JP2005348929A - Inhalator - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an inhalator capable of milling the masses of a medicine being an obstacle for inhaling such as aggregated masses of the powder medicine to make the powder medicine reach the deepest part of the lung of a patient. <P>SOLUTION: The inhalor is constituted such that a capsule 11 is arranged in a holding member 8 of a powder medicine receiving chamber 3, a sliding member 4 is moved to compress the powder medicine receiving chamber 3 and a hole is bored in the capsule by a boring member 7, compressed air in an outer space S flows into the inside of the capsule, the powder medicine is released to an outside through the path of a lid body 6 while milling the masses of powder being the obstacle such as the powder medicine for the inhalation, and the powder medicine can be sucked from an inhalation opening 6A. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an inhalation-type dispensing device for allowing a patient to inhale a powder formulation filled in a capsule.

  Conventionally, there has been a dispenser for administering a powder medicine filled in a capsule from a mouth or nose to a pulmonary bronchus or nasal mucosa of a patient.

  As a conventional example regarding such a dispenser, there is one disclosed in Patent Document 1. The prescription device disclosed in this publication is composed of a prescription device main body and a housing that is slidable and rotatable on the outer periphery of the prescription device main body.

  A powder storage chamber is formed in the prescription device main body, and this powder storage chamber is partitioned by a partition wall having a large number of small holes, and is divided into a front chamber and a rear chamber.

  An inhalation opening is formed at the front end of the prescription device main body, and the front chamber of the powder storage chamber is opened, and an opening of the rear chamber of the powder storage chamber is formed at the rear end of the prescription device main body. Further, ribs are formed protruding from the rear chamber.

  The housing covers the opening of the prescription device main body, and a capsule inlet is formed at a position covering the opening.

  In the above-described configuration, in a conventional dispensing device, a capsule containing medicinal powder is inserted from a capsule insertion port, and the inserted capsule is held in a state where the front cap protrudes into the medicinal powder containing chamber.

  Next, when the housing is rotated with respect to the prescription device main body, the rib collides with the front cap of the capsule, the front cap is detached from the rear cap, and the powder in the capsule is opened to the powder storage chamber.

When the patient holds and sucks the suction port at the front end of the prescription device body, the inside of the powder storage chamber is depressurized, and this depressurization causes the powder to be inhaled from the patient's mouth and adhere to the lung mucous membrane and the like. ing.
Japanese Patent Publication No. 1-27750

  However, the conventional example disclosed in Patent Document 1 described above is configured such that the rib removes the front cap of the capsule and releases the powder filled in the capsule by rotating the housing with respect to the main body of the dispenser. It had been.

  However, simply removing the capsule cap and releasing the powder in this way will not reduce the released drug powder from the aggregated or granulated secondary particles to the planned primary particles (fine particles). However, there is a problem that the powder cannot reach the deepest part of the lung to which the powder is administered.

  The present invention has been made in order to solve such a conventional problem. The object of the present invention is to pressurize the powder storage chamber and use the pressure to inhal the powder drug agglomerates. An object of the present invention is to provide an inhalation-type dosage device capable of improving the efficiency of inhalation by pulverizing a lump of particles that become an obstacle.

  In order to achieve the above object, the invention according to claim 1 is configured to pressurize the powder powder storage chamber with a sliding member, and use this pressure to remove a lump of particles that obstruct inhalation, such as agglomerate of drug powder. Since it grind | pulverizes, the efficiency which a patient inhales a powder can be improved. This makes it possible for the drug powder to reach the deepest part of the patient's lungs.

  According to the second aspect of the present invention, a cap for airtightly fitting a punching member that opens a hole in a capsule communicating with the punching member insertion hole of the sliding member is provided on one end side of the sliding member. Since the gap between the perforating member insertion hole and the perforating member of the sliding member can be filled, it is possible to more effectively pressurize the powder storage chamber, thereby further reliably reaching the deepest part of the patient's lungs. It is possible to reach the drug powder.

  In the inhalation-type dispensing device according to the present invention, the powder storage chamber is pressurized, a pressure difference is created between the inside and outside of the capsule, and then the inside and outside of the capsule are communicated with each other. Inhalation efficiency can be improved by pulverizing a mass of particles that obstruct inhalation, such as agglomerates of the drug, thereby allowing the powder to reach the deepest part of the patient's lungs.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a cross-sectional view showing a configuration of an embodiment of an inhalation-type dispensing device according to the present invention. As shown in the figure, an inhalation-type prescription device 1 is slidable on a cylindrical housing 2, a drug powder storage chamber 3 provided at a substantially central portion in the axial direction of the housing 2, and one end of the housing 2. The substantially cylindrical sliding member 4 provided, the seal member 5 provided on the outer periphery of the sliding member 4 and sealing the powder storage chamber 3, and provided at the other end of the housing 2, the powder storage chamber 3 A lid 6 having a passage communicating with the outside, and a punching member 7 for punching a capsule 11 (shown by a one-dot chain line in the figure) installed in the drug powder storage chamber 3.

  Here, FIG. 2 shows a cross-sectional view taken along line AA in FIG. As shown in FIG. 2, a plurality of holding members 8 for holding capsules 11 filled with drug powder to be administered to a patient are formed in the drug powder storage chamber 3 in a rib shape, and the capsules 11 are held. When set between the members 8, an outer space S is formed around the capsule 11.

  The sliding member 4 is installed so as to be slidable in the axial direction in the housing 2 by sealing the drug substance housing chamber 3 with a ring-shaped sealing member 5 which is mounted around the outer periphery. A passage 9 as a hole-piercing member insertion hole for passing the needle portion 7A of the hole-piercing member 7 is provided on the central axis of the sliding member 4, and the needle portion of the hole-piercing member 7 is passed through this passage 9. 7A is inserted so that the capsule can be pierced. In addition, a cap 10 for receiving and inserting the perforating member 7 is provided at the tip of the sliding member 4 on the side of the drug substance housing chamber 3. A gap between the passage 9 of the sliding member 4 and the perforating member 7 is filled in the cap 10, so that pressure can be applied more effectively when the drug powder storage chamber 3 is pressurized. It has become.

  Further, the lid 6 is formed in a shape so as to be in close contact with the capsule 11 installed in the drug substance storage chamber 3. This makes it possible to pressurize the powder storage chamber 3. The lid 6 is screwed to the other end of the housing 2. In the center of the lid body 6, a suction port 6 </ b> A through which the needle portion 7 </ b> A of the piercing member 7 can pass is formed.

  Next, a method for using the inhalation-type dispensing device 1 of the present embodiment will be described. First, a capsule 11 filled with medicinal powder to be administered to a patient is placed in the medicinal powder containing chamber 3 in the holding member 8 of the medicinal powder containing chamber 3. When the lid body 6 is set, the lid body 6 is formed so as to be in close contact with the capsule, so that the powder storage chamber 3 is sealed.

  Here, when the sliding member 4 is moved to the state shown in FIG. 3 by moving in the arrow B direction in FIG. 1, since the sealing member 5 is hermetically sealed, the powder storage chamber 3 is in a pressurized state, A pressure difference is generated between the space S and the space in the capsule.

  In this state, as shown in FIG. 3, when the punching member 7 is moved in the direction of arrow B and moved to the state shown in FIG. 4, the capsule 11 is punched by the needle portion 7 </ b> A of the punching member 7. It is done. At this time, due to the pressure difference between the inside and outside space S of the capsule, air flows from the outside space S into the capsule, and the powder in the capsule 11 is dispersed and atomized by the air flow. Then, as shown in FIG. 5, after pulling out the hole-opening member 7, the patient only has to put the mouth against the suction port 6 </ b> A of the lid body 6 and suck the drug powder.

  As described above, in the inhalation-type dispenser 1 according to the present embodiment, the outer space S is provided in the powder storage chamber 3 as shown in FIG. 2 and the powder storage chamber 3 is added by pushing the sliding member 4. The capsule is punched by the punching member 7 and air is abruptly poured into the capsule to disperse the lump of particles that obstruct the inhalation, such as agglomerated lump of the drug powder, into fine particles. The efficiency of inhaling can be improved. Thereby, in the inhalation-type dispensing device 1 of the present embodiment, for example, it is possible to make the powder reach the deepest part of the patient's lung.

  Further, in the inhalation-type prescription device 1 according to the present embodiment, the cap 10 for housing the perforated member 7 is provided at the tip of the sliding member 4 on the side of the powder storage chamber 3, thereby allowing the passage of the sliding member 4. Since the gap between 9 and the perforating member 7 can be filled, the powder storage chamber 3 can be more effectively pressurized.

  Furthermore, in the inhalation-type dispenser 1 according to the present embodiment, the lid 6 is formed in a shape such that the capsules are in close contact with each other, so that the pressure can be applied more effectively when the powder storage chamber 3 is pressurized. Is possible.

  Further, in the inhalation-type dispensing device 1 according to the present embodiment, since the capsule is fixed by providing the holding member 8 in the powder container 3, when the capsule is opened by the punching member 7, It is possible to stably and reliably open the capsule and release the powder from the capsule.

  As described above, the inhalation-type dispensing device of the present invention has been described based on the illustrated embodiment. However, the present invention is not limited to this, and the configuration of each part is replaced with an arbitrary configuration having the same function. Can do.

  For example, in the above-described embodiment, an example in which the housing 2 is formed in a cylindrical shape is illustrated. However, the cross-sectional shape of the housing 2 may be other shapes such as a square as long as it is cylindrical.

  Further, in this embodiment, the punching member 7 is configured to make a hole in the capsule through the passage 9 of the sliding member 4, but the punching member is inserted from the passage on the lid body 6 side to make the hole in the capsule. May be configured to open. In this case, since it is not necessary to provide the passage 9 in the sliding member 4, the powder storage chamber 3 can be easily sealed, whereby the powder storage chamber 3 can be reliably pressurized. .

In an inhalation-type dispensing device that allows a patient to inhale a powder formulation filled in a capsule, the mass of particles that interfere with inhalation, such as agglomerates of medicinal powder, is pulverized to reach the deepest part of the patient's lungs. It is extremely useful as a technique for the

1 is a cross-sectional view showing a configuration of an inhalation-type dispensing device according to an embodiment of the present invention. It is AA sectional drawing of FIG. It is sectional drawing which shows the state which moved the sliding member in the inhalation-type prescription device which concerns on embodiment of this invention, and pressurized the powder storage chamber. It is sectional drawing which shows the state which moved the punching member in the inhalation-type prescription device which concerns on embodiment of this invention, and opened the capsule. It is sectional drawing which shows the state which removed the piercing | open_hole member in the inhalation-type prescription device concerning embodiment of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Inhalation-type prescription device 2 Housing 3 Powder storage chamber 4 Sliding member 5 Sealing member 6 Lid 6A Inhalation port 7 Drilling member 8 Holding member 9 Passage 10 Cap S Outer space

Claims (2)

A tubular housing;
A powder storage chamber formed inside the housing;
A hole-piercing member insertion hole is formed that is slidable back and forth and airtightly fitting toward one end side of the housing toward the powder-powder storage chamber, and allows the hole-piercing member to be inserted along the fitting direction. A sliding member;
A lid body provided on the other end side in the housing and having a passage communicating the powder storage chamber and the atmosphere;
An inhalation-type dosing device comprising:   2. The cap according to claim 1, wherein a cap that is airtightly fitted to a punching member that opens a hole in a capsule communicating with a punching member insertion hole of the sliding member is provided on one end side of the sliding member. Inhaler.

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