JP2005168545A - Solid object to be sterilized and sterilizing method of solid object - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an iodine gas generating method executing sufficient sterilization with neither disinfectant left nor the performance of a solid object impaired. <P>SOLUTION: This solid object is constituted to be sterilized with iodine gas brought into contact with . The iodine gas is generated by sublimating solid iodine in a gas medium, and the solid object is sterilized with the mixed gas of the iodine gas and the gas medium brought into contact with. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a solid article sterilized with iodine gas and a sterilization method.

  Solid article sterilization methods include spraying, coating, dipping, coating treatment with a bactericide, blending treatment of bactericides into solid article raw materials, dry heat sterilization treatment, steam sterilization treatment, ultraviolet irradiation treatment, ethylene oxide gas sterilization treatment, etc. In recent years, the use of various compounds has been refrained, and sterilization treatment by methods other than chemical treatment has been studied. For example, although heat treatment is generally performed for medical devices and the like, depending on the processing conditions, the device may be deteriorated and damaged, or sterilization may be insufficient. Moreover, in the chemical | medical agent immersion process, the chemical | medical agent which remains after a process may have a bad influence on an instrument.

On the other hand, iodine has a bactericidal effect, and is usually used as a liquid bactericidal agent in which iodine is dissolved, and is subjected to a bactericidal treatment by a method such as immersion or coating. For example, Non-Patent Document 1 describes that iodine has sublimability, but gaseous iodine also has a bactericidal effect. However, there are no reports of technologies that can be put to practical use.
Isao Shibazaki, “Recent Topics on Iodine Environmental Disinfectants”, Food Industry, Vol. 29, No. 2, pages 60-71, especially page 68 (1986)

  In view of the situation as described above, an object of the present invention is to realize an iodine gas sterilization method capable of performing sufficient sterilization without sterilizing agent remaining and without impairing the performance of the solid article.

  According to the present invention for achieving the above object, a solid article sterilized with iodine gas is provided.

  Moreover, according to this invention, the sterilization method of the solid article by iodine gas is provided.

  According to the present invention, solid iodine has a high sublimation property, so that the persistence is low, a disinfectant does not remain, and an iodine gas sterilization method capable of sufficient sterilization without impairing the performance of the solid article can be realized.

  The present invention is described in detail below.

(Solid goods)
The solid article sterilized by iodine gas is not particularly limited. However, as a solid article, the conventional sterilization method deteriorates, the sterilization is insufficient, the cost is high, and the workability of the sterilization method is not good. Those which are sufficient or have a risk of inconvenience such as remaining of a disinfectant are suitable.

  Specific examples of such solid articles include livestock products such as eggs, packaged cheese, butter, ham and bacon, livestock tools for producing these livestock products, and livestock producing these livestock products. Livestock products such as livestock breeding tools used in breeding; marine products such as packaged sea cucumbers, chikuwa, tarako, raw oysters, marine products for producing these marine products, producing these marine products Marine products such as fish and shellfish breeding tools used for fish and shellfish breeding; insect-related products such as bees and eggs, insect-related tools for producing these insect-related products, and breeding of insects that produce these insect-related products Insect-related articles such as insect breeding tools used for foods; luxury goods such as tobacco, luxury goods such as pipes, and luxury goods such as luxury goods production tools for producing such luxury goods and luxury goods; Playing equipment such as sand, clay, blocks, tsukimiki, playing cards, etc .; leisure equipment such as fishing gear, shruff; medical instruments such as syringes, tubes, scalpels, bandages, thermometers, bankoukou; tooth drilling machine parts, tooth cutting Machine parts, dental supplies such as bridges; baby items such as pacifiers and baby bottles; hygiene items such as masks, swabs, cotton, portable toilets; clothing such as underwear, shoes, pantyhose, handkerchiefs; wigs, gloves, hats Linen articles such as sheets and pillow covers; stationery such as writing utensils and erasers; daily necessities such as bathing articles, brushes, toothbrushes, shavers, combs, and glasses; cups, straws, chopsticks, hawks, spoons Food and drink supplies such as kitchen knives, cutting boards, dishcloths, etc .; Sports equipment such as ski boots, dumbbells and swimwear Pet-related items for breeding pets such as dogs, cats, birds; home appliances such as telephones, vacuum cleaners, washing machines, hair dryers, air conditioners, etc. and their parts; travel such as suitcases and disposable underwear Supplies: Cards such as telephone cards, cash cards, and commuter passes.

