JP2005218494A - Film base material for adhesive skin patch and adhesive skin patch - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a film base material for an adhesive skin patch having a favorable moisture permeability and preventing swelling deformation and to provide the adhesive skin patch using the same. <P>SOLUTION: This film base material for the adhesive skin patch is composed of, at least, one type selected from a group of polyoxytetramethyleneglycol, butanediol, polyethyleneglycol and polypropylene glycol as diol components; and ether-based urethane resin obtained from methane diphenylenediisocyanate as isocyanate components. Preferably, this film base material for the adhesive skin patch has the moisture permeability of 800-4,000 g/m<SP>2</SP>×24 hrs. This adhesive skin patch can be manufactured by forming a pressure-sensitive adhesive layer on one face of the film base material for the adhesive skin patch. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a film base for skin patch and a skin patch, and more particularly to a film base for skin patch and a skin patch having moisture permeability.

  Adhesive tapes for medical use and hygiene materials must be able to prevent entry of water, bacteria, viruses, and the like from the outside, and have flexibility to follow the curved surface and movement of the skin. Therefore, a thin elastomer film having a low elastic modulus similar to that of the skin is generally used as a support for such an adhesive tape. In addition, adhesive tapes for medical and hygiene materials, such as dressing materials, are required to have excellent moisture permeability so that moisture generated by sweating from the skin can be evaporated. If moisture permeability is poor, moisture generated from the skin is stored between the skin and the pressure-sensitive adhesive layer, causing the adhesive layer to lose its adhesive force, causing the adhesive sheet to lose its fixing function or to be stored on the skin surface. Moisture causes maceration of the skin, and skin damage is likely to occur.

  In order to impart moisture permeability to the film, inorganic fine particles and the like are mixed to form a film, and the film is stretched to form a film having a large number of micropores in the film or foamed at the time of film formation. A film having fine pores was formed. Moreover, the through-hole was formed after film formation and the film which has a micropore in the film was formed.

  However, when such a film having fine pores is stuck on the skin, the moisture permeability is lowered due to clogging caused by sweat, dirt, dust and the like. Therefore, research has been conducted on films having no fine pores, that is, films having no permeability, which are non-porous films. For example, a non-porous moisture-permeable polyurethane resin film has been proposed.

However, the conventional moisture-permeable polyurethane resin film may have a significant decrease in strength due to the absorption of a large amount of water, or the film may swell due to excessive moisture absorption.
JP 2002-315775 A

  The present invention has been made to solve the above problems, and the present invention provides a film base material for a skin patch made of an ether-based urethane resin excellent in moisture permeability, and for this skin patch. It aims at providing the skin patch which uses a film base material.

  The film base material for skin patch of the present invention comprises, as a diol component, at least one selected from the group consisting of polyoxytetramethylene glycol, butanediol, polyethylene glycol and polypropylene glycol, and methanediphenylene diisocyanate as an isocyanate component. It consists of the ether type urethane resin obtained.

Here, it is preferable to use polyoxytetramethylene glycol and polyethylene glycol and / or polypropylene glycol as the diol component.
For example, it is preferable to contain 5 to 60% by weight of the polyoxytetramethylene glycol and 10 to 50% by weight of the polyethylene glycol in the ether-based urethane resin.

The film base material for skin patch of the present invention preferably has a moisture permeability of 800 to 4,000 g / m ² · 24 hrs.

The skin patch of the present invention is characterized by having an adhesive layer on one side of any one of the above-mentioned film bases for skin patches.
Here, the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is an acrylic pressure-sensitive adhesive mainly composed of (meth) acrylic acid ester, a silicone pressure-sensitive adhesive mainly composed of polyorganosiloxane, and polyether polyurethane and / or Or it is preferable that it is at least 1 type chosen from the group which consists of a urethane type adhesive which has polyester polyurethane as a main component.

