JP2005192619A - Adhesive preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide adhesive preparation having superior storage stability in the adhesive preparation such as a plaster and a poultice. <P>SOLUTION: This adhesive preparation 1 which has a support body 2, an adhesive layer 3 stacked on one face of the support body 2, and a release liner 5 releasably attached to the adhesive layer 3 is characterized in that the release liner 5 is formed with an extension area non-attached to the adhesive layer 3 and a notch 6 is provided only in an edge of the extension area as a cutting facilitation part. The other parts of the release liner cover the adhesive layer and airtightly or liquidtightly seal it to stabilize the state of the adhesive layer for a long period of time. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a patch such as a plaster or a poultice.

  A conventional general drug-containing patch is composed of a support made of a nonwoven fabric or the like, an adhesive layer laminated on the whole, and a release liner attached to the adhesive layer in a peelable manner. Moreover, the drug is contained in the adhesive that constitutes the adhesive layer. When using such a patch, the release liner is peeled off, and the exposed surface of the adhesive layer is attached to the skin.

  In order to make it easy to peel the release liner from the adhesive layer, various means have been conventionally proposed.

  For example, a type is known in which a linear cut is formed so as to cross the release liner, and a portion along the cut of the release liner is floated from the adhesive layer by bending the support.

Moreover, the patch as shown in Patent Document 1 is provided with at least two notches at the edge of the release liner in place of the cut across the release liner. In this patch, a method is adopted in which the user picks and tears the edge between two notches, and then peels off the remaining release liner.
JP 2001-247455 A

  However, in the type of patch in which a linear cut is provided in the substantially central part of the release liner, there is a possibility that the adhesive or drug constituting the adhesive layer may leak from the cut, and conversely, air passes through the cut. May cause contact with adhesives or drugs. For this reason, the preservation | save state of the drug before use is unpreferable. On the other hand, when processing the cut, the support that is the back side is inevitably damaged because of the contact relationship between the blade dies used. For this reason, characteristics such as barrier properties and appearance designed for the support are deteriorated, resulting in an unfavorable preparation in terms of drug release and storage stability.

  Moreover, the above-mentioned cut | interruption is not provided in the patch shown to patent document 1. FIG. However, since the support and the release liner have the same shape and dimensions, the notch is located on the support. For this reason, there is a problem that an adhesive or a drug leaks from the notch or air enters.

  This invention is made | formed in view of the subject which the said prior art has, and aims at providing the patch with the preservability of an adhesion layer.

  The patch of the present invention is a patch comprising a support, an adhesive layer laminated on one surface of the support, and a release liner that is releasably attached to the adhesive layer, wherein the release liner is the edge of the support. It has the area | region extended outside the part, The cutting | disconnection facilitation part which makes easy cutting | disconnection of a peeling liner is provided only in the edge part of this area | region.

  Here, “providing an easy-to-cut portion only at the edge” means notches, small holes, perforations, straight cuts in portions other than the edge, particularly the release liner adhering to the adhesive layer. This means that no transmissive part such as is provided. Therefore, according to the patch of the present invention, the pressure-sensitive adhesive layer is completely airtight or liquid-tightly sealed by the release liner, and the pressure-sensitive adhesive constituting the pressure-sensitive adhesive layer leaks out, or conversely, the pressure-sensitive adhesive layer touches the air. It can be greatly reduced.

  Moreover, since the patch of this invention is provided with the cutting | disconnection facilitating part in the edge part of the release liner, it can cut | disconnect a peeling liner from the cutting | disconnection facilitating part as a starting point, and can peel off from an adhesion layer. Thereby, the release liner can be easily removed from the adhesive layer of the patch. In particular, the cutting facilitating part is preferably a notch having a cut in the edge of the release liner.

  The release liner preferably has a single layer structure or a laminated structure including at least one selected from the group consisting of a resin film, an aluminum foil, and paper. When made of these groups of materials, the release liner can be suitably attached to the adhesive layer and can be peeled off from the adhesive layer with a weak force.