  Note that an article in which two or more of the above solid articles are combined can be sterilized well with iodine gas.

  In the iodine gas sterilization method, the pathogen tissue is fatally damaged by chemical action such as oxidation by iodine gas, so that the spectrum of pathogens that can be sterilized by iodine gas is wider than other sterilization methods. Specifically, pathogenic animals such as bacteria, molds, fungi, viruses, nematodes and eggs thereof can be sterilized with iodine gas. After sterilizing these pathogens with iodine gas, the concentration of the pathogen present in the solid article is below the critical concentration necessary for pathogenesis.

  As a method for quantifying the concentration of pathogens, for example, (a) the number of pathogens present per unit mass (for example, 1 g) of a solid article (number / g), and (b) possessing pathogens in all solid articles The ratio (%) of the solid article that is used is adopted. The number of pathogens is measured by (a) extracting pathogens held by solid articles, growing them on a plate, etc., and measuring the number of colonies and plaques. Pathogens that can be observed in light and electron microscopes such as pathogenic animal eggs are measured using light and electron microscopes. Use a method such as direct measurement of pathogens.

  Since the iodine gas sterilization method has high sterilization efficiency, the pathogen concentration of the solid article after iodine gas sterilization is preferably 1.0 times or less, more preferably 0.9 times or less of the critical concentration of the pathogen necessary for pathogenesis of the solid article. More preferably, 0.8 times or less can be realized.

  Moreover, since the iodine gas sterilization method has high sterilization efficiency, the ratio (sterilization rate,%) killed by sterilization of the pathogen present per unit mass (for example, 1 g) of the solid article is high, preferably 60% or more, More preferably 80% or more, still more preferably 90% or more, and in some cases 98% or more can be realized.

  Furthermore, since the iodine gas sterilization method has a high sterilization efficiency, the proportion of solid articles having a pathogen in all solid articles after sterilization (bacterial retention rate,%) is low, preferably 80% or less, more preferably 70%. Hereinafter, more preferably 60% or less can be realized.

(Iodine gas sterilization method)
As a specific form of the sterilization method using iodine gas, (a) as a first form, iodine is generated by sublimating solid iodine in a gaseous medium, and this iodine gas is mixed with the gaseous medium. The gas is brought into contact with the solid article. (B) As a second form, a liquid containing iodine is sprayed on the solid article, and iodine is distributed from the liquid to the gas phase part to generate iodine gas. (C) As a third form, solid iodine is mixed with a solid article, the solid iodine is sublimated, iodine gas is generated, and the solid article is brought into contact. Hereinafter, each form is demonstrated.

(A) 1st form In FIG. 1, as an example of an apparatus for the 1st form, the iodine gas generation part 110, the iodine gas generated in the iodine gas generation part, and a solid article are contacted, and a solid article is sterilized. A sterilization apparatus including the solid article sterilization unit 111 is shown. The entire apparatus is sucked by the pump 116, and the gas medium 113 is introduced into the iodine gas generation unit. The flow rate of the gaseous medium is controlled by the valve 114 and measured by the flow meter 115. The iodine gas generating part is filled with solid iodine, and the solid iodine is sublimated to generate iodine gas, and this iodine gas is transported to the solid article sterilization part 111 by a gas medium air flow. The solid article sterilization unit is filled with the solid article, and the solid article is sterilized by contacting iodine gas with the solid article.

  In addition, as a gaseous medium, air, humidified air, dry air, nitrogen, helium, argon, carbon dioxide, C1-C5 unsaturated and saturated hydrocarbon, etc. are used, and these are used together as needed. You can also.

  As solid iodine, flake products (flaky products), prill products (spherical products), granule products (square granular products), etc. are used. Prill is preferred because of the occurrence of

  Furthermore, the iodine gas generating part is preferably a replaceable cassette filled with solid iodine. This is because new solid iodine can be safely and easily installed after all solid iodine is used.

  The solid article sterilization part is a container in which the solid article is charged, and it is desirable that the iodine gas transported and introduced by the gas medium air flow in the solid article sterilization part is in uniform contact with the solid article, while the solid article is being stirred. A structure that is sterilized by contact with iodine gas is preferred. In this case, since the solid article is agitated during sterilization, sterilization proceeds efficiently and uniformly. In addition, when introducing a gas containing iodine gas, the flow rate is increased and the solid article can be sterilized under the condition of stirring with an air flow, so that no further stirring means is required, so the sterilization apparatus becomes complicated. In addition, the airtightness of the apparatus is not lowered.