  ADVANTAGE OF THE INVENTION According to this invention, it has the softness | flexibility which can track skin etc. and can provide the film base material for skin patches with the outstanding moisture permeability.

BEST MODE FOR CARRYING OUT THE INVENTION

The film base material for skin patches of the present invention is a film base material made of an ether urethane resin obtained from a diol component and an isocyanate component. Here, as the diol component, polyoxytetramethylene glycol (hereinafter sometimes abbreviated as “OTMG”), butanediol (hereinafter also abbreviated as “BD”), polyethylene glycol (hereinafter “PEG”). And at least one selected from the group consisting of polypropylene glycol (hereinafter also abbreviated as “PPG”) and methanediphenylene diisocyanate (hereinafter “MDI”) as the isocyanate component. May be abbreviated as).
In the present invention, “film” includes a sheet, and “sheet” includes a film.

  The polyoxytetramethylene glycol, polyethylene glycol, and polypropylene glycol used as the diol component are preferably selected from those having an appropriate molecular weight depending on the application. For example, the weight average molecular weight is 500 to 3,000. Are mentioned as preferred.

In the present invention, it is preferable to use polyoxytetramethylene glycol and polyethylene glycol and / or polypropylene glycol as the diol component. In particular, the ether-based urethane resin preferably contains 5 to 60% by weight of polyoxytetramethylene glycol and 10 to 50% by weight of polyethylene glycol, 5 to 45% by weight of polyoxytetramethylene glycol, and polyethylene glycol. It is more preferable to contain 20 to 45% by weight.
In addition, for example, by using a random copolymer of polyoxytetramethylene glycol and polyethylene glycol as the diol component, it is possible to ensure high moisture permeability while suppressing water swellability, so water swellability is also considered. In some cases, it is desirable to use a random copolymer of OTMG and PEG.

  In the present invention, a chain extender can be further used. As the chain extender, conventionally known materials can be used, and examples thereof include diols such as ethylene glycol, propylene glycol, and butanediol, and diamines such as ethylenediamine.

  In the present invention, additives usually used for the film, for example, an ultraviolet absorber, an anti-aging agent, a filler, a pigment, a colorant, a flame retardant, an antistatic agent and the like can be added as necessary. These additives are used in normal amounts depending on the type.

The ether urethane resin can be polymerized using, for example, a one-shot method or a prepolymer method. Moreover, even if it is bulk polymerization which does not use a solvent, you may superpose | polymerize in a solution for viscosity reduction.
Below, bulk polymerization is demonstrated concretely. A diol component is put into a reaction vessel, and an isocyanate component is added to cause urethanization while adjusting the temperature to 50 to 80 ° C. and stirring. Furthermore, after adding a chain extender and reacting, the reaction product is transferred to a tray and held at 100 to 150 ° C. for 4 hours or longer to complete the reaction, thereby obtaining a bulky ether urethane resin. Can do.

  Next, the ether-based urethane resin is pulverized and pelletized, and the resin pellet is melted and then extruded into a sheet using a T-die extruder or an inflation die extruder. The film base material which consists of can be formed. In addition, the film base material extruded into the sheet form is usually wound up. Alternatively, a film base made of an ether urethane resin is formed by calendering, rolling and stretching an ether urethane resin between two heated rolls, and forming into a sheet. It is wound up. Alternatively, the resin pellets are dissolved in a solvent such as N, N-dimethylamide, and this solution is applied onto a release liner such as a polyester film using a bar coater or the like, and dried to remove the solvent. A film substrate made of an ether urethane resin may be formed.

In the present invention, the thickness of the film substrate made of an ether-based urethane resin is preferably in the range of 10 to 150 μm in the case of a pressure-sensitive adhesive sheet (skin patch) used for medical or hygiene materials. . When the thickness of the film is less than 10 μm, the film tends to be difficult to handle when being applied to the skin or peeled off, and the operability is lowered to a level that is impractical in normal usage. On the other hand, if the thickness of the film is greater than 150 μm, sufficient moisture permeability cannot be obtained, so that the film is not suitable as a skin patch on the premise that it is applied to the skin. When the skin patch is used for dressing applications, the thickness of the film is particularly preferably in the range of 20 to 60 μm. Moreover, in the case of the use which requires a thin skin patch, it is preferable that it is 10-50 micrometers.
In addition, the film base material for skin patches can be made into a multilayer structure, for example, it is good also as a laminated body of an ether type urethane resin film.

