JP2005521485A - 経鼻装置 - Google Patents
経鼻装置 Download PDFInfo
- Publication number
- JP2005521485A JP2005521485A JP2003579923A JP2003579923A JP2005521485A JP 2005521485 A JP2005521485 A JP 2005521485A JP 2003579923 A JP2003579923 A JP 2003579923A JP 2003579923 A JP2003579923 A JP 2003579923A JP 2005521485 A JP2005521485 A JP 2005521485A
- Authority
- JP
- Japan
- Prior art keywords
- patient
- substance
- delivery device
- nasal
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 claims abstract description 155
- 238000000034 method Methods 0.000 claims description 29
- 239000000463 material Substances 0.000 claims description 22
- 230000004044 response Effects 0.000 claims description 20
- 210000000492 nasalseptum Anatomy 0.000 claims description 7
- 230000000750 progressive effect Effects 0.000 claims description 7
- 230000008859 change Effects 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 238000001514 detection method Methods 0.000 description 19
- 230000007246 mechanism Effects 0.000 description 14
- 210000000613 ear canal Anatomy 0.000 description 9
- 239000012530 fluid Substances 0.000 description 9
- 210000001331 nose Anatomy 0.000 description 9
- 238000004891 communication Methods 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 239000002245 particle Substances 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 210000003928 nasal cavity Anatomy 0.000 description 5
- 210000002850 nasal mucosa Anatomy 0.000 description 5
- 229960005486 vaccine Drugs 0.000 description 5
- 206010028735 Nasal congestion Diseases 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 4
- 238000012864 cross contamination Methods 0.000 description 4
- 150000005828 hydrofluoroalkanes Chemical class 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 239000003380 propellant Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000009885 systemic effect Effects 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- 230000000172 allergic effect Effects 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 239000000850 decongestant Substances 0.000 description 3
- 229940124581 decongestants Drugs 0.000 description 3
- 210000000959 ear middle Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000012768 mass vaccination Methods 0.000 description 3
- 210000001989 nasopharynx Anatomy 0.000 description 3
- 210000003695 paranasal sinus Anatomy 0.000 description 3
- 150000003431 steroids Chemical class 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 206010033078 Otitis media Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 210000002534 adenoid Anatomy 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000008499 blood brain barrier function Effects 0.000 description 2
- 210000001218 blood-brain barrier Anatomy 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000001969 hypertrophic effect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000006199 nebulizer Substances 0.000 description 2
- 208000005923 otitis media with effusion Diseases 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 208000024036 serous otitis media Diseases 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000011200 topical administration Methods 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 102000055006 Calcitonin Human genes 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 206010021518 Impaired gastric emptying Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010023644 Lacrimation increased Diseases 0.000 description 1
- 208000001705 Mouth breathing Diseases 0.000 description 1
- 208000000592 Nasal Polyps Diseases 0.000 description 1
- 208000026344 Nasal disease Diseases 0.000 description 1
- 206010028741 Nasal inflammation Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 208000030880 Nose disease Diseases 0.000 description 1
