JP2005533072A - 環置換されたジフェニルアゼチジノン、その製造方法、該化合物を含む医薬およびそれらの使用 - Google Patents
環置換されたジフェニルアゼチジノン、その製造方法、該化合物を含む医薬およびそれらの使用 Download PDFInfo
- Publication number
- JP2005533072A JP2005533072A JP2004514660A JP2004514660A JP2005533072A JP 2005533072 A JP2005533072 A JP 2005533072A JP 2004514660 A JP2004514660 A JP 2004514660A JP 2004514660 A JP2004514660 A JP 2004514660A JP 2005533072 A JP2005533072 A JP 2005533072A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- substituted
- conh
- cooh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 CC[N+](C)(CC)CCC(C)=* Chemical compound CC[N+](C)(CC)CCC(C)=* 0.000 description 5
- SCUYUVZFXMGTTE-UHFFFAOYSA-N COc1ccc(C(C(CCC(c(cc2)ccc2F)O)C2=O)N2c(cc2)ccc2OCc2ccc(CBr)cc2)cc1 Chemical compound COc1ccc(C(C(CCC(c(cc2)ccc2F)O)C2=O)N2c(cc2)ccc2OCc2ccc(CBr)cc2)cc1 SCUYUVZFXMGTTE-UHFFFAOYSA-N 0.000 description 1
- PTFDTWIBRQZXNG-UHFFFAOYSA-O NCC[N+]1(Cc2ccc(CC(NCc3ccc(C(C(CCC(c(cc4)ccc4F)O)C4=O)N4c(cc4)ccc4F)cc3)=O)cc2)CCCCC1 Chemical compound NCC[N+]1(Cc2ccc(CC(NCc3ccc(C(C(CCC(c(cc4)ccc4F)O)C4=O)N4c(cc4)ccc4F)cc3)=O)cc2)CCCCC1 PTFDTWIBRQZXNG-UHFFFAOYSA-O 0.000 description 1
- AFWOTISQYXZPAB-UHFFFAOYSA-N OCC(C(C(C(CNC(c(cc1)ccc1Oc(cc1)ccc1C(NCc(cc1)ccc1N(C(C1CCC(c2ccccc2)O)c2ccccc2)C1=O)=O)=O)O)O)O)O Chemical compound OCC(C(C(C(CNC(c(cc1)ccc1Oc(cc1)ccc1C(NCc(cc1)ccc1N(C(C1CCC(c2ccccc2)O)c2ccccc2)C1=O)=O)=O)O)O)O)O AFWOTISQYXZPAB-UHFFFAOYSA-N 0.000 description 1
- LIEIRVFMJMFDLW-UHFFFAOYSA-N OCC(C(C(C(CNCc1cc(COc2ccc(C(C(CCC(c(cc3)ccc3F)O)C3=O)N3c(cc3)ccc3F)cc2)ccc1)O)O)O)O Chemical compound OCC(C(C(C(CNCc1cc(COc2ccc(C(C(CCC(c(cc3)ccc3F)O)C3=O)N3c(cc3)ccc3F)cc2)ccc1)O)O)O)O LIEIRVFMJMFDLW-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M [O-]C(C(F)(F)F)=O Chemical compound [O-]C(C(F)(F)F)=O DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10227506A DE10227506A1 (de) | 2002-06-19 | 2002-06-19 | Ringsubstituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| PCT/EP2003/005815 WO2004000804A1 (de) | 2002-06-19 | 2003-06-04 | Ringsubstituierte diphenylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533072A true JP2005533072A (ja) | 2005-11-04 |
| JP2005533072A5 JP2005533072A5 (enExample) | 2006-07-13 |
Family
ID=29719281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004514660A Abandoned JP2005533072A (ja) | 2002-06-19 | 2003-06-04 | 環置換されたジフェニルアゼチジノン、その製造方法、該化合物を含む医薬およびそれらの使用 |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1517892B1 (enExample) |
| JP (1) | JP2005533072A (enExample) |
| CN (1) | CN1662493A (enExample) |
| AR (1) | AR039689A1 (enExample) |
| AT (1) | ATE478842T1 (enExample) |
| AU (1) | AU2003242616B2 (enExample) |
| BR (1) | BR0311940A (enExample) |
| CA (1) | CA2490109A1 (enExample) |
| DE (2) | DE10227506A1 (enExample) |
| EC (1) | ECSP045498A (enExample) |
| HN (1) | HN2003000183A (enExample) |
| HR (1) | HRP20041203A2 (enExample) |
| IL (1) | IL165791A0 (enExample) |
| MA (1) | MA27252A1 (enExample) |
| MX (1) | MXPA04012236A (enExample) |
| MY (1) | MY135850A (enExample) |
| NO (1) | NO20050073L (enExample) |