In the film base material for skin patch of the present invention, the moisture permeability of a film having a thickness of 30 μm is preferably 800 g / m ² · 24 hrs to 4,000 g / m ² · 24 hrs, preferably 1,000 g / m. ² · 24hrs or more, still more preferably less ^{4,000g / m 2 · 24hrs, 1,300g} / m 2 · 24hrs or more, and particularly preferably not more than 4,000g ^/ m 2 · 24hrs.
Here, the moisture permeability of the film or the like is an amount of water vapor permeating per 1 m ² of the film or the like under a predetermined condition. After a predetermined amount of water is put into a container having a predetermined diameter, Cover mouth with film, temperature 40 ° C., relative humidity 30% R.D. H. The amount of water decrease when left for 24 hours under the above conditions is a value converted per 1 m ² . It can be said that the higher the moisture permeability, the less the film is peeled.

  The skin patch of the present invention has an adhesive layer on one surface of the film base for skin patch. Specifically, an adhesive layer is provided on the film base material for skin patch made of the ether urethane resin. The pressure-sensitive adhesive layer is composed of an acrylic pressure-sensitive adhesive mainly composed of an acrylate ester, a silicone pressure-sensitive adhesive mainly composed of polyorganosiloxane, and a urethane-based pressure-sensitive adhesive mainly composed of polyether polyurethane and / or polyester polyurethane. It is preferably formed from at least one selected from the group.

  When the pressure-sensitive adhesive layer is formed from an acrylic pressure-sensitive adhesive, for example, a carboxylic acid ester that is compatible with the acrylic acid ester-based polymer and a cross-linking agent are mixed with the acrylic acid ester-based polymer, if necessary, for crosslinking. It can be obtained by processing. However, the carboxylic acid ester has 16 or more carbon atoms and is liquid or pasty at room temperature.

  The acrylic ester polymer is a copolymer of a (meth) acrylic ester as a main component and a copolymerizable monomer as required. (Meth) acrylic acid ester is preferably a (meth) acrylic acid alkyl ester having 2 or more carbon atoms, preferably 2 or more and 18 or less carbon atoms in the alkyl group. Examples include (meth) acrylic acid ethyl ester, propyl ester, butyl ester, pentyl ester, hexyl ester, octyl ester, nonyl ester, decyl ester, dodecyl ester, and the like. Among these (meth) acrylic acid esters, it is preferable to use one or more kinds. These alkyl ester chains may be linear or branched.

  As a monomer copolymerizable with (meth) acrylic acid ester, for example, a monomer containing a carboxyl group such as (meth) acrylic acid, itaconic acid, maleic acid, (meth) acrylic acid 2-hydroxyethyl, (meth) Monomers containing hydroxyl groups such as 2-hydroxypropyl acrylate, methoxyethyl (meth) acrylate, ethoxyethyl (meth) acrylate, butoxyethyl (meth) acrylate, methoxypolyethylene glycol (meth) acrylate, (meth ) Monomers containing alkoxy groups such as ethoxydiethylene glycol acrylate, vinyl monomers such as styrene and styrene derivatives, vinyl acetate and N-vinyl-2-pyrrolidone. One or more of these monomers can be used by copolymerizing with (meth) acrylic acid ester as required.

  The acrylate polymer preferably has a glass transition temperature of 260K or lower. By setting the glass transition temperature of the acrylic ester polymer to 260 K or less, the skin adhesiveness can be sufficiently expressed, which is desirable as a pressure-sensitive adhesive layer of a pressure-sensitive adhesive sheet for medical use and hygiene materials.

