JP2005535281A5 - - Google Patents
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- Publication number
- JP2005535281A5 JP2005535281A5 JP2003547592A JP2003547592A JP2005535281A5 JP 2005535281 A5 JP2005535281 A5 JP 2005535281A5 JP 2003547592 A JP2003547592 A JP 2003547592A JP 2003547592 A JP2003547592 A JP 2003547592A JP 2005535281 A5 JP2005535281 A5 JP 2005535281A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- nucleic acid
- substituted
- proline
- codon encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001413 amino acids Chemical class 0.000 claims 4
- 108020004705 Codon Proteins 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
Claims (2)
- プロリンをコードする置換された核酸コドンが、アミノ酸システインをコードする核酸コドンから15の核酸コドン内に配置される請求項1記載のポリペプチド。
- その配列内に少なくとも１つのアミノ酸が、アミノ酸プロリンに代え置換されたアミノ酸配列を含むポリペプチド。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34064801P | 2001-11-30 | 2001-11-30 | |
| PCT/EP2002/013059 WO2003046160A2 (en) | 2001-11-30 | 2002-11-21 | Methods of increasing protein expression levels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005535281A JP2005535281A (ja) | 2005-11-24 |
| JP2005535281A5 true JP2005535281A5 (ja) | 2006-01-12 |
Family
ID=23334343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003547592A Pending JP2005535281A (ja) | 2001-11-30 | 2002-11-21 | タンパク質の発現レベルを増大させるための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7258997B2 (ja) |
| EP (1) | EP1448772B1 (ja) |
| JP (1) | JP2005535281A (ja) |
| AT (1) | ATE367438T1 (ja) |
| AU (1) | AU2002338947B2 (ja) |
| CA (1) | CA2466298A1 (ja) |
| DE (1) | DE60221273D1 (ja) |
| DK (1) | DK1448772T3 (ja) |
| ES (1) | ES2290337T3 (ja) |
| IL (1) | IL162133A0 (ja) |
| PT (1) | PT1448772E (ja) |
| WO (1) | WO2003046160A2 (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005535281A (ja) * | 2001-11-30 | 2005-11-24 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | タンパク質の発現レベルを増大させるための方法 |
| EP1697414A2 (en) * | 2003-12-23 | 2006-09-06 | Applied Research Systems ARS Holding N.V. | Process for the production of tumor necrosis factor-binding proteins |
| US8722348B2 (en) * | 2008-05-28 | 2014-05-13 | Wayne State University | Method and composition for a protein transduction technology and its applications |
| WO2012151234A2 (en) | 2011-05-02 | 2012-11-08 | Wayne State University | A protein-induced pluripotent cell technology uses thereof |
| CN112245592A (zh) | 2013-10-25 | 2021-01-22 | 韦恩州立大学 | 与通过蛋白诱导的体内细胞重编程的细胞转化相关的方法、系统和组合物 |
| WO2020257655A1 (en) * | 2019-06-21 | 2020-12-24 | Kernal Biologics, Inc. | Engineered oncoselective protein expression |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59010941D1 (de) * | 1989-04-21 | 2005-03-24 | Amgen Inc | TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs |
| EP0614353A1 (en) * | 1991-11-25 | 1994-09-14 | Richardson-Vicks, Inc. | Compositions for regulating skin wrinkles and/or skin atrophy |
| IL107268A0 (en) * | 1993-10-12 | 1994-01-25 | Yeda Res & Dev | Molecules influencing the shedding of the tnf receptor, their preparation and their use |
| CA2448253A1 (en) * | 2001-05-25 | 2002-11-28 | Genset S.A. | Human cdnas and proteins and uses thereof |
| JP2005535281A (ja) * | 2001-11-30 | 2005-11-24 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | タンパク質の発現レベルを増大させるための方法 |
-
2002
- 2002-11-21 JP JP2003547592A patent/JP2005535281A/ja active Pending
- 2002-11-21 CA CA002466298A patent/CA2466298A1/en not_active Abandoned
- 2002-11-21 EP EP02777356A patent/EP1448772B1/en not_active Expired - Lifetime
- 2002-11-21 IL IL16213302A patent/IL162133A0/xx unknown
- 2002-11-21 PT PT02777356T patent/PT1448772E/pt unknown
- 2002-11-21 WO PCT/EP2002/013059 patent/WO2003046160A2/en active IP Right Grant
- 2002-11-21 AU AU2002338947A patent/AU2002338947B2/en not_active Ceased
- 2002-11-21 AT AT02777356T patent/ATE367438T1/de not_active IP Right Cessation
- 2002-11-21 DK DK02777356T patent/DK1448772T3/da active
- 2002-11-21 US US10/496,218 patent/US7258997B2/en not_active Expired - Fee Related
- 2002-11-21 DE DE60221273T patent/DE60221273D1/de not_active Expired - Lifetime
- 2002-11-21 ES ES02777356T patent/ES2290337T3/es not_active Expired - Lifetime
-
2007
- 2007-07-16 US US11/778,593 patent/US20080014635A1/en not_active Abandoned
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