JP2005506346A5 - - Google Patents
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- Publication number
- JP2005506346A5 JP2005506346A5 JP2003535724A JP2003535724A JP2005506346A5 JP 2005506346 A5 JP2005506346 A5 JP 2005506346A5 JP 2003535724 A JP2003535724 A JP 2003535724A JP 2003535724 A JP2003535724 A JP 2003535724A JP 2005506346 A5 JP2005506346 A5 JP 2005506346A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- phenyl
- phenylalkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCCC(C[C@]1**C(C)C1)C(*)=C Chemical compound CCCC(C[C@]1**C(C)C1)C(*)=C 0.000 description 5
- CFSFEIZUJGTCRB-UHFFFAOYSA-N CC1CC(C2)C2C1 Chemical compound CC1CC(C2)C2C1 CFSFEIZUJGTCRB-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/982,123 US6531467B2 (en) | 1996-09-12 | 2001-10-16 | Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors |
| US10/007,632 US6610683B2 (en) | 1996-09-12 | 2001-11-13 | Treatment of infectious disease using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors |
| PCT/US2002/033157 WO2003032918A2 (en) | 2001-10-16 | 2002-10-16 | Treatment of infectious disease using interleukin-1 beta converting enzyme (ice)/ced-3 family inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005506346A JP2005506346A (ja) | 2005-03-03 |
| JP2005506346A5 true JP2005506346A5 (https=) | 2006-01-05 |
Family
ID=26677222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003535724A Pending JP2005506346A (ja) | 2001-10-16 | 2002-10-16 | インターロイキン−１β−変換酵素（ＩＣＥ）／ＣＥＤ−３ファミリーインヒビターを使用する感染症の治療 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6610683B2 (https=) |
| EP (1) | EP1443935A4 (https=) |
| JP (1) | JP2005506346A (https=) |
| AU (1) | AU2002357660A1 (https=) |
| CA (1) | CA2463729A1 (https=) |
| WO (1) | WO2003032918A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6184244B1 (en) * | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| CA2534352A1 (en) * | 2003-08-08 | 2005-02-17 | Arriva Pharmaceuticals, Inc. | Methods of protein production in yeast |
| EP1672681B8 (en) * | 2003-10-08 | 2011-09-21 | Miyagi Nikon Precision Co., Ltd. | Exposure apparatus, substrate carrying method, exposure method, and method for producing device |
| JP2007511539A (ja) * | 2003-11-14 | 2007-05-10 | バクスター・インターナショナル・インコーポレイテッド | α１−抗トリプシン組成物およびこのような組成物を用いた処置方法 |
| CA2559062A1 (en) * | 2004-03-09 | 2005-09-22 | Arriva Pharmaceuticals, Inc. | Treatment of chronic obstructive pulmonary disease by low dose inhalation of protease inhibitor |
| MXPA06013256A (es) | 2004-05-15 | 2007-02-08 | Vertex Pharma | Tratamiento de crisis convulsivas utilizando inhibidores ice. |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| CA2567080A1 (en) | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
| US7384558B2 (en) * | 2004-07-26 | 2008-06-10 | Baxter International Inc. | Compositions capable of inhibiting reactive oxygen and carbonyl species |
| US20060073504A1 (en) * | 2004-09-20 | 2006-04-06 | The Regents Of The University Of California | Treatment of pain by inhibition of caspase signaling |
| US20070105768A1 (en) * | 2004-11-10 | 2007-05-10 | Rajiv Nayar | Dry recombinant human alpha 1-antitrypsin formulation |