- 102400000050 Oxytocin Human genes 0.000 description 1
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 description 1
- 101800000989 Oxytocin Proteins 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 206010041235 Snoring Diseases 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000009285 allergic inflammation Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000002460 anti-migrenic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 229940125683 antiemetic agent Drugs 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
- 229960004015 calcitonin Drugs 0.000 description 1
- 239000002327 cardiovascular agent Substances 0.000 description 1
- 229940125692 cardiovascular agent Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000027744 congestion Diseases 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 210000005225 erectile tissue Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000001288 gastroparesis Diseases 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000010226 intestinal metabolism Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000004317 lacrimation Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000000420 mucociliary effect Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000010352 nasal breathing Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
- 229960001723 oxytocin Drugs 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000008786 sensory perception of smell Effects 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 210000001944 turbinate Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/06—Respiratory or anaesthetic masks
- A61M16/0666—Nasal cannulas or tubing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0098—Activated by exhalation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
- A61M16/202—Controlled valves electrically actuated
- A61M16/203—Proportional
- A61M16/204—Proportional used for inhalation control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
- A61M16/202—Controlled valves electrically actuated
- A61M16/203—Proportional
- A61M16/205—Proportional used for exhalation control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
- A61M16/202—Controlled valves electrically actuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- External Artificial Organs (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
本発明の1つの目的は、患者の経鼻エアウエイに対して物質を配送するための改良された経鼻配送装置および方法を提供することにある。
Claims (47)
- 患者の経鼻エアウエイに物質を配送するための経鼻配送装置であって、
患者のそれぞれの鼻孔に適合するためのノーズピースをそれぞれが有する第1及び第2のノーズピースユニットと、
患者の経鼻エアウエイへ配送される物質を供給するための少なくとも1つの物質供給ユニットと、
前記少なくとも1つの物質供給ユニットを前記ノーズピースユニットのそれぞれに対して交互に選択的に流体的に接続するためのバルブユニットと
を備えることを特徴とする経鼻配送装置。 - 使用時に患者が排気するマウスピースを更に備える請求項1に記載の配送装置。
- 前記少なくとも1つの物質供給ユニットによって供給される物質を飛沫同伴する気体流を供給するための気体供給チャネルを更に備える請求項1または2に記載の配送装置。
- 前記マウスピースは前記気体供給チャネルに対して流体的に接続され、これにより患者の呼息によって発生された空気流は前記気体流となる請求項2に従属するときの請求項3に記載の配送装置。
- 前記気体供給チャネルを通して気体流を配送するために、前記気体供給チャネルに対して流体的に接続された気体供給ユニットを更に備える請求項3に記載の配送装置。
- 前記気体供給ユニットは、呼息により作動可能なユニットであって、患者による呼息に応じて作動されるように、前記マウスピースに対して流体的に接続されている請求項2に従属するときの請求項5に記載の配送装置。
- 前記バルブユニットは、交互に流体的に、前記ノーズピースユニットの一方を前記少なくとも1つの物質供給ユニットに対して接続し且つ前記ノーズピースユニットの他方を排気するように構成され、前記気体流が鼻中隔の後部縁を回って経鼻エアウエイを通して流れることを可能にする駆動圧力下にある場合、前記一方のノーズピースユニットを通して配送された前記気体流は、前記他方のノーズピースユニットを通して排気される請求項3〜6のいずれかに記載の配送装置。
- 前記他方のノーズピースユニットを排気する少なくとも1つのフロー抵抗体を更に備える請求項7に記載の配送装置。
- 前記フロー抵抗体は一定のフロー抵抗を有して、一定のフロー抵抗を前記気体流に与える請求項8に記載の配送装置。
- 前記フロー抵抗体は漸進性抵抗体であって、増加するフロー抵抗を前記気体流に漸進的に与える請求項8に記載の配送装置。
- 前記漸進性抵抗体は、漸進的に増加する抵抗を前記気体流に与える拡張可能な部材を備える請求項10に記載の配送装置。
- 前記第1及び第2のノーズピースユニットのそれぞれを通して物質を交互に配送するように前記バルブユニットを制御するための制御ユニットを更に備える請求項1〜11のいずれかに記載の配送装置。
- 前記第1及び第2のノーズピースユニットのそれぞれに交互に配送される物質を供給するための単一の物質供給ユニットを備える請求項1〜12のいずれかに記載の配送装置。
