CN115089825A - Lung drug delivery device - Google Patents
Lung drug delivery device Download PDFInfo
- Publication number
- CN115089825A CN115089825A CN202210797624.5A CN202210797624A CN115089825A CN 115089825 A CN115089825 A CN 115089825A CN 202210797624 A CN202210797624 A CN 202210797624A CN 115089825 A CN115089825 A CN 115089825A
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- CN
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- Prior art keywords
- shell
- drug
- medicine
- bin
- air inlet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012377 drug delivery Methods 0.000 title claims abstract description 6
- 210000004072 lung Anatomy 0.000 title claims abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 195
- 229940079593 drug Drugs 0.000 claims abstract description 55
- 230000002685 pulmonary effect Effects 0.000 claims description 7
- 210000000078 claw Anatomy 0.000 claims description 6
- 238000005192 partition Methods 0.000 claims description 5
- 230000001681 protective effect Effects 0.000 claims description 4
- 239000000843 powder Substances 0.000 abstract description 30
- 239000002775 capsule Substances 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012383 pulmonary drug delivery Methods 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 229940041682 inhalant solution Drugs 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1025—Respiratory system
- A61M2210/1039—Lungs
Abstract
The invention relates to the technical field of medical instruments, and provides a lung drug delivery device which comprises a shell, wherein a drug bin opening is formed in one side of the shell, a drug bin shell with an opening formed in one side is detachably and fixedly inserted in the drug bin opening, a drug bin is inserted in the drug bin shell, a drug storage groove is formed in one side, located in the drug bin shell, of the drug bin, a drug bin cover abutting against one side of the drug bin is elastically inserted in the drug bin shell, a drug suction opening is formed in one side of the top of the shell, a first air inlet is formed in the bottom of the shell, vent holes are formed in the upper side and the lower side of the drug bin shell, and the drug suction opening and the first air inlet are respectively communicated with the two vent holes. When the medicine powder is inhaled, the strip-shaped holes on the upper side and the lower side of the medicine bin are designed asymmetrically, so that the airflow generates rotary airflow during passing through the medicine storage groove, more medicine powder can be taken out, and the requirement of large-dose medicine taking is met.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a pulmonary drug delivery device.
Background
Oral formulations have particular advantages in the treatment of respiratory diseases such as asthma, chronic obstructive pulmonary disease, such as: quick action, good targeting property, small dosage, small side effect, no liver first-pass effect, high bioavailability, good compliance, etc.
The oral inhalation preparation mainly comprises an atomized inhalation solution (Nebulizer), an aerosol (MDI) and a dry powder inhalation preparation (DPI, also called as a powder aerosol). DPI is a new dosage form developed on the basis of MDI, and requires a special inhalation device, the device is filled with micronized drug or drug mixed with carrier, the drug is inhaled along with the airflow of a patient, and the drug is dispersed into microparticles with aerodynamic particle size of 1-5 microns as much as possible to enter the lower respiratory tract of the human body through an airflow channel specially designed in the device, thereby playing a local or systemic role.
DPI overcomes the disadvantages of poor portability, inaccurate dosage, high coordination requirement of MDI inhalation hand and inhalation stimulation of atomized inhalation solution.
The mainstream dry powder inhalation preparations in the market can be divided into capsule type, reservoir type and blister type according to the form of carrying micronized drug. The capsule type dry powder inhalation preparation fills the medicine which can be used for a single time into the capsule, when a patient uses the capsule, the capsule is punctured by pressing a press button of a pressure device, and the medicine powder in the capsule is released by the inhalation airflow of the patient to achieve the effect of medicine pulmonary administration. However, the capsule type inhalation preparation is extremely sensitive to humidity, and when the capsule is punctured, the capsule is easy to crack and generate fragments and deform, and the medicine powder in the capsule after deformation is not easy to empty, so that the medicine delivery effect is influenced. The reservoir type dry powder inhalation preparation encapsulates drug powder meeting the usage amount of a patient in the device body at one time, and enhances the dispersion of drug particles and the lung administration effect by virtue of a drug loading unit and an airflow channel which are specially designed in the reservoir type dry powder inhalation preparation. But the device for storing the dry powder inhalation preparation has the advantages of small single dose, easy powder leakage, large inhalation resistance, high requirement on the temperature and humidity of the medicine powder storage environment, and mostly non-detachable design and non-reusable device. Most of blister type dry powder inhalation preparations are designed to be non-detachable, and the device needs to be discarded as a whole after use and cannot be reused, so that it is necessary to design a pulmonary drug delivery device to solve the problem.
