JP2004535245A - 多孔質細胞外基質支持骨格材料および方法 - Google Patents
多孔質細胞外基質支持骨格材料および方法 Download PDFInfo
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Botany (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Dispersion Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30578601P | 2001-07-16 | 2001-07-16 | |
| US38876102P | 2002-06-14 | 2002-06-14 | |
| PCT/US2002/022393 WO2003007789A2 (en) | 2001-07-16 | 2002-07-15 | Porous extracellular matrix scaffold and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004535245A true JP2004535245A (ja) | 2004-11-25 |
| JP2004535245A5 JP2004535245A5 (enExample) | 2005-11-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003513403A Pending JP2004535245A (ja) | 2001-07-16 | 2002-07-15 | 多孔質細胞外基質支持骨格材料および方法 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1425024A4 (enExample) |
| JP (1) | JP2004535245A (enExample) |
| AU (1) | AU2002354915B8 (enExample) |
| WO (1) | WO2003007789A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010524458A (ja) * | 2007-04-17 | 2010-07-22 | 炳顯 閔 | 細胞由来細胞外マトリックス支持体の製造方法 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040081704A1 (en) | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
| CA2365376C (en) | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
| US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
| US20040078090A1 (en) | 2002-10-18 | 2004-04-22 | Francois Binette | Biocompatible scaffolds with tissue fragments |
| US8197837B2 (en) | 2003-03-07 | 2012-06-12 | Depuy Mitek, Inc. | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
| GB0307011D0 (en) | 2003-03-27 | 2003-04-30 | Regentec Ltd | Porous matrix |
| US8226715B2 (en) | 2003-06-30 | 2012-07-24 | Depuy Mitek, Inc. | Scaffold for connective tissue repair |
| US10583220B2 (en) * | 2003-08-11 | 2020-03-10 | DePuy Synthes Products, Inc. | Method and apparatus for resurfacing an articular surface |
| US7316822B2 (en) | 2003-11-26 | 2008-01-08 | Ethicon, Inc. | Conformable tissue repair implant capable of injection delivery |
| US11395865B2 (en) | 2004-02-09 | 2022-07-26 | DePuy Synthes Products, Inc. | Scaffolds with viable tissue |
| US8221780B2 (en) | 2004-04-20 | 2012-07-17 | Depuy Mitek, Inc. | Nonwoven tissue scaffold |
| US8137686B2 (en) | 2004-04-20 | 2012-03-20 | Depuy Mitek, Inc. | Nonwoven tissue scaffold |
| US8657881B2 (en) * | 2004-04-20 | 2014-02-25 | Depuy Mitek, Llc | Meniscal repair scaffold |
| FR2895675B1 (fr) * | 2006-01-03 | 2011-07-22 | Oreal | Composition cosmetique comprenant une huile |
| US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
| EP2907531A1 (en) * | 2008-07-30 | 2015-08-19 | Mesynthes Limited | Method of separating or decellularising layers of tissue |
| JP2013517292A (ja) * | 2010-01-14 | 2013-05-16 | オーガノジェネシス・インコーポレイテッド | 生物工学によって作られた組織コンストラクトならびにそれを生成および使用するための方法 |
| AU2011329054B2 (en) | 2010-11-15 | 2015-05-28 | Zimmer Orthobiologics, Inc. | Bone void fillers |
| GB201119173D0 (en) | 2011-11-07 | 2011-12-21 | Fujifilm Mfg Europe Bv | Porous tissue scaffolds |
| CN107281552A (zh) * | 2017-07-12 | 2017-10-24 | 上海白衣缘生物工程有限公司 | 一种用于引导骨再生的复合膜及其制备方法 |
| CN116059451B (zh) * | 2023-02-20 | 2024-08-30 | 青岛大学 | 一种具有三维多孔结构的气凝胶人工皮肤及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000032250A1 (en) * | 1998-12-01 | 2000-06-08 | Cook Biotech, Inc. | A multi-formed collagenous biomaterial medical device |
| JP2000508931A (ja) * | 1996-04-16 | 2000-07-18 | デピュイ オーソピーディックス,インコーポレイテッド | 組織修復用生体内受食性重合接着剤 |
| JP2000509084A (ja) * | 1996-04-16 | 2000-07-18 | デピュイ オーソピーディックス,インコーポレイテッド | インプラント製作用のポリエステルアイオノマー |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4610397A (en) * | 1983-10-27 | 1986-09-09 | Urschel Laboratories Incorporated | Comminuting equipment |
| CA1295796C (en) * | 1984-03-27 | 1992-02-18 | Conrad Whyne | Biodegradable matrix and methods for producing same |