- 前記第1及び第2のノーズピースユニットのそれぞれに配送される物質を供給するための第1及び第2の物質供給ユニットを備える請求項1〜12のいずれかに記載の配送装置。
- 前記バルブユニットは第1及び第2のバルブを備え、各バルブは前記第1及び第2のノーズピースユニットの対応する1つに流体的に接続される請求項1〜14のいずれかに記載の配送装置。
- 患者の経鼻エアウエイに物質を配送するための方法であって、
患者のそれぞれの鼻孔に第1及び第2のノーズピースユニットを適合する工程と、
前記ノーズピースユニットのそれぞれを通して交互に物質を配送する工程とを備えることを特徴とする方法。 - 物質の配送中にマウスピースを通して排気する工程を更に備える請求項16に記載の方法。
- 物質は気体流で配送される請求項17に記載の方法。
- 前記気体流は患者の呼息によって発生された空気流である請求項18に記載の方法。
- 前記気体流は患者の呼息と分離された気体流である請求項18に記載の方法。
- 物質は前記ノーズピースユニットに対して交互に配送され、且つ前記ノーズピースユニットの他方は排気され、前記気体流が鼻中隔の後部縁を回って経鼻エアウエイを通して流れることを可能にする駆動圧力下にある場合、前記一方のノーズピースユニットを通して配送された前記気体流は、前記他方のノーズピースユニットを通して排気される請求項18〜20のいずれかに記載の方法。
- 前記気体流は1つのフロー抵抗体を通して排気される請求項21に記載の方法。
- 前記フロー抵抗体は一定のフロー抵抗を有して、一定のフロー抵抗を前記気体流に与える請求項22に記載の方法。
- 前記フロー抵抗体は漸進性抵抗体であって、漸進的に増加するフロー抵抗を前記気体流に与える請求項22に記載の方法。
- 前記漸進性抵抗体は、漸進的に増加する抵抗を前記気体流に与える拡張可能な部材を備える請求項24に記載の方法。
- 物質は単一の物質供給ユニットから供給される請求項16〜25のいずれかに記載の方法。
- 物質は前記第1及び第2の物質供給ユニットのそれぞれから前記第1及び第2のノーズピースユニットに供給される請求項16〜25のいずれかに記載の方法。
- 患者の経鼻エアウエイに物質を配送するための経鼻配送装置であって、
患者の経鼻エアウエイへ物質を配送するための少なくとも1つの配送ユニットと、
患者の経鼻エアウエイ内に変化する圧力を加えるための気体供給ユニットと
を備えることを特徴とする経鼻配送装置。 - 前記気体供給ユニットは、患者の経鼻エアウエイ内の圧力を周期的に変化させるように構成されている請求項28に記載の配送装置。
- 前記気体供給ユニットは、患者の経鼻エアウエイ内に交互に変化する圧力を与えるように構成されている請求項29に記載の配送装置。
- 使用時に患者が排気するマウスピースを更に備える請求項28〜30のいずれかに記載の配送装置。
- 前記気体供給ユニットは、呼息により作動可能なユニットであって、患者による呼息に応じて作動されるように、前記マウスピースに対して流体的に接続されている請求項31に記載の配送装置。
- 患者の経鼻エアウエイに物質を配送するための方法であって、
患者の経鼻エアウエイへ物質を配送する工程と、
患者の経鼻エアウエイ内に変化する圧力を加える工程と
を備えることを特徴とする方法。 - 患者の経鼻エアウエイ内に変化する圧力を加える工程は、患者の経鼻エアウエイ内の圧力を周期的に変化させる工程を備える請求項33に記載の方法。
- 患者の経鼻エアウエイ内に変化する圧力を加える工程は、患者の経鼻エアウエイ内の圧力を交互に変化させる工程を備える請求項34に記載の方法。
- 物質の配送中にマウスピースを通して排気する工程を更に備える請求項33〜35のいずれかに記載の方法。
- 患者の経鼻エアウエイに物質を配送するための経鼻配送装置であって、
患者の経鼻エアウエイへ物質を配送するための少なくとも1つの配送ユニットと、
患者の経鼻エアウエイを通して所定体積の気体を交互に配送および回収して、飛沫同伴された物質が患者の経鼻エアウエイを通して交互の方向に流れるようにするための気体供給ユニットと
を備えることを特徴とする経鼻配送装置。 - 使用時に患者が排気するマウスピースを更に備える請求項37に記載の配送装置。
- 患者の経鼻エアウエイに物質を配送するための方法であって、
患者の経鼻エアウエイへ物質を配送する工程と、
患者の経鼻エアウエイを通して所定体積の気体を交互に配送および回収して、飛沫同伴された物質が患者の経鼻エアウエイを通して交互の方向に流れるようにする工程と
を備えることを特徴とする方法。 - 物質の配送中にマウスピースを通して排気する工程を更に備える請求項39に記載の方法。
- 経鼻配送装置に取り付けるためのインターフェース部材であって、患者の鼻孔に適合するための少なくとも1つのノーズピースと、使用時に患者が排気するマウスピースとを、一体的な要素として備えることを特徴とするインターフェース部材。
- 患者のそれぞれの鼻孔に適合するための第1及び第2のノーズピースを備える請求項41に記載のインターフェース部材。
- 使い捨て部材である請求項41または42に記載のインターフェース部材。
- 前記マウスピースは、使用時に患者が排気する管状部を備える請求項41〜43のいずれかに記載のインターフェース部材。
- 前記マウスピースは、前記マウスピース内への呼息に応じて偏向される柔軟部材を含む請求項41〜43のいずれかに記載のインターフェース部材。
- 前記マウスピースは、使用時に患者が排気する空洞を備え、前記空洞の一部は前記柔軟部材によって規定される請求項45に記載のインターフェース部材。
- 前記柔軟部材は弾性部材を備える請求項45または46に記載のインターフェース部材。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0207422.7 | 2002-03-28 | ||
GBGB0207422.7A GB0207422D0 (en) | 2002-03-28 | 2002-03-28 | Nasal devices |
PCT/IB2003/001557 WO2003082393A1 (en) | 2002-03-28 | 2003-03-28 | Nasal devices |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009209845A Division JP2010012291A (ja) | 2002-03-28 | 2009-09-10 | 経鼻装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005521485A true JP2005521485A (ja) | 2005-07-21 |
JP4732695B2 JP4732695B2 (ja) | 2011-07-27 |
Family
ID=9933974
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003579923A Expired - Lifetime JP4732695B2 (ja) | 2002-03-28 | 2003-03-28 | 経鼻装置 |
JP2009209845A Pending JP2010012291A (ja) | 2002-03-28 | 2009-09-10 | 経鼻装置 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009209845A Pending JP2010012291A (ja) | 2002-03-28 | 2009-09-10 | 経鼻装置 |
Country Status (7)
Country | Link |
---|---|
US (1) | US8146589B2 (ja) |
EP (1) | EP1492587B1 (ja) |
JP (2) | JP4732695B2 (ja) |
AU (1) | AU2003222621A1 (ja) |
ES (1) | ES2397059T3 (ja) |
GB (2) | GB0207422D0 (ja) |
WO (1) | WO2003082393A1 (ja) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007509674A (ja) * | 2003-10-28 | 2007-04-19 | バルワー エス.アー.エス. | 流体製品スプレー装置 |