  The acrylic ester polymer can be obtained, for example, by a known polymerization method such as a solution polymerization method, an emulsion polymerization method, or a suspension polymerization method. Moreover, it can obtain by performing radical polymerization using radical polymerization initiators, such as a peroxide type compound and an azo type compound.

  The carboxylic acid ester that is compatible with the acrylate polymer is preferably liquid or pasty at room temperature. When a pressure-sensitive adhesive layer is formed by mixing a solid carboxylic acid ester such as wax, the adhesiveness may be lowered.

  In the present invention, a gel-like pressure-sensitive adhesive layer can be obtained by mixing an acrylic ester polymer, a carboxylic acid ester, and a crosslinking agent to form a crosslinked body at least partially. The pressure-sensitive adhesive layer thus obtained can reduce the elastic modulus in the micro-deformation region, and improves the adhesion (wetability) of the surface of the pressure-sensitive adhesive layer with respect to the unevenness of the skin surface. Can exhibit excellent adhesiveness. Moreover, when peeling the skin patch, the stress on the skin surface can be relaxed or dispersed, so there is almost no physical irritation to the skin surface at the time of peeling, and the keratin on the skin surface is Peeling and the like hardly occur, and the skin damage is extremely small.

Examples of the carboxylic acid ester preferably used in the present invention include phthalic acid, maleic acid, adipic acid, stearic acid, esters of various fatty acids and alkyl alcohols, esters of polyhydric alcohols such as ethylene glycol and glycerin, and the like. Can be used. For example, ethyl myristate, isopropyl myristate, isopropyl palmitate, butyl stearate, isopropyl isostearate, hexyl laurate, cetyl lactate, myristyl lactate, diethyl phthalate, dioctyl phthalate, octyldodecyl myristate, octyldodecyl oleate, Esters using monohydric alcohols such as hexyldecyl dimethyloctanoate, cetyl 2-ethylhexanoate, isocetyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, dioctyl succinate, propylene glycol dicaprylate, propylene glycol dicaprate , Propylene glycol diisostearate, glyceryl monocaprylate, glyceryl tricaprylate, glyceryl tri-2-ethylhexanoate, tricaprin Glyceryl, mention may be made trilaurate, glyceryl triisostearate, glyceryl trioleate glyceryl, an ester with a bivalent or higher polyvalent alcohol such as tri-2-ethylhexanoate trimethylolpropane.
However, the carboxylic acid ester used here needs to have 16 or more carbon atoms. This is because when the carbon number of the carboxylic acid ester is 15 or less, the film base material absorbs a large amount of liquid components and the film base material undergoes expansion deformation.

  In this invention, when mix | blending the said carboxylic acid ester, at least 1 sort (s) is dissolved in an acrylic ester polymer. Although a compounding quantity is not specifically limited, For example, it is preferable to contain carboxylic acid ester within the range of 30-100 mass parts with respect to 100 mass parts of acrylic ester-type polymers.

  In the present invention, in the case of using an acrylate ester-based polymer in which the carboxylic acid ester is dissolved, it is necessary that a crosslinked body is formed in a part thereof. In order to form a crosslinked body, a crosslinking treatment is performed. For example, an organic peroxide, an isocyanate compound, an organic metal salt, a metal chelate, an epoxy compound, or the like may be used, and a chemical crosslinking treatment may be performed. Physical crosslinking treatment may be performed using actinic radiation.

  If necessary, the resin composition (adhesive) forming the adhesive layer may be a plasticizer such as glycerin or polyethylene glycol, a water-soluble or water-absorbing resin such as polyacrylic acid or polyvinylpyrrolidone, rosin, or terpene. Various additives such as tackifiers such as petroleum and petroleum, various softeners, fillers, and pigments can be blended. In particular, when a carboxylic acid ester having an unsaturated bond is used, there is a concern that a change in physical properties may occur due to oxidative degradation due to oxygen in the atmosphere, and the desired properties may not be exhibited. It is preferable to mix | blend an inhibitor in a resin composition (adhesive).

