1 (en) | 2013-11-04 | 2020-10-28 | LifeCell Corporation | Methods of removing alpha-galactose |
| WO2018195402A1 (en) | 2017-04-20 | 2018-10-25 | Egenesis, Inc. | Methods for generating genetically modified animals |
| US10883084B2 (en) | 2018-10-05 | 2021-01-05 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same |
| KR20210089659A (ko) | 2018-10-05 | 2021-07-16 | 제노세라퓨틱스, 인코포레이티드 | 이종이식 생성물 및 방법 |
| EP3945799A1 (en) | 2019-03-25 | 2022-02-09 | Xenotherapeutics, Inc. | Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non- human) donor and methods and products relating to same |
| JP2023551404A (ja) | 2020-11-20 | 2023-12-08 | レビビコア， インコーポレイテッド | 異種間移植のための成長ホルモン受容体ノックアウトを有する多重トランスジェニックブタ |
| KR20240099180A (ko) | 2021-09-20 | 2024-06-28 | 레비비코르 인코포레이션 | 이종이식을 위한 10개의 유전자 변형을 포함하는 다중전이유전자 돼지 |
| US20240294869A1 (en) | 2023-03-03 | 2024-09-05 | Nugift Medical Llc | Pig xenotransplants into humans without chronic immunosuppression |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4038236B2 (ja) | 1993-03-16 | 2008-01-23 | オースチン・リサーチ・インスティテュート | 異種移植治療におけるブタＧａ１α（１，３）ガラクトシルトランスフェラーゼの使用 |
| US6331658B1 (en) | 1993-04-20 | 2001-12-18 | Integris Baptist Medical Center, Inc. | Genetically engineered mammals for use as organ donors |
| US5849991A (en) | 1994-01-27 | 1998-12-15 | Bresatch Limited | Mice homozygous for an inactivated α 1,3-galactosyl transferase gene |
| JPH09508277A (ja) | 1994-01-27 | 1997-08-26 | ブレサゲン リミテッド | ヒト異種移植における超急性拒絶の管理のための物質及び方法 |
| DE69535752D1 (de) * | 1994-04-13 | 2008-06-26 | Biotransplant Inc | Alpha(1,3)galactosyltransferase-negatives schwein |
| US6166288A (en) | 1995-09-27 | 2000-12-26 | Nextran Inc. | Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor |
| WO1997016064A1 (en) | 1995-11-03 | 1997-05-09 | The Mount Sinai Medical Center | Methods and compositions for the reduction of xenotransplantation rejection |
| WO2001088096A2 (en) | 2000-05-15 | 2001-11-22 | Geron Corporation | Ovine tissue for xenotransplantation |
-
2003
- 2003-08-13 AU AU2003265415A patent/AU2003265415A1/en not_active Abandoned
- 2003-08-13 JP JP2004529314A patent/JP2005535343A/ja active Pending
- 2003-08-13 EP EP03788393A patent/EP1534066A4/en not_active Withdrawn
- 2003-08-13 CA CA002507486A patent/CA2507486A1/en not_active Abandoned
- 2003-08-13 WO PCT/US2003/025199 patent/WO2004016742A2/en not_active Ceased
- 2003-08-13 US US10/524,381 patent/US7547522B2/en not_active Expired - Lifetime
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