JP2005507648A5 - - Google Patents

Info

Publication number

JP2005507648A5

JP2005507648A5 JP2003514007A JP2003514007A JP2005507648A5 JP 2005507648 A5 JP2005507648 A5 JP 2005507648A5 JP 2003514007 A JP2003514007 A JP 2003514007A JP 2003514007 A JP2003514007 A JP 2003514007A JP 2005507648 A5 JP2005507648 A5 JP 2005507648A5

Authority

JP

Japan

Prior art keywords

polypeptide

compound

nucleic acid

ntb

activity

Prior art date

2002-07-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 22
• 229920001184 polypeptide Polymers 0.000 claims 21
• 102000004196 processed proteins & peptides Human genes 0.000 claims 21
• 108090000765 processed proteins & peptides Proteins 0.000 claims 21
• 108020004707 nucleic acids Proteins 0.000 claims 14
• 102000039446 nucleic acids Human genes 0.000 claims 14
• 150000007523 nucleic acids Chemical class 0.000 claims 14
• 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 claims 12
• 102100029197 SLAM family member 6 Human genes 0.000 claims 10
• 238000000034 method Methods 0.000 claims 10
• 230000000694 effects Effects 0.000 claims 7
• 210000004027 cell Anatomy 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 238000012216 screening Methods 0.000 claims 5
• 150000001413 amino acids Chemical class 0.000 claims 3
• 230000000295 complement effect Effects 0.000 claims 3
• 210000000822 natural killer cell Anatomy 0.000 claims 3
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000002773 nucleotide Substances 0.000 claims 2
• 125000003729 nucleotide group Chemical group 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 1
• 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 230000004075 alteration Effects 0.000 claims 1
• 210000000628 antibody-producing cell Anatomy 0.000 claims 1
• 230000006037 cell lysis Effects 0.000 claims 1
• 230000001461 cytolytic effect Effects 0.000 claims 1
• 230000004064 dysfunction Effects 0.000 claims 1
• 102000046571 human SLAMF6 Human genes 0.000 claims 1
• 230000036737 immune function Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 230000003993 interaction Effects 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 239000002853 nucleic acid probe Substances 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 239000000523 sample Substances 0.000 claims 1
• 238000000926 separation method Methods 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1