  In order to prevent solid iodine from condensing and crystallizing on the solid article in the solid article sterilization section, it is preferable to control the temperature of the solid article sterilization section to be equal to or higher than the temperature of the iodine gas generation section. In the case of the sterilization apparatus of FIG. 1, the temperature of the iodine gas generation unit is controlled by the temperature controller 117, and the temperature of the solid article sterilization unit is controlled by the temperature controller 118.

  If necessary, a means 112 for removing iodine in the discarded gas is provided. As the iodine gas removing means, for example, an alkali absorption method such as a 1% by mass sodium hydroxide aqueous solution, a reducing agent absorption method such as a sodium thiosulfate aqueous solution, an adsorption method using an adsorbent such as activated carbon, or the like is used.

  In addition, if at least one of the iodine gas generation unit and the solid article sterilization unit has means for diluting iodine gas, a wider range of iodine gas concentrations can be realized, and the treatment is performed with particularly low concentration iodine gas. The case is suitable, and the operability of adjusting the iodine gas concentration is improved. For example, as shown in FIG. 1, the second gaseous medium 122 is introduced and mixed through a three-way cock 119 to dilute iodine gas. The flow rate of the second gas medium is controlled by the valve 121 and measured by the flow meter 120.

  Furthermore, if such a structure is adopted, a gas not containing iodine gas such as the second gas medium can be introduced into the solid article sterilization unit by operating the three-way cock after the sterilization is completed. As a result, solid iodine remaining in the solid article can be sublimated and removed.

  In addition, it is preferable that the site | part which contacts iodine gas is comprised by at least any one of glass and non-corrosive resin, in order to suppress the corrosion by iodine gas. As the non-corrosive resin, vinyl chloride resin, fluorine resin, or the like is used.

  In the case of the sterilization apparatus shown in FIG. 1 as described above, iodine gas generated from the iodine gas generation unit passes through the solid article sterilization unit, and then is removed by the iodine gas removal means and discarded. is there. For this reason, there exists a possibility that the use efficiency of iodine gas may become inadequate. On the other hand, after the iodine gas in the apparatus reaches a predetermined concentration, the use efficiency of iodine gas can be improved by adopting a so-called circulation system in which a gas medium containing iodine gas is circulated through a path passing through the solid article sterilization unit. .

  FIG. 2 shows an example of a circulation type sterilizer. The iodine gas generation unit 210, the solid article sterilization unit 211, and the iodine gas removal unit 212 are the same as those in FIG. In the case of the sterilizer of FIG. 2, first, the corrosion-resistant pump 221 is operated, the three-way cock 213 is operated, and the gaseous medium 216 is introduced into the sterilizer. At this time, the three-way cock 218 is operated to introduce the gas medium into the iodine gas generation unit, the three-way cock 219 is operated to be introduced into the solid article sterilization unit, and the three-way cock 220 is operated to remove the gas medium from the corrosion-resistant pump side. To transport. Thereafter, the three-way cock 213 is operated to stop the introduction of the gas medium 216, and the gas medium is circulated in a sealed path passing through the iodine gas generation unit and the solid article sterilization unit. The flow rate of the gaseous medium is controlled by flow meters 214 and 217.

  When the circulation of the gaseous medium is continued, the concentration of iodine gas increases while sterilization proceeds. When the iodine gas concentration reaches a predetermined value, the three-way cock 218 is operated so that the gaseous medium does not pass through the iodine gas generating part, and in the sealed path passing through the solid article sterilizing part without passing through the iodine gas generating part. Circulate the gaseous medium further and continue sterilization. In the case of loss due to adsorption to a solid article or the like during the treatment, iodine is supplied into the switching gas medium so that the circulation path of the gas medium is introduced into the iodine gas sterilization unit. Thus, if it processes by an airflow circulation type, since the iodine of an iodine gas generation part is not sublimated wastefully, the consumption of iodine can be reduced.