  The thickness of the pressure-sensitive adhesive layer is preferably set in the range of 10 to 100 μm. If the thickness of the pressure-sensitive adhesive layer is less than 10 μm, sufficient adhesion may not be exhibited during application to the skin, and if it exceeds 100 μm, the level of water vapor permeability required for a skin patch cannot be obtained. Sometimes.

When a skin patch is applied to the skin surface of a human body, although there are some variations depending on individual differences and the site to be applied, 40 ° C., 30% R.D. H. The moisture permeability when stored for 24 hours in an atmosphere of 600 g / m ² · 24 h · 40 ° C · 30% R.V. H. That is necessary. If an adhesive sheet having only a moisture permeability less than this is pasted on the skin for one week or longer, continuous swelling occurs and causes skin irritation. Skin patch, the moisture permeability of ^{800g / m 2 · 24h · 40} ℃ · 30% RH~2,400g / m 2 · 24h · 40 ℃ · 30% R. H. It is preferable to set within the range.

  The film base material for skin patch of the present invention needs to have little deformation after the pressure-sensitive adhesive layer is formed. This is because if the deformation is too large, it is impossible to realize an adhesive tape or the like, and a skin patch cannot be formed. Therefore, the film base material for skin patches has an absorption rate of 50% with respect to the liquid component of the pressure-sensitive adhesive forming the pressure-sensitive adhesive layer, such as caprylic acid triglyceride (hereinafter sometimes abbreviated as “GTC”). In the following, the deformation rate is preferably 10% or less.

  In the present invention, a medical tape or sheet such as a bandage can be formed using this skin patch. For example, cut the skin patch to an appropriate size to form an adhesive bandage, or a covering material for covering the wound, a post-surgical patch, a catheter needle insertion part, a cover material for gauze, etc. A medical product such as a fixing tape or a device holding tape can be formed by forming a tape or a sheet, or by combining another base material with the skin patch. In addition, it goes without saying that the base material for skin patch and the skin patch of the present invention can be used other than the above medical applications as long as they are applied to the skin, for example, adhesive piercings, tattoo tapes, wig fixing It can also be used for tapes and artificial hair transplantation tapes.

  Hereinafter, the present invention will be described in detail using examples, but the present invention is not limited thereto. The measurement methods and evaluation methods used in the following examples are shown below.

<Measurement method and evaluation method>
(1) Water vapor permeability of film base material 20 mL of purified water is placed in a glass container (weighing bottle) having an inner diameter of 40 mm and a height of 40 mm, and the adhesive film is applied to the film base material for skin patch cut into a straight line of 50 mm. It was stuck and fixed to the mouth of the container facing downward. After measuring the weight (W1) of the entire container to which the pressure-sensitive adhesive sheet was attached, this was measured at 40 ° C. and 30% relative humidity. H. Were placed in a constant temperature and humidity chamber, and the weight (W2) after being left for 24 hours was measured. The moisture permeability was calculated based on the following formula. However, the moisture permeability was calculated in terms of a thickness of 30 μm, assuming that the moisture permeability was inversely proportional to the thickness.

Moisture permeability (g / m ² · 24h · 40 ° C · 30% RH) =
(W1-W2) / (0.02 × 0.02 × π)

(2) Moisture permeability of skin patch (1) Moisture permeability was determined in the same manner as the measurement of moisture permeability of the film substrate. However, the skin patch was fixed so that the adhesive layer was on the water (water vapor) side, that is, the adhesive layer was in contact with the mouth of the glass container.