  The release liner preferably has a resin film layer containing an inorganic filler. Thereby, the tear strength of the release liner can be weakened, and the release liner can be easily torn. In particular, titanium oxide is effective as such an inorganic filler.

  The adhesive layer can contain a drug. As a result, the patch of the present invention can function as a plaster or a poultice, and the drug contained in the adhesive layer can be kept stable.

As one form of the patch according to the present invention, the release liner is substantially rectangular, the support is substantially elliptical, and the major axis of the support is substantially parallel to the edge on the long side of the release liner. In some cases, the support is attached to the release liner concentrically. In such a case, the cutting facilitating portion is provided on at least one of the edges on the long side of the release liner, and the position of the cutting facilitating portion is a half of the entire length of the support along the long axis of the support. It is preferable that the position corresponding to 5 to 90% of the length (L ₁ ) of the release liner is separated from the center of the edge of the release liner.

  At this position, when the extension region of the release liner is gripped by a finger, the finger can be prevented from being applied to a cutting facilitating part such as a notch. In the state where the release liner is cut and a part thereof is removed, the exposed adhesive layer has an appropriate area for temporarily fixing to an object such as skin. Therefore, the patch can be preliminarily fixed to the object and the remaining release liner can be suitably peeled off.

  As described above, the patch of the present invention can prevent the release or deterioration of components contained in the adhesive layer because the adhesive layer has good storage stability while ensuring the ease of peeling of the release liner. This is particularly effective when the adhesive layer contains a highly volatile component, a hydrophilic component, a component containing a large amount of moisture, or the like.

  DESCRIPTION OF EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. In the drawings, the same or corresponding parts are denoted by the same reference numerals.

  FIG. 1 is a plan view showing an example of a preferred embodiment of the patch of the present invention, and FIG. 2 is an enlarged schematic sectional view taken along line II-II in FIG.

  As shown in FIGS. 1 and 2, the patch 1 of the present embodiment includes a support body 2, an adhesive body 4 including an adhesive layer 3 laminated on almost the entire surface of the support body 2, and an adhesive layer 3. The release liner 5 is detachably attached to the surface.

  The constituent material of the support 2 is not particularly limited as long as it is a material generally used as a support for patches, but polyesters such as polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, ethylene-vinyl acetate copolymer, poly Block copolymer resin mainly composed of vinyl chloride, polyethylene, polypropylene, polybutadiene, styrene-butadiene or styrene-isoprene, butadiene-styrene-methyl methacrylate copolymer resin, nylon, polyurethane, polyurethane / vinyl chloride copolymer, alkoxyalkyl Examples include (meth) acrylate copolymers, synthetic resins such as cellulose derivatives such as polyvinyl acetal, polyamide, and rayon, films and foils made of cotton, hemp, pulp and aluminum, woven fabrics, knitted fabrics, and nonwoven fabrics. It is. In particular, resin films such as PET, polyethylene naphthalate, nylon, polypropylene, polyethylene, and vinyl chloride, aluminum foil, and paper are preferably used.

  The support 2 may have a single layer structure, and is more effective in a two or more layered structure in which a plurality of the above-described constituent materials are stacked.

  The constituent material of the pressure-sensitive adhesive layer 3 is not particularly limited as long as it is a pressure-sensitive adhesive generally used for patches, but when used for a poultice or a plaster, the adhesive strength that can fix the drug to the skin surface at room temperature for a long time. And pressure-sensitive adhesive properties are preferable, and examples thereof include acrylic pressure-sensitive adhesives, rubber-based pressure-sensitive adhesives, polyurethane-based pressure-sensitive adhesives, silicon-based pressure-sensitive adhesives, and gel-forming polymers. More specifically, natural rubber, synthetic isoprene rubber, polyisobutylene, polyvinyl ether, polyisoprene, polybutadiene, styrene-butadiene copolymer, styrene-isoprene copolymer, styrene-isoprene-styrene block (SIS) copolymer. Agar, gelatin, sodium polyacrylate and the like are preferably used.