  A gas medium containing a predetermined concentration of iodine gas is circulated for a predetermined time, and sterilization is terminated. Thereafter, the three-way cock 213 is operated to introduce the gaseous medium 216 again into the sterilizer. At this time, the three-way cock 218 is operated to prevent the gaseous medium from being introduced into the iodine gas generation unit, the gaseous medium not containing iodine gas is introduced into the solid article sterilization unit, and the three-way cock 220 is operated to remove the gaseous medium. Introduce into iodine gas removal means. By introducing a gaseous medium not containing iodine gas into the solid article sterilization section, solid iodine remaining in the solid article is sublimated and removed.

  In the case of the sterilizer of FIG. 2, the temperature of the iodine gas generation unit is controlled by the temperature controller 222, the temperature of the solid article sterilization unit is controlled by the temperature controller 223, and the temperature of the solid article sterilization unit is generated by iodine gas. The temperature is set to be equal to or higher than the temperature of the part, and iodine is condensed and solidified in the solid article sterilization part to suppress crystallization on the solid article.

  Moreover, it is preferable that the site | part which contacts iodine gas is comprised with at least any one of glass and non-corrosive resin, in order to suppress the corrosion by iodine gas. As the non-corrosive resin, vinyl chloride resin, fluorine resin, or the like is used.

(A) Second form As an example of the apparatus for the second form, a solid article sprayed with an iodine-containing liquid is put into a container, and iodine gas is distributed to a gas phase portion in the container to sterilize the solid article. There is a device to do. Such an apparatus is considered suitable for a batch type.

  The iodine-containing liquid is preferably a liquid that has high volatility such as water and alcohols and does not deteriorate the performance of the solid article.

  In addition, from the viewpoint of suppressing iodine from condensing at the site where the solid article is sterilized, it is preferable to adjust the temperature of the site where the solid article is sterilized with iodine gas.

  Furthermore, it is preferable that the part which contacts iodine gas is comprised with at least any one of glass and non-corrosive resin, in order to suppress the corrosion by iodine gas. As the non-corrosive resin, vinyl chloride resin, fluorine resin, or the like is used.

(C) Third form As an example of the apparatus for the third form, solid iodine and a solid article are mixed in a container, and iodine gas is distributed to the gas phase portion in the container to sterilize the solid article. There is. Such an apparatus is considered suitable for a batch type.

  In the case of the third embodiment, as in the case of the second embodiment, the temperature of the portion for sterilizing the solid article with iodine gas is controlled from the viewpoint of suppressing iodine from condensing on the portion for sterilizing the solid article. Is preferred.

  Further, as in the case of the second embodiment, the portion in contact with iodine gas is preferably composed of at least one of glass and non-corrosive resin in order to suppress corrosion by iodine gas. As the non-corrosive resin, vinyl chloride resin, fluorine resin, or the like is used.

(Disinfection conditions for iodine gas sterilization)
Sterilization conditions such as iodine gas concentration, sterilization temperature, sterilization time, and agitation conditions are carefully optimized to achieve sufficient sterilization without compromising the performance of the solid article. Among these sterilization conditions, optimization of iodine gas concentration, sterilization temperature, and sterilization time is important.

  The concentration of iodine gas is preferably 10 ppm by volume or more, more preferably 1,000 ppm by volume or more, from the viewpoint of realizing a sufficient sterilizing effect. On the other hand, from the viewpoint of suppressing a large amount of iodine from remaining on the surface of the solid article and ensuring safety even when iodine gas leaks, it is preferably 10,000 ppm by volume or less, and 5,000 ppm by volume. The following is more preferable, and 2,000 ppm by volume or less is still more preferable.

  Depending on the type of the solid article, a sufficient sterilizing effect can be realized with a low concentration of iodine gas, or iodine may easily remain on the surface. In the case of such a solid article, the iodine gas concentration is lowered, and the lower limit thereof is preferably 0.1 ppm by volume or more, more preferably 1 ppm by volume or more, and still more preferably 10 ppm by volume or more.

  Although it depends on the concentration of iodine gas, the sterilization time is preferably 10 minutes or more, more preferably 60 minutes or more, and still more preferably 120 minutes or more from the viewpoint of realizing a sufficient sterilization effect. On the other hand, from the viewpoint of suppressing a large amount of iodine from remaining on the surface of the solid article and improving work efficiency, it is preferably 24 hours or shorter, more preferably 12 hours or shorter, and even more preferably 6 hours or shorter.