(3) Liquid component absorbability (deformation rate, absorption rate)
Immediately after producing the film base material for skin patches, the sample piece is cut into a size of 50 mm × 50 mm. The length and weight of one side of the sample piece are measured (herein referred to as “initial length” or “initial weight”). After immersing the sample piece in triglyceride caprylate for 3 days, taking out and wiping off the liquid adhering to the surface, the length and weight of one side are measured (here, “length after immersion” or “immersion”). Labeled as “weight after”). Based on the following formula, the deformation rate and absorption rate of the film base material for skin patch were calculated.

Deformation rate (%) = [(length after storage−initial length) / initial length] × 100

Absorption rate (%) = [(weight after storage−initial weight) / initial weight] × 100

(Example 1)
In a reaction vessel equipped with a cooling tube, a heating device, a thermometer, and a stirring device, as a polyol, 38 g of polyoxytetramethylene glycol (OTMG) having a weight average molecular weight of 1,000 and a weight average molecular weight of 2,000 are used. 26 g of polyethylene glycol (PEG) and 6 g of 1,4-butanediol (BD) are added and mixed. The temperature was adjusted to 70 ° C., and 30 g of methylene diphenyl diisocyanate (MDI) adjusted to 50 ° C. was added as a polyisocyanate while stirring and stirred for 5 minutes. Thereafter, the reaction product was transferred to a tray, placed in a hot air dryer and aged at 140 ° C. for 5 hours to obtain a bulky ether-based urethane resin. The obtained massive ether-based urethane resin was pulverized and dissolved in N, N-dimethylformamide (DMF) to prepare a solution having a concentration of 30%. This solution is cast on the release-treated surface of a polyester film (38 μm thick) using an applicator so that the thickness after drying is 30 μm, and dried at 160 ° C. for 5 minutes in a hot air circulating dryer. Thus, a film base material for skin patch made of ether urethane resin was obtained.

Next, an adhesive layer is formed on the obtained film base material for skin patch.
Isonyl acrylate (NA), methoxyethyl acrylate (MEA), and acrylic acid (AA) were copolymerized to obtain an alkyl acrylate polymer. However, the blending ratio of the acrylic acid alkyl ester polymer is NA: MEA: AA = 65: 30: 5 in weight ratio. 100 parts by weight (solid content) of the resulting acrylic acid alkyl ester polymer, 60 parts by weight of caprylic acid triglyceride (GTC) as a carboxylic acid ester component, and 0.2 parts by weight of a trifunctional isocyanate compound as a crosslinking agent component A solution for the pressure-sensitive adhesive layer (concentration 33%) was prepared by mixing in toluene. This pressure-sensitive adhesive layer solution was applied on the release-treated surface of the paper separator subjected to the release treatment so that the thickness after drying was 30 μm, and dried in a hot air dryer at 110 ° C. for 3 minutes. A layer was formed.

  After bonding the film base material which consists of the produced ether type urethane resin on the obtained adhesive layer, it preserve | saved for 3 days in 60 degreeC atmosphere in a hot-air dryer, and performs aging, and the adhesive layer of The cross-linking reaction was completed to prepare a skin patch for dressing material.

  The moisture permeability of the obtained film base material for skin patch was measured. Moreover, it measured about the liquid component (GTC) absorptivity of the film base material for skin patches. The results are shown in Table 1.

(Example 2)
In Example 1, as a polyol, 6 g of polyoxytetramethylene glycol (OTMG) having a weight average molecular weight of 1,000, 40 g of polyethylene glycol (PEG) having a weight average molecular weight of 2,000, and a weight average molecular weight of 2 are used. 10 g of polypropylene glycol (PPG) of 1,000, and 8 g of 1,4-butanediol (BD) were added and mixed, and the temperature was adjusted to 70 ° C. A film base material for skin patch was prepared in the same manner as in Example 1 except that 36 g of methylenediphenyl diisocyanate (MDI) was added and stirred for 5 minutes.
Further, using the obtained film base material for skin patch, a skin patch was prepared in the same manner as in Example 1.
The obtained film base material for skin patch and skin patch were measured and evaluated in the same manner as in Example 1. The results are shown in Table 1.