  An appropriate tackifier, softener or other component may be added to the adhesive layer 3 as necessary. Examples of such tackifiers include alicyclic saturated hydrocarbon resins, rosin esters, hydrogenated rosin esters, hydrogenated alicyclic hydrocarbons, polyterpene resins, and petroleum resins. Examples of the softening agent include liquid paraffin, polybutene, liquid polyisobutylene, and animal and vegetable oils.

  Other components included in the adhesive layer 3 are specifically a solubilizer, a solubilizer, a filler, an anti-aging agent, an antioxidant, an antiseptic, an ultraviolet absorber, a colorant, a flavoring agent, an interface. An activator, a pH adjuster, etc. are mentioned, These components can be mix | blended and included in the adhesion layer 3 according to the objective of a patch.

  Moreover, the patch 1 can be used for a poultice, a plaster agent, etc. by mix | blending a medicine with the adhesion layer 3. FIG.

  The drug compounded in the adhesive layer 3 is not particularly limited, but is a general anesthetic, sleep, analgesic, antipyretic and anti-inflammatory analgesic, steroid hormone agent, stimulant / stimulant, neuropsychiatric agent, local anesthetic, skeletal muscle relaxant, Autonomic nerve agent, antiallergic agent, antihistamine, cardiotonic agent, arrhythmia agent, diuretic, antihypertensive agent, vasoconstrictor, vasodilator, calcium antagonist, antibacterial agent, parasitic skin disease agent, emollient Antibiotics, antidotes, antitussives, antitussives, hypnotics, psychoactive agents, asthma agents, hormone secretagogues, anti-ulcer agents, anticancer agents, vitamins, etc., depending on the purpose of the patch Can be blended and included in the adhesive layer 3.

  Furthermore, the penetration of the drug into the skin can be enhanced by blending an absorption promoter with the drug in the adhesive layer 3.

  The absorption enhancer blended in the adhesive layer 3 is not particularly limited as long as it is an absorption enhancer generally used in a poultice or plaster, but fatty acid esters (isopropyl myristate, diethyl sebacate, sorbitan monolaur) Glyceryl monooleate), sodium oleyl phosphate, sodium lauryl sulfate, octylphenyl ether, lauryl ether, lauroyl diethanolamide, lauroyl sarcosine, oleoyl sarcosine sugar ester, lecithin, glycyrrhetin, urea, salicylic acid, methyl salicylate, glycol salicylate, Examples include L-menthol, light oil, limonene, calcium thioglycolate, lactic acid, lactic acid ester, olive oil, squalene, lanolin, liquid paraffin, and glycerin. It can be formulated in accordance with the release profile of the drug.

  The constituent material of the release liner 5 is not particularly limited as long as it is a material that is generally used as a release liner for patches. For example, polyester films such as polyethylene terephthalate and polyethylene naphthalate, resin films such as nylon, polypropylene, polyethylene, and vinyl chloride. A sheet having a thickness of about 20 to 150 μm, which is obtained by subjecting an aluminum foil or paper to a release treatment, is preferably used.

  Moreover, the release liner 5 may have a single layer structure, or may have a laminated structure of two or more layers in which a plurality of the above constituent materials are laminated.

  Furthermore, in order to facilitate the peeling between the release liner 5 and the pressure-sensitive adhesive layer 3, the surface of the release liner 5 can be surface-treated with silicon, Teflon (registered trademark), a surfactant or the like.

  Although the release liner 5 will be described in detail below, it is preferable that the release liner 5 has a resin film layer containing an inorganic filler to facilitate tearing. Examples of the material that weakens the tear strength of the release liner 5 include titanium oxide, talc, and calcium carbonate. In particular, titanium oxide can be preferably used.