| US4902508A (en) * | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
| US4956178A (en) * | 1988-07-11 | 1990-09-11 | Purdue Research Foundation | Tissue graft composition |
| US5281422A (en) * | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
| EP0656939B1 (en) * | 1992-08-07 | 2004-03-31 | TEI Biosciences, Inc. | Production of graft tissue from extracellular matrix |
| US5275826A (en) * | 1992-11-13 | 1994-01-04 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
| US5641518A (en) * | 1992-11-13 | 1997-06-24 | Purdue Research Foundation | Method of repairing bone tissue |
| US5352463A (en) * | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
| WO1995005083A1 (en) * | 1993-08-13 | 1995-02-23 | Smith & Nephew Richards Inc | Microporous polymeric foams and microtextured surfaces |
| US5916265A (en) * | 1994-03-30 | 1999-06-29 | Hu; Jie | Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant |
| US5891558A (en) * | 1994-11-22 | 1999-04-06 | Tissue Engineering, Inc. | Biopolymer foams for use in tissue repair and reconstruction |
| US5709934A (en) * | 1994-11-22 | 1998-01-20 | Tissue Engineering, Inc. | Bipolymer foams having extracellular matrix particulates |
| GB9721585D0 (en) * | 1997-10-10 | 1997-12-10 | Geistlich Soehne Ag | Chemical product |
| US5554389A (en) | 1995-04-07 | 1996-09-10 | Purdue Research Foundation | Urinary bladder submucosa derived tissue graft |
| US5711969A (en) * | 1995-04-07 | 1998-01-27 | Purdue Research Foundation | Large area submucosal tissue graft constructs |
| US5788625A (en) * | 1996-04-05 | 1998-08-04 | Depuy Orthopaedics, Inc. | Method of making reconstructive SIS structure for cartilaginous elements in situ |
| US6171344B1 (en) | 1996-08-16 | 2001-01-09 | Children's Medical Center Corporation | Bladder submucosa seeded with cells for tissue reconstruction |
| CA2267449C (en) | 1996-11-05 | 2008-10-14 | Purdue Research Foundation | Myocardial graft constructs |
| AU736572B2 (en) | 1996-12-10 | 2001-08-02 | Purdue Research Foundation | Artificial vascular valves |
| AU743779B2 (en) | 1996-12-10 | 2002-02-07 | Cook Biotech, Inc. | Tubular grafts from purified submucosa |
| WO1998025636A1 (en) | 1996-12-10 | 1998-06-18 | Purdue Research Foundation | Stomach submucosa derived tissue graft |
| CA2274033C (en) | 1996-12-10 | 2010-05-11 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
| US7087089B2 (en) * | 2001-06-28 | 2006-08-08 | Cook Biotech Incorporated | Graft prosthesis devices containing renal capsule collagen |
| US20030032961A1 (en) * | 2001-07-16 | 2003-02-13 | Pelo Mark Joseph | Devices from naturally occurring biologically derived materials |
-
2002
- 2002-07-15 AU AU2002354915A patent/AU2002354915B8/en not_active Ceased
- 2002-07-15 JP JP2003513403A patent/JP2004535245A/ja active Pending
- 2002-07-15 WO PCT/US2002/022393 patent/WO2003007789A2/en not_active Ceased
- 2002-07-15 EP EP02752339A patent/EP1425024A4/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000508931A (ja) * | 1996-04-16 | 2000-07-18 | デピュイ オーソピーディックス,インコーポレイテッド | 組織修復用生体内受食性重合接着剤 |
| JP2000509084A (ja) * | 1996-04-16 | 2000-07-18 | デピュイ オーソピーディックス,インコーポレイテッド | インプラント製作用のポリエステルアイオノマー |
| WO2000032250A1 (en) * | 1998-12-01 | 2000-06-08 | Cook Biotech, Inc. | A multi-formed collagenous biomaterial medical device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010524458A (ja) * | 2007-04-17 | 2010-07-22 | 炳顯 閔 | 細胞由来細胞外マトリックス支持体の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1425024A4 (en) | 2007-04-18 |
| AU2002354915B2 (en) | 2008-03-20 |
| WO2003007789A2 (en) | 2003-01-30 |
| EP1425024A2 (en) | 2004-06-09 |
| WO2003007789A3 (en) | 2003-05-22 |
| AU2002354915B8 (en) | 2008-04-17 |
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