JP2005027930A - Bone substitute - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To easily and inexpensively ensure bone substitute at a defective part at a bone of a human body. <P>SOLUTION: In a pseudo body liquid 2 adjusted to an original component, β-TCP is settled by discharging in liquid. When the supernatant of the slurry of β-TCP is removed, β-TCP of the slurry which is alkali of PH 11 etc is generated. It is added with collagen solution treated with hydrochloric acid and mixed, thereby curing is started by neutralization reaction. Finally, compound material of hydroxyapatite is formed in the state of agar to obtain the bone anaplerotic material. Curing occurs early only by β-TCP obtained by polymerization reaction of phosphoric acid, and hydrogen bond of collagen, and uniform bone replenishment is realized by utilizing β-TCP. In addition. Since the bone substitute is easily cured even when including water, anaplerosis is possible even at a bleeding site, and the material can be utilized also as the carrier of another drug. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The disclosed technology belongs to the field of production technology for bone replacement in which a damaged portion of a bone such as a jawbone in a human body is in a natural bone state.

There are bones that form important components such as the jawbone inside the human body, but the bones may be significantly missing due to excessive cutting or traffic accidents during medical treatment, etc. Various bone filling techniques have been developed as follows, which fill a bone portion and integrate it with the surrounding bone portion.
Soichiro Ito et al. `` Development of an artificial vertebralbody using a novel biomaterial, hydroxyapatite / collagen composite '' BiomaterialsVolume 23 Issue 19 P3919-3926 (October 2002) Myung Chui Chang et al. “FT-IR study for hydroxyapatite / collagen nanocomposite cross-linked by glutaraldehyde” Biomaterials Volume 23, Issue 24 P4811-4818 (December 2002) Myung Chui Chang et al. “XPS study for the microstructure development of hydroxyapatite-collagen nanocomposites cross-linked using glutaraldehyde” Biomaterials Volume 23 Isuue 18 P3879-3885 (October 2002) Yong Zhang et al., Calcium phosphate / chitosanc composite scaffolds for controlled in vitro antibiotic drug release, Journal of Biomedical Materials Research Volume 62 Issue 3 P378-386 (December 2002). Despite being composed of a complex of collagen, what has been studied by other researchers so far is merely a mixture of hydroxyapatite and a collagen solution. Even if it is a mixture of calcium hydroxide, phosphoric acid solution, and collagen, it will only be solated, so that it does not harden as a complex, and glutaraldehyde etc. may be added alternately. , It must be irradiated with ultraviolet rays, and it has the disadvantage of being extremely expensive, so it cannot be a composite , Β-TCP has a demerit that has not been studied at all.

  Then, the simple mixture is simply made into a block after freeze-drying and then molded and filled appropriately, and there is a difficulty that it is impossible to fill the chair side during treatment.

  In addition, there is a disadvantage that the cost becomes high due to the use of ultraviolet rays and the practicality is low.

  In order to freeze-dry and fill these admixtures, there are restraining conditions such as the use of a plate such as a work in terms of form, and there is a disadvantage that the practicality is poor.

  The object of the invention of this application is that it cannot be made into a complex by simply mixing the hydroxyapatite and collagen solution based on the above-mentioned prior art, and it can be bone-filled freely in view of the fact that it cannot be applied to actual biology, and the cost In particular, it is intended to provide an excellent bone prosthetic material that is beneficial to the technical field of processing technology in the medical hygiene industry so that it is cheap and easy to operate.

  In order to solve the above-mentioned problems, the composition of the invention of the present application, which is summarized in the scope of the above-mentioned claims along the above-mentioned object, is a bone grafting material having β-TCP obtained from a mixture of a simulated body fluid and a collagen solution. The basis is to be a complex composed of β-TCP and collagen obtained from the simulated body fluid adjusted to the original component, and the β-TCP is obtained by submerged discharge in the simulated body fluid And β-TCP is an alkaline slurry, and technical measures are taken to allow the composite to be formed on the chair side.

  As an effect of the invention of this application, there is no constraint condition of the form such as using a block shaped like the conventional one, it can be appropriately kneaded and filled, and it can be operated at the chair side at the time of treatment There is an effect of high practicality that it is easily performed.