  As mentioned above, although the constituent material of the support body 2, the adhesion layer 3, and the release liner 5 was demonstrated, any combination may be sufficient as these. In particular, the patch 1 according to the present embodiment will be described below. However, since the adhesive 1 is used to prevent leakage of adhesives and drugs constituting the adhesive layer 3 and air deterioration, the softening agent as the adhesive layer 3 is used. , A pressure-sensitive adhesive having a relatively low molecular weight and a liquid component at room temperature, such as a drug solubilizer, solubilizer, surfactant, absorption accelerator, etc., that is, generally natural rubber, polyisobutylene, It is particularly effective to use an adhesive layer mainly composed of styrene-isoprene-styrene block copolymer. In addition, as drugs, volatile and sublimable drugs, layers that are not adjacent to the support adhesive layer, materials that are not adjacent to the adhesive inner layer for packaging patches, and layers that are not adjacent to the liner adhesive layer It is particularly effective for drugs such as a drug that easily undergoes a reaction such as oxidation or crystallization or crystallization in the atmosphere inside the package in the packaged state of the patch. That is, as an example, it is effective in methyl salicylate, glycol salicylate, nicotine, nitroglycerin, isosorbide nitrate, estradiol, fentanyl, ketoprofen, fernavik, diclofenac and the like.

  As shown in FIG. 1, the release liner 5 has a substantially rectangular shape. The patch body 4 is substantially elliptical. The long side of the release liner 5 is longer than the long axis of the patch body 4, and the short side of the release liner 5 is longer than the short axis of the patch body 4. That is, the area of the release liner 5 is larger than the area of the patch body 4. The release liner 5 is concentrically attached to the adhesive layer 3 of the patch body 4. Further, the edge on the long side of the release liner 5 is oriented so as to be substantially parallel to the long axis of the patch body 4. In such an arrangement, an extension region extending outward from the periphery of the patch body 4 is formed on the peripheral portion of the release liner 5.

  A notch 6 is formed at the edge of the extended portion of the release liner 5 as a cutting facilitating portion for easily cutting the release liner 5. The notches 6 are formed symmetrically one by one at both edges on the long side of the release liner 5. The reason why the notch 6 is formed at the edge on the long side is that it is easier to tear along the short side. The notch 6 is provided offset from the center of the edge (to the right in FIG. 1). This is in consideration of the user's dominant hand. That is, in the right-handed case, the configuration of FIG. 1 would utilize the upper notch 6 to cut the release liner 5 and, if left-handed, would use the lower notch 6. Of course, it is good also as providing the notch 6 only in any one.

  The shape of the notch 6 is not particularly limited as long as the notch 6 can be used as a starting point of cutting and the release liner 5 can be easily torn without stress. For example, as shown in FIG. Examples include a base shape 13, a U shape 14, and a semicircular shape 15.

  The depth 18 of the notch 6 is not particularly limited as long as the release liner 5 can be torn, but is preferably 0.5 mm or more so that it can be visually recognized. However, it is important that the notch 6 does not extend to the area of the release liner 5 that overlaps the patch body 4. That is, the notch 6 is formed only at the edge of the extension region of the release liner 5, and the release liner has airtightness or liquid-tightness in other portions.

  Therefore, the patch 1 of the present embodiment has the entire surface of the pressure-sensitive adhesive layer 3 attached to the release liner 5, and the release liner 5 does not have a transmissive portion such as a cut that contacts the pressure-sensitive adhesive layer 3. Will not leak. Moreover, since the contact of the adhesive layer 3 with air is greatly reduced, the state of the adhesive layer can be kept stable for a long time. In particular, when the adhesive layer 3 contains highly volatile components such as l-menthol and camphor, hydrophilic components such as water and ethanol, and components containing a lot of moisture, these are sensitive to air. Is extremely effective.

  Note that the notch 6 can be easily formed by an appropriate means such as a press or a cutter.

  Next, the usage method of the patch 1 of this embodiment is demonstrated.

  First, the release liner 5 is picked with the left and right fingers with one notch 6 of the patch 1 sandwiched therebetween. At this time, if the user is right-handed, the upper notch 6 in FIG. 1 is used as the cutting start point, and the portion to be peeled first is the right portion of the upper notch 6. Therefore, in detail, as understood from the two-dot chain line in FIG. 1, the finger of the left hand grips the patch body 4 in the vicinity of the notch 6, and the finger of the right hand grips the upper right of the release liner 1. Only the extension area of the part is gripped.