JP2007195965A (ja) * | 2006-01-09 | 2007-08-09 | Pari Gmbh Spezialisten Fuer Effektive Inhalation | エアロゾル療法デバイス |
JP2008513078A (ja) * | 2004-09-15 | 2008-05-01 | オプティノーズ アズ | 経鼻配送装置 |
JP2008259858A (ja) * | 2007-04-11 | 2008-10-30 | Pari Gmbh Spezialisten Fuer Effektive Inhalation | エアロゾル療法装置 |
US7644714B2 (en) | 2005-05-27 | 2010-01-12 | Apnex Medical, Inc. | Devices and methods for treating sleep disorders |
US7809442B2 (en) | 2006-10-13 | 2010-10-05 | Apnex Medical, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US8372071B2 (en) | 2005-08-12 | 2013-02-12 | Fujinon Corporation | High-frequency treatment tool |
US8386046B2 (en) | 2011-01-28 | 2013-02-26 | Apnex Medical, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
US8855771B2 (en) | 2011-01-28 | 2014-10-07 | Cyberonics, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
US9186511B2 (en) | 2006-10-13 | 2015-11-17 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US9205262B2 (en) | 2011-05-12 | 2015-12-08 | Cyberonics, Inc. | Devices and methods for sleep apnea treatment |
US9744354B2 (en) | 2008-12-31 | 2017-08-29 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US11383083B2 (en) | 2014-02-11 | 2022-07-12 | Livanova Usa, Inc. | Systems and methods of detecting and treating obstructive sleep apnea |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0121568D0 (en) * | 2001-09-06 | 2001-10-24 | Optinose As | Nasal delivery device |
GB0114272D0 (en) | 2001-06-12 | 2001-08-01 | Optinose As | Nasal delivery device |
WO2000051672A1 (en) * | 1999-03-03 | 2000-09-08 | Optinose As | Nasal delivery device |
ZA200306564B (en) * | 2001-02-26 | 2004-10-15 | Optinose As | Nasal devices. |
GB0207422D0 (en) | 2002-03-28 | 2002-05-08 | Optinose As | Nasal devices |
GB0209494D0 (en) * | 2002-04-25 | 2002-06-05 | Optinose As | Nasal devices |
GB0215270D0 (en) | 2002-07-02 | 2002-08-14 | Optinose As | Nasal devices |
GB0215904D0 (en) * | 2002-07-09 | 2002-08-21 | Team Holdings Uk Ltd | Drug delivery system and method |
DE10239321B3 (de) | 2002-08-27 | 2004-04-08 | Pari GmbH Spezialisten für effektive Inhalation | Aerosoltherapievorrichtung |
GB0311570D0 (en) | 2003-05-20 | 2003-06-25 | Optinose As | Delivery device and method |
GB0319119D0 (en) * | 2003-08-14 | 2003-09-17 | Optinose As | Delivery devices |
GB0320171D0 (en) | 2003-08-28 | 2003-10-01 | Optinose As | Delivery devices |
WO2005058400A1 (en) * | 2003-12-15 | 2005-06-30 | Bespak Plc | Nasal drug delivery |
GB0503738D0 (en) * | 2005-02-23 | 2005-03-30 | Optinose As | Powder delivery devices |
US10478574B2 (en) | 2006-01-19 | 2019-11-19 | Optinose As | Nasal administration |
WO2007092634A2 (en) * | 2006-02-09 | 2007-08-16 | Christy Frank L | Nasal comfort devices and methods |
WO2007093784A1 (en) * | 2006-02-14 | 2007-08-23 | Optinose As | Delivery device and method |
GB0602980D0 (en) * | 2006-02-14 | 2006-03-29 | Optinose As | Delivery device and method |
GB0604319D0 (en) * | 2006-03-03 | 2006-04-12 | Optinose As | Nasal delivery |
GB0604444D0 (en) * | 2006-03-06 | 2006-04-12 | Optinose As | Nasal devices |
GB0605799D0 (en) * | 2006-03-23 | 2006-05-03 | Optinose As | Nasal delivery devices |
GB2437488A (en) * | 2006-04-25 | 2007-10-31 | Optinose As | Pharmaceutical oily formulation for nasal or buccal administration |
GB2438834A (en) * | 2006-06-08 | 2007-12-12 | Optinose As | Intranasal protein administration |
GB2440316A (en) | 2006-07-25 | 2008-01-30 | Optinose As | Nasal inhaler with scrubber |
GB0623731D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Delivery device |
GB0623732D0 (en) | 2006-11-28 | 2007-01-10 | Optinose As | Powder delivery devices |
GB0623728D0 (en) * | 2006-11-28 | 2007-01-10 | Optinose As | Delivery devices |
