JP2005504770A5 - - Google Patents
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- Publication number
- JP2005504770A5 JP2005504770A5 JP2003521232A JP2003521232A JP2005504770A5 JP 2005504770 A5 JP2005504770 A5 JP 2005504770A5 JP 2003521232 A JP2003521232 A JP 2003521232A JP 2003521232 A JP2003521232 A JP 2003521232A JP 2005504770 A5 JP2005504770 A5 JP 2005504770A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- following formula
- haloalkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 50
- 125000000217 alkyl group Chemical group 0.000 claims 41
- 229910052736 halogen Inorganic materials 0.000 claims 14
- 150000002367 halogens Chemical class 0.000 claims 14
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 11
- 229910052802 copper Inorganic materials 0.000 claims 11
- 239000010949 copper Substances 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000001475 halogen functional group Chemical group 0.000 claims 7
- 239000012351 deprotecting agent Substances 0.000 claims 6
- 239000002904 solvent Substances 0.000 claims 6
- 239000002738 chelating agent Substances 0.000 claims 5
- 230000008878 coupling Effects 0.000 claims 4
- 238000010168 coupling process Methods 0.000 claims 4
- 238000005859 coupling reaction Methods 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 150000001412 amines Chemical class 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 150000003456 sulfonamides Chemical class 0.000 claims 3
- GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 claims 2
- -1 -OH Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 2
- 229940125758 compound 15 Drugs 0.000 claims 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical compound [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 125000001033 ether group Chemical group 0.000 claims 2
- 150000003459 sulfonic acid esters Chemical class 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical group N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 229940125773 compound 10 Drugs 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000005561 phenanthryl group Chemical group 0.000 claims 1
- 239000003223 protective agent Substances 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 0 *NCc1ccccc1 Chemical compound *NCc1ccccc1 0.000 description 2
- DIDKWCOCQJWMDJ-UHFFFAOYSA-N Oc(c1ncccc11)c(C(NCc(cc2)ccc2F)=O)nc1N(CCCC1)S1(=O)=O Chemical compound Oc(c1ncccc11)c(C(NCc(cc2)ccc2F)=O)nc1N(CCCC1)S1(=O)=O DIDKWCOCQJWMDJ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31337601P | 2001-08-17 | 2001-08-17 | |
| PCT/US2002/027151 WO2003016309A1 (en) | 2001-08-17 | 2002-08-13 | Process for preparing 5-sulfonamido-8-hydroxy-1, 6-naphthyridine-7-carboxamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005504770A JP2005504770A (ja) | 2005-02-17 |
| JP2005504770A5 true JP2005504770A5 (cg-RX-API-DMAC7.html) | 2006-01-05 |
Family
ID=23215476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003521232A Withdrawn JP2005504770A (ja) | 2001-08-17 | 2002-08-13 | ５−スルホンアミド−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミドの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050014780A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1427726A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2005504770A (cg-RX-API-DMAC7.html) |
| AR (1) | AR036352A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2456155A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2003016309A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE430745T1 (de) | 2000-10-12 | 2009-05-15 | Merck & Co Inc | Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase |
| EP2210892A3 (en) | 2002-10-04 | 2010-10-27 | Prana Biotechnology Limited | Neurologically-active compounds |
| DE602004021611D1 (de) | 2003-09-19 | 2009-07-30 | Gilead Sciences Inc | Azachinolinolphosphonatverbindungen als integraseinhibitoren |
| EP1888581A2 (en) * | 2005-05-16 | 2008-02-20 | Gilead Sciences, Inc. | Hiv-integrase inhibitor compounds |
| JP5290147B2 (ja) | 2006-04-14 | 2013-09-18 | プラナ バイオテクノロジー リミティッド | 加齢黄斑変性症（ａｍｄ）の処置方法 |
| EP3313420B1 (en) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
| AU2017235461B2 (en) | 2016-03-15 | 2023-02-23 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
| TW202334089A (zh) | 2021-11-02 | 2023-09-01 | 美商夫雷爾醫療公司 | Ｐｐａｒｇ反向激動劑及其用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH214351A (de) * | 1938-08-30 | 1941-04-15 | Cilag Chemisches Ind Lab A G | Verfahren zur Darstellung eines Derivates des 2-Aminopyridins. |
| ATE430745T1 (de) * | 2000-10-12 | 2009-05-15 | Merck & Co Inc | Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase |
-
2002
- 2002-08-13 CA CA002456155A patent/CA2456155A1/en not_active Abandoned
- 2002-08-13 EP EP02763531A patent/EP1427726A1/en not_active Withdrawn
- 2002-08-13 JP JP2003521232A patent/JP2005504770A/ja not_active Withdrawn
- 2002-08-13 WO PCT/US2002/027151 patent/WO2003016309A1/en not_active Ceased
- 2002-08-13 US US10/486,535 patent/US20050014780A1/en not_active Abandoned
- 2002-08-15 AR ARP020103083A patent/AR036352A1/es unknown