| NZ (1) | NZ537304A (enExample) |
| OA (1) | OA12868A (enExample) |
| PA (1) | PA8576001A1 (enExample) |
| PE (1) | PE20040577A1 (enExample) |
| PL (1) | PL372690A1 (enExample) |
| RS (1) | RS108504A (enExample) |
| RU (1) | RU2315754C2 (enExample) |
| SV (1) | SV2004001549A (enExample) |
| TN (1) | TNSN04255A1 (enExample) |
| TW (1) | TW200404774A (enExample) |
| UY (1) | UY27851A1 (enExample) |
| WO (1) | WO2004000804A1 (enExample) |
| ZA (1) | ZA200409381B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| US7447226B2 (en) * | 2003-10-31 | 2008-11-04 | International Business Machines Corporation | Methods and apparatus for continuous connectivity between mobile device and network using dynamic connection spreading |
| ATE485267T1 (de) | 2003-12-23 | 2010-11-15 | Astrazeneca Ab | Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung |
| US7700597B2 (en) | 2004-12-03 | 2010-04-20 | Schering Corporation | Substituted piperazines as CB1 antagonists |
| BRPI0609614A2 (pt) * | 2005-04-04 | 2010-04-20 | Univ Pontificia Catolica Chile | uso de ezetimiba na prevenção e tratamento de litìases de colesterol na árvore biliar |
| DE602006010870D1 (de) | 2005-06-20 | 2010-01-14 | Schering Corp | Als antagonisten von histamin h3 geeignete piperidinderivate |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| KR20090091120A (ko) * | 2006-11-02 | 2009-08-26 | 사노피-아벤티스 도이칠란트 게엠베하 | 향상된 약리학적 특성을 갖는 피페라진-1-설폰산으로 치환된 신규한 디페닐아제티디논 |
| DE102007002260A1 (de) | 2007-01-16 | 2008-07-31 | Sanofi-Aventis | Verwendung von substituierten Pyranonsäurederivaten zur Herstellung von Medikamenten zur Behandlung des Metabolischen Syndroms |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| WO2010100255A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
| CN101993403B (zh) | 2009-08-11 | 2012-07-11 | 浙江海正药业股份有限公司 | 氮杂环丁酮类化合物及医药应用 |
| SG178880A1 (en) | 2009-08-26 | 2012-04-27 | Sanofi Sa | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| BR112021002207A2 (pt) | 2018-08-10 | 2021-05-04 | Diapin Therapeutics, Llc | tri-peptídeos e tratamento de distúrbios metabólicos, cardiovasculares e inflamatórios |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
| PT877750E (pt) * | 1995-10-31 | 2002-09-30 | Schering Corp | 2-azetidinonas substituidas por acucar uteis como agentes hipocolesterolemiantes |
| DE10042447A1 (de) * | 2000-08-29 | 2002-03-28 | Aventis Pharma Gmbh | Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports |
-
2002
- 2002-06-19 DE DE10227506A patent/DE10227506A1/de not_active Withdrawn
-
2003
- 2003-01-17 HN HN2003000183A patent/HN2003000183A/es unknown
- 2003-06-02 SV SV2003001549A patent/SV2004001549A/es not_active Application Discontinuation
- 2003-06-04 AU AU2003242616A patent/AU2003242616B2/en not_active Ceased
- 2003-06-04 CN CN03814087XA patent/CN1662493A/zh active Pending
- 2003-06-04 BR BR0311940-8A patent/BR0311940A/pt not_active IP Right Cessation
- 2003-06-04 WO PCT/EP2003/005815 patent/WO2004000804A1/de not_active Ceased
