JP2005239652A - Composition for oral cavity - Google Patents
Composition for oral cavity Download PDFInfo
- Publication number
- JP2005239652A JP2005239652A JP2004053204A JP2004053204A JP2005239652A JP 2005239652 A JP2005239652 A JP 2005239652A JP 2004053204 A JP2004053204 A JP 2004053204A JP 2004053204 A JP2004053204 A JP 2004053204A JP 2005239652 A JP2005239652 A JP 2005239652A
- Authority
- JP
- Japan
- Prior art keywords
- arbutin
- sodium
- mass
- gums
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 210000000214 mouth Anatomy 0.000 title claims abstract description 10
- BJRNKVDFDLYUGJ-ZIQFBCGOSA-N alpha-Arbutin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-ZIQFBCGOSA-N 0.000 claims abstract description 30
- 229940033280 alpha-arbutin Drugs 0.000 claims abstract description 30
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 16
- 239000000606 toothpaste Substances 0.000 description 15
- -1 alkali metal alginate Chemical class 0.000 description 14
- 238000007796 conventional method Methods 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- 238000009472 formulation Methods 0.000 description 12
- 229940034610 toothpaste Drugs 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000008213 purified water Substances 0.000 description 11
- 239000003205 fragrance Substances 0.000 description 10
- 239000002674 ointment Substances 0.000 description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 235000011187 glycerol Nutrition 0.000 description 9
- 239000002202 Polyethylene glycol Substances 0.000 description 8
- 239000000551 dentifrice Substances 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 8
- 230000008099 melanin synthesis Effects 0.000 description 8
- 229920001223 polyethylene glycol Polymers 0.000 description 8
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 7
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 7
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 7
- 229940085605 saccharin sodium Drugs 0.000 description 7
- 229960000984 tocofersolan Drugs 0.000 description 7
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000001768 carboxy methyl cellulose Chemical class 0.000 description 6
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical class C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 5
- 208000012641 Pigmentation disease Diseases 0.000 description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical class [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000002324 mouth wash Substances 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 5
- 229920001027 sodium carboxymethylcellulose Chemical class 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000004694 pigment cell Anatomy 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 230000002087 whitening effect Effects 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 102000004139 alpha-Amylases Human genes 0.000 description 3
- 108090000637 alpha-Amylases Proteins 0.000 description 3
- 229940024171 alpha-amylase Drugs 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 3
- 239000004359 castor oil Substances 0.000 description 3
- 235000019438 castor oil Nutrition 0.000 description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229940112822 chewing gum Drugs 0.000 description 3
- 235000015218 chewing gum Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000019700 dicalcium phosphate Nutrition 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 230000019612 pigmentation Effects 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 230000000391 smoking effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 2
- 239000004382 Amylase Substances 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 108010014251 Muramidase Proteins 0.000 description 2
- 102000016943 Muramidase Human genes 0.000 description 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 229960002684 aminocaproic acid Drugs 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 2
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 2
- 229960003720 enoxolone Drugs 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000004325 lysozyme Substances 0.000 description 2
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 229940051866 mouthwash Drugs 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 229940042585 tocopherol acetate Drugs 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
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- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
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- JQBCKRZQAMELAD-UHFFFAOYSA-N 1-hydroxypyrrolidin-2-one Chemical class ON1CCCC1=O JQBCKRZQAMELAD-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- YOBWBLFILQYRFY-UHFFFAOYSA-N 2-hexadecylpyridine;hydrochloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCC1=CC=CC=[NH+]1 YOBWBLFILQYRFY-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- KGKRDKISRBUFHF-UHFFFAOYSA-N 4-(4-hydroxybutyl)benzoic acid Chemical compound OCCCCC1=CC=C(C(O)=O)C=C1 KGKRDKISRBUFHF-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
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Abstract
Description
本発明は口腔用組成物に関し、さらに具体的には特に歯ぐきに接触させて使うことで喫煙、歯の修復物、歯周疾患による歯ぐきの色調の変化を防止し、歯ぐきをより自然で健康的な色調へと改善する作用を有し、且つ安全性の高い口腔用組成物に関する。 The present invention relates to a composition for oral cavity, and more specifically, by using it in contact with the gums, preventing changes in the color of the gums due to smoking, dental restorations, and periodontal diseases, making the gums more natural and healthy The composition for oral cavity which has the effect | action which improves to a favorable color tone, and is highly safe.
