JP2005511708A5 - - Google Patents
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- Publication number
- JP2005511708A5 JP2005511708A5 JP2003550646A JP2003550646A JP2005511708A5 JP 2005511708 A5 JP2005511708 A5 JP 2005511708A5 JP 2003550646 A JP2003550646 A JP 2003550646A JP 2003550646 A JP2003550646 A JP 2003550646A JP 2005511708 A5 JP2005511708 A5 JP 2005511708A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- drug
- cyclodextrin
- composition according
- nitrosothiol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 229920000858 Cyclodextrin Polymers 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 4
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical group O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 3
- ICRHORQIUXBEPA-UHFFFAOYSA-N thionitrous acid Chemical compound SN=O ICRHORQIUXBEPA-UHFFFAOYSA-N 0.000 claims 3
- -1 alkyl nitrite Chemical compound 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- QQZWEECEMNQSTG-UHFFFAOYSA-N Ethyl nitrite Chemical group CCON=O QQZWEECEMNQSTG-UHFFFAOYSA-N 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 239000002840 nitric oxide donor Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 229940124549 vasodilator Drugs 0.000 claims 1
- 239000003071 vasodilator agent Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33617501P | 2001-12-06 | 2001-12-06 | |
| PCT/US2002/036138 WO2003049593A2 (en) | 2001-12-06 | 2002-12-02 | Prevention of flap necrosis in plastic surgery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009275959A Division JP5266191B2 (ja) | 2001-12-06 | 2009-12-03 | 形成外科における組織弁壊死の予防 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005511708A JP2005511708A (ja) | 2005-04-28 |
| JP2005511708A5 true JP2005511708A5 (https=) | 2006-01-26 |
| JP4563679B2 JP4563679B2 (ja) | 2010-10-13 |
Family
ID=23314894
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003550646A Expired - Fee Related JP4563679B2 (ja) | 2001-12-06 | 2002-12-02 | 形成外科における組織弁壊死の予防 |
| JP2009275959A Expired - Fee Related JP5266191B2 (ja) | 2001-12-06 | 2009-12-03 | 形成外科における組織弁壊死の予防 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009275959A Expired - Fee Related JP5266191B2 (ja) | 2001-12-06 | 2009-12-03 | 形成外科における組織弁壊死の予防 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060153931A1 (https=) |
| EP (1) | EP1463440B1 (https=) |
| JP (2) | JP4563679B2 (https=) |
| AT (1) | ATE450187T1 (https=) |
| AU (1) | AU2002365036B2 (https=) |
| CA (1) | CA2467245A1 (https=) |
| DE (1) | DE60234642D1 (https=) |
| WO (1) | WO2003049593A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9226909B2 (en) | 2004-04-19 | 2016-01-05 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| WO2005102307A2 (en) | 2004-04-19 | 2005-11-03 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| KR101643797B1 (ko) | 2009-06-24 | 2016-07-28 | 스트러티직 사이언스 앤드 테크놀로지스, 엘엘씨 | 이부프로펜을 함유하는 국소 조성물 |
| US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| US12138268B2 (en) | 2009-06-24 | 2024-11-12 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| WO2010151241A1 (en) | 2009-06-24 | 2010-12-29 | Strategic Science & Technologies, Llc | Topical composition containing naproxen |
| EP4491225A3 (en) | 2010-12-29 | 2025-03-26 | Strategic Science & Technologies, LLC | Treatment of erectile dysfunction and other indications |
| JP2014501283A (ja) | 2010-12-29 | 2014-01-20 | ストラテジック サイエンス アンド テクノロジーズ， エルエルシー | アレルギーおよび他の適応症の処置のためのシステムおよび方法 |
| WO2020185674A1 (en) * | 2019-03-08 | 2020-09-17 | South Dakota Board Of Regents | A vasoactive topical compound to affect tissue blood flow, reduce tissue necrosis and promote healing |
| CN112843241B (zh) * | 2021-01-14 | 2023-07-25 | 中国药科大学 | 可生物响应的一氧化氮供体型聚合物前药及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5300302A (en) * | 1990-10-04 | 1994-04-05 | Nestec S.A. | Pharmaceutical composition in gel form in a dispensing package |
| JP2599031B2 (ja) * | 1990-11-30 | 1997-04-09 | 宇部興産株式会社 | 高純度亜硝酸アルキルエステルの製造法 |
| JP3211892B2 (ja) * | 1994-05-27 | 2001-09-25 | セイジィ ファーマスーティカルス インコーポレーテッド | 肛門疾患を治療する窒素酸化物供与体及び方法 |
| US6232434B1 (en) * | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US5770645A (en) * | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US5797887A (en) * | 1996-08-27 | 1998-08-25 | Novovasc Llc | Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation |
| AU750295B2 (en) * | 1997-05-02 | 2002-07-11 | Baxter Biotech Technology S.A.R.L. | Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging |
| JP2002542147A (ja) * | 1998-12-14 | 2002-12-10 | セレジィ ファーマシューティカルス， インコーポレイテッド | 肛門直腸障害の処置のための組成物および方法 |
| WO2000054773A1 (en) * | 1999-03-12 | 2000-09-21 | Nitromed, Inc. | Dopamine agonists in combination with nitric oxide donors, compositions and methods of use |
| US6359182B1 (en) * | 2000-10-26 | 2002-03-19 | Duke University | C-nitroso compounds and use thereof |
-
2002
- 2002-12-02 JP JP2003550646A patent/JP4563679B2/ja not_active Expired - Fee Related
- 2002-12-02 CA CA002467245A patent/CA2467245A1/en not_active Abandoned
- 2002-12-02 EP EP02804687A patent/EP1463440B1/en not_active Expired - Lifetime
- 2002-12-02 DE DE60234642T patent/DE60234642D1/de not_active Expired - Lifetime
- 2002-12-02 AT AT02804687T patent/ATE450187T1/de not_active IP Right Cessation
- 2002-12-02 US US10/521,394 patent/US20060153931A1/en not_active Abandoned
- 2002-12-02 AU AU2002365036A patent/AU2002365036B2/en not_active Ceased
- 2002-12-02 WO PCT/US2002/036138 patent/WO2003049593A2/en not_active Ceased
-
2009
- 2009-12-03 JP JP2009275959A patent/JP5266191B2/ja not_active Expired - Fee Related
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