Disclosure of Invention
The present invention aims to provide a pulmonary drug delivery device that solves the problems set forth in the background above.
In order to achieve the purpose, the invention provides the following technical scheme:
the lung drug delivery device comprises a housing, a drug bin opening is formed in one side of the housing, a drug bin shell with an opening is arranged on one side of the drug bin opening in a detachable and fixed mode in the drug bin opening, a drug bin is inserted in the drug bin shell, a drug storage groove is formed in one side, located in the drug bin shell, of the drug bin shell, a drug bin cover which is abutted to one side of the drug bin is elastically inserted in the drug bin shell, a drug suction opening is formed in one side of the top of the housing, a first air inlet is formed in the bottom of the housing, vent holes are formed in the upper side and the lower side of the drug bin shell, the drug suction opening and the first air inlet are respectively communicated with the two vent holes, two asymmetric strip-shaped holes are formed in the upper side and the lower side of the drug bin, and the strip-shaped holes are respectively communicated with the corresponding vent holes.
Preferably, the spring is inserted in the medicine bin shell, one side of the spring is connected to the inner wall of the medicine bin shell, the other side of the spring is connected to one side of the medicine bin cover, which is far away from the medicine bin, the medicine bin cover can always push the medicine bin to move towards the opening on one side of the medicine bin shell under the elastic action of the spring, and the medicine bin cover can block one side of the medicine storage groove.
Preferably, an air inlet II is formed in one side of the shell, the air inlet II is communicated with the interior of the medicine suction port, when a patient sucks air in the medicine suction port, air flow can enter the shell through the air inlet II and intersect with air flow with medicine powder entering from the air inlet I in the medicine suction port so as to accelerate air flow, impact and disperse the medicine powder.
Preferably, the draw-in groove that communicates with medicine storehouse mouth inside is all seted up to the both sides of casing, two all be provided with in the draw-in groove and play the button, the equal fixedly connected with lock joint in both sides of medicine storehouse shell pulls out the claw on corresponding bullet button, presses down two bullet buttons toward the casing with two fingers and can follow the casing internal dismantlement with medicine storehouse shell and go out.
Preferably, the bottom of the inner wall of the housing is provided with a plurality of partition plates which are sequentially distributed from top to bottom and are positioned between the first air inlet and the corresponding vent hole from left to right, so that air flow entering the housing from the first air inlet can flow in a continuous U shape, and the design can also prevent the leakage of the medicine powder from the first air inlet.
Preferably, the bottom of casing can be dismantled fixedly and cup jointed and to have sheltered from the protective housing of inhaling medicine mouth, air inlet one and air inlet two to can hide dirt ash blocking to inhaling medicine mouth, air inlet one and air inlet two.
Compared with the prior art, the invention has the beneficial effects that:
1. when the medicine powder is inhaled, the strip-shaped holes on the upper side and the lower side of the medicine bin are designed asymmetrically, so that the airflow generates rotary airflow during passing through the medicine storage groove, more medicine powder can be taken out, and the requirement of large-dose medicine taking is met.
2. The medicine powder is protected layer by the medicine bin, the medicine bin shell and the shell, and compared with the traditional medicine core, the medicine core has good stability, and is not easy to deform when the environment temperature and humidity change or the external force extrusion is carried out, so that the medicine delivery performance of the device is not influenced.