  There is an effect that it can be hardened rapidly in a very short time by simply mixing β-TCP and a collagen solution.

  Pseudo body fluids (m · SBF-) containing sodium, phosphorus, calcium, potassium ions, etc., which have essentially the same components as the body fluids, are precipitated in the body by discharging the pseudo body fluids. Precipitate.

By discarding the supernatant of the electrolyzed solution, an alkaline β-TCP slurry is obtained.
The alkali β-TCP slurry is neutralized by adding a collagen solution previously oxidized with hydrochloric acid and mixing, and then the hardening is started and finally agar-like hydroxyapatite and collagen complex Is cured in a short time of about 30 seconds, and the bone grafting is formed as a result of the progress of the polymerization reaction of phosphoric acid and the crosslinking reaction by hydrogen bonding of collagen.

  At this time, since the aqueous solution hardens even if it contains water, it can be filled even if the filling site is a bleeding site, and can be used as a carrier for other drugs.

  Next, embodiments of the invention of this application will be described as embodiments of the present invention with reference to the drawings.

表１に示す通りに、枠内でオリジナル成分に調整した水分を有する当該表１のm・SBF-で
示す擬似体液２を作成し、図１に示す様に、電気分解槽１内に擬似体液２を所定量収納し、該擬似体液２中にプラチナの陰極４とその対面にプラチナの陽極５を浸漬させて電源３より１００ボルトで２アンペアで液中放電を行い液中の成分を沈殿させると、底部分にβ−ＴＣＰリン酸カルシウムのβ型６が沈殿する。そして当該溶液分の上澄部分を除去すると、アルカリの（ＰＨ１１程度の）β−ＴＣＰのスラリー６が沈殿分として出来る。

As shown in Table 1, a simulated body fluid 2 indicated by m · SBF- in Table 1 having moisture adjusted to the original component within the frame is prepared, and the simulated body fluid is stored in the electrolysis tank 1 as shown in FIG. 2 is stored, and a platinum cathode 4 and a platinum anode 5 are immersed in the simulated body fluid 2 and discharged from the power source 3 at 100 volts at 2 amps to precipitate components in the liquid. Then, β-TCP calcium phosphate β-type 6 precipitates at the bottom. When the supernatant portion of the solution is removed, an alkaline (about PH11) β-TCP slurry 6 can be formed as a precipitate.

  When the collagen solution (not shown) previously oxidized with hydrochloric acid is mixed with the precipitate 6, a neutralization reaction begins, liquefaction hardening begins, and an agar-like hydroxyapatite / collagen complex is formed. can get.

  According to experimental data, the curing time was about 30 seconds, and it was sufficiently practical.

  As a result, it was found that the composite sufficiently withstands practical use as bone replacement.

  And since a composite_body | complex is solid even if it contains water, it can be filled enough also in a bleeding site practically.

  As described above, according to the bone filling of the present invention, even if it contains water, it hardens, so that it is possible to sufficiently fill even the bleeding site of the human body.

  And there exists an advantage which can be utilized also as carriers of other chemical | medical agents, such as medicines, such as antibiotics.

  And since it is very cheap in terms of cost, it is extremely practical in terms of speed.

  And the superposition | polymerization reaction of phosphoric acid and the crosslinking reaction by the hydrogen bond of collagen show the outstanding effect which can arise only by (beta) -TCP.

  And there is an advantage that you can use the chair side during treatment

It is a perspective view of the submerged discharge.

Explanation of symbols

1 Electrolysis tank 2 Simulated body fluid 3 Power supply 4 Platinum (cathode)
5 Platinum (Anode)
6 Precipitation

Claims (4)

A bone filling material having β-TCP obtained from a mixture of a simulated body fluid and a collagen solution, wherein the bone filling material is a composite comprising β-TCP and collagen obtained from the simulated body fluid adjusted to the original component. Wood. The bone grafting material according to claim 1, wherein the β-TCP is obtained by submerged discharge in the simulated body fluid. The bone grafting material according to claim 1, wherein the β-TCP is an alkaline slurry. 2. The bone grafting material according to claim 1, wherein the composite is formed on a chair side.

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