歯ぐきには、皮膚と同じように色素細胞が存在している。喫煙、歯の修復物から溶出される金属、炎症、口腔内の乾燥等の要因によって色素細胞からメラニン色素の生成が増加し、歯ぐきの色素沈着を引き起こすことが知られている。また、喫煙による歯ぐきへのヤニの付着や血行の悪化も要因の一つとして考えられている。
口腔粘膜の中でも歯ぐきは色素沈着する頻度が高く、かつ見えやすい部位である。近年のデンタルエステティックに関する意識の高まりから、歯においては美しく白い歯が求められ、ホワイトニングが一般化している。それに併せて、歯ぐきに関しても自然で健康的なピンク色の色調が求められている。
In the gums, pigment cells are present just like skin. It is known that the production of melanin pigment from pigment cells is increased by factors such as smoking, metal eluted from dental restorations, inflammation, and dryness in the oral cavity, leading to pigmentation of gums. Another factor is considered to be the adhesion of spears to the gums and deterioration of blood circulation due to smoking.
In the oral mucosa, gums are frequently pigmented and easy to see. With the recent increase in awareness regarding dental esthetics, teeth are required to be beautiful and white, and whitening has become common. At the same time, a natural and healthy pink color tone is required for gums.
歯ぐきの着色には紫外線による皮膚の色素沈着同様にメラニン色素によるものがとても多い。従来から、皮膚の色素沈着抑制のために種々の研究が行われてきた。メラニン色素を産生する色素細胞に直接的に働きかける方法か、あるいはメラニンを生成する律速酵素であるチロシナーゼを阻害する方法、紫外線により生成する色素細胞増殖因子の抑制等である。
一方、口腔粘膜の変色防止剤としてヒドロキシ-2-ピロリドン誘導体を含有した口腔用組成物が提案されている(例えば、特許文献1参照。)。
しかしながら、従来から用いられる物質の多くは安定性、安全性において問題があり、また色素の沈着を防ぐ効果は未だ十分に満足し得るものでなく、より優れた薬剤の開発が期待されている。
The coloration of gums is often due to melanin as well as the skin pigmentation by ultraviolet rays. Conventionally, various studies have been carried out to suppress skin pigmentation. These include a method of directly acting on pigment cells that produce melanin pigment, a method of inhibiting tyrosinase, which is a rate-limiting enzyme that produces melanin, and suppression of pigment cell growth factor produced by ultraviolet rays.
On the other hand, an oral composition containing a hydroxy-2-pyrrolidone derivative has been proposed as an anti-discoloration agent for oral mucosa (see, for example, Patent Document 1).
However, many of the conventionally used substances have problems in stability and safety, and the effect of preventing pigment deposition is not yet satisfactory, and development of better drugs is expected.
本発明の目的は、歯ぐきをより自然で健康的な色調へと改善する作用を有し、且つ安全性の高い口腔用組成物を提供することである。 An object of the present invention is to provide an oral composition that has an action of improving gums to a more natural and healthy color tone and has high safety.
本発明者らは、上記事情に鑑み鋭意研究を重ねた結果、α−アルブチンに優れたメラニン生成抑制効果があることに注目し、歯ぐきを自然で健康的な色調へと改善する作用を発揮できることを見出し、すなわちα−アルブチンが歯ぐきへのいわゆる美白成分として有効であることを見出し、本発明を完成させるに至った。
従って本発明は、α−アルブチンを含有することを特徴とする口腔用組成物である。本発明の実施態様では、口腔用組成物中、α−アルブチンを0.001〜10質量%含有させることが適当である。
As a result of intensive studies in view of the above circumstances, the present inventors have noted that α-arbutin has an excellent melanin production inhibitory effect, and can exhibit an effect of improving gums to a natural and healthy color tone. That is, α-arbutin was found to be effective as a so-called whitening component for gums, and the present invention was completed.
Accordingly, the present invention is an oral composition containing α-arbutin. In the embodiment of the present invention, it is appropriate to contain 0.001 to 10% by mass of α-arbutin in the composition for oral cavity.
本発明のα−アルブチンを含む口腔用組成物は、優れたメラニン生成抑制作用を発揮することができ、歯ぐきの色素沈着に対して高い抑制効果を発揮し、歯ぐきの自然で健康的な色調への改善に有効である。 The composition for oral cavity containing α-arbutin of the present invention can exhibit an excellent inhibitory action on melanin production, exhibits a high inhibitory effect on the pigmentation of gums, and a natural and healthy color tone of gums. It is effective for improvement.
