JP2004532218A - 徐放性プロフィールの変更 - Google Patents

徐放性プロフィールの変更 Download PDF

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Publication number
JP2004532218A
JP2004532218A JP2002580900A JP2002580900A JP2004532218A JP 2004532218 A JP2004532218 A JP 2004532218A JP 2002580900 A JP2002580900 A JP 2002580900A JP 2002580900 A JP2002580900 A JP 2002580900A JP 2004532218 A JP2004532218 A JP 2004532218A
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JP
Japan
Prior art keywords
sustained release
poly
biologically active
active agent
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002580900A
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English (en)
Japanese (ja)
Other versions
JP2004532218A5 (enExample
Inventor
ダシュ，ジェームス，アール．
ライリー，エム．，ガリー，アイ．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Controlled Therapeutics Inc
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Alkermes Controlled Therapeutics Inc
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Publication date
Application filed by Alkermes Controlled Therapeutics Inc filed Critical Alkermes Controlled Therapeutics Inc
Publication of JP2004532218A publication Critical patent/JP2004532218A/ja
Publication of JP2004532218A5 publication Critical patent/JP2004532218A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002580900A 2001-04-13 2002-03-19 徐放性プロフィールの変更 Pending JP2004532218A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/835,001 US6558702B2 (en) 2001-04-13 2001-04-13 Method of modifying the release profile of sustained release compositions
PCT/US2002/008440 WO2002083096A1 (en) 2001-04-13 2002-03-19 Modification of the sustained release profile

Publications (2)

Publication Number Publication Date
JP2004532218A true JP2004532218A (ja) 2004-10-21
JP2004532218A5 JP2004532218A5 (enExample) 2005-12-22

Family

ID=25268316

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002580900A Pending JP2004532218A (ja) 2001-04-13 2002-03-19 徐放性プロフィールの変更

Country Status (6)

Country Link
US (3) US6558702B2 (enExample)
EP (1) EP1395240A4 (enExample)
JP (1) JP2004532218A (enExample)
AU (1) AU2002244314B2 (enExample)
CA (1) CA2444421A1 (enExample)
WO (1) WO2002083096A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015143259A (ja) * 2011-04-25 2015-08-06 シャントン ルーイエ ファーマシューティカル カンパニー リミテッド リスペリドン徐放性ミクロスフェア組成物

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US7456254B2 (en) * 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015143259A (ja) * 2011-04-25 2015-08-06 シャントン ルーイエ ファーマシューティカル カンパニー リミテッド リスペリドン徐放性ミクロスフェア組成物
US9532991B2 (en) 2011-04-25 2017-01-03 Shandong Luye Pharmaceutical Co., Ltd. Risperidone sustained release microsphere composition
US10098882B2 (en) 2011-04-25 2018-10-16 Shandong Luye Pharmaceutical Co., Ltd. Risperidone sustained release microsphere composition
US10406161B2 (en) 2011-04-25 2019-09-10 Shandong Luye Pharmaceutical Co., Ltd. Risperidone sustained release microsphere composition
US11110094B2 (en) 2011-04-25 2021-09-07 Shandong Luye Pharmaceutical Co., Ltd. Risperidone sustained release microsphere composition

Also Published As

Publication number Publication date
CA2444421A1 (en) 2002-10-24
US20030236192A1 (en) 2003-12-25
US20040147488A1 (en) 2004-07-29
EP1395240A1 (en) 2004-03-10
US6558702B2 (en) 2003-05-06
AU2002244314B2 (en) 2006-10-05
WO2002083096A1 (en) 2002-10-24
US7074432B2 (en) 2006-07-11
US20030004100A1 (en) 2003-01-02
EP1395240A4 (en) 2005-11-09

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