3. Compared with the traditional medicine core, the medicine core does not need to be punctured by a puncturing mechanism such as a steel needle and the like for use, so that fragments generated when the medicine core is punctured are avoided, and the fragments and the medicine are inhaled into a human body together.
4. The invention has simple operation, can complete the drug loading and unloading process by simple pressing, the device can be repeated for many times, and the drug core can be combined or replaced according to the drug administration/prescription requirement.
5. According to the invention, through the arrangement of the partition plate, the air flow entering the shell from the air inlet I can flow in a continuous U shape, and the design can also prevent the medicine powder from leaking from the air inlet I.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic plan view of the present invention;
FIG. 3 is a schematic cross-sectional view taken along line A-A of FIG. 2 according to the present invention;
FIG. 4 is an exploded view of the housing structure of the present invention;
FIG. 5 is an exploded view of the cartridge housing structure of the present invention;
in the figure: 1. a housing; 2. a cartridge housing; 21. a vent; 22. claw pulling; 3. a medicine bin; 4. a strip-shaped hole; 5. a medicine suction port; 6. a first air inlet; 7. a medicine bin cover; 8. a spring; 9. a second air inlet; 10. snapping a button; 11. a protective shell.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments of the present disclosure.
Referring to fig. 1-5, the present invention provides a pulmonary delivery device: comprises a shell 1, one side of the shell 1 is provided with a medicine bin opening, one side of the medicine bin opening is detachably and fixedly inserted with a medicine bin shell 2, one side of the medicine bin shell 2 is internally inserted with a medicine bin 3, one side of the medicine bin 3 positioned in the medicine bin shell 2 is provided with a medicine storage groove, the medicine powder is stored in the medicine storage groove, a medicine bin cover 7 which is abutted against one side of the medicine bin 3 is elastically inserted in the medicine bin shell 2, one side of the top of the shell 1 is provided with a medicine suction opening 5, the bottom of the shell 1 is provided with an air inlet I6, the upper side and the lower side of the medicine bin shell 2 are both provided with air vents 21, the medicine suction opening 5 and the air inlet I6 are respectively communicated with the two air vents 21, the upper side and the lower side of the medicine bin 3 are respectively provided with two asymmetric strip-shaped holes 4, and the two strip-shaped holes 4 are respectively communicated with the corresponding air vents 21, through the design, when the device is used, a patient can hold one side of the top of the shell 1 with a mouth and suck air from the medicine suction opening 5, at the moment, the airflow can enter the medicine storage groove through the air inlet I6 and the vent hole 21 at the bottom of the medicine bin shell 2, the medicine powder with the medicine storage groove enters the medicine suction port 5 from the vent hole 21 at the top of the medicine bin shell 2 and is sent into a patient, when the medicine core needs to be replaced, the medicine bin shell 2 of a new medicine core is pushed and pressed into one side of the device shell 1 by taking the medicine bin shell 2 out of the medicine bin port, the inner wall of the medicine bin shell 2 is attached to the inner wall surface of the suction device at the moment to ensure that the medicine powder cannot be spilled out from the gap, and along with the insertion of the medicine bin shell 2 back into the medicine bin port, one side of the medicine bin 3 can be abutted against the inner wall of the shell 1 and gradually extruded towards the direction of the medicine bin cover 7, so that the two strip-shaped holes 4 can be communicated with the corresponding vent holes 21 to achieve the state of opening the medicine storage groove for use, when the medicine powder is sucked, because the strip-shaped holes 4 at the upper side and the lower side of the medicine bin 3 are asymmetrically designed, make the air current produce rotatory air current during through storing up the medicine groove, with can take more powder out, satisfy the demand that the bulk dose was used medicine, and powder is by medicine storehouse 3, medicine storehouse shell 2 and casing 1 protect layer upon layer, compare traditional medicine core stability good, when environment humiture changes or receives external force extrusion, the difficult deformation that produces of medicine core, thereby do not influence device drug delivery performance, need not to puncture the medicine core with the help of puncturing mechanisms such as steel needles and use when using, the piece that produces when avoiding the medicine core to puncture and inhale the human body together with the medicine, and the device easy operation, the medicine carrying is very convenient with the process of unloading the medicine, can repeat many times, the medicine core can be according to the combination of dosing/prescription demand or replacement.