  Depending on the type of the solid article, there may be a case where a sufficient sterilizing effect can be realized by a short time treatment, or iodine may easily remain on the surface. In the case of such a solid article, the sterilization time is shortened, and the lower limit thereof is preferably 1 second or longer, more preferably 10 seconds or longer, and further preferably 1 minute or longer.

  On the other hand, depending on the type of solid article, a long time treatment may be required for a sufficient sterilizing effect, or iodine may not easily remain on the surface. In the case of such a solid article, the sterilization time is lengthened, and the upper limit thereof is preferably 1 month or less, more preferably 7 days or less, and further preferably 3 days or less.

  The sterilization temperature is preferably 0 ° C. or higher, more preferably 10 ° C. or higher, from the viewpoint of realizing a sufficient sterilizing effect. On the other hand, from the viewpoint of suppressing the deterioration of the performance of the solid article, 80 ° C. or lower is preferable, 60 ° C. or lower is more preferable, and 40 ° C. or lower is further preferable.

  Furthermore, as an indicator of sterilization conditions, the product of iodine gas concentration and sterilization time is preferably 100 ppm by volume or more from the viewpoint of realizing a sufficient sterilization effect, while a large amount of iodine is applied to the surface of the solid article. From the viewpoint of suppressing remaining and improving work efficiency, 50,000 ppm by volume or less is preferable.

  The sterilization methods are roughly classified into a method of sterilizing for a long time with low-concentration iodine gas and a method of sterilizing for a short time with high-concentration iodine gas. Of these methods, iodine gas is sufficiently sealed. Then, the method of sterilizing for a short time with high-concentration iodine gas is preferable from the viewpoint of suppressing iodine gas from penetrating into the solid article and reducing the performance of the solid article. As a specific example of such conditions, for example, the treatment is performed with iodine gas of 3,500 to 5,000 volume ppm for 30 to 90 minutes. Moreover, if such conditions are employed, the solid article can be sufficiently sterilized.

(Characteristics of iodine gas sterilization method)
In addition to sufficient sterilization without impairing the performance of the solid article, the iodine gas sterilization method has the following advantages over the existing sterilization methods.

  (A) Compared with chemical immersion, cleaning and drying after sterilization and disposal of chemicals are not necessary.

  (A) Suitable for solid articles that deteriorate when immersed in chemicals.

  (C) Suitable for solid articles such as dry heat sterilization and steam sterilization, in which the performance of the solid article decreases when heated.

  (D) Compared with fumigation treatment, gas treatment after treatment is easy, no harmful substances are generated, and safety is high.

  Furthermore, the iodine gas sterilization method has the following advantages.

  (E) Although a small amount of iodine is considered to be adsorbed on the solid article after sterilization, the sterilization effect is retained by the adsorbed iodine.

  (F) Residual iodine adsorbed on the solid article is safe because it volatilizes little by little without irritation and corrosion.

  (G) Iodine used for sterilization is an element, and since it is an essential element for humans, it is less harmful to the human body.

  (H) Since the spectrum of pathogenic bacteria that can be sterilized by iodine gas is wide, molds, bacteria, viruses, nematodes and the like can be sterilized by a single treatment.

  Hereinafter, the present invention will be described in more detail with reference to examples. Unless otherwise specified, commercially available high-purity products were used as reagents.

(Example 1) Sterilized eggs Salmonella enteritidis (SE bacteria) present in chicken eggs is sterilized with iodine gas. SE bacteria cause acute gastroenteritis in humans and are one of the causative bacteria of food poisoning.

  First, the air containing iodine gas is circulated while passing through the iodine gas generation part and the solid article sterilization part where the egg is stored, and after the iodine concentration reaches 5,000 ppm, it passes only through the solid article sterilization part. Circulation was continued, and after 40 minutes, air containing no iodine gas was introduced into the solid article sterilization unit. The concentration of iodine gas is calculated by measuring the iodine concentration in the absorbing solution and the gas flow rate.

  SE bacteria possessed by chicken eggs obtained as described above are detected. First, a chicken egg is put into a sterilized physiological saline to suspend SE bacteria. This suspension is diluted to an appropriate amount with sterilized physiological saline, and the diluted solution is applied to a selective medium of SE bacteria. Thereafter, the cells are cultured, and the colonies of SE bacteria produced on the medium are measured for the culture sample having a dilution ratio that can be measured, and converted into the number of pathogenic bacteria (g / g) per gram of chicken egg. The critical concentration at which SE bacteria cause acute gastroenteritis in humans is considered to be 400,000 SE bacteria / 1 g chicken egg.

