JP2005519619A5 - - Google Patents
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- JP2005519619A5 JP2005519619A5 JP2003576594A JP2003576594A JP2005519619A5 JP 2005519619 A5 JP2005519619 A5 JP 2005519619A5 JP 2003576594 A JP2003576594 A JP 2003576594A JP 2003576594 A JP2003576594 A JP 2003576594A JP 2005519619 A5 JP2005519619 A5 JP 2005519619A5
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- JP
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- Prior art keywords
- antibody
- atcc deposit
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- number pta
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- Prior art date
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- Pending
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- 230000027455 binding Effects 0.000 claims description 29
- 241000712461 unidentified influenza virus Species 0.000 claims description 18
- 210000004408 hybridoma Anatomy 0.000 claims description 17
- 210000004027 cell Anatomy 0.000 claims description 15
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 15
- 108020004707 nucleic acids Proteins 0.000 claims description 14
- 102000039446 nucleic acids Human genes 0.000 claims description 14
- 150000007523 nucleic acids Chemical class 0.000 claims description 14
- 230000009385 viral infection Effects 0.000 claims description 11
- 239000012634 fragment Substances 0.000 claims description 8
- 206010022000 influenza Diseases 0.000 claims description 8
- 208000024891 symptom Diseases 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 claims description 3
- 238000012286 ELISA Assay Methods 0.000 claims description 2
- 241000712431 Influenza A virus Species 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 8
- 239000013604 expression vector Substances 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 101710085938 Matrix protein Proteins 0.000 claims 3
- 101710132653 Protein M2 Proteins 0.000 claims 3
- 239000003443 antiviral agent Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 206010011224 Cough Diseases 0.000 claims 2
- 206010014020 Ear pain Diseases 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 2
- 206010028735 Nasal congestion Diseases 0.000 claims 2
- 206010068319 Oropharyngeal pain Diseases 0.000 claims 2
- 208000005141 Otitis Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 201000007100 Pharyngitis Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 206010040742 Sinus congestion Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 206010006451 bronchitis Diseases 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 208000019258 ear infection Diseases 0.000 claims 2
- 206010016256 fatigue Diseases 0.000 claims 2
- 231100000869 headache Toxicity 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000004400 mucous membrane Anatomy 0.000 claims 2
- 201000009890 sinusitis Diseases 0.000 claims 2
- 230000029812 viral genome replication Effects 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 108091008324 binding proteins Proteins 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 210000000867 larynx Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 210000003800 pharynx Anatomy 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 3
- 241000699802 Cricetulus griseus Species 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36499702P | 2002-03-13 | 2002-03-13 | |
| PCT/US2003/008147 WO2003078600A2 (en) | 2002-03-13 | 2003-03-13 | Human monoclonal antibodies to influenza m2 protein and methods of making and using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005519619A JP2005519619A (ja) | 2005-07-07 |
| JP2005519619A5 true JP2005519619A5 (https=) | 2006-04-27 |
Family
ID=28041999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003576594A Pending JP2005519619A (ja) | 2002-03-13 | 2003-03-13 | インフルエンザｍ２タンパク質に対するヒトモノクローナル抗体および上記抗体を作製しかつ利用する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20030219442A1 (https=) |
| EP (1) | EP1490099A4 (https=) |
| JP (1) | JP2005519619A (https=) |
| KR (1) | KR20040111402A (https=) |
| CN (1) | CN1652815A (https=) |
| AU (1) | AU2003223285A1 (https=) |
| CA (1) | CA2478973A1 (https=) |
| TW (1) | TW200407161A (https=) |
| WO (1) | WO2003078600A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1819732A2 (en) * | 2004-12-06 | 2007-08-22 | Kirin Beer Kabushiki Kaisha | Human monoclonal antibodies to influenza m2 protein and methods of making and using same |
| GB0522460D0 (en) * | 2005-11-03 | 2005-12-14 | Prendergast Patrick T | Composition and method for the treatment of avian influenza |
| US8148085B2 (en) | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
| EP2024393A2 (en) * | 2006-05-15 | 2009-02-18 | Sea Lane Biotechnologies,llc. | Neutralizing antibodies to influenza viruses |
| US8080645B2 (en) | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
| US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
| US8652782B2 (en) | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
| US8097419B2 (en) | 2006-09-12 | 2012-01-17 | Longhorn Vaccines & Diagnostics Llc | Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009 |
| US20090098527A1 (en) * | 2006-09-12 | 2009-04-16 | Fischer Gerald W | Biological organism identification product and methods |
| WO2008110937A2 (en) * | 2007-03-13 | 2008-09-18 | Humabs Llc | Antibodies against h5n1 strains of influenza a virus |