  In order to pick only this region with a finger, there is no particular problem if the shortest distance from the center of the long side edge of the release liner 5 to the patch body 4 is sufficiently long. As shown in FIG. 1, it is desirable to provide the notch 6 in an offset state from the center.

For this purpose, in the configuration shown in FIG. 1, the notch 6 has a length L that is one-half of the total length of the support along the long axis of the support, ie from the center point C to the right or right edge. by a length L ₂ which corresponds to ₁ of at least 5%, preferably provided in positions spaced from the center of the edge of the long side of the release liner. This is because at a position close to the center of less than 5%, the right finger must be placed away from the notch 6 and cutting becomes difficult.

  If the right place of the patch 1 is grasped with fingers, when the left and right fingers are pulled apart in opposite directions, the release liner 5 is torn starting from the notch 6, but the cutting progresses generally along the planned cutting line 7. To do. As described above, when an inorganic filler such as titanium oxide particles is added to the release liner 5, the cutting is performed more easily and accurately along the planned cutting line 7. Since the finger of the left hand sandwiches the patch body 4 and the release liner 5, the right side portion of the release liner 5 is peeled from the patch body 4.

  Subsequently, the surface of the pressure-sensitive adhesive layer 3 exposed after peeling is pasted to a target pasting place to preliminarily fix the patch 1.

It is desirable that this fixing be performed relatively firmly even if preliminary. Therefore, the offset amount L ₂ of the notch 6 is preferably plaster is within 90% of the radius L ₁ of the longitudinal direction of the body 4. When exceeding 90%, when the part of the release liner 5 on the one side (the right side in FIG. 1 when the user is right-handed) with the planned cutting line 7 as a boundary, the exposed surface of the adhesive layer 3 is small, It is difficult to fix the release liner 5 to the target object to a desired degree, and in addition, it becomes difficult to peel the remaining release liner 5 from the patch body 4. Incidentally, the small offset amount L ₂ than 5% of the, too large exposed portion of the adhesive preparation main body 4 is easily bent, handling becomes difficult. Therefore, the offset amount L ₂ of notches 6, in the range 5 to 90% of the radius L ₁ long axis direction of the adhesive preparation main body 4 is preferable.

  Next, when the preliminary fixing of the patch body 4 is completed, the edge along the cut line of the remaining release liner 5 is bent by slightly bending the non-fixed side and causing the release liner 5 to warp. The part can be lifted from the adhesive layer 3. As described above, since the pressure-sensitive adhesive layer 3 is exposed and firmly fixed in an appropriate area, the work of lifting the remaining portion of the release liner 5 can be performed stably. Then, the lifted edge of the release liner 5 is picked with a finger, and the adhesive layer 3 that is gradually exposed is attached to the application target portion while the remaining portion of the release liner 5 is peeled off from the patch body 4. In this way, the patch body 4 is simply pasted to the intended pasting location.

  As mentioned above, although preferred embodiment of this invention was described in detail, it cannot be overemphasized that this invention is not limited to the said embodiment. For example, the cutting facilitating part is not limited to the notch 6, and even a circular hollow part as indicated by reference numeral 16 in FIG. 3 or a short straight perforation indicated by reference numeral 17 is formed in the vicinity of the edge. Then, the release liner 5 can be easily cut. Moreover, a means of making the edge of the release liner 5 brittle by processing such as heat treatment without forming a notch or a hole is also conceivable.

  In the case of a roll-like patch, an extension region of the release liner is provided along the edge in the direction orthogonal to the winding direction, and a notch or the like is provided at the edge of the extension region at regular intervals in the winding direction. A cutting facilitating part can be provided.

[Example 1]
After heating and dissolving 20.5 parts by mass of SIS base, 13.0 parts by mass of polyisobutylene, 36.0 parts by mass of a tackifier (hydrogenated rosin), and 22.5 parts by mass of a softener (liquid paraffin), 1.0 part by mass of estradiol and 5.0 parts by mass of crotamiton were added and mixed by stirring to obtain a uniform mixture.