WO2008091592A1 (en) | 2007-01-22 | 2008-07-31 | Targacept, Inc. | Intranasal, buccal, and sublingual administration of metanicotine analogs |
GB2448183A (en) * | 2007-04-05 | 2008-10-08 | Optinose As | Nasal powder delivery device |
GB2448193A (en) * | 2007-04-05 | 2008-10-08 | Optinose As | Nasal delivery device |
GB0719299D0 (en) | 2007-10-03 | 2007-11-14 | Optinose As | Nasal delivery devices |
ES2648196T3 (es) | 2008-02-07 | 2017-12-29 | The University Of Washington | Dispositivo aerosol circunferencial |
WO2009102976A2 (en) * | 2008-02-15 | 2009-08-20 | Timothy Sean Immel | Aerosol therapy device with high frequency delivery |
FR2938770B1 (fr) * | 2008-11-27 | 2011-08-26 | Diffusion Tech Francaise Sarl | Dispositif d'administration de gaz et d'aerosol a visee nasale ou nasosinusienne |
WO2010076713A1 (en) * | 2008-12-30 | 2010-07-08 | Koninklijke Philips Electronics, N.V. | System and respiration appliance for supporting the airway of a subject |
CN102271631B (zh) * | 2008-12-30 | 2013-12-04 | 皇家飞利浦电子股份有限公司 | 用于支撑对象气道的系统和呼吸器具 |
AU2009334353B2 (en) * | 2008-12-30 | 2015-02-12 | Koninklijke Philips Electronics, N.V. | System and respiration appliance for supporting the airway of a subject |
BRPI1012951A2 (pt) | 2009-06-09 | 2016-07-26 | Defyrus Inc | "administração de interferon para profilaxia ou tratamento de infecção por patôgeno" |
FR2954707B1 (fr) | 2009-12-28 | 2016-01-08 | Diffusion Tech Francaise Sarl | Dispositif d'administration d'aerosol par voie buccale a visee rhinopharyngee, nasale ou nasosinusienne |
GB201015371D0 (en) | 2010-09-14 | 2010-10-27 | Optinose As | Nasal delivery |
BR122021002471B8 (pt) | 2011-03-03 | 2022-10-25 | Impel Neuropharma Inc | Dispositivo de distribuição de droga nasal |
US9949923B2 (en) | 2011-03-15 | 2018-04-24 | Optinose As | Nasal delivery |
WO2012154859A1 (en) | 2011-05-09 | 2012-11-15 | Impel Neuropharma Inc. | Nozzles for nasal drug delivery |
MX352029B (es) | 2012-02-24 | 2017-11-07 | Optinose As | Dispositivos de suministro nasal. |
MX358061B (es) | 2012-02-24 | 2018-08-03 | Optinose As | Dispositivos de suministro nasal. |
US10179216B2 (en) | 2012-02-24 | 2019-01-15 | Optinose As | Nasal delivery devices |
US11554229B2 (en) | 2013-03-26 | 2023-01-17 | OptiNose Inc. | Nasal administration |
JP2016520378A (ja) | 2013-04-28 | 2016-07-14 | インペル ニューロファーマ インコーポレイテッド | 医用単位用量コンテナ |
USD761951S1 (en) | 2013-05-23 | 2016-07-19 | Optinose As | Nosepiece unit |
EP2868334B1 (de) | 2013-11-05 | 2017-01-11 | Benedict Gerber | Nasendusche |
NZ731209A (en) | 2014-10-03 | 2018-10-26 | Aut Univ | A method and apparatus for the controlled delivery of gases |
CN107106792B (zh) | 2014-11-19 | 2020-08-18 | 奥普蒂诺斯公司 | 经鼻给药 |
MX2018002895A (es) | 2015-09-10 | 2018-07-06 | Impel Neuropharma Inc | Dispositivo de administracion nasal en linea. |
BR112018009538B1 (pt) * | 2015-11-13 | 2023-02-14 | Applied Lifesciences and Systems, LLC | Sistemas para entrega de uma substância ao olho de um animal |
JP7191099B2 (ja) | 2017-11-21 | 2022-12-16 | インペル ファーマシューティカルズ インコーポレイテッド | 浸漬管を備えた鼻腔内装置 |
CN111372635B (zh) | 2017-11-21 | 2022-08-16 | 英倍尔制药公司 | 带有入口接口的鼻内装置 |
AU2019205329B2 (en) | 2018-01-05 | 2023-04-20 | Impel Pharmaceuticals Inc. | Intranasal delivery of olanzapine by precision olfactory device |
AU2019205318B2 (en) | 2018-01-05 | 2022-02-03 | Impel Pharmaceuticals Inc. | Intranasal delivery of dihydroergotamine by precision olfactory device |
WO2020018959A1 (en) | 2018-07-19 | 2020-01-23 | Impel Neuropharma, Inc. | Respiratory tract delivery of levodopa and dopa decarboxylase inhibitor for treatment of parkinson's disease |
WO2020142206A1 (en) | 2019-01-03 | 2020-07-09 | Impel Neuropharma, Inc. | Nasal drug delivery device |
BR112021023049A8 (pt) | 2019-05-17 | 2022-10-18 | Impel Neuropharma Inc | Dispositivo de dispensação nasal de uso único |