| US9683256B2 (en) | 2007-10-01 | 2017-06-20 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system |
| US11041215B2 (en) | 2007-08-24 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | PCR ready compositions and methods for detecting and identifying nucleic acid sequences |
| AU2008293504B2 (en) | 2007-08-27 | 2012-04-12 | Longhorn Vaccines & Diagnostics, Llc | Immunogenic compositions and methods |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| US11041216B2 (en) | 2007-10-01 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples |
| CA2861667C (en) | 2007-10-01 | 2017-06-13 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system and methods of use |
| NZ585500A (en) * | 2007-11-12 | 2012-06-29 | Theraclone Sciences Inc | Antibodies which bind to an epitope in the extracellular domain of the matrix 2 ectodomain polypeptide of an influenza virus |
| US20110033476A1 (en) * | 2007-11-12 | 2011-02-10 | Theraclone Sciences Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| EP2065398A1 (en) | 2007-11-29 | 2009-06-03 | Cytos Biotechnology AG | Human monoclonal nicotine specific antibodies |
| TWI473621B (zh) * | 2008-11-12 | 2015-02-21 | Theraclone Sciences Inc | 供治療和診斷流感用之組成物和方法 |
| WO2010063675A1 (en) * | 2008-12-04 | 2010-06-10 | Cytos Biotechnology Ag | Fully human influenza m2 specific antibodies |
| WO2010110737A1 (en) * | 2009-03-23 | 2010-09-30 | Temasek Life Sciences Laboratory Limited | Monoclonal antibody against a conserved domain of m2e polypeptide in influenza viruses |
| CN101881770B (zh) * | 2009-05-08 | 2013-07-10 | 青岛农业大学 | 猪圆环病毒2型胶体金抗体快速检测试纸条的制备方法 |
| JP2012527473A (ja) * | 2009-05-20 | 2012-11-08 | セラクローン サイエンシーズ， インコーポレイテッド | インフルエンザの治療および診断のための組成物および方法 |
| ES2602971T3 (es) | 2010-03-02 | 2017-02-23 | Kyowa Hakko Kirin Co., Ltd. | Composición de anticuerpo modificado |
| WO2013112916A1 (en) | 2012-01-26 | 2013-08-01 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| EP3092007A4 (en) * | 2014-01-10 | 2017-06-07 | Allermabs Co. Ltd. | Transgenic animals capable of producing humanized ige at much higher levels than mouse ige |
| RU2682049C2 (ru) * | 2014-01-27 | 2019-03-14 | Дженентек, Инк. | Лечение вируса гриппа а h7n9 |
| WO2016183292A1 (en) | 2015-05-14 | 2016-11-17 | Longhorn Vaccines And Diagnostics, Llc | Rapid methods for the extraction of nucleic acids from biological samples |
| CN106478816B (zh) * | 2016-12-12 | 2019-08-16 | 青岛蔚蓝生物制品有限公司 | 一种抗禽流感h9n2病毒的单链抗体 |
| WO2021201677A1 (en) | 2020-04-01 | 2021-10-07 | Kiadis Pharma Intellectual Property B.V. | Compositions and methods targeting influenza |
| CN112961237B (zh) * | 2021-03-10 | 2022-03-22 | 中国计量科学研究院 | 人源化IgM单克隆抗体标准物质及制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6103243A (en) * | 1985-05-15 | 2000-08-15 | Biotechnology Australia Pty, Ltd | Oral vaccines |
| US5811128A (en) * | 1986-10-24 | 1998-09-22 | Southern Research Institute | Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor |
| US5332567A (en) * | 1989-08-24 | 1994-07-26 | Immunomedics | Detection and treatment of infections with immunoconjugates |
| US5290686A (en) * | 1991-07-31 | 1994-03-01 | The United States Of America As Represented By The Department Of Health And Human Services | Expression of influenza a M2 protein in baculovirus |
| US5240694A (en) * | 1991-09-23 | 1993-08-31 | University Of Virginia | Combined antiviral and antimediator treatment of common colds |
| US5686078A (en) * | 1992-09-14 | 1997-11-11 | Connaught Laboratories, Inc. | Primary and secondary immunization with different physio-chemical forms of antigen |
| EP0678034B1 (en) * | 1993-01-11 | 1999-05-26 | Dana Farber Cancer Institute | Inducing cytotoxic t lymphocyte responses |
| WO1994015640A1 (en) * | 1993-01-12 | 1994-07-21 | Anthony George Gristina | Methods and compositions for the direct concentrated delivery of passive immunity |
| JP2996864B2 (ja) * | 1994-03-30 | 2000-01-11 | 寳酒造株式会社 | 抗体可変領域ｄｎａ |
| US6096291A (en) * | 1996-12-27 | 2000-08-01 | Biovector Therapeutics, S.A. | Mucosal administration of substances to mammals |
| ES2255181T3 (es) * | 1997-08-05 | 2006-06-16 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Antigeno inmunoprotector contra la gripe y su uso en vacunacion. |
| US6169175B1 (en) * | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| WO2000032626A1 (en) * | 1998-11-25 | 2000-06-08 | Regents Of The University Of Minnesota | Methods of using epitope peptides of human pathogens |
| DE60043708D1 (de) * | 1999-10-13 | 2010-03-04 | Novartis Vaccines & Diagnostic | Verfahren zur erhaltung zellimmuneantworten gegen proteinen |
-
2003
- 2003-03-13 KR KR10-2004-7014352A patent/KR20040111402A/ko not_active Ceased
- 2003-03-13 CA CA002478973A patent/CA2478973A1/en not_active Abandoned
- 2003-03-13 WO PCT/US2003/008147 patent/WO2003078600A2/en not_active Ceased
- 2003-03-13 CN CNA03810797XA patent/CN1652815A/zh active Pending
- 2003-03-13 AU AU2003223285A patent/AU2003223285A1/en not_active Abandoned
- 2003-03-13 TW TW092105484A patent/TW200407161A/zh unknown
- 2003-03-13 US US10/389,221 patent/US20030219442A1/en not_active Abandoned
- 2003-03-13 JP JP2003576594A patent/JP2005519619A/ja active Pending
- 2003-03-13 EP EP03719398A patent/EP1490099A4/en not_active Withdrawn
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