  Next, the obtained mixture was spread on the silicon-treated surface of a release liner of polyethylene terephthalate (thickness 75 μm, single-sided silicon treated), and then this was supported on a laminate film (polyethylene terephthalate having a thickness of 50 μm / polyethylene terephthalate having a thickness of 6 μm). Covered with pressure transfer.

Subsequently, vertical 31mm up adhesive surface of the release liner from the surface of the support side, then cut into oval transverse 43 mm, peeling the support of the outer portion of the oval from the release liner, the support of 9cm ² oval Shaped.

  Thereafter, the release liner was cut into a rectangle having a length of 37 mm and a width of 43 mm with an elliptical support placed in the center.

  Finally, a V-shaped notch having a depth of 3 mm was placed at a position 12 mm from the side edge of the release liner with a cutter knife to prepare the patch of Example 1.

[Comparative Example 1]
After heating and dissolving 20.5 parts by mass of SIS base, 13.0 parts by mass of polyisobutylene, 36.0 parts by mass of a tackifier (hydrogenated rosin), and 22.5 parts by mass of a softener (liquid paraffin), 1.0 part by mass of estradiol and 5.0 parts by mass of crotamiton were added and mixed by stirring to obtain a uniform mixture.

  Next, the obtained mixture was spread on the silicon-treated surface of a release liner of polyethylene terephthalate (thickness 75 μm, single-sided silicon treated), and then this was supported on a laminate film (polyethylene terephthalate having a thickness of 50 μm / polyethylene terephthalate having a thickness of 6 μm). Covered with pressure transfer.

Subsequently, a slit was made by applying a leather knife to the surface on the release liner side. Thereafter, vertical 31mm up adhesive surface of the release liner from the surface of the support side, then cut into oval transverse 43 mm, peeling the support of the outer portion of the oval from the release liner, the shape of the support oval 9cm ² It was. When the support was cut, the cutting position was adjusted so that the release liner bonded to the elliptical support had a slit.

  Finally, the release liner was cut into a rectangle having a length of 37 mm and a width of 43 mm with an elliptical support placed in the center, and a patch of Comparative Example 1 was produced.

(Storage stability evaluation test 1)
Immediately after the preparation of the patch of Example 1, the estradiol release rate was measured after 3 hours and 6 hours after storage at 25 ° C. for 6 months and after storage at 25 ° C. for 12 months. The result is shown in FIG. Circle mark 21 indicates the release rate of the patch immediately after preparation, triangle mark 22 indicates the release rate of the patch after storage at 25 ° C. for 6 months, and square mark 23 indicates the release rate of the patch after storage at 25 ° C. for 12 months. .

  Further, immediately after the preparation of the patch of Comparative Example 1, the estradiol release rate was measured after 3 hours and 6 hours after storage at 25 ° C. for 6 months and after storage at 25 ° C. for 12 months. The result is shown in FIG. Circle mark 31 indicates the release rate of the patch immediately after preparation, triangle mark 32 indicates the release rate of the patch after storage at 25 ° C. for 6 months, and square mark 33 indicates the release rate of the patch after storage at 25 ° C. for 12 months. .

  As is clear from FIGS. 4A and 4B, the patch of Example 1 has a relatively higher estradiol release rate after a predetermined time than the patch of Comparative Example 1. It was confirmed.

(Storage stability evaluation test 2)
Immediately after preparation of the patch of Example 1, after 3 months storage at 25 ° C., after 6 months storage at 25 ° C., after 9 months storage at 25 ° C., after 12 months storage at 25 ° C., 3 hours and 6 hours later The release rate of estradiol was measured.

  Further, immediately after preparation of the patch of Comparative Example 1, after 3 months storage at 25 ° C., 6 months storage at 25 ° C., 9 months storage at 25 ° C., 12 months storage at 25 ° C., 3 hours later, 6 The estradiol release rate after time was measured

  The release rate of estradiol after 3 hours in Example 1 and Comparative Example 1 is shown together in FIG. 5 (a), and the release rate of estradiol after 6 hours is shown together in FIG. 5 (b). The square mark 41 and the square mark 51 are for the patch of Example 1, and the circle mark 42 and the circle mark 52 are for the patch of Comparative Example 1.

