JP2004536558A - Ｓｒｃ−２発現のアンチセンスモジュレーション - Google Patents

Ｓｒｃ−２発現のアンチセンスモジュレーション Download PDF

Info

Publication number
JP2004536558A
JP2004536558A JP2002545129A JP2002545129A JP2004536558A JP 2004536558 A JP2004536558 A JP 2004536558A JP 2002545129 A JP2002545129 A JP 2002545129A JP 2002545129 A JP2002545129 A JP 2002545129A JP 2004536558 A JP2004536558 A JP 2004536558A
Authority
JP
Japan
Prior art keywords
acid
src
oligonucleotide
oligonucleotides
antisense
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2002545129A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004536558A5 (enExample
Inventor
オモーリー，バート・ダブリュー
ベネット，フランク・シー
カウサート，レックス・エム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Ionis Pharmaceuticals Inc
Original Assignee
Baylor College of Medicine
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine, Isis Pharmaceuticals Inc filed Critical Baylor College of Medicine
Publication of JP2004536558A publication Critical patent/JP2004536558A/ja
Publication of JP2004536558A5 publication Critical patent/JP2004536558A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002545129A 2000-11-27 2001-11-26 Ｓｒｃ−２発現のアンチセンスモジュレーション Withdrawn JP2004536558A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72353000A 2000-11-27 2000-11-27
PCT/US2001/044220 WO2002042423A2 (en) 2000-11-27 2001-11-26 Antisense modulation of src-2 expression

Publications (2)

Publication Number Publication Date
JP2004536558A true JP2004536558A (ja) 2004-12-09
JP2004536558A5 JP2004536558A5 (enExample) 2005-05-19

Family

ID=24906651

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002545129A Withdrawn JP2004536558A (ja) 2000-11-27 2001-11-26 Ｓｒｃ−２発現のアンチセンスモジュレーション

Country Status (4)

Country Link
EP (1) EP1343913A2 (enExample)
JP (1) JP2004536558A (enExample)
AU (1) AU2002237678A1 (enExample)
WO (1) WO2002042423A2 (enExample)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8142198A (en) * 1997-06-12 1998-12-30 Regents Of The University Of California, The A transcription factor coactivator protein, p/cip

Also Published As

Publication number Publication date
WO2002042423A2 (en) 2002-05-30
EP1343913A2 (en) 2003-09-17
WO2002042423A3 (en) 2003-01-30
AU2002237678A1 (en) 2002-06-03

Similar Documents

Publication Publication Date Title
JP4054192B2 (ja) Ｐｔｐ１ｂ発現のアンチセンス阻害
JP4397585B2 (ja) クラスタリン発現のアンチセンスモジュレーション
JP2003505351A (ja) Ｍａｐキナーゼキナーゼ６発現のアンチセンスモジュレーション
JP2004509619A (ja) Ｆｌｉｐ−ｃ発現のアンチセンスモジュレーション
JP2003520241A (ja) Ｍｅｋｋ２発現のアンチセンスモジュレーション
JP2003520584A (ja) カスパーゼ３発現のアンチセンスモジュレーション
JP2003503048A (ja) Ｓｈｉｐ−２発現のアンチセンスモジュレーション
JP2003520586A (ja) Ｓｍａｄ７発現のアンチセンスモジュレーション
JP2003505027A (ja) Ｐｉ３キナーゼｐ１１０デルタ発現のアンチセンスモジュレーション
JP2003520042A (ja) 誘導性一酸化窒素シンターゼ発現のアンチセンスモジュレーション
JP2003505062A (ja) Ｐｔｅｎ発現のアンチセンスモジュレーション
AU768799B2 (en) Antisense modulation of integrin-linked kinase expression
JP2003505063A (ja) Ｍｅｋｋ５発現のアンチセンスモジュレーション
JP2003508089A (ja) ＰＩ３キナーゼｐ１１０ベータ発現のアンチセンスモジュレーション
JP2003520585A (ja) ペルオキシソーム増殖因子−活性化受容体ガンマ発現のアンチセンスモジュレーション発現のアンチセンスモジュレーション
JP2003505092A (ja) Ｓｈｐ−２発現のアンチセンスモジュレーション
JP2003520051A (ja) Ｐｅｐｃｋ−サイトゾル発現のアンチセンスモジュレーション
JP2003505026A (ja) 肝臓グリコーゲンホスホリラーゼ発現のアンチセンスモジュレーション
JP2003525058A (ja) Ｅ２ｆ転写因子１発現のアンチセンスモジュレーション
JP2003531630A (ja) Ｄｎａ結合阻害剤−１発現のアンチセンスモジュレーション
JP2004503232A (ja) Ｃ／ＥＢＰβ発現のアンチセンスモジュレーション
JP2003518928A (ja) Ａｋｔ−３発現のアンチセンスモジュレーション
JP2003527085A (ja) Ｐｅｐｃｋ−ミトコンドリア発現のアンチセンスモジュレーション
JP2003512079A (ja) タンパク質キナーゼｃ−シータ発現のアンチセンスモジュレーション
JP2005525829A (ja) 糖質コルチコイド受容体発現のアンチセンス調節

Legal Events

Date Code Title Description
A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20050204

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050328