本発明でいう口腔用組成物は、使用時に歯ぐきとの接触が可能である形態であれば特に制限されるものでなく、歯磨剤、洗口剤、歯ぐきをマッサージする形態など種々の剤形とすることができる。該口腔用組成物の具体的な形態として、例えば粉歯磨剤、練歯磨剤、液状歯磨剤、潤製歯磨剤、液体歯磨剤などの歯磨剤、洗口液、マウスウォッシュ、口中清涼剤、うがい用錠剤、軟膏状製剤、クリーム状製剤、チューインガムなどがある。
本明細書中でα−アルブチンとは、ハイドロキノン−α−D−グルコピラノシドを意図し、その構造は以下のとおりである。
The oral composition as used in the present invention is not particularly limited as long as it can be in contact with the gums at the time of use, and includes various dosage forms such as dentifrices, mouthwashes, and massage the gums. can do. Specific forms of the oral composition include, for example, toothpastes, toothpastes, liquid dentifrices, moisturized dentifrices, liquid dentifrices and other toothpastes, mouthwashes, mouthwashes, mouth fresheners, and gargles. Tablet, ointment preparation, cream preparation, chewing gum and the like.
In the present specification, α-arbutin means hydroquinone-α-D-glucopyranoside, and its structure is as follows.
α−アルブチンは、例えば細菌由来の酵素によるハイドロキノンの配糖化により得られるもので、この酵素はα−アミラーゼであり、このα−アミラーゼは例えば特許第2662667号公報に開示されたアミラーゼX−23であってよい。α−アミラーゼはまた、市販されており市場で入手することができ、本発明では市販品を使用することができる。
本発明の口腔用組成物におけるα−アルブチンの含有量は、本発明が目的とする効果を発揮し且つコストの観点から、口腔組成物の全質量に基づいて0.001〜10質量%が適当であり、好ましくは0.01〜5質量%であり、より好ましくは0.1〜5質量%である。
α-Arbutin is obtained, for example, by glycosylation of hydroquinone with an enzyme derived from bacteria. This enzyme is α-amylase, and this α-amylase is, for example, amylase X-23 disclosed in Japanese Patent No. 2666667. It may be. α-amylase is also commercially available and can be obtained on the market, and a commercially available product can be used in the present invention.
The content of α-arbutin in the oral composition of the present invention is suitably 0.001 to 10% by mass based on the total mass of the oral composition from the viewpoint of cost and the effects intended by the present invention. Preferably, it is 0.01-5 mass%, More preferably, it is 0.1-5 mass%.
本発明の口腔用組成物は、口腔用組成物の各種形態に応じて、従来から用いられている適当な基剤や添加剤を配合し、常法に従って調製することができる。
例えば練歯磨剤といった歯磨剤には、例示すると次のような基剤や添加剤を配合することができる。
研磨剤:結晶質シリカ、非晶質シリカ、その他の無水ケイ酸、含水ケイ酸といったシリカ系研磨剤、アルミノシリケート、酸化アルミニウム、水酸化アルミニウム、不溶性メタリン酸ナトリウム、不溶性メタリン酸カリウム、酸化チタン、第2リン酸カルシウム・2水和物、第2リン酸カルシウム・無水和物、重質炭酸カルシウム、軽質炭酸カルシウム、ピロリン酸カルシウム等(通常配合量3〜99質量%)。
The oral composition of the present invention can be prepared according to a conventional method by blending appropriate bases and additives conventionally used according to various forms of the oral composition.
For example, the following bases and additives can be blended in a dentifrice such as a toothpaste.
Abrasive: Silica-based abrasive such as crystalline silica, amorphous silica, other silicic anhydride, hydrous silicic acid, aluminosilicate, aluminum oxide, aluminum hydroxide, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, Dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, heavy calcium carbonate, light calcium carbonate, calcium pyrophosphate, etc. (usually 3 to 99% by mass).
粘結剤:カラギーナン、カルボキシメチルセルロース、カルボキシメチルセルロースナトリウム、メチルセルロース、ヒドロキシメチルセルロース、カルボキシメチルヒドロキシメチルセルロースナトリウムなどのセルロース誘導体、アルギン酸ナトリウムなどのアルカリ金属アルギネート、アルギン酸プロピレングリコールエステル、キサンタンガム、トラガントガム、カラヤガム、アラビアガムなどのガム類、ポリビニルアルコール、ポリアクリル酸ナトリウム、カルボキシビニルポリマー、ポリビニルピロリドンなどの合成粘結剤、ゲル化性シリカ、ゲル化性アルミニウムシリカ、ビーガント、ラポナイト等の無機粘結剤(通常配合量0.5〜10質量%)。
湿潤剤:ソルビット、グリセリン、エチレングリコール、プロピレングリコール、1,3−ブチレングリコール、ポリエチレングリコール、ポリプロピレングリコール、キシリット、マルチット、ラクチットなど(通常配合量1〜50質量%)。
Binder: Carrageenan, carboxymethylcellulose, sodium carboxymethylcellulose, cellulose derivatives such as methylcellulose, hydroxymethylcellulose, sodium carboxymethylhydroxymethylcellulose, alkali metal alginate such as sodium alginate, propylene glycol alginate, xanthan gum, tragacanth gum, caraya gum, gum arabic, etc. Synthetic binders such as gums, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, and inorganic binders such as gelling silica, gelling aluminum silica, vegant, and laponite (normal blending amount 0) .5 to 10% by mass).
Wetting agent: sorbit, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylit, maltite, lactit, etc. (usually 1 to 50% by mass).
界面活性剤:ラウリル硫酸ナトリウム、α−オレフィンスルホン酸ナトリウム、ドデシルベンゼンスルホン酸ナトリウム、ラウリルスルホ酢酸ナトリウム、N−ラウロイルザルコシン酸ナトリウム、N−アシルグルタミン酸塩、ショ糖脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンポリオキシプロピレンブロック共重合体、アルキルグリコシド類、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、アルキルジメチルアミンオキシドなど(配合量は通常0〜5質量%である)。 Surfactant: sodium lauryl sulfate, sodium α-olefin sulfonate, sodium dodecylbenzene sulfonate, sodium lauryl sulfoacetate, sodium N-lauroyl sarcosine, N-acyl glutamate, sucrose fatty acid ester, polyoxyethylene hydrogenated castor Oil, polyoxyethylene polyoxypropylene block copolymer, alkylglycoside, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyldimethylamine oxide, etc. (the amount is usually 0 to 5% by mass).
更に任意成分として、例えばサッカリンナトリウム、ステビオサイド、グリチルリチン、ペリラルチン、タウマチン、アスパラチルフェニルアラニンメチルエステル、p−メトキシシンアミックアルデヒド、ショ糖、果糖、サイクラミン酸ナトリウムなどの甘味料;スペアミント油、ペパーミント油、ウインターグリーン油、サッサフラス油、チョウジ油、ユーカリ油、セージ油、マヨナラ油、タイム油、レモン油、オレンジ油、l-メントール、カルボン、アネトール、オイゲノール、チモール、サリチル酸メチルなどの香料;安息香酸、安息香酸ナトリウム、p−ヒドロキシプロピルベンゾイックアシッド、p−ヒドロキシブチルベンゾイックアシッド、低級脂肪酸モノグリセライド、パラベンなどの防腐剤;第4級アンモニウム塩、トリクロサン、塩酸アルキルジアミノエチルグリシン、塩化セチルピリジニウム、塩化デカリニウム、塩化ベンゼトニウムなどの殺菌剤;ε−アミノカプロン酸、デキストラナーゼ、アミラーゼ、プロテアーゼ、ムタナーゼ、溶菌酵素、リゾチームなどの酵素類;モノフルオロリン酸ナトリウム、モノフルオロリン酸カリウム、フッ化ナトリウム、フッ化アンモニウム、フッ化第一スズなどのフッ化物;クロルヘキシジン塩類、ジヒドロコレステロール、グリチルレチン塩類、グリチルレチン酸、クロロフィル、カロペプタイド、酢酸トコフェロール、アズレン、塩化リゾチーム、ゼオライトやポリリン酸などの歯石防止剤、歯垢防止剤、硝酸カリウム、乳酸アルミニウムなどを添加することができる。
なお、これらの任意成分の添加量は、本発明の効果を防げない範囲で通常量とすることができる。
Further, as optional components, for example, sweeteners such as saccharin sodium, stevioside, glycyrrhizin, perilartin, thaumatin, aspartylphenylalanine methyl ester, p-methoxycinamic aldehyde, sucrose, fructose, sodium cyclamate; spearmint oil, peppermint oil, winter green Perfume such as oil, sassafras oil, clove oil, eucalyptus oil, sage oil, mayonnaise oil, thyme oil, lemon oil, orange oil, l-menthol, carvone, anethole, eugenol, thymol, methyl salicylate; benzoic acid, sodium benzoate , P-hydroxypropyl benzoic acid, p-hydroxybutyl benzoic acid, lower fatty acid monoglycerides, parabens and other preservatives; quaternary ammonium salts, tri Bactericides such as Losan, alkyldiaminoethylglycine hydrochloride, cetylpyridinium chloride, decalinium chloride, benzethonium chloride; enzymes such as ε-aminocaproic acid, dextranase, amylase, protease, mutanase, lytic enzyme, lysozyme; monofluorophosphoric acid Fluorides such as sodium, potassium monofluorophosphate, sodium fluoride, ammonium fluoride, stannous fluoride; chlorhexidine salts, dihydrocholesterol, glycyrrhetin salts, glycyrrhetinic acid, chlorophyll, caropeptide, tocopherol acetate, azulene, lysozyme chloride, Anticalculus agents such as zeolite and polyphosphoric acid, anti-plaque agents, potassium nitrate, aluminum lactate and the like can be added.
In addition, the addition amount of these arbitrary components can be made into a normal amount in the range which cannot prevent the effect of this invention.
以下に試験例を示す。なお、単に%の記載は質量%を意味する。
[メラニン生成抑制作用の試験]
α−アルブチンについて、メラニン生成抑制作用について試験した。
[試験方法および評価方法]
25cm2培養フラスコにマウス由来B16メラノーマ細胞を播種し、10%FBSを含むイーグルMEM培地を用い、二酸化炭素濃度5%、37℃の条件下で培養した。培養24時間後に10%FBSおよびテオフィリン(0.08mg/ml)含有イーグルMEM培地に交換し、α−アルブチンを最終濃度が10、100μg/mlとなるように添加し、混和した。さらに二日間培養後、培地を除去し、リン酸緩衝液で洗浄後、トリプシンおよびEDTA含有培地を使用して細胞をフラスコから剥離させ、細胞懸濁液から遠心分離により細胞を回収した。得られた細胞は10%DMSO含有1N NaOHを加え、80℃で60分間加熱、溶解させ405nmの吸光度を測定し、下記式によりメラニン生成抑制率を求めた。
なお、メラニン量は細胞あたりの量として求めた。また、比較としてβ−アルブチンについても同様に試験を行った。
メラニン生成抑制率(%)={(コントロールメラニン量−試料メラニン量)/コントロールメラニン量}×100
結果を表1に示す。
Test examples are shown below. In addition, description of only% means the mass%.
[Test of melanin production inhibitory effect]
α-Arbutin was tested for melanin production inhibitory action.
[Test method and evaluation method]
Mouse-derived B16 melanoma cells were seeded in a 25 cm 2 culture flask and cultured under conditions of carbon dioxide concentration 5% and 37 ° C. using Eagle's MEM medium containing 10% FBS. After 24 hours of culture, the medium was replaced with Eagle's MEM medium containing 10% FBS and theophylline (0.08 mg / ml), and α-arbutin was added to a final concentration of 10, 100 μg / ml and mixed. After further culturing for two days, the medium was removed, washed with a phosphate buffer, cells were detached from the flask using trypsin and EDTA-containing medium, and the cells were collected from the cell suspension by centrifugation. The obtained cells were added with 1N NaOH containing 10% DMSO, heated and dissolved at 80 ° C. for 60 minutes, the absorbance at 405 nm was measured, and the inhibition rate of melanin production was determined by the following formula.
The amount of melanin was determined as the amount per cell. For comparison, β-arbutin was similarly tested.
Melanin production inhibition rate (%) = {(control melanin amount−sample melanin amount) / control melanin amount} × 100
The results are shown in Table 1.
以下の表2に示す組成(単位:質量%)にて常法により練歯磨剤を調製し、α−アルブチンを配合した場合の歯ぐき美白効果を調べた。なお比較のためα−アルブチンを含まない練歯磨剤を調製した。
試験方法は、被検歯磨剤1品につき男性10名とし、毎日、朝と夜の2回、歯ブラシにつけて歯ぐきをマッサージするように使用した。試験は40日行った。より本来の歯ぐきの色にもどることを美白効果として、以下の基準によって評価し、10名のスコアを合計した。その結果を表2に示す。
スコア3 著効
スコア2 有効
スコア1 やや有効
スコア0 無効
A toothpaste was prepared by a conventional method with the composition (unit: mass%) shown in Table 2 below, and the gum whitening effect when α-arbutin was blended was examined. For comparison, a toothpaste containing no α-arbutin was prepared.
The test method was 10 males for each dentifrice, and was used to massage the gums on a toothbrush twice daily in the morning and evening. The test was conducted for 40 days. As a whitening effect, returning to the original gum color was evaluated according to the following criteria, and the scores of 10 people were totaled. The results are shown in Table 2.
Score 3 Excellent score 2 Effective score 1 Slightly effective score 0 Invalid
練歯磨剤の調製
以下の処方(単位:質量%)にて、練歯磨剤を常法に従って調製した。
リン酸水素カルシウム無水和物 20.0
リン酸水素カルシウム2水和物 20.0
無水ケイ酸 5.0
カラーギナン 0.7
カルボキシメチルセルロースナトリウム 0.3
グリセリン 20.0
70%ソルビット液 10.0
パラオキシ安息香酸メチル 0.1
トリクロサン 0.1
サッカリンナトリウム 0.1
ラウリル硫酸ナトリウム 1.5
DL−α−トコフェロール 0.1
ポリエチレングリコール 1.0
α−アルブチン 0.1
香料 1.0
精製水 残
100.0%
Preparation of toothpaste A toothpaste was prepared according to a conventional method with the following formulation (unit: mass%).
Calcium hydrogen phosphate anhydrate 20.0
Calcium hydrogen phosphate dihydrate 20.0
Silicic anhydride 5.0
Color Guinan 0.7
Sodium carboxymethylcellulose 0.3
Glycerin 20.0
70% sorbite solution 10.0
Methyl paraoxybenzoate 0.1
Triclosan 0.1
Saccharin sodium 0.1
Sodium lauryl sulfate 1.5
DL-α-tocopherol 0.1
Polyethylene glycol 1.0
α-Arbutin 0.1
Fragrance 1.0
Purified water remaining
100.0%
練歯磨剤の調製
以下の処方(単位:質量%)にて、練歯磨剤を常法に従って調製した。
無水ケイ酸 20.0
二酸化チタン 0.5
カラーギナン 1.0
プロピレングリコール 3.0
70%ソルビット液 20.0
グリセリン 20.0
パラオキシ安息香酸メチル 0.1
モノフルオロリン酸ナトリウム 0.05
塩化セチルピリジニウム 0.1
ラウリル硫酸ナトリウム 1.7
ラウロイルサルコシンナトリウム 0.3
銅クロロフィリンナトリウム 0.05
DL−α−トコフェロール 0.1
ポリエチレングリコール 1.0
α−アルブチン 0.1
香料 1.0
精製水 残
100.0%
Preparation of toothpaste A toothpaste was prepared according to a conventional method with the following formulation (unit: mass%).
Silica anhydride 20.0
Titanium dioxide 0.5
Color Guinan 1.0
Propylene glycol 3.0
70% sorbite solution 20.0
Glycerin 20.0
Methyl paraoxybenzoate 0.1
Sodium monofluorophosphate 0.05
Cetylpyridinium chloride 0.1
Sodium lauryl sulfate 1.7
Lauroyl sarcosine sodium 0.3
Copper chlorophyllin sodium 0.05
DL-α-tocopherol 0.1
Polyethylene glycol 1.0
α-Arbutin 0.1
Fragrance 1.0
Purified water remaining
100.0%
練歯磨剤の調製
以下の処方(単位:質量%)にて、練歯磨剤を常法に従って調製した。
水酸化アルミニウム 30.0
無水ケイ酸 5.0
塩化ナトリウム 10.0
カルボキシメチルセルロースナトリウム 1.0
グリセリン 20.0
ラウリル硫酸ナトリウム 1.8
イソプロピルメチルフェノール 0.02
酢酸トコフェロール 0.1
ポリオキシエチレン硬化ヒマシ油 3.0
パラオキシ安息香酸エチル 0.1
DL−α−トコフェロール 0.1
ポリエチレングリコール 1.0
α−アルブチン 0.1
香料 1.0
精製水 残
100.0%
Preparation of toothpaste A toothpaste was prepared according to a conventional method with the following formulation (unit: mass%).
Aluminum hydroxide 30.0
Silicic anhydride 5.0
Sodium chloride 10.0
Sodium carboxymethylcellulose 1.0
Glycerin 20.0
Sodium lauryl sulfate 1.8
Isopropylmethylphenol 0.02
Tocopherol acetate 0.1
Polyoxyethylene hydrogenated castor oil 3.0
Ethyl paraoxybenzoate 0.1
DL-α-tocopherol 0.1
Polyethylene glycol 1.0
α-Arbutin 0.1
Fragrance 1.0
Purified water remaining
100.0%
練歯磨剤の調製
以下の処方(単位:質量%)にて、練歯磨剤を常法に従って調製した。
ピロリン酸カルシウム 32.0
無水ケイ酸 6.0
カルボキシメチルセルロースナトリウム 1.0
グリセリン 25.0
グリチルレチン酸 0.2
塩化セチルピリジニウム 0.05
イプシロンアミノカプロン酸 0.1
DL−α−トコフェロール 0.1
ポリエチレングリコール 1.0
α−アルブチン 0.1
香料 0.1
精製水 残
100.0%
Preparation of toothpaste A toothpaste was prepared according to a conventional method with the following formulation (unit: mass%).
Calcium pyrophosphate 32.0
Silica anhydride 6.0
Sodium carboxymethylcellulose 1.0
Glycerin 25.0
Glycyrrhetinic acid 0.2
Cetylpyridinium chloride 0.05
Epsilon aminocaproic acid 0.1
DL-α-tocopherol 0.1
Polyethylene glycol 1.0
α-Arbutin 0.1
Fragrance 0.1
Purified water remaining
100.0%
液状歯磨剤の調製
以下の処方(単位:質量%)にて、液状歯磨剤を常法に従って調製した。
無水ケイ酸 10.0
キサンタンガム 1.0
グリセリン 10.0
70%ソルビット液 30.0
キシリトール 1.0
パラオキシ安息香酸エチル 0.1
パラオキシ安息香酸ブチル 0.05
リン酸二水素ナトリウム2水和物 0.3
水酸化ナトリウム 0.05
DL−α−トコフェロール 0.1
ポリエチレングリコール 1.0
α−アルブチン 0.1
香料 0.5
精製水 残
100.0%
Preparation of liquid dentifrice A liquid dentifrice was prepared according to a conventional method with the following formulation (unit: mass%).
Silicic acid 10.0
Xanthan gum 1.0
Glycerin 10.0
70% sorbite solution 30.0
Xylitol 1.0
Ethyl paraoxybenzoate 0.1
Butyl paraoxybenzoate 0.05
Sodium dihydrogen phosphate dihydrate 0.3
Sodium hydroxide 0.05
DL-α-tocopherol 0.1
Polyethylene glycol 1.0
α-Arbutin 0.1
Fragrance 0.5
Purified water remaining
100.0%
洗口剤の調製
以下の処方(単位:質量%)にて、洗口液を常法に従って調製した。
エタノール 5.0
ポリオキシエチレン硬化ヒマシ油 0.5
グリセリン 5.0
キシリトール 25.0
塩化セチルピリジニウム 0.05
グリチルリチン酸ジカリウム 0.05
パラオキシ安息香酸エチル 0.05
パラオキシ安息香酸プロピル 0.05
クエン酸 0.03
クエン酸ナトリウム 0.12
黄色4号 0.0002
緑色3号 0.0002
DL−α−トコフェロール 0.1
ポリエチレングリコール 1.0
α−アルブチン 0.1
精製水 残
100.0%
Preparation of mouthwash A mouthwash was prepared according to a conventional method with the following formulation (unit: mass%).
Ethanol 5.0
Polyoxyethylene hydrogenated castor oil 0.5
Glycerin 5.0
Xylitol 25.0
Cetylpyridinium chloride 0.05
Dipotassium glycyrrhizinate 0.05
Ethyl paraoxybenzoate 0.05
Propyl paraoxybenzoate 0.05
Citric acid 0.03
Sodium citrate 0.12
Yellow No. 0.0002
Green No. 3 0.0002
DL-α-tocopherol 0.1
Polyethylene glycol 1.0
α-Arbutin 0.1
Purified water remaining
100.0%
チューインガムの調製
以下の処方(単位:質量%)にて、チューインガムを常法に従って調製した。
ガムベース 40.0
炭酸カルシウム 2.0
水アメ 15.0
砂糖 30.0
クエン酸マグネシウム 2.55
ソルビン酸 0.2
DL−α−トコフェロール 0.1
ポリエチレングリコール 1.0
α−アルブチン 0.1
精製水 残
100.0%
Preparation of chewing gum Chewing gum was prepared according to a conventional method with the following formulation (unit: mass%).
Gum base 40.0
Calcium carbonate 2.0
Water candy 15.0
Sugar 30.0
Magnesium citrate 2.55
Sorbic acid 0.2
DL-α-tocopherol 0.1
Polyethylene glycol 1.0
α-Arbutin 0.1
Purified water remaining
100.0%
軟膏の調製
以下の処方(単位:質量%)にて、軟膏を常法に従って調製した。
セタノール 20.0
スクワラン 5.0
ソルビタンモノオレイン酸エステル 1.0
サッカリンナトリウム 0.1
香料 0.3
α−アルブチン 0.1
精製水 残
100.0%
Preparation of Ointment An ointment was prepared according to a conventional method with the following formulation (unit: mass%).
Cetanol 20.0
Squalane 5.0
Sorbitan monooleate 1.0
Saccharin sodium 0.1
Fragrance 0.3
α-Arbutin 0.1
Purified water remaining
100.0%
軟膏の調製
以下の処方(単位:重量%)にて,軟膏を常法に従って調製した
白色ワセリン 10.0
プロピレングリコール 5.0
ステアリルアルコール 10.0
ヒドロキシプロピルセルロース 2.0
ポリエチレングリコール400 60.0
サッカリンナトリウム 0.1
香料 0.3
α−アルブチン 0.1
精製水 残
100.0%
Preparation of ointment White petrolatum prepared according to a conventional method with the following formulation (unit:% by weight) 10.0
Propylene glycol 5.0
Stearyl alcohol 10.0
Hydroxypropylcellulose 2.0
Polyethylene glycol 400 60.0
Saccharin sodium 0.1
Fragrance 0.3
α-Arbutin 0.1
Purified water remaining
100.0%
軟膏の調製
以下の処方(単位:質量%)にて、軟膏を常法に従って調製した。
濃グリセリン 30.0
カルボキシメチルセルロースナトリウム 2.0
サッカリンナトリウム 0.1
香料 0.3
α−アルブチン 0.1
精製水 残
100.0%
Preparation of Ointment An ointment was prepared according to a conventional method with the following formulation (unit: mass%).
Concentrated glycerin 30.0
Sodium carboxymethylcellulose 2.0
Saccharin sodium 0.1
Fragrance 0.3
α-Arbutin 0.1
Purified water remaining
100.0%
軟膏の調製
以下の処方(単位:質量%)にて、軟膏を常法に従って調製した。
濃グリセリン 30.0
寒天 2.0
サッカリンナトリウム 0.1
香料 0.3
α−アルブチン 0.1
精製水 残
100.0%
Preparation of Ointment An ointment was prepared according to a conventional method with the following formulation (unit: mass%).
Concentrated glycerin 30.0
Agar 2.0
Saccharin sodium 0.1
Fragrance 0.3
α-Arbutin 0.1
Purified water remaining
100.0%
軟膏の調製
以下の処方(単位:重量%)にて、軟膏を常法に従って調製した。
エタノール 1.0
サッカリンナトリウム 0.1
香料 0.3
α−アルブチン 0.1
ゲル化炭化水素 残
100.0%
Preparation of Ointment An ointment was prepared according to a conventional method with the following formulation (unit: wt%).
Ethanol 1.0
Saccharin sodium 0.1
Fragrance 0.3
α-Arbutin 0.1
Gelled hydrocarbon remaining
100.0%
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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JP2004053204A JP4344844B2 (en) | 2004-02-27 | 2004-02-27 | Oral composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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JP2004053204A JP4344844B2 (en) | 2004-02-27 | 2004-02-27 | Oral composition |
Publications (2)
Publication Number | Publication Date |
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JP2005239652A true JP2005239652A (en) | 2005-09-08 |
JP4344844B2 JP4344844B2 (en) | 2009-10-14 |
Family
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Family Applications (1)
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JP2004053204A Expired - Lifetime JP4344844B2 (en) | 2004-02-27 | 2004-02-27 | Oral composition |
Country Status (1)
Country | Link |
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JP (1) | JP4344844B2 (en) |
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2004
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JP4344844B2 (en) | 2009-10-14 |
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