  As is clear from FIGS. 5 (a) and 5 (b), the patch of Example 1 is less likely to decrease the estradiol release rate after a predetermined time than the patch of Comparative Example 1. confirmed.

(Storage stability evaluation test 3)
Immediately after the production of Example 1 and Comparative Example 1, the content of estradiol was measured after 3 months storage at 25 ° C., 6 months storage at 25 ° C., 9 months storage at 25 ° C., and 12 months storage at 25 ° C. . Further, the patches of Example 1 and Comparative Example 1 were stored at 60 ° C., and the estradiol content immediately after production and one month later was measured. The measurement results when stored at 25 ° C. are shown in FIG. 6A, and the measurement results when stored at 60 ° C. are shown in FIG. 6B. Square mark 61 and square mark 71 are for the patch of Example 1, and circle mark 62 and circle mark 72 are for the patch of Comparative Example 1.

  As is clear from FIGS. 6A and 6B, it was confirmed that the patch of Example 1 had a lower decrease rate of estradiol than the patch of Comparative Example 1.

(Tear strength test of release liner)
A roll film A (75 μm thick polyethylene terephthalate), a film B (50 μm thick polyethylene terephthalate), and a film C (50 μm thick titanium oxide-containing polyethylene terephthalate) were prepared.

Next, in each film, two strip samples having a roll winding direction (M direction) and a direction perpendicular to the roll winding direction (T direction) as the longitudinal direction are prepared, and the edge of the strip shape is prepared. A V-shaped notch having a depth of 2 mm was made with a cutter knife, and the tear strength was measured with a tensile tester. The measurement was performed under the condition of 300 mm / min. The obtained results are shown in Table 1.

  As apparent from Table 1, it was confirmed that the film C containing titanium oxide can be easily torn compared to the films A and B containing no titanium oxide.

It is a top view which shows one Embodiment of the patch by this invention. It is an expansion schematic sectional drawing along the II-II line of FIG. It is a figure for demonstrating the cutting | disconnection facilitation part of the patch of this embodiment. It is a figure which shows the result of the evaluation test 1 of storage stability. It is a figure which shows the result of the evaluation test 2 of storage stability. It is a figure which shows the result of the storage stability evaluation test 3. FIG.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 ... Patch, 2 ... Support body, 3 ... Adhesion layer, 5 ... Release liner, 11, 12, 13, 14, 15, 16, 17 ... Cutting | disconnection facilitation part.

Claims (7)

A patch comprising: a support; an adhesive layer laminated on one surface of the support; and a release liner attached to the adhesive layer in a peelable manner,
The release liner has a region extending outward from the edge of the support, and a cutting facilitating portion that facilitates cutting of the release liner is provided only at the edge of the region. A patch characterized by.   The patch according to claim 1, wherein the cutting facilitating part is a notch.   The patch according to claim 1 or 2, wherein the release liner includes at least one selected from the group consisting of a resin film, an aluminum foil, and paper.   The patch according to any one of claims 1 to 3, wherein the release liner has a resin film layer containing an inorganic filler.   The patch according to claim 4, wherein the inorganic filler is titanium oxide.   The patch according to any one of claims 1 to 5, wherein the adhesive contains a drug. The release liner is substantially rectangular;
The support is substantially elliptical, and the support is attached to the release liner concentrically such that the long axis of the support is substantially parallel to the edge of the release liner on the long side. And
The cutting facilitating part is provided on at least one of the edges on the long side of the release liner;
The position of the cutting facilitating part is the length (L ₂ ) corresponding to 5 to 90% of the half length (L ₁ ) of the entire length of the support along the long axis of the support. The patch according to any one of claims 1 to 6, wherein the patch is a position separated from the center of the edge of the release liner.

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