  The solid iodine remaining in the egg sterilized with iodine gas is below the detection limit, and deterioration of the appearance and flavor of the contents is not confirmed. Moreover, the density | concentration of SE bacteria after sterilization is 5,000 pieces / g egg, and the critical concentration is 0.01, and sterilization is enough.

(Example 2) Sterilized sand The roundworm eggs present in the sand are sterilized with iodine gas.

  First, air containing iodine gas is circulated while passing through the iodine gas generation unit and the solid article sterilization unit in which sand is stored, and after the iodine concentration reaches 5,000 ppm, it passes only through the solid article sterilization unit. Circulation is continued, and after 40 minutes, air containing no iodine gas is introduced into the solid article sterilization unit. The concentration of iodine gas is calculated by measuring the iodine concentration in the absorbing solution and the gas flow rate.

  The moldable roundworm eggs possessed by the sand obtained as described above are detected by microscopic observation after the sand is incubated.

  Solid iodine remaining in the sand sterilized with iodine gas is below the detection limit, and no deterioration of the sand is confirmed. Further, the concentration of the roundworm eggs that can be processed before sterilization is 0.5 / g sand, the concentration of the roundworm eggs that can be processed after sterilization is 0 / g sand, and the sterilization rate is 100%. The retention rate is 0%, and sterilization is sufficient.

(Example 3)
Similarly, sterilize at 50 vol ppm for 5 minutes.

Example 4
Sterilize the slipper with iodine gas. Fungi such as ringworm can be sterilized by iodine gas.

(Example 5)
Sterilize cutting board and knife with iodine gas.

  By using the iodine gas sterilization method, the sterilizing agent can be sterilized at a very high sterilization rate without leaving the sterilizing agent on the solid article and without deteriorating the solid article, and a high quality and stable solid article can be provided. .

It is a typical sectional view for explaining an iodine gas sterilizer. It is a typical sectional view for explaining an iodine gas sterilizer.

Explanation of symbols

DESCRIPTION OF SYMBOLS 110 Iodine gas generation part 111 Solid article sterilization part 112 Iodine gas removal means 113 Gas medium 114 Valve 115 Flow meter 116 Pump 117 Temperature controller 118 Temperature controller 119 Three-way cock 120 Flow meter 121 Valve 122 Second gas medium 210 Iodine gas generation Section 211 Solid article sterilization section 212 Iodine gas removing means 213 Three-way cock 214 Flowmeter 215 Valve 216 Gas medium 217 Flowmeter 218 Three-way cock 219 Three-way cock 220 Three-way cock 221 Pump 222 Temperature controller 223 Temperature controller

Claims (10)

  Solid article sterilized with iodine gas.   Livestock products, marine products, insect-related goods, luxury goods, play goods, leisure goods, medical equipment, dental goods, baby goods, hygiene goods, clothing, decorations, linen goods, stationery, daily necessities, cooking goods, sports The solid article according to claim 1, comprising at least one selected from the group consisting of goods, pet-related goods, home appliances, travel goods, and cards.   A method for sterilizing solid articles with iodine gas.   4. The solid article sterilization method according to claim 3, wherein the iodine gas is generated by sublimating solid iodine in a gaseous medium, and the mixed gas of the iodine gas and the gaseous medium is brought into contact with the solid article.   4. The solid article sterilization method according to claim 3, wherein the iodine gas is generated by distributing the iodine gas to a gas phase part from an iodine-containing liquid sprayed on the solid article.   4. The solid article sterilization method according to claim 3, wherein the iodine gas is generated by sublimating solid iodine mixed with the solid article.   The method for sterilizing a solid article according to any one of claims 3 to 6, wherein the iodine gas has a concentration of 0.1 to 10,000 ppm by volume.   The method for sterilizing a solid article according to any one of claims 3 to 7, wherein the sterilization time with iodine gas is 1 second to 1 month.   The solid product sterilization method according to any one of claims 3 to 8, wherein the product of the concentration of iodine gas and the sterilization time is 100 ppm by volume to 50,000 ppm by volume.   The method for sterilizing a solid article according to any one of claims 3 to 9, wherein the sterilization temperature by the iodine gas is 0 to 80 ° C.

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