IL294485A (en) | 2020-01-22 | 2022-09-01 | Seelos Therapeutics Inc | Reduction of side effects of nmda antagonists |
WO2022241214A1 (en) | 2021-05-14 | 2022-11-17 | Seelos Therapeutics, Inc. | Methods of using nmda receptor antagonists |
WO2023135237A1 (en) | 2022-01-14 | 2023-07-20 | Cybin Irl Limited | Tryptamine compositions and methods |
WO2023156453A1 (en) | 2022-02-15 | 2023-08-24 | Cybin Irl Limited | Phenethylamine derivatives, compositions, and methods of use |
WO2023156450A1 (en) | 2022-02-15 | 2023-08-24 | Cybin Irl Limited | Therapeutic phenethylamine compositions and methods of use |
WO2023186963A1 (en) | 2022-03-31 | 2023-10-05 | Cybin Irl Limited | Combination of nitrous oxide and 5-ht2a receptor agonists |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB408856A (en) * | 1933-08-14 | 1934-04-19 | Wietske Van Seters Bosch | Improvements in and relating to inhalers |
US2078180A (en) * | 1933-10-24 | 1937-04-20 | Kronenberg Isaac Bert | Medical apparatus |
JPH1133117A (ja) * | 1997-07-15 | 1999-02-09 | Unisia Jecs Corp | 鼻腔用投薬器 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2566806A (en) * | 1949-04-09 | 1951-09-04 | A C Bonebrake | Combined atomizer and suction device |
GB2082462B (en) * | 1980-08-29 | 1984-05-23 | Tschernezky Wladimir | Apparatus for inhalation |
US5099836A (en) * | 1987-10-05 | 1992-03-31 | Hudson Respiratory Care Inc. | Intermittent oxygen delivery system and cannula |
US5134995A (en) | 1989-05-19 | 1992-08-04 | Puritan-Bennett Corporation | Inspiratory airway pressure system with admittance determining apparatus and method |
US5046491A (en) * | 1990-03-27 | 1991-09-10 | Derrick Steven J | Apparatus and method for respired gas collection and analysis |
US5271391A (en) * | 1991-12-20 | 1993-12-21 | Linda Graves | Apparatus for delivering a continuous positive airway pressure to an infant |
US5392772A (en) * | 1993-05-07 | 1995-02-28 | Zilbershtein; Michael | Endotracheal tube set for anesthesia having a valve and valve position indicator for single or double lung ventilation |
SE506208C2 (sv) * | 1995-07-05 | 1997-11-24 | Aerocrine Systems Kb | Anordning för uppsamling av gas från de övre luftvägarna och leverans av denna gas till inandningsluften i en respirator |
EP0986413B1 (en) * | 1997-05-27 | 2004-09-01 | Direct-Haler A/S | Inhaler for powdered medicaments |
WO1999019013A1 (en) * | 1997-10-09 | 1999-04-22 | Paul Viranyi | Adaptor for use with a double lumen endobronchial tube |
US6142147A (en) * | 1998-03-31 | 2000-11-07 | The General Hospital Corporation | Nasal delivery system for inhaled nitric oxide |
WO2000051672A1 (en) * | 1999-03-03 | 2000-09-08 | Optinose As | Nasal delivery device |
GB0121568D0 (en) * | 2001-09-06 | 2001-10-24 | Optinose As | Nasal delivery device |
GB0114272D0 (en) * | 2001-06-12 | 2001-08-01 | Optinose As | Nasal delivery device |
AU4687600A (en) | 1999-04-27 | 2000-11-10 | Loma Linda University Medical Center | Device and method for the administration of oxygen |
US6644305B2 (en) | 2000-04-14 | 2003-11-11 | Trudell Medical International | Nasal inhaler |
GB0015309D0 (en) * | 2000-06-21 | 2000-08-16 | Djupesland Per G | Apparatus |
ZA200306564B (en) * | 2001-02-26 | 2004-10-15 | Optinose As | Nasal devices. |
GB0207422D0 (en) | 2002-03-28 | 2002-05-08 | Optinose As | Nasal devices |
GB0209494D0 (en) * | 2002-04-25 | 2002-06-05 | Optinose As | Nasal devices |
GB0215270D0 (en) * | 2002-07-02 | 2002-08-14 | Optinose As | Nasal devices |
GB0311570D0 (en) * | 2003-05-20 | 2003-06-25 | Optinose As | Delivery device and method |
GB0320171D0 (en) * | 2003-08-28 | 2003-10-01 | Optinose As | Delivery devices |
-
2002
- 2002-03-28 GB GBGB0207422.7A patent/GB0207422D0/en not_active Ceased