- 2003-06-04 RU RU2005101091/04A patent/RU2315754C2/ru not_active IP Right Cessation
- 2003-06-04 RS YUP-1085/04A patent/RS108504A/sr unknown
- 2003-06-04 HR HR20041203A patent/HRP20041203A2/xx not_active Application Discontinuation
- 2003-06-04 DE DE50313017T patent/DE50313017D1/de not_active Expired - Lifetime
- 2003-06-04 PL PL03372690A patent/PL372690A1/xx not_active Application Discontinuation
- 2003-06-04 AT AT03760591T patent/ATE478842T1/de active
- 2003-06-04 JP JP2004514660A patent/JP2005533072A/ja not_active Abandoned
- 2003-06-04 NZ NZ537304A patent/NZ537304A/en unknown
- 2003-06-04 MX MXPA04012236A patent/MXPA04012236A/es active IP Right Grant
- 2003-06-04 EP EP03760591A patent/EP1517892B1/de not_active Expired - Lifetime
- 2003-06-04 OA OA1200400330A patent/OA12868A/en unknown
- 2003-06-04 CA CA002490109A patent/CA2490109A1/en not_active Abandoned
- 2003-06-16 UY UY27851A patent/UY27851A1/es unknown
- 2003-06-17 AR ARP030102142A patent/AR039689A1/es unknown
- 2003-06-17 TW TW092116319A patent/TW200404774A/zh unknown
- 2003-06-18 PE PE2003000613A patent/PE20040577A1/es not_active Application Discontinuation
- 2003-06-18 PA PA20038576001A patent/PA8576001A1/es unknown
- 2003-06-18 MY MYPI20032289A patent/MY135850A/en unknown
-
2004
- 2004-11-22 ZA ZA200409381A patent/ZA200409381B/xx unknown
- 2004-12-08 MA MA27990A patent/MA27252A1/fr unknown
- 2004-12-15 IL IL16579104A patent/IL165791A0/xx unknown
- 2004-12-16 EC EC2004005498A patent/ECSP045498A/es unknown
- 2004-12-17 TN TNP2004000255A patent/TNSN04255A1/en unknown
-
2005
- 2005-01-06 NO NO20050073A patent/NO20050073L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UY27851A1 (es) | 2003-12-31 |
| AR039689A1 (es) | 2005-03-09 |
| DE10227506A1 (de) | 2004-01-08 |
| DE50313017D1 (de) | 2010-10-07 |
| TW200404774A (en) | 2004-04-01 |
| HRP20041203A2 (en) | 2005-06-30 |
| IL165791A0 (en) | 2006-01-15 |
| OA12868A (en) | 2006-09-15 |
| MXPA04012236A (es) | 2005-02-25 |
| MA27252A1 (fr) | 2005-03-01 |
| NO20050073L (no) | 2005-01-06 |
| ZA200409381B (en) | 2006-05-31 |
| WO2004000804A1 (de) | 2003-12-31 |
| AU2003242616B2 (en) | 2008-12-11 |
| SV2004001549A (es) | 2004-03-19 |
| TNSN04255A1 (en) | 2007-03-12 |
| PA8576001A1 (es) | 2004-02-07 |
| ATE478842T1 (de) | 2010-09-15 |
| PE20040577A1 (es) | 2004-10-11 |
| ECSP045498A (es) | 2005-03-10 |
| HN2003000183A (es) | 2003-08-01 |
| PL372690A1 (en) | 2005-07-25 |
| EP1517892B1 (de) | 2010-08-25 |
| AU2003242616A1 (en) | 2004-01-06 |
| CN1662493A (zh) | 2005-08-31 |
| BR0311940A (pt) | 2005-04-05 |
| CA2490109A1 (en) | 2003-12-31 |
| RU2315754C2 (ru) | 2008-01-27 |
| MY135850A (en) | 2008-07-31 |
| EP1517892A1 (de) | 2005-03-30 |
| NZ537304A (en) | 2005-10-28 |
| RS108504A (sr) | 2007-02-05 |
| RU2005101091A (ru) | 2005-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060522 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060522 |
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| A762 | Written abandonment of application |
Free format text: JAPANESE INTERMEDIATE CODE: A762 Effective date: 20090811 |