| US8410149B2 (en) | 2004-12-06 | 2013-04-02 | Siga Technologies Inc. | Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| CA2590962A1 (en) * | 2004-12-06 | 2006-06-15 | Siga Technologies, Inc. | Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| US7994221B2 (en) | 2004-12-06 | 2011-08-09 | Siga Technologies, Inc. | Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses |
| WO2008045017A2 (en) * | 2005-06-22 | 2008-04-17 | Diamond Scott L | Sars and ebola inhibitors and use thereof, and methods for their discovery |
| CN101034257B (zh) * | 2007-04-06 | 2010-09-08 | 上海复旦天臣新技术有限公司 | 用于全息记录的感光薄膜及其制备方法 |
| US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
| CN103196739A (zh) * | 2013-04-10 | 2013-07-10 | 哈尔滨体育学院 | 一种优秀冰雪运动员肌细胞凋亡鉴定方法 |
| CN107029221A (zh) * | 2017-01-26 | 2017-08-11 | 上海交通大学 | 胱氨酸蛋白酶抑制剂在制备防治紫外光诱导的皮肤损伤药物、保健品及各种制剂中的应用 |
| KR20240132016A (ko) * | 2021-12-08 | 2024-09-02 | 사이토사이트 바이오파마 인코포레이티드 | 그랜자임 b에 특이적인 화합물 및 그의 용도 |
| KR20240116797A (ko) * | 2021-12-08 | 2024-07-30 | 사이토사이트 바이오파마 인코포레이티드 | 그랜자임 b에 특이적인 화합물에 대한 전구약물 및 그의 용도 |
| TW202508601A (zh) * | 2023-06-07 | 2025-03-01 | 美商塞托賽特生物製藥股份有限公司 | 對顆粒酶ｂ具有特異性之化合物之前驅藥及其用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| WO1991015577A1 (en) | 1990-04-04 | 1991-10-17 | Black, Roy, A. | INTERLEUKIN 1'beta' PROTEASE |
| AU657701B2 (en) | 1991-08-30 | 1995-03-23 | Vertex Pharmaceuticals Incorporated | Interleukin 1beta protease and interleukin 1beta protease inhibitors |
| EP0547699A1 (en) | 1991-12-19 | 1993-06-23 | Merck & Co. Inc. | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme |
| US5514694A (en) * | 1992-09-21 | 1996-05-07 | Georgia Tech Research Corp | Peptidyl ketoamides |
| US5504080A (en) | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
| EP0706525A1 (en) | 1993-06-30 | 1996-04-17 | Novartis AG | Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ace |
| KR20000036056A (ko) * | 1996-09-12 | 2000-06-26 | 아이디유엔 파마슈티칼즈, 인코포레이티드 | 인터루킨-1β 전환 효소 및 관련 프로테아제의 억제제로서의 Ｃ-말단 변형된 (Ｎ-치환된)-2-인돌릴 디펩티드 |
| NZ330451A (https=) * | 1996-09-12 | 2000-01-28 | Idun Pharmaceuticals Inc | |
| US5869519A (en) * | 1996-12-16 | 1999-02-09 | Idun Pharmaceuticals, Inc. | C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US5968927A (en) * | 1996-09-20 | 1999-10-19 | Idun Pharmaceuticals, Inc. | Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes |
| US6184244B1 (en) * | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| FR2775594B1 (fr) * | 1998-03-06 | 2002-12-27 | Oreal | Utilisation d'un compose inhibant l'activite d'un canal sodium ou d'un canal calcium dans une composition a usage topique |
-
2001
- 2001-11-13 US US10/007,632 patent/US6610683B2/en not_active Expired - Lifetime
-
2002
- 2002-07-29 US US10/208,729 patent/US6693096B2/en not_active Expired - Lifetime
- 2002-10-16 AU AU2002357660A patent/AU2002357660A1/en not_active Abandoned
- 2002-10-16 EP EP02792195A patent/EP1443935A4/en not_active Withdrawn
- 2002-10-16 WO PCT/US2002/033157 patent/WO2003032918A2/en not_active Ceased
- 2002-10-16 CA CA002463729A patent/CA2463729A1/en not_active Abandoned
- 2002-10-16 JP JP2003535724A patent/JP2005506346A/ja active Pending
-
2003
- 2003-09-02 US US10/653,607 patent/US20040058850A1/en not_active Abandoned
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