-
2003
- 2003-03-28 GB GB0307213A patent/GB2389049B/en not_active Expired - Lifetime
- 2003-03-28 JP JP2003579923A patent/JP4732695B2/ja not_active Expired - Lifetime
- 2003-03-28 US US10/509,552 patent/US8146589B2/en not_active Expired - Fee Related
- 2003-03-28 EP EP03717460A patent/EP1492587B1/en not_active Expired - Lifetime
- 2003-03-28 WO PCT/IB2003/001557 patent/WO2003082393A1/en active Application Filing
- 2003-03-28 AU AU2003222621A patent/AU2003222621A1/en not_active Abandoned
- 2003-03-28 ES ES03717460T patent/ES2397059T3/es not_active Expired - Lifetime
-
2009
- 2009-09-10 JP JP2009209845A patent/JP2010012291A/ja active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB408856A (en) * | 1933-08-14 | 1934-04-19 | Wietske Van Seters Bosch | Improvements in and relating to inhalers |
US2078180A (en) * | 1933-10-24 | 1937-04-20 | Kronenberg Isaac Bert | Medical apparatus |
JPH1133117A (ja) * | 1997-07-15 | 1999-02-09 | Unisia Jecs Corp | 鼻腔用投薬器 |
Cited By (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007509674A (ja) * | 2003-10-28 | 2007-04-19 | バルワー エス.アー.エス. | 流体製品スプレー装置 |
JP4778905B2 (ja) * | 2003-10-28 | 2011-09-21 | バルワー エス.アー.エス. | 流体製品スプレー装置 |
JP2008513078A (ja) * | 2004-09-15 | 2008-05-01 | オプティノーズ アズ | 経鼻配送装置 |
US10398859B2 (en) | 2004-09-15 | 2019-09-03 | Optinose As | Nasal delivery devices |
US7644714B2 (en) | 2005-05-27 | 2010-01-12 | Apnex Medical, Inc. | Devices and methods for treating sleep disorders |
US8372071B2 (en) | 2005-08-12 | 2013-02-12 | Fujinon Corporation | High-frequency treatment tool |
JP2007195965A (ja) * | 2006-01-09 | 2007-08-09 | Pari Gmbh Spezialisten Fuer Effektive Inhalation | エアロゾル療法デバイス |
US8417343B2 (en) | 2006-10-13 | 2013-04-09 | Apnex Medical, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US8639354B2 (en) | 2006-10-13 | 2014-01-28 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US11517746B2 (en) | 2006-10-13 | 2022-12-06 | Livanova Usa, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US7809442B2 (en) | 2006-10-13 | 2010-10-05 | Apnex Medical, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US8428727B2 (en) | 2006-10-13 | 2013-04-23 | Apnex Medical, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US8498712B2 (en) | 2006-10-13 | 2013-07-30 | Apnex Medical, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US8626304B2 (en) | 2006-10-13 | 2014-01-07 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US8311645B2 (en) | 2006-10-13 | 2012-11-13 | Apnex Medical, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US8718783B2 (en) | 2006-10-13 | 2014-05-06 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US8744589B2 (en) | 2006-10-13 | 2014-06-03 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US11471685B2 (en) | 2006-10-13 | 2022-10-18 | Livanova Usa, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
USRE48024E1 (en) | 2006-10-13 | 2020-06-02 | Livanova Usa, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US9186511B2 (en) | 2006-10-13 | 2015-11-17 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
USRE48025E1 (en) | 2006-10-13 | 2020-06-02 | Livanova Usa, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US10632308B2 (en) | 2006-10-13 | 2020-04-28 | Livanova Usa, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
JP2008259858A (ja) * | 2007-04-11 | 2008-10-30 | Pari Gmbh Spezialisten Fuer Effektive Inhalation | エアロゾル療法装置 |