About the concrete connection mode between medicine storehouse lid 7 and the medicine storehouse shell 2 as follows, the inside of medicine storehouse shell 2 is pegged graft and is had spring 8, the inner wall at medicine storehouse shell 2 is connected to one side of spring 8, one side that medicine storehouse 3 was kept away from to medicine storehouse lid 7 is connected to spring 8's opposite side, so that medicine storehouse lid 7 can form the elastic connection in medicine storehouse shell 2, and medicine storehouse lid 7 can promote medicine storehouse 3 toward medicine storehouse shell 2 one side opening part removal under spring 8's elastic action always, and make medicine storehouse lid 7 can carry out the shutoff with one side in storage medicine groove.
Referring to fig. 3 and 4, one side of the housing 1 is provided with a second air inlet 9, and the second air inlet 9 is communicated with the inside of the medicine suction port 5, so that when a patient inhales in the medicine suction port 5, air flow can enter the housing 1 through the second air inlet 9 and meet air flow with medicine powder entering from the first air inlet 6 in the medicine suction port 5, and the two air flows can generate an effect of colliding and crushing particles and can accelerate the air flow.
Specific reason that can dismantle in medicine storehouse shell 2 in medicine storehouse mouth is as follows, the draw-in groove that communicates with medicine storehouse mouth inside is all seted up to casing 1's both sides, all be provided with bullet button 10 in two draw-in grooves, the equal fixedly connected with lock joint in the both sides of medicine storehouse shell 2 pulls out claw 22 on corresponding draw-in groove inner wall, thus, can press two bullet buttons 10 toward casing 1 with two fingers, can make bullet button 10 can extrude and pull out claw 22 and make and pull out claw 22 and break away from in the draw-in groove, just so can promote medicine storehouse 3 and pop out from medicine storehouse shell 2 one side opening part under spring 8's effect, and can promote one side of medicine storehouse shell 2 and extend in the medicine storehouse mouth in order to accomplish the dismantlement, user operation has also been simplified to such design, only need simply to press and can accomplish the medicine loading and unload the medicine process.
As shown in fig. 3, a plurality of partition plates are formed at the bottom of the inner wall of the housing 1 from left to right, and the partition plates are sequentially distributed up and down and located between the air inlet one 6 and the corresponding vent 21, so that the air flow entering the housing 1 from the air inlet one 6 can flow in a continuous U shape, and the design can also prevent the medicine powder from leaking from the air inlet one 6.
And in addition, the bottom of the shell 1 can be dismantled and fixedly sleeved with a protective shell 11 which can shield the medicine suction port 5, the first air inlet 6 and the second air inlet 9 so as to shield dust and ash from the medicine suction port 5, the first air inlet 6 and the second air inlet 9 and avoid pollution when the device is not used at ordinary times.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (6)
1. The lung drug delivery device comprises a shell (1) and is characterized in that a drug bin opening is formed in one side of the shell (1), a drug bin shell (2) with an opening formed in one side is detachably and fixedly inserted in the drug bin opening, a drug bin (3) is inserted in the drug bin shell (2), a drug storage groove is formed in one side, located in the drug bin shell (2), of the drug bin (3), a drug bin cover (7) abutting against one side of the drug bin (3) is elastically inserted in the drug bin shell (2), a drug suction opening (5) is formed in one side of the top of the shell (1), a first air inlet (6) is formed in the bottom of the shell (1), vent holes (21) are formed in the upper side and the lower side of the drug bin shell (2), the drug suction opening (5) and the first air inlet (6) are respectively communicated with the two vent holes (21), two asymmetric strip-shaped holes (4) are respectively formed in the upper side and the lower side of the drug bin (3), and the two strip-shaped holes (4) are respectively communicated with the corresponding air vents (21).
2. The pulmonary delivery device of claim 1, wherein: the medicine cabin is characterized in that a spring (8) is inserted into the medicine cabin shell (2), one side of the spring (8) is connected to the inner wall of the medicine cabin shell (2), and the other side of the spring (8) is connected to one side, far away from the medicine cabin (3), of the medicine cabin cover (7).
3. The pulmonary delivery device of claim 1, wherein: and a second air inlet (9) is formed in one side of the shell (1), and the second air inlet (9) is communicated with the interior of the medicine suction port (5).
4. The pulmonary delivery device of claim 1, wherein: the utility model discloses a medicine storehouse, including casing (1), the draw-in groove that communicates with medicine storehouse mouth inside all seted up in the both sides of casing (1), two all be provided with in the draw-in groove and play button (10), the equal fixedly connected with lock joint in both sides of medicine storehouse shell (2) pulls out claw (22) on corresponding bullet button (10).
5. The pulmonary delivery device of claim 1, wherein: the bottom of the inner wall of the shell (1) is provided with a plurality of partition plates which are sequentially distributed from top to bottom and are positioned between the air inlet I (6) and the corresponding air vent (21).
6. The pulmonary delivery device of claim 3, wherein: the bottom of the shell (1) is detachably and fixedly sleeved with a protective shell (11) capable of shielding the medicine suction port (5), the first air inlet (6) and the second air inlet (9).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210797624.5A CN115089825A (en) | 2022-07-06 | 2022-07-06 | Lung drug delivery device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210797624.5A CN115089825A (en) | 2022-07-06 | 2022-07-06 | Lung drug delivery device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115089825A true CN115089825A (en) | 2022-09-23 |
Family
ID=83295968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210797624.5A Pending CN115089825A (en) | 2022-07-06 | 2022-07-06 | Lung drug delivery device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115089825A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1478138A (en) * | 1973-07-18 | 1977-06-29 | Beecham Group Ltd | Device for the administration of powders |
| CN1314190A (en) * | 2001-04-29 | 2001-09-26 | 张世和 | Administration method by respiratory tract and administration device thereof |
| CN101554504A (en) * | 2003-09-04 | 2009-10-14 | 曼恩坎德公司 | Unit dose cartridge and dry powder inhaler |
| CN102228725A (en) * | 2011-06-13 | 2011-11-02 | 上海秀新臣邦医药科技有限公司 | Dry powder administration device |
| CN103998087A (en) * | 2011-12-16 | 2014-08-20 | 诺华股份有限公司 | Aerosolization apparatus for inhalation profile-independent drug delivery |
| CN108778249A (en) * | 2016-01-29 | 2018-11-09 | 曼金德公司 | Diskus |
| CN113694320A (en) * | 2021-08-31 | 2021-11-26 | 英华融泰医疗科技股份有限公司 | Storage tank type multifunctional atomizer |
-
2022
- 2022-07-06 CN CN202210797624.5A patent/CN115089825A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1478138A (en) * | 1973-07-18 | 1977-06-29 | Beecham Group Ltd | Device for the administration of powders |
| CN1314190A (en) * | 2001-04-29 | 2001-09-26 | 张世和 | Administration method by respiratory tract and administration device thereof |
| CN101554504A (en) * | 2003-09-04 | 2009-10-14 | 曼恩坎德公司 | Unit dose cartridge and dry powder inhaler |
| CN102228725A (en) * | 2011-06-13 | 2011-11-02 | 上海秀新臣邦医药科技有限公司 | Dry powder administration device |
| CN103998087A (en) * | 2011-12-16 | 2014-08-20 | 诺华股份有限公司 | Aerosolization apparatus for inhalation profile-independent drug delivery |
| CN108778249A (en) * | 2016-01-29 | 2018-11-09 | 曼金德公司 | Diskus |
| CN113694320A (en) * | 2021-08-31 | 2021-11-26 | 英华融泰医疗科技股份有限公司 | Storage tank type multifunctional atomizer |
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