(Example 3)
In Example 1, as a polyol, 58 g of polyoxytetramethylene glycol (OTMG) having a weight average molecular weight of 1,000 and 10 g of 1,4-butanediol (BD) were added and mixed. In the same manner as in Example 1, except that 32 g of methylenediphenyl diisocyanate (MDI) adjusted to 50 ° C. was added as a polyisocyanate and stirred for 5 minutes while stirring. Was made.
Further, using the obtained film base material for skin patch, a skin patch was prepared in the same manner as in Example 1.
The obtained film base material for skin patch and skin patch were measured and evaluated in the same manner as in Example 1. The results are shown in Table 1.

(Comparative Example 1)
A polyether polyamide film having a thickness of 25 μm was prepared as a non-porous moisture-permeable film. A pressure-sensitive adhesive layer was formed on one surface of the film in the same manner as in Example 1 to prepare a skin patch.
The polyether polyamide film and the prepared skin patch were evaluated in the same manner as in Example 1. The results are shown in Table 1.

As is clear from Table 1, the film substrates for skin patches of Examples 1 to 3 have a moisture permeability of 1,000 g / m ² · 24 h · 40 ° C. · 30% R.D. H. It was above, and it turned out that it has the outstanding moisture permeability. In particular, the film base materials for skin patches of Examples 1 and 2 using PEG as the diol component have a moisture permeability of 1,900 g / m ² · 24 h · 40 ° C. · 30% R.D. H. It was above, and it turned out that it has the especially outstanding moisture permeability.
On the other hand, the film base material for skin patch of Comparative Example 1 made of polyetheramide was excellent in moisture permeability, but its absorption rate with respect to caprylic acid triglyceride was as high as 60%, and deformation due to absorption of liquid components was large. It was not possible to realize a good skin patch.

Moreover, when the moisture permeability of the skin patch of Example 1 and Example 2 was measured, the moisture permeability of the skin patch of Example 1 was 1,030 g / m ² · 24 h. The humidity was 1,180 g / m ² · 24 h. That is, it was found that the skin patch material film base materials of Example 1 and Example 2 have excellent moisture permeability even when having a pressure-sensitive adhesive layer.

  In addition, the skin patch of Examples 1 to 3 had an appropriate adhesive force and was excellent in followability to the skin and the like.

The skin patch of the present invention can be used in the form of sheets and tapes of various sizes, and can also be stored in a roll form. These skin patch materials can be used in the fields of skin patch application, for example, medical hygiene field, external use, and the like. Specifically, they are suitably used for bandages, adhesive bandages, dressing materials and the like.

Claims (6)

  The diol component comprises at least one selected from the group consisting of polyoxytetramethylene glycol, butanediol, polyethylene glycol and polypropylene glycol, and the ether component urethane resin obtained from methanediphenylene diisocyanate as the isocyanate component. Film base material for skin patch.   The film base material for skin patches according to claim 1, wherein polyoxytetramethylene glycol and polyethylene glycol and / or polypropylene glycol are used as the diol component.   The film base material for skin patches according to claim 2, wherein the ether-based urethane resin contains 5 to 60% by weight of the polyoxytetramethylene glycol and 10 to 50% by weight of the polyethylene glycol. The film base material for skin patches according to any one of claims 1 to 3, wherein the moisture permeability is 800 to 4,000 g / m ² · 24 hrs.   A skin patch having an adhesive layer on one side of the film base material for a skin patch according to any one of claims 1 to 4. The pressure-sensitive adhesive forming the pressure-sensitive adhesive layer is an acrylic pressure-sensitive adhesive mainly composed of (meth) acrylic acid ester, a silicone pressure-sensitive adhesive mainly composed of polyorganosiloxane, and polyether polyurethane and / or polyester polyurethane. The skin patch according to claim 5, wherein the skin patch is at least one selected from the group consisting of urethane-based pressure-sensitive adhesives containing as a main component.