US10632306B2 (en) | 2008-12-31 | 2020-04-28 | Livanova Usa, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US11400287B2 (en) | 2008-12-31 | 2022-08-02 | Livanova Usa, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US10105538B2 (en) | 2008-12-31 | 2018-10-23 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US9744354B2 (en) | 2008-12-31 | 2017-08-29 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US10737094B2 (en) | 2008-12-31 | 2020-08-11 | Livanova Usa, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US11529514B2 (en) | 2011-01-28 | 2022-12-20 | Livanova Usa, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US10231645B2 (en) | 2011-01-28 | 2019-03-19 | Livanova Usa, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
US9913982B2 (en) | 2011-01-28 | 2018-03-13 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
US9555247B2 (en) | 2011-01-28 | 2017-01-31 | Cyberonics, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
US8386046B2 (en) | 2011-01-28 | 2013-02-26 | Apnex Medical, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
US9113838B2 (en) | 2011-01-28 | 2015-08-25 | Cyberonics, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
US8855771B2 (en) | 2011-01-28 | 2014-10-07 | Cyberonics, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
US11000208B2 (en) | 2011-01-28 | 2021-05-11 | Livanova Usa, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
US9757564B2 (en) | 2011-05-12 | 2017-09-12 | Cyberonics, Inc. | Devices and methods for sleep apnea treatment |
US9205262B2 (en) | 2011-05-12 | 2015-12-08 | Cyberonics, Inc. | Devices and methods for sleep apnea treatment |
US10864375B2 (en) | 2011-10-03 | 2020-12-15 | Livanova Usa, Inc. | Devices and methods for sleep apnea treatment |
US10052484B2 (en) | 2011-10-03 | 2018-08-21 | Cyberonics, Inc. | Devices and methods for sleep apnea treatment |
US11383083B2 (en) | 2014-02-11 | 2022-07-12 | Livanova Usa, Inc. | Systems and methods of detecting and treating obstructive sleep apnea |
Also Published As
Publication number | Publication date |
---|---|
AU2003222621A1 (en) | 2003-10-13 |
EP1492587A1 (en) | 2005-01-05 |
US20050235992A1 (en) | 2005-10-27 |
US8146589B2 (en) | 2012-04-03 |
JP4732695B2 (ja) | 2011-07-27 |
GB0307213D0 (en) | 2003-04-30 |
ES2397059T3 (es) | 2013-03-04 |
GB2389049B (en) | 2004-10-27 |
GB0207422D0 (en) | 2002-05-08 |
WO2003082393A1 (en) | 2003-10-09 |
EP1492587B1 (en) | 2012-10-10 |
JP2010012291A (ja) | 2010-01-21 |
GB2389049A (en) | 2003-12-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4732695B2 (ja) | 経鼻装置 | |
JP7018497B2 (ja) | 経鼻配送装置 | |
EP1363692B1 (en) | Nasal delivery devices | |
US10737045B2 (en) | Delivery devices | |
EP1988953B1 (en) | Delivery device | |
GB2402886A (en) | Nasal device with varying pressure gas supply |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060328 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090310 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090608 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090615 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090707 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090714 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090807 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090814 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090910 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20100330 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100730 Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20100730 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20101108 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20101201 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20110222 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110323 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110401 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20